TWI689490B - 用於治療纖維化之經取代之芳族化合物及相關方法 - Google Patents
用於治療纖維化之經取代之芳族化合物及相關方法 Download PDFInfo
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- TWI689490B TWI689490B TW103108723A TW103108723A TWI689490B TW I689490 B TWI689490 B TW I689490B TW 103108723 A TW103108723 A TW 103108723A TW 103108723 A TW103108723 A TW 103108723A TW I689490 B TWI689490 B TW I689490B
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- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
- C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Biotechnology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798269P | 2013-03-15 | 2013-03-15 | |
| US61/798,269 | 2013-03-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201441186A TW201441186A (zh) | 2014-11-01 |
| TWI689490B true TWI689490B (zh) | 2020-04-01 |
Family
ID=51535669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW103108723A TWI689490B (zh) | 2013-03-15 | 2014-03-12 | 用於治療纖維化之經取代之芳族化合物及相關方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10023518B2 (OSRAM) |
| EP (1) | EP2970089B1 (OSRAM) |
| JP (1) | JP6448562B2 (OSRAM) |
| KR (1) | KR102196721B1 (OSRAM) |
| CN (2) | CN110105200B (OSRAM) |
| AR (1) | AR095429A1 (OSRAM) |
| AU (1) | AU2014231648B2 (OSRAM) |
| BR (1) | BR112015022008A2 (OSRAM) |
| CA (1) | CA2905621C (OSRAM) |
| CL (1) | CL2015002535A1 (OSRAM) |
| DK (1) | DK2970089T3 (OSRAM) |
| EA (1) | EA030651B1 (OSRAM) |
| ES (1) | ES2741439T3 (OSRAM) |
| IL (1) | IL241178B (OSRAM) |
| MX (1) | MX379424B (OSRAM) |
| MY (1) | MY180305A (OSRAM) |
| NZ (1) | NZ712797A (OSRAM) |
| PH (1) | PH12015502011B1 (OSRAM) |
| PL (1) | PL2970089T3 (OSRAM) |
| PT (1) | PT2970089T (OSRAM) |
| SG (1) | SG11201507408XA (OSRAM) |
| TW (1) | TWI689490B (OSRAM) |
| UY (1) | UY35402A (OSRAM) |
| WO (1) | WO2014138906A1 (OSRAM) |
| ZA (1) | ZA201507061B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2943485B1 (en) | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| ME03780B (me) | 2013-01-15 | 2021-04-20 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| TWI689489B (zh) * | 2013-03-15 | 2020-04-01 | 英商邊緣生物科技有限公司 | 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物 |
| TW201605866A (zh) | 2013-08-23 | 2016-02-16 | 英塞特公司 | 可用作ｐｉｍ激酶抑制劑之呋喃并－及噻吩并－吡啶甲醯胺化合物 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
| TWI699200B (zh) | 2014-10-10 | 2020-07-21 | 英商邊緣生物科技有限公司 | 用於預防及治療骨質疏鬆症之經取代之芳族化合物及醫藥組合物 |
| AU2015330643B2 (en) * | 2014-10-10 | 2020-05-14 | Liminal Biosciences Limited | Substituted aromatic compounds and pharmaceutical compositions for the prevention and treatment of diabetes |
| CN107106526B (zh) | 2014-11-12 | 2021-05-28 | 普罗米蒂克医药Smt有限公司 | 用于组织自修复和再生的经取代芳族化合物和药物组合物 |
| CN107614484B (zh) * | 2015-03-18 | 2020-09-25 | 维克图斯生物系统有限公司 | 用于治疗肾脏和/或肝脏疾病的组合物 |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| HK1254295A1 (zh) * | 2015-11-23 | 2019-07-19 | 默克专利股份有限公司 | 用於治疗纤维化和/或纤维化病症的抗-αＶ整合素抗体 |
| WO2017198114A1 (zh) * | 2016-05-19 | 2017-11-23 | 长弘生物科技股份有限公司 | 用于延缓肺纤维化的发病及/或治疗肺纤维化的药剂 |
| TW201822805A (zh) | 2016-12-15 | 2018-07-01 | 深圳瑞健生命科學硏究院有限公司 | 一種預防和治療脂肪異常沉積導致的組織損傷的方法 |
| US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| KR102126389B1 (ko) * | 2018-09-14 | 2020-06-25 | 셀라이온바이오메드 주식회사 | 벤즈히드릴티오 아세트아미드 화합물을 유효성분으로 포함하는 간 질환의 예방 또는 치료용 조성물 |
| MX2021003750A (es) | 2018-10-11 | 2021-06-15 | Basf As | Compuestos aromaticos y usos farmaceuticos de los mismos. |
| CA3195137A1 (en) * | 2020-10-06 | 2022-04-14 | Lyne Gagnon | Substituted aromatic compounds and pharmaceutical compositions thereof |
| KR102543789B1 (ko) * | 2021-03-08 | 2023-06-20 | 주식회사 온코크로스 | 토르세미드 및 크로몰린을 포함하는 대사질환 예방 또는 치료용 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020183519A1 (en) * | 2001-03-13 | 2002-12-05 | Herbert Nar | Antithrombotic carboxylic acid amides |
| AU2007267612A1 (en) * | 2006-05-26 | 2007-12-06 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted carboxylic acid compounds |
| BRPI0807285A2 (pt) * | 2007-02-08 | 2014-05-06 | Emisphere Tech Inc | "composição, método para preparar composição farmacêutica, forma unitária de dosagem, método para admnistrar um agente biologicamente ativo a um animal necessitando o agente, método para aumentar a biodisponibilidade de um agente biologicamente ativo, método para preparar uma composição e composto" |
| MX2011011757A (es) * | 2009-05-04 | 2012-01-25 | Prometic Biosciences Inc | Compuestos aromaticos substituidos y usos farmaceuticos. |
| DK2427417T3 (da) * | 2009-05-04 | 2014-01-20 | Prometic Biosciences Inc | Salte af 3-pentylphenyleddikesyre og farmaceutiske anvendelser deraf |
| AT509045B1 (de) * | 2010-01-29 | 2011-06-15 | Planta Naturstoffe Vertriebsges M B H | Verbindungen zur behandlung von asthma bronchiale |
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2014
- 2014-03-12 TW TW103108723A patent/TWI689490B/zh not_active IP Right Cessation
- 2014-03-13 UY UY0001035402A patent/UY35402A/es not_active Application Discontinuation
- 2014-03-13 AR ARP140100973A patent/AR095429A1/es unknown
- 2014-03-14 PL PL14764458T patent/PL2970089T3/pl unknown
- 2014-03-14 KR KR1020157029293A patent/KR102196721B1/ko not_active Expired - Fee Related
- 2014-03-14 AU AU2014231648A patent/AU2014231648B2/en not_active Ceased
- 2014-03-14 DK DK14764458.7T patent/DK2970089T3/da active
- 2014-03-14 US US14/776,328 patent/US10023518B2/en active Active
- 2014-03-14 NZ NZ712797A patent/NZ712797A/en not_active IP Right Cessation
- 2014-03-14 MY MYPI2015002293A patent/MY180305A/en unknown
- 2014-03-14 CN CN201910355464.7A patent/CN110105200B/zh not_active Expired - Fee Related
- 2014-03-14 EA EA201591775A patent/EA030651B1/ru not_active IP Right Cessation
- 2014-03-14 WO PCT/CA2014/000236 patent/WO2014138906A1/en not_active Ceased
- 2014-03-14 EP EP14764458.7A patent/EP2970089B1/en active Active
- 2014-03-14 JP JP2015561849A patent/JP6448562B2/ja not_active Expired - Fee Related
- 2014-03-14 MX MX2015011878A patent/MX379424B/es unknown
- 2014-03-14 CA CA2905621A patent/CA2905621C/en active Active
- 2014-03-14 ES ES14764458T patent/ES2741439T3/es active Active
- 2014-03-14 CN CN201480013578.9A patent/CN105189438A/zh active Pending
- 2014-03-14 PT PT14764458T patent/PT2970089T/pt unknown
- 2014-03-14 BR BR112015022008-8A patent/BR112015022008A2/pt active Search and Examination
- 2014-03-14 SG SG11201507408XA patent/SG11201507408XA/en unknown
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2015
- 2015-09-03 IL IL241178A patent/IL241178B/en active IP Right Grant
- 2015-09-09 PH PH12015502011A patent/PH12015502011B1/en unknown
- 2015-09-09 CL CL2015002535A patent/CL2015002535A1/es unknown
- 2015-09-22 ZA ZA2015/07061A patent/ZA201507061B/en unknown
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2018
- 2018-04-04 US US15/945,408 patent/US10550066B2/en not_active Expired - Fee Related
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2020
- 2020-02-03 US US16/780,316 patent/US11524930B2/en active Active
Also Published As
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| US11524930B2 (en) | Substituted aromatic compounds and related method for the treatment of fibrosis | |
| TWI689489B (zh) | 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物 | |
| HK1220440B (en) | Substituted aromatic compounds | |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |