JP6563894B2 - Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用 - Google Patents

Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用 Download PDF

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JP6563894B2
JP6563894B2 JP2016502479A JP2016502479A JP6563894B2 JP 6563894 B2 JP6563894 B2 JP 6563894B2 JP 2016502479 A JP2016502479 A JP 2016502479A JP 2016502479 A JP2016502479 A JP 2016502479A JP 6563894 B2 JP6563894 B2 JP 6563894B2
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patient
weeks
compound
hcv
treatment
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Japanese (ja)
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JP2016513703A (ja
JP2016513703A5 (enExample
Inventor
バーンスタイン，バリー・エム
ダッタ，サンディープ
リウ，ウエイ
ポツァデツキ，トーマス・ジェイ
キャンベル，アンドリュー・エル
メノン，ラジェーフ・エム
リン，チー−ウエイ
ワン，ティアニル
アウニ，ワリード・エム
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AbbVie Inc
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AbbVie Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016502479A 2013-03-14 2014-03-14 Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用 Expired - Fee Related JP6563894B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361783437P 2013-03-14 2013-03-14
US61/783,437 2013-03-14
PCT/US2014/027556 WO2014152635A1 (en) 2013-03-14 2014-03-14 Combination of direct acting antiviral agents and ribavirin for treating hcv patients

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2019087535A Division JP2019167347A (ja) 2013-03-14 2019-05-07 Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用
JP2019135865A Division JP2019214585A (ja) 2013-03-14 2019-07-24 Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用

Publications (3)

Publication Number Publication Date
JP2016513703A JP2016513703A (ja) 2016-05-16
JP2016513703A5 JP2016513703A5 (enExample) 2017-04-13
JP6563894B2 true JP6563894B2 (ja) 2019-08-21

Family

ID=50771575

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016502479A Expired - Fee Related JP6563894B2 (ja) 2013-03-14 2014-03-14 Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用
JP2019087535A Pending JP2019167347A (ja) 2013-03-14 2019-05-07 Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用
JP2019135865A Pending JP2019214585A (ja) 2013-03-14 2019-07-24 Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019087535A Pending JP2019167347A (ja) 2013-03-14 2019-05-07 Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用
JP2019135865A Pending JP2019214585A (ja) 2013-03-14 2019-07-24 Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用

Country Status (28)

Country Link
US (1) US20140274934A1 (enExample)
EP (4) EP3318258B1 (enExample)
JP (3) JP6563894B2 (enExample)
KR (2) KR20180045055A (enExample)
CN (3) CN109908353A (enExample)
AU (3) AU2014239322B2 (enExample)
BR (1) BR112015020918A2 (enExample)
CA (1) CA2901818C (enExample)
CY (1) CY1121474T1 (enExample)
DK (1) DK2968302T3 (enExample)
EA (2) EA030482B1 (enExample)
ES (1) ES2654109T3 (enExample)
HK (1) HK1255257A1 (enExample)
HR (1) HRP20171898T1 (enExample)
HU (1) HUE036069T2 (enExample)
IL (2) IL240445B (enExample)
LT (1) LT2968302T (enExample)
MX (1) MX2015012536A (enExample)
NO (1) NO3090119T3 (enExample)
PL (1) PL2968302T4 (enExample)
PT (1) PT2968302T (enExample)
RS (1) RS56735B1 (enExample)
SG (2) SG11201507361YA (enExample)
SI (1) SI2968302T1 (enExample)
SM (1) SMT201800017T1 (enExample)
TW (2) TWI678205B (enExample)
WO (1) WO2014152635A1 (enExample)
ZA (1) ZA201705080B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019167347A (ja) * 2013-03-14 2019-10-03 アッヴィ・インコーポレイテッド Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用
JP2019214578A (ja) * 2014-04-02 2019-12-19 アッヴィ・インコーポレイテッド Ｈｃｖを処置するための方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
CN105658219A (zh) * 2013-10-25 2016-06-08 艾伯维公司 用于治疗hcv的方法
US20150174194A1 (en) * 2013-12-19 2015-06-25 Abbvie Inc. Methods for treating liver transplant recipients
US20160375017A1 (en) 2015-06-26 2016-12-29 Abbvie Inc. Solid Pharmaceutical Compositions for Treating HCV
EP3383662B1 (en) 2016-01-08 2020-09-02 Entrust Datacard Corporation Card printing mechanism with card return path
JP7129703B2 (ja) 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
MA46292A (fr) * 2016-09-23 2019-07-31 Abbvie Inc Réglage de dose
CA2994496A1 (en) * 2017-02-14 2018-08-14 Abbvie Inc. Methods for treating hcv
CA2981993A1 (en) * 2017-08-02 2019-02-02 Abbvie Inc. Methods for treating hcv
CN108329332A (zh) * 2018-03-16 2018-07-27 安徽华昌高科药业有限公司 一种制备Glecaprevir的方法
CN112351799A (zh) * 2018-04-10 2021-02-09 阿堤亚制药公司 具有硬化的hcv感染患者的治疗

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011522862A (ja) * 2008-06-10 2011-08-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ テラプレビル（Ｔｅｌａｐｒｅｖｉｒ）投薬養生法
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
EP2853531A3 (en) * 2009-06-11 2015-08-12 AbbVie Bahamas Ltd. Antiviral compounds
US8937150B2 (en) * 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
TWI523658B (zh) * 2010-09-21 2016-03-01 安塔製藥公司 巨環脯胺酸衍生之ｈｃｖ絲胺酸蛋白酶抑制劑
CN104023726A (zh) 2011-10-21 2014-09-03 艾伯维公司 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333)
DE112012003510T5 (de) 2011-10-21 2015-03-19 Abbvie Inc. Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon
EP3318258B1 (en) 2013-03-14 2020-05-13 AbbVie Inc. Combination of direct acting antiviral agents and ribavirin for treating hcv patients

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019167347A (ja) * 2013-03-14 2019-10-03 アッヴィ・インコーポレイテッド Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用
JP2019214585A (ja) * 2013-03-14 2019-12-19 アッヴィ・インコーポレイテッド Ｈｃｖ患者を治療するための直接的に作用する抗ウイルス剤とリバビリンとの併用
JP2019214578A (ja) * 2014-04-02 2019-12-19 アッヴィ・インコーポレイテッド Ｈｃｖを処置するための方法

Also Published As

Publication number Publication date
CY1121474T1 (el) 2020-05-29
PL2968302T3 (pl) 2018-04-30
WO2014152635A9 (en) 2014-12-11
EP3318258B1 (en) 2020-05-13
CA2901818C (en) 2021-05-04
EP2968302A1 (en) 2016-01-20
LT2968302T (lt) 2017-12-27
EP3733180A1 (en) 2020-11-04
IL267927A (en) 2019-09-26
SG11201507361YA (en) 2015-10-29
SG10201709840UA (en) 2018-01-30
WO2014152635A1 (en) 2014-09-25
EP2968302B1 (en) 2017-09-06
TW202002979A (zh) 2020-01-16
CN109908353A (zh) 2019-06-21
DK2968302T3 (en) 2017-12-18
ZA201705080B (en) 2019-02-27
PT2968302T (pt) 2018-01-03
TWI678205B (zh) 2019-12-01
EA201890507A1 (ru) 2018-07-31
MX2015012536A (es) 2016-01-12
HUE036069T2 (hu) 2018-06-28
CN108187056A (zh) 2018-06-22
CN105007921B (zh) 2018-12-11
KR20180045055A (ko) 2018-05-03
JP2019167347A (ja) 2019-10-03
NO3090119T3 (enExample) 2018-03-31
HK1213191A1 (en) 2016-06-30
EA030482B1 (ru) 2018-08-31
US20140274934A1 (en) 2014-09-18
JP2019214585A (ja) 2019-12-19
AU2018202581A1 (en) 2018-05-10
AU2020201656A1 (en) 2020-03-26
HRP20171898T1 (hr) 2018-04-06
RS56735B1 (sr) 2018-03-30
BR112015020918A2 (pt) 2017-07-18
IL240445A0 (en) 2015-09-24
JP2016513703A (ja) 2016-05-16
AU2014239322A1 (en) 2015-08-27
SMT201800017T1 (it) 2018-03-08
IL240445B (en) 2019-07-31
KR101853605B1 (ko) 2018-05-03
EA201591701A1 (ru) 2016-02-29
EP3318258A1 (en) 2018-05-09
CN105007921A (zh) 2015-10-28
PL2968302T4 (pl) 2018-04-30
TW201505633A (zh) 2015-02-16
KR20150129035A (ko) 2015-11-18
CA2901818A1 (en) 2014-09-25
AU2014239322B2 (en) 2018-04-05
SI2968302T1 (en) 2018-04-30
AU2018202581B2 (en) 2019-12-05
EP3915559A1 (en) 2021-12-01
EP2968302B9 (en) 2019-02-13
ES2654109T3 (es) 2018-02-12
HK1255257A1 (en) 2019-08-09

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