TWI683662B - 抗癌症組成物(一) - Google Patents

抗癌症組成物(一) Download PDF

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Publication number
TWI683662B
TWI683662B TW104140458A TW104140458A TWI683662B TW I683662 B TWI683662 B TW I683662B TW 104140458 A TW104140458 A TW 104140458A TW 104140458 A TW104140458 A TW 104140458A TW I683662 B TWI683662 B TW I683662B
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TW
Taiwan
Prior art keywords
arn
solid dispersion
patent application
poly
meth
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TW104140458A
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English (en)
Chinese (zh)
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TW201632187A (zh
Inventor
吉爾特 凡瑞克
Original Assignee
美商艾瑞岡醫藥公司
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52006905&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI683662(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 美商艾瑞岡醫藥公司 filed Critical 美商艾瑞岡醫藥公司
Publication of TW201632187A publication Critical patent/TW201632187A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW104140458A 2014-12-05 2015-12-03 抗癌症組成物(一) TWI683662B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196591.3 2014-12-05
EP14196591 2014-12-05

Publications (2)

Publication Number Publication Date
TW201632187A TW201632187A (zh) 2016-09-16
TWI683662B true TWI683662B (zh) 2020-02-01

Family

ID=52006905

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104140458A TWI683662B (zh) 2014-12-05 2015-12-03 抗癌症組成物(一)

Country Status (31)

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US (3) US20170360707A1 (cg-RX-API-DMAC7.html)
EP (2) EP3842034B1 (cg-RX-API-DMAC7.html)
JP (1) JP6767368B2 (cg-RX-API-DMAC7.html)
KR (1) KR102348325B1 (cg-RX-API-DMAC7.html)
CN (2) CN106999430A (cg-RX-API-DMAC7.html)
AR (1) AR102924A1 (cg-RX-API-DMAC7.html)
AU (1) AU2015358493B2 (cg-RX-API-DMAC7.html)
CA (1) CA2969661C (cg-RX-API-DMAC7.html)
CL (1) CL2017001372A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017005573A2 (cg-RX-API-DMAC7.html)
CR (1) CR20170217A (cg-RX-API-DMAC7.html)
CY (1) CY1123856T1 (cg-RX-API-DMAC7.html)
DK (1) DK3226842T3 (cg-RX-API-DMAC7.html)
EA (1) EA035988B1 (cg-RX-API-DMAC7.html)
ES (2) ES2839128T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20201902T1 (cg-RX-API-DMAC7.html)
HU (1) HUE051888T2 (cg-RX-API-DMAC7.html)
IL (1) IL252324B (cg-RX-API-DMAC7.html)
LT (1) LT3226842T (cg-RX-API-DMAC7.html)
MA (2) MA41108B1 (cg-RX-API-DMAC7.html)
MD (1) MD3226842T2 (cg-RX-API-DMAC7.html)
MX (1) MX384382B (cg-RX-API-DMAC7.html)
NI (1) NI201700069A (cg-RX-API-DMAC7.html)
PL (1) PL3226842T3 (cg-RX-API-DMAC7.html)
PT (1) PT3226842T (cg-RX-API-DMAC7.html)
RS (1) RS61466B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201704264UA (cg-RX-API-DMAC7.html)
SI (1) SI3226842T1 (cg-RX-API-DMAC7.html)
TW (1) TWI683662B (cg-RX-API-DMAC7.html)
UA (1) UA121123C2 (cg-RX-API-DMAC7.html)
WO (1) WO2016090101A1 (cg-RX-API-DMAC7.html)

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LT3305285T (lt) 2012-09-26 2020-12-10 Aragon Pharmaceuticals, Inc. Anti-androgenai, skirti gydyti nametastazavusį kastracijai atsparų prostatos vėžį
PL3226843T3 (pl) 2014-12-05 2021-12-13 Aragon Pharmaceuticals, Inc. Kompozycje przeciwnowotworowe
CN114886852A (zh) 2014-12-05 2022-08-12 阿拉贡药品公司 抗癌组合物
CA3079135A1 (en) 2017-10-16 2019-04-25 Arturo Molina Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
WO2019193488A1 (en) * 2018-04-06 2019-10-10 Capsugel Belgium Nv Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)]
WO2020144646A1 (en) 2019-01-10 2020-07-16 Aragon Pharmaceuticals, Inc. Apalutamide dispersed in applesauce for treating prostate cancer
CA3143199A1 (en) 2019-01-30 2020-08-06 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
US20220160695A1 (en) 2019-01-30 2022-05-26 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of metastatic castration-sensitive prostate cancer
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
EP4054572A1 (en) 2019-11-04 2022-09-14 Aragon Pharmaceuticals, Inc. Androgen receptor inhibitors for the treatment of non-metastatic castration-resistant prostate cancer in subjects with severe hepatic impairment
WO2021245285A1 (en) 2020-06-05 2021-12-09 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
WO2022049523A1 (en) 2020-09-04 2022-03-10 Aragon Pharmaceuticals, Inc. Methods for treating prostate cancer
WO2022195407A1 (en) 2021-03-19 2022-09-22 Aragon Pharmaceuticals, Inc. Methods for treating prostate cancer
WO2023152611A1 (en) 2022-02-11 2023-08-17 Aragon Pharmaceuticals, Inc. Apalutamide and relugolix for the treatment of prostate cancer
WO2023209555A1 (en) 2022-04-26 2023-11-02 Aragon Pharmaceuticals, Inc. Approved drug products and methods for treating prostate cancer
CN121038790A (zh) 2023-03-16 2025-11-28 拜耳消费者护理股份有限公司 用于治疗激素敏感性前列腺癌生化复发患者的雄激素受体拮抗剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005055987A1 (en) * 2003-12-15 2005-06-23 Council Of Scientific & Industrial Research TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER
WO2012174436A1 (en) * 2011-06-15 2012-12-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer

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BR0208421A (pt) 2001-04-02 2004-03-30 Astrazeneca Ab Formulação farmacêutica para administração a um paciente através das mucosas, dose farmacêutica diária, dispersão sólida, uso de pvp em dispersão sólida com 4'-ciano-alfa', alfa', alfa'-trifluoro-3-(4-fluoro fenilsulfonil)-2-hidróxi-2-metilpropiono-m-toluidet o, e, métodos para aumentar a estabilidade em armazenagem, a biodisponibilidade da droga e para reduzir a variação de concentrações de plasma do 4'-ciano-alfa', alfa', alfa',-trifluoro-3-(4-fluorofenilsulfonil)-2-hidróxi-2 -metilpropiono-m-toluideto entre pacientes
WO2003077827A1 (en) * 2002-03-19 2003-09-25 Nippon Shinyaku Co., Ltd. Process for producing drug solid dispersion
SI3412290T1 (sl) * 2006-03-27 2021-09-30 The Regents Of The University Of California Modulator androgenih receptorjev za zdravljenje raka prostate in bolezni, povezanih z androgenimi receptorji
US9108944B2 (en) * 2010-02-16 2015-08-18 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
WO2013152342A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
MY187500A (en) 2012-06-07 2021-09-24 Aragon Pharmaceuticals Inc Crystalline forms of an androgen receptor modulator
US10668156B2 (en) 2012-06-22 2020-06-02 Basf Se Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers
DK3725778T3 (da) * 2012-09-11 2021-09-20 Medivation Prostate Therapeutics Llc Formuleringer af enzalutamid
LT3305285T (lt) * 2012-09-26 2020-12-10 Aragon Pharmaceuticals, Inc. Anti-androgenai, skirti gydyti nametastazavusį kastracijai atsparų prostatos vėžį
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
EA028009B1 (ru) * 2013-01-22 2017-09-29 Ф.Хоффманн-Ля Рош Аг Фармацевтическая композиция с улучшенной биодоступностью
WO2014167428A2 (en) 2013-04-10 2014-10-16 Shilpa Medicare Limited Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide
BR112016002970A2 (pt) * 2013-08-12 2017-09-12 Tokai Pharmaceuticals Inc biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio
AU2015215000B2 (en) * 2014-02-05 2017-10-19 Lek Pharmaceuticals D.D. Solid pharmaceutical compositions of androgen receptor antagonists

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2005055987A1 (en) * 2003-12-15 2005-06-23 Council Of Scientific & Industrial Research TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER
WO2012174436A1 (en) * 2011-06-15 2012-12-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer

Non-Patent Citations (1)

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Title
Clegg NJ, et al."ARN-509: a novel antiandrogen for prostate cancer treatment.", Cancer Res. 2012 Mar 15;72(6):1494-1503. *

Also Published As

Publication number Publication date
KR102348325B1 (ko) 2022-01-06
MD3226842T2 (ro) 2021-03-31
MA41108B1 (fr) 2021-03-31
HUE051888T2 (hu) 2021-03-29
ES2839128T3 (es) 2021-07-05
CA2969661A1 (en) 2016-06-09
CN115837010A (zh) 2023-03-24
AU2015358493A1 (en) 2017-06-08
UA121123C2 (uk) 2020-04-10
CN106999430A (zh) 2017-08-01
JP6767368B2 (ja) 2020-10-14
CA2969661C (en) 2023-04-25
EP3842034A1 (en) 2021-06-30
WO2016090101A1 (en) 2016-06-09
HRP20201902T1 (hr) 2021-07-23
MX384382B (es) 2025-03-14
CR20170217A (es) 2017-08-30
JP2017536401A (ja) 2017-12-07
BR112017011787A2 (pt) 2017-12-26
PT3226842T (pt) 2020-12-23
CN115837010B (zh) 2025-03-14
US20220151931A1 (en) 2022-05-19
SG11201704264UA (en) 2017-06-29
IL252324B (en) 2021-10-31
CL2017001372A1 (es) 2018-01-05
CY1123856T1 (el) 2022-05-27
ES3021508T3 (en) 2025-05-27
EA035988B1 (ru) 2020-09-09
MA41108A (fr) 2016-06-09
MA55404A (fr) 2022-02-02
EP3226842B1 (en) 2020-11-25
LT3226842T (lt) 2021-03-25
EP3226842A1 (en) 2017-10-11
IL252324A0 (en) 2017-07-31
US20170360707A1 (en) 2017-12-21
US20240293321A1 (en) 2024-09-05
TW201632187A (zh) 2016-09-16
EA201791252A1 (ru) 2017-10-31
KR20170086657A (ko) 2017-07-26
NI201700069A (es) 2017-10-31
AU2015358493B2 (en) 2021-05-06
SI3226842T1 (sl) 2021-04-30
CO2017005573A2 (es) 2017-09-29
RS61466B1 (sr) 2021-03-31
PL3226842T3 (pl) 2021-07-12
MX2017007201A (es) 2018-01-30
AR102924A1 (es) 2017-04-05
DK3226842T3 (da) 2021-01-25
EP3842034B1 (en) 2025-02-12

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