TWI688385B - 治療低血壓之方法 - Google Patents
治療低血壓之方法 Download PDFInfo
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- TWI688385B TWI688385B TW104122255A TW104122255A TWI688385B TW I688385 B TWI688385 B TW I688385B TW 104122255 A TW104122255 A TW 104122255A TW 104122255 A TW104122255 A TW 104122255A TW I688385 B TWI688385 B TW I688385B
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- angiotensin
- blood pressure
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- arterial blood
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- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
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- 229960000553 somatostatin Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 229960005461 torasemide Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/085—Angiotensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462022054P | 2014-07-08 | 2014-07-08 | |
| US62/022,054 | 2014-07-08 |
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| TW201625231A TW201625231A (zh) | 2016-07-16 |
| TWI688385B true TWI688385B (zh) | 2020-03-21 |
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| TW104122255A TWI688385B (zh) | 2014-07-08 | 2015-07-08 | 治療低血壓之方法 |
| TW110149288A TW202214219A (zh) | 2014-07-08 | 2015-07-08 | 治療低血壓之方法 |
| TW109105582A TWI754225B (zh) | 2014-07-08 | 2015-07-08 | 治療低血壓之方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| TW110149288A TW202214219A (zh) | 2014-07-08 | 2015-07-08 | 治療低血壓之方法 |
| TW109105582A TWI754225B (zh) | 2014-07-08 | 2015-07-08 | 治療低血壓之方法 |
Country Status (14)
| Country | Link |
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| US (3) | US20160074465A1 (enExample) |
| EP (2) | EP3007722A4 (enExample) |
| JP (2) | JP2017519799A (enExample) |
| KR (1) | KR20170026486A (enExample) |
| CN (1) | CN106794224A (enExample) |
| AU (2) | AU2015287955A1 (enExample) |
| BR (1) | BR112017000303A2 (enExample) |
| CA (1) | CA2954016A1 (enExample) |
| EA (2) | EA036514B1 (enExample) |
| IL (1) | IL249936A0 (enExample) |
| MX (1) | MX2017000306A (enExample) |
| SG (2) | SG11201610897VA (enExample) |
| TW (3) | TWI688385B (enExample) |
| WO (1) | WO2016007589A1 (enExample) |
Families Citing this family (8)
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|---|---|---|---|---|
| US9572856B2 (en) | 2009-12-16 | 2017-02-21 | The George Washington University a Congressionally Chartered Not-for-Profit Corporation | Method of treating low blood pressure |
| CN119700926A (zh) | 2013-12-18 | 2025-03-28 | 乔治华盛顿大学国会特许非营利公司 | 血管紧张素ii单独或以组合方式用于治疗低血压 |
| US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| EP3400000B1 (en) | 2016-01-07 | 2023-12-06 | La Jolla Pharma, LLC | Methods for administering angiotensin ii |
| US11583568B2 (en) | 2017-04-14 | 2023-02-21 | La Jolla Pharma, Llc | Methods for administering angiotensin II |
| TW201927331A (zh) * | 2017-12-15 | 2019-07-16 | 美商拉荷亞製藥公司 | 血管收縮素組合物及與其相關之方法 |
| US10653646B2 (en) | 2018-03-23 | 2020-05-19 | Nevakar Inc. | Epinephrine compositions and containers |
| KR102258546B1 (ko) | 2018-10-26 | 2021-06-01 | 양성심 | 유기농 케일을 주 성분으로 하는 건강기능식품 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| AU2006297839B2 (en) * | 2005-09-29 | 2011-04-14 | Fibrogen, Inc. | Methods for reducing blood pressure |
| KR20110096553A (ko) * | 2008-11-28 | 2011-08-30 | 아보트 러보러터리즈 | 안정한 항체 조성물 및 이의 안정화 방법 |
| US9572856B2 (en) * | 2009-12-16 | 2017-02-21 | The George Washington University a Congressionally Chartered Not-for-Profit Corporation | Method of treating low blood pressure |
| CN119700926A (zh) * | 2013-12-18 | 2025-03-28 | 乔治华盛顿大学国会特许非营利公司 | 血管紧张素ii单独或以组合方式用于治疗低血压 |
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2015
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- 2015-07-08 WO PCT/US2015/039499 patent/WO2016007589A1/en not_active Ceased
- 2015-07-08 BR BR112017000303A patent/BR112017000303A2/pt not_active Application Discontinuation
- 2015-07-08 EA EA201692534A patent/EA036514B1/ru unknown
- 2015-07-08 CN CN201580048068.XA patent/CN106794224A/zh active Pending
- 2015-07-08 TW TW110149288A patent/TW202214219A/zh unknown
- 2015-07-08 KR KR1020177001649A patent/KR20170026486A/ko not_active Ceased
- 2015-07-08 SG SG11201610897VA patent/SG11201610897VA/en unknown
- 2015-07-08 TW TW109105582A patent/TWI754225B/zh active
- 2015-07-08 AU AU2015287955A patent/AU2015287955A1/en not_active Abandoned
- 2015-07-08 EP EP15775357.5A patent/EP3007722A4/en not_active Ceased
- 2015-07-08 US US14/794,102 patent/US20160074465A1/en not_active Abandoned
- 2015-07-08 EA EA202091873A patent/EA202091873A3/ru unknown
- 2015-07-08 EP EP18158219.8A patent/EP3381465A1/en not_active Withdrawn
- 2015-07-08 SG SG10201804034QA patent/SG10201804034QA/en unknown
- 2015-07-08 JP JP2017500389A patent/JP2017519799A/ja active Pending
- 2015-07-08 MX MX2017000306A patent/MX2017000306A/es unknown
- 2015-07-08 CA CA2954016A patent/CA2954016A1/en not_active Abandoned
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2017
- 2017-01-05 IL IL249936A patent/IL249936A0/en unknown
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2018
- 2018-06-22 US US16/016,088 patent/US20180311306A1/en not_active Abandoned
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2020
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- 2020-05-27 JP JP2020092321A patent/JP2020143139A/ja active Pending
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2021
- 2021-03-17 AU AU2021201669A patent/AU2021201669A1/en not_active Abandoned
Non-Patent Citations (3)
| Title |
|---|
| LW Busse et al., Angiotensin II may be useful for the treatment of hypotension in distributive shock, but a safe and efficacious dose is unknown, Crit Care.,vol.18, 20140317, pp.S57 |
| LW Busse et al., Angiotensin II may be useful for the treatment of hypotension in distributive shock, but a safe and efficacious dose is unknown, Crit Care.,vol.18, 20140317, pp.S57 Yunge M et al., Angiotensin for septic shock unresponsive to noradrenaline,Arch Dis Child., vol.82, 2000, pp.388-389 * |
| Yunge M et al., Angiotensin for septic shock unresponsive to noradrenaline,Arch Dis Child., vol.82, 2000, pp.388-389 |
Also Published As
| Publication number | Publication date |
|---|---|
| SG10201804034QA (en) | 2018-07-30 |
| WO2016007589A1 (en) | 2016-01-14 |
| EA036514B1 (ru) | 2020-11-18 |
| IL249936A0 (en) | 2017-03-30 |
| MX2017000306A (es) | 2017-07-10 |
| TW202214219A (zh) | 2022-04-16 |
| US20160074465A1 (en) | 2016-03-17 |
| JP2017519799A (ja) | 2017-07-20 |
| TW201625231A (zh) | 2016-07-16 |
| KR20170026486A (ko) | 2017-03-08 |
| BR112017000303A2 (pt) | 2017-11-07 |
| AU2021201669A1 (en) | 2021-04-08 |
| JP2020143139A (ja) | 2020-09-10 |
| CN106794224A (zh) | 2017-05-31 |
| EP3381465A1 (en) | 2018-10-03 |
| US20200237853A1 (en) | 2020-07-30 |
| EA202091873A3 (ru) | 2021-01-29 |
| SG11201610897VA (en) | 2017-01-27 |
| EP3007722A4 (en) | 2016-05-25 |
| EA202091873A2 (ru) | 2020-11-30 |
| TWI754225B (zh) | 2022-02-01 |
| EA201692534A1 (ru) | 2017-06-30 |
| AU2015287955A1 (en) | 2017-02-02 |
| TW202038927A (zh) | 2020-11-01 |
| CA2954016A1 (en) | 2016-01-14 |
| EP3007722A1 (en) | 2016-04-20 |
| US20180311306A1 (en) | 2018-11-01 |
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