TWI667236B - 作為蛋白激酶抑制劑的胺基噻唑化合物 - Google Patents
作為蛋白激酶抑制劑的胺基噻唑化合物 Download PDFInfo
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- TWI667236B TWI667236B TW107120014A TW107120014A TWI667236B TW I667236 B TWI667236 B TW I667236B TW 107120014 A TW107120014 A TW 107120014A TW 107120014 A TW107120014 A TW 107120014A TW I667236 B TWI667236 B TW I667236B
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| CN112469414A (zh) | 2018-05-25 | 2021-03-09 | 昂科库博疗法有限责任公司 | 作为新型候选抗癌药物的高效力tacc3抑制剂 |
| KR20220103744A (ko) * | 2019-11-14 | 2022-07-22 | 에이2에이 파마수티칼스, 잉크. | 항암제로서 tacc3을 표적으로 하는 이속사졸 유도체 |
| US11299489B1 (en) | 2020-11-19 | 2022-04-12 | National Health Research Institutes | Thiazole compounds as protein kinase inhibitors |
| KR20240005751A (ko) * | 2021-04-12 | 2024-01-12 | 에이2에이 파마수티칼스, 잉크. | 암 치료를 위한 조성물 및 방법 |
| CA3246244A1 (en) | 2022-03-24 | 2023-09-28 | A2A Pharmaceuticals, Inc. | CANCER COMPOSITIONS AND TREATMENT METHODS |
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| TWI434834B (zh) * | 2011-03-04 | 2014-04-21 | Nat Health Research Institutes | 作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途 |
| CN106279143A (zh) * | 2015-05-11 | 2017-01-04 | 天津国际生物医药联合研究院 | 噻唑杂环类化合物及其制备方法和应用 |
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| MX2007012392A (es) * | 2005-04-04 | 2007-12-05 | Ab Science | Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa. |
| JP2008543754A (ja) * | 2005-06-09 | 2008-12-04 | メルク エンド カムパニー インコーポレーテッド | チェックポイントキナーゼの阻害剤 |
| GB0610909D0 (en) * | 2006-06-05 | 2006-07-12 | Merck Sharp & Dohme | Therapeutic treatment |
| WO2008033746A2 (en) | 2006-09-11 | 2008-03-20 | Curis, Inc. | Tyrosine kinase inhibitors containing a zinc binding moiety |
| TW200906825A (en) * | 2007-05-30 | 2009-02-16 | Scripps Research Inst | Inhibitors of protein kinases |
| ES2573831T3 (es) * | 2011-07-27 | 2016-06-10 | Ab Science | Derivados de oxazol y tiazol como inhibidores selectivos de la proteína quinasa (C-kit) |
| CN104024246B (zh) * | 2012-03-27 | 2016-03-02 | 广东东阳光药业有限公司 | 作为欧若拉激酶抑制剂的取代嘧啶衍生物 |
| WO2018106643A1 (en) * | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
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| TWI434834B (zh) * | 2011-03-04 | 2014-04-21 | Nat Health Research Institutes | 作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途 |
| CN106279143A (zh) * | 2015-05-11 | 2017-01-04 | 天津国际生物医药联合研究院 | 噻唑杂环类化合物及其制备方法和应用 |
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| TWI770858B (zh) * | 2020-03-06 | 2022-07-11 | 財團法人國家衛生研究院 | 嘧啶化合物及其醫藥用途 |
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| US10300061B2 (en) | 2019-05-28 |
| CA3064081A1 (en) | 2018-12-20 |
| MY201291A (en) | 2024-02-15 |
| ES2949616T3 (es) | 2023-10-02 |
| JP2020523348A (ja) | 2020-08-06 |
| AU2018284249B2 (en) | 2021-06-24 |
| MX2019014845A (es) | 2020-08-06 |
| CA3064081C (en) | 2023-03-21 |
| KR20200014350A (ko) | 2020-02-10 |
| WO2018231910A1 (en) | 2018-12-20 |
| MX393992B (es) | 2025-03-24 |
| CN110831596A (zh) | 2020-02-21 |
| KR102372288B1 (ko) | 2022-03-08 |
| EP3638237A1 (en) | 2020-04-22 |
| ZA202000107B (en) | 2020-12-23 |
| US20180353509A1 (en) | 2018-12-13 |
| NZ759327A (en) | 2021-08-27 |
| RU2019137573A (ru) | 2021-05-24 |
| AU2018284249A1 (en) | 2019-12-12 |
| TW201906836A (zh) | 2019-02-16 |
| CN110831596B (zh) | 2025-01-24 |
| BR112019026577A2 (pt) | 2020-06-23 |
| JP6979595B2 (ja) | 2021-12-15 |
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