TWI673062B - 粒狀疫苗調配物 - Google Patents

粒狀疫苗調配物 Download PDF

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Publication number
TWI673062B
TWI673062B TW101133392A TW101133392A TWI673062B TW I673062 B TWI673062 B TW I673062B TW 101133392 A TW101133392 A TW 101133392A TW 101133392 A TW101133392 A TW 101133392A TW I673062 B TWI673062 B TW I673062B
Authority
TW
Taiwan
Prior art keywords
antigen
seq
antigens
vaccine formulation
cationic lipid
Prior art date
Application number
TW101133392A
Other languages
English (en)
Chinese (zh)
Other versions
TW201317001A (zh
Inventor
艾多 法蘭克 貝都
葛雷高瑞 康恩
艾瑞克 賈克柏森
卡羅 默瑟
肯亞 強森
Original Assignee
美商Ｐｄｓ生技公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商Ｐｄｓ生技公司 filed Critical 美商Ｐｄｓ生技公司
Publication of TW201317001A publication Critical patent/TW201317001A/zh
Application granted granted Critical
Publication of TWI673062B publication Critical patent/TWI673062B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
TW101133392A 2011-09-12 2012-09-12 粒狀疫苗調配物 TWI673062B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161533512P 2011-09-12 2011-09-12
US61/533,512 2011-09-12

Publications (2)

Publication Number Publication Date
TW201317001A TW201317001A (zh) 2013-05-01
TWI673062B true TWI673062B (zh) 2019-10-01

Family

ID=47883670

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101133392A TWI673062B (zh) 2011-09-12 2012-09-12 粒狀疫苗調配物

Country Status (8)

Country Link
US (2) US20150110823A1 (enExample)
EP (1) EP2755680B1 (enExample)
JP (2) JP6600459B2 (enExample)
CN (2) CN110075292A (enExample)
ES (1) ES2689799T3 (enExample)
PL (1) PL2755680T3 (enExample)
TW (1) TWI673062B (enExample)
WO (1) WO2013039989A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
BRPI0910464B1 (pt) 2008-04-17 2021-08-10 Pds Biotechnology Corporation Uso de uso de um lipídio catiônico quiral consistindo de r-dotap a preparação de composição farmacêutica
US20150110823A1 (en) * 2011-09-12 2015-04-23 Pds Biotechnology Corporation Particulate vaccine formulations
RU2649365C2 (ru) 2012-06-15 2018-04-02 ПиДиЭс БАЙОТЕКНОЛОДЖИ КОРПОРЭЙШН Вакцинные композиции с катионными липидами и способы применения
CN105101991A (zh) 2012-09-21 2015-11-25 Pds生物科技公司 改进的疫苗组合物和使用方法
EP3374496A4 (en) 2015-11-13 2019-07-10 PDS Biotechnology Corporation LIPIDES AS SYNTHETIC VECTORS FOR IMPROVING ANTIGEN PROCESSING AND PRESENTATION EX-VIVO IN DENDRITIC CELL THERAPY
US20180221475A1 (en) * 2016-10-05 2018-08-09 Pds Biotechnology Corporation Methods to alter the tumor microenvironment for effective cancer immunotherapy
SG11201902988UA (en) * 2016-10-05 2019-05-30 Pds Biotechnology Corp Novel hpv16 non hla-restricted t-cell vaccines, compositions and methods of use thereof
CN113557035B (zh) * 2019-01-12 2025-09-05 卫理公会医院 自组装肽纳米颗粒和其用途
US20220409708A1 (en) * 2019-11-01 2022-12-29 Korea Advanced Institute Of Science And Technology Small lipid nanoparticles, and cancer vaccine including same
WO2023145749A1 (ja) * 2022-01-27 2023-08-03 一般財団法人阪大微生物病研究会 免疫賦活剤
US20250281592A1 (en) 2022-04-22 2025-09-11 Universitat Autònoma De Barcelona Immunogenic composition with protein micro- and nanoparticles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008116078A2 (en) * 2007-03-22 2008-09-25 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
US20110110972A1 (en) * 2008-04-17 2011-05-12 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids

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US6183745B1 (en) * 1990-12-12 2001-02-06 The University Of Queensland Subunit papilloma virus vaccine and peptides for use therein
AUPM500494A0 (en) * 1994-04-12 1994-05-05 Minister For Agriculture & Rural Affairs For The State Of New South Wales, The Composition for use in increasing mucosal immunity
JPH11510046A (ja) * 1995-07-21 1999-09-07 ローヌ−プーラン ローラー ファーマシューティカルズ インコーポレイテッド アデノ関連ウイルスリポソーム及び樹状細胞をトランスフェクトして特異性免疫を刺激することにおけるそれらの使用
FR2794370B1 (fr) * 1999-06-03 2003-10-17 Biovector Therapeutics Fragments proteiques polyepitopiques, leur obtention et leurs utilisations notamment en vaccination
JP2004537501A (ja) * 2001-02-01 2004-12-16 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 肺への遺伝子送達のための安定化ポリマーエアロゾル
US20050031587A1 (en) * 2002-10-04 2005-02-10 Yamanouchi Pharmaceutical Co., Ltd. Immune response induction method
EP2481422A3 (en) * 2003-09-03 2013-04-03 Dendritherapeutics, Inc. Multiplex vaccines
CN1559607A (zh) * 2004-02-20 2005-01-05 �й�ũҵ��ѧ 一种核酸物质与蛋白质类组合物及其生产方法和在免疫调节中的应用
US7303881B2 (en) * 2004-04-30 2007-12-04 Pds Biotechnology Corporation Antigen delivery compositions and methods of use
DE102004057303A1 (de) * 2004-11-26 2006-06-01 Merck Patent Gmbh Stabile Kristallmodifikationen von DOTAP Chlorid
WO2007022152A2 (en) * 2005-08-15 2007-02-22 The Research Foundation Of State University Of New York Lipid nano particulates containing antigens as cancer vaccines
EP1969001A2 (en) * 2005-11-22 2008-09-17 Novartis Vaccines and Diagnostics, Inc. Norovirus and sapovirus antigens
JP2007238559A (ja) * 2006-03-10 2007-09-20 Nagoya City Univ 未成熟樹状細胞活性化剤及びその使用
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US20150110823A1 (en) * 2011-09-12 2015-04-23 Pds Biotechnology Corporation Particulate vaccine formulations

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2008116078A2 (en) * 2007-03-22 2008-09-25 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
US20110110972A1 (en) * 2008-04-17 2011-05-12 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids

Also Published As

Publication number Publication date
CN104066444A (zh) 2014-09-24
CN110075292A (zh) 2019-08-02
WO2013039989A1 (en) 2013-03-21
JP2014527965A (ja) 2014-10-23
US20150110823A1 (en) 2015-04-23
PL2755680T3 (pl) 2019-03-29
TW201317001A (zh) 2013-05-01
EP2755680A1 (en) 2014-07-23
EP2755680A4 (en) 2015-04-15
EP2755680B1 (en) 2018-07-04
JP6600459B2 (ja) 2019-10-30
JP2018065821A (ja) 2018-04-26
US20190275145A1 (en) 2019-09-12
ES2689799T3 (es) 2018-11-15

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