TWI678205B - 治療hcv的方法 - Google Patents

治療hcv的方法 Download PDF

Info

Publication number
TWI678205B
TWI678205B TW103109528A TW103109528A TWI678205B TW I678205 B TWI678205 B TW I678205B TW 103109528 A TW103109528 A TW 103109528A TW 103109528 A TW103109528 A TW 103109528A TW I678205 B TWI678205 B TW I678205B
Authority
TW
Taiwan
Prior art keywords
weeks
compound
hcv
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
TW103109528A
Other languages
English (en)
Chinese (zh)
Other versions
TW201505633A (zh
Inventor
貝瑞 伯斯丁
Barry Bernstein
珊迪普 杜塔
Sandeep Dutta
劉巍
Wei Liu
湯瑪士J 波薩迪奇
Thomas J. PODSADECKI
安德魯L 坎貝爾
Andrew L. Campbell
瑞吉夫M 曼諾
Rajeev M. Menon
林志威
Chih Wei Lin
王恬力
Wianli Wang
瓦立德M 澳尼
Walid M. Awni
Original Assignee
美商艾伯維有限公司
Abbvie Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50771575&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI678205(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 美商艾伯維有限公司, Abbvie Inc. filed Critical 美商艾伯維有限公司
Publication of TW201505633A publication Critical patent/TW201505633A/zh
Application granted granted Critical
Publication of TWI678205B publication Critical patent/TWI678205B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW103109528A 2013-03-14 2014-03-14 治療hcv的方法 TWI678205B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783437P 2013-03-14 2013-03-14
US61/783,437 2013-03-14

Publications (2)

Publication Number Publication Date
TW201505633A TW201505633A (zh) 2015-02-16
TWI678205B true TWI678205B (zh) 2019-12-01

Family

ID=50771575

Family Applications (2)

Application Number Title Priority Date Filing Date
TW103109528A TWI678205B (zh) 2013-03-14 2014-03-14 治療hcv的方法
TW108114285A TW202002979A (zh) 2013-03-14 2014-03-14 治療hcv的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW108114285A TW202002979A (zh) 2013-03-14 2014-03-14 治療hcv的方法

Country Status (28)

Country Link
US (1) US20140274934A1 (enExample)
EP (4) EP2968302B9 (enExample)
JP (3) JP6563894B2 (enExample)
KR (2) KR20180045055A (enExample)
CN (3) CN108187056A (enExample)
AU (3) AU2014239322B2 (enExample)
BR (1) BR112015020918A2 (enExample)
CA (1) CA2901818C (enExample)
CY (1) CY1121474T1 (enExample)
DK (1) DK2968302T3 (enExample)
EA (2) EA030482B1 (enExample)
ES (1) ES2654109T3 (enExample)
HK (1) HK1255257A1 (enExample)
HR (1) HRP20171898T1 (enExample)
HU (1) HUE036069T2 (enExample)
IL (2) IL240445B (enExample)
LT (1) LT2968302T (enExample)
MX (1) MX2015012536A (enExample)
NO (1) NO3090119T3 (enExample)
PL (1) PL2968302T3 (enExample)
PT (1) PT2968302T (enExample)
RS (1) RS56735B1 (enExample)
SG (2) SG11201507361YA (enExample)
SI (1) SI2968302T1 (enExample)
SM (1) SMT201800017T1 (enExample)
TW (2) TWI678205B (enExample)
WO (1) WO2014152635A1 (enExample)
ZA (1) ZA201705080B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
HUE036069T2 (hu) 2013-03-14 2018-06-28 Abbvie Inc Közvetlenül ható vírusellenes szerek és ribavirin kombinációja HCV-betegek kezelésére
WO2015061742A2 (en) * 2013-10-25 2015-04-30 Abbvie, Inc. Methods for treating hcv
US20150174194A1 (en) * 2013-12-19 2015-06-25 Abbvie Inc. Methods for treating liver transplant recipients
CA2943054A1 (en) * 2014-04-02 2015-10-08 Abbvie Inc. Methods for treating hcv
US20160375017A1 (en) 2015-06-26 2016-12-29 Abbvie Inc. Solid Pharmaceutical Compositions for Treating HCV
DK3383662T3 (da) 2016-01-08 2020-10-26 Entrust Datacard Corp Kortudskrivningsmekanisme med kortreturneringsvej
CA3022119A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
BR112019005725A2 (pt) * 2016-09-23 2019-07-09 Abbvie Inc ajuste de dose
JP2018131439A (ja) * 2017-02-14 2018-08-23 アッヴィ・インコーポレイテッド Hcvを処置する方法
CA2981993A1 (en) * 2017-08-02 2019-02-02 Abbvie Inc. Methods for treating hcv
CN108329332A (zh) * 2018-03-16 2018-07-27 安徽华昌高科药业有限公司 一种制备Glecaprevir的方法
EP3773753A4 (en) * 2018-04-10 2021-12-22 ATEA Pharmaceuticals, Inc. TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120004196A1 (en) * 2009-06-11 2012-01-05 Abbott Labaoratories Anti-Viral Compounds
US20120070416A1 (en) * 2010-09-21 2012-03-22 Enanta Pharmaceuticals, Inc. Macrocyclic Proline Derived HCV Serine Protease Inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010013522A (es) * 2008-06-10 2011-05-03 Janssen Pharmaceutica Nv Uso de telaprevir en combinacion con interferon pegilado y ribavirina para tratar el virus de la hepatitis c.
RS52854B (sr) * 2009-06-11 2013-12-31 Abbvie Bahamas Limited Inhibitori hepatitis c virusa
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
AU2013201406B2 (en) 2011-10-21 2014-10-02 Abbvie Ireland Unlimited Company Methods for treating HCV
CH707030B1 (de) 2011-10-21 2015-03-13 Abbvie Inc Kombinationsbehandlung von DAAs zur Verwendung in der Behandlung von HCV
HUE036069T2 (hu) 2013-03-14 2018-06-28 Abbvie Inc Közvetlenül ható vírusellenes szerek és ribavirin kombinációja HCV-betegek kezelésére

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120004196A1 (en) * 2009-06-11 2012-01-05 Abbott Labaoratories Anti-Viral Compounds
US20120070416A1 (en) * 2010-09-21 2012-03-22 Enanta Pharmaceuticals, Inc. Macrocyclic Proline Derived HCV Serine Protease Inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AS Barritt,MW. Fried,"Maximizing Opportunities and Avoiding Mistakes in Triple Therapy for Hepatitis C Virus",GASTROENTEROLOGY 2012;142:1314–1323. *

Also Published As

Publication number Publication date
NO3090119T3 (enExample) 2018-03-31
ZA201705080B (en) 2019-02-27
CN109908353A (zh) 2019-06-21
TW202002979A (zh) 2020-01-16
EP3318258A1 (en) 2018-05-09
HUE036069T2 (hu) 2018-06-28
CN108187056A (zh) 2018-06-22
AU2014239322A1 (en) 2015-08-27
WO2014152635A9 (en) 2014-12-11
EP2968302B9 (en) 2019-02-13
JP2019167347A (ja) 2019-10-03
SG11201507361YA (en) 2015-10-29
RS56735B1 (sr) 2018-03-30
CA2901818A1 (en) 2014-09-25
JP2019214585A (ja) 2019-12-19
CN105007921B (zh) 2018-12-11
US20140274934A1 (en) 2014-09-18
EP3318258B1 (en) 2020-05-13
TW201505633A (zh) 2015-02-16
EP2968302A1 (en) 2016-01-20
AU2018202581A1 (en) 2018-05-10
WO2014152635A1 (en) 2014-09-25
PL2968302T4 (pl) 2018-04-30
KR20150129035A (ko) 2015-11-18
EP3915559A1 (en) 2021-12-01
LT2968302T (lt) 2017-12-27
HRP20171898T1 (hr) 2018-04-06
EA201591701A1 (ru) 2016-02-29
JP2016513703A (ja) 2016-05-16
CN105007921A (zh) 2015-10-28
DK2968302T3 (en) 2017-12-18
JP6563894B2 (ja) 2019-08-21
AU2018202581B2 (en) 2019-12-05
AU2020201656A1 (en) 2020-03-26
HK1255257A1 (en) 2019-08-09
ES2654109T3 (es) 2018-02-12
IL240445A0 (en) 2015-09-24
CA2901818C (en) 2021-05-04
SI2968302T1 (en) 2018-04-30
BR112015020918A2 (pt) 2017-07-18
HK1213191A1 (en) 2016-06-30
KR20180045055A (ko) 2018-05-03
KR101853605B1 (ko) 2018-05-03
EA201890507A1 (ru) 2018-07-31
IL267927A (en) 2019-09-26
SMT201800017T1 (it) 2018-03-08
EA030482B1 (ru) 2018-08-31
PT2968302T (pt) 2018-01-03
AU2014239322B2 (en) 2018-04-05
IL240445B (en) 2019-07-31
EP2968302B1 (en) 2017-09-06
EP3733180A1 (en) 2020-11-04
MX2015012536A (es) 2016-01-12
CY1121474T1 (el) 2020-05-29
PL2968302T3 (pl) 2018-04-30
SG10201709840UA (en) 2018-01-30

Similar Documents

Publication Publication Date Title
TWI642436B (zh) 治療hcv的方法
TWI678205B (zh) 治療hcv的方法
AU2015240754B2 (en) Methods for treating HCV
JP2019214578A (ja) Hcvを処置するための方法
HK40037284A (en) Combination of direct acting antiviral agents and ribavirin for treating hcv patients
TW201924678A (zh) 治療hcv之方法
HK1244668B (en) Combination of two antivirals for treating hepatitis c
HK1223817B (en) Combination of two antivirals for treating hepatitis c

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees