TWI659043B - 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗 - Google Patents

對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗 Download PDF

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TWI659043B
TWI659043B TW107126293A TW107126293A TWI659043B TW I659043 B TWI659043 B TW I659043B TW 107126293 A TW107126293 A TW 107126293A TW 107126293 A TW107126293 A TW 107126293A TW I659043 B TWI659043 B TW I659043B
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kif20a
cells
peptide
hla
cancer
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TW107126293A
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Chinese (zh)
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TW201840581A (zh
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西村泰治
冨田雄介
大沢龍司
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日商腫瘤療法.科學股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0008Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C07KPEPTIDES
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    • C07KPEPTIDES
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07KPEPTIDES
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    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N5/0636T lymphocytes
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    • C12Y306/00Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/04Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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TW107126293A 2012-07-10 2013-07-10 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗 TWI659043B (zh)

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US201261669999P 2012-07-10 2012-07-10
US61/669,999 2012-07-10

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TW107126293A TWI659043B (zh) 2012-07-10 2013-07-10 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗
TW106132933A TWI636791B (zh) 2012-07-10 2013-07-10 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗
TW108106455A TW201925220A (zh) 2012-07-10 2013-07-10 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗
TW102124659A TWI609879B (zh) 2012-07-10 2013-07-10 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗

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TW106132933A TWI636791B (zh) 2012-07-10 2013-07-10 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗
TW108106455A TW201925220A (zh) 2012-07-10 2013-07-10 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗
TW102124659A TWI609879B (zh) 2012-07-10 2013-07-10 對於th1細胞之kif20a抗原決定位胜肽及含此之疫苗

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US (3) US9561265B2 (enExample)
EP (1) EP2872530A4 (enExample)
JP (1) JP6259983B2 (enExample)
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WO (1) WO2014010231A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015164826A2 (en) * 2014-04-24 2015-10-29 Rhode Island Hospital ASPARTATE-β-HYDROXYLASE INDUCES EPITOPE-SPECIFIC T CELL RESPONSES IN TUMORS
GB201522667D0 (en) * 2015-12-22 2016-02-03 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers
HRP20210698T1 (hr) 2015-12-22 2021-09-17 Immatics Biotechnologies Gmbh Peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma dojke i drugih karcinoma
WO2018092755A1 (en) * 2016-11-18 2018-05-24 Oncotherapy Science, Inc. Mphosph1 epitope peptides for th1 cells and vaccines containing the same
JP2019535270A (ja) * 2016-11-18 2019-12-12 オンコセラピー・サイエンス株式会社 Th1細胞のためのDEPDC1エピトープペプチドおよびこれを含有するワクチン
US11564980B2 (en) 2018-04-23 2023-01-31 Nantcell, Inc. Tumor treatment method with an individualized peptide vaccine
TWI816603B (zh) * 2018-04-23 2023-09-21 美商南特細胞公司 新抗原表位疫苗及免疫刺激組合物及方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010047062A1 (en) * 2008-10-22 2010-04-29 Oncotherapy Science, Inc. Rab6kifl/kif20a epitope peptide and vaccines containing the same

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
WO1992003918A1 (en) 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5804566A (en) 1993-08-26 1998-09-08 The Regents Of The University Of California Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
US5679647A (en) 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US5739118A (en) 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
US5922687A (en) 1995-05-04 1999-07-13 Board Of Trustees Of The Leland Stanford Junior University Intracellular delivery of nucleic acids using pressure
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
US6294378B1 (en) 1996-07-26 2001-09-25 Sloan-Kettering Institute For Cancer Research Method and reagents for genetic immunization
AU749544B2 (en) 1998-06-25 2002-06-27 Dainippon Sumitomo Pharma Co., Ltd. Tumor antigen peptides originating in cyclophilin B
US7504490B1 (en) * 1998-10-16 2009-03-17 Oscient Pharmaceuticals Corporation Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics
US6395527B1 (en) * 2000-08-17 2002-05-28 Cytokinetics, Inc. Motor proteins and methods for their use
WO2002101075A2 (en) * 2001-06-13 2002-12-19 Millennium Pharmaceuticals, Inc. Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US20060143729A1 (en) * 2004-06-30 2006-06-29 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
JP5109131B2 (ja) 2005-02-10 2012-12-26 オンコセラピー・サイエンス株式会社 膀胱癌を診断する方法
EP2305811A1 (en) 2005-07-27 2011-04-06 Oncotherapy Science, Inc. Method of diagnosing smal cell lung cancer
WO2007027866A2 (en) * 2005-08-30 2007-03-08 Monsanto Technology Llc Transgenic plants with enhanced agronomic traits
AU2007218045B2 (en) * 2006-02-20 2011-11-10 Phylogica Limited Method of constructing and screening libraries of peptide structures
EP2052088A2 (en) * 2006-08-02 2009-04-29 Genizon Biosciences Genemap of the human genes associated with psoriasis
WO2008102906A1 (en) 2007-02-20 2008-08-28 Oncotherapy Science, Inc. Hspc-hrpc transition genes
TWI615403B (zh) 2007-02-21 2018-02-21 腫瘤療法 科學股份有限公司 表現腫瘤相關抗原之癌症的胜肽疫苗
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
US10706955B2 (en) * 2010-03-23 2020-07-07 Iogenetics, Llc Bioinformatic processes for determination of peptide binding

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010047062A1 (en) * 2008-10-22 2010-04-29 Oncotherapy Science, Inc. Rab6kifl/kif20a epitope peptide and vaccines containing the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Melief, Cornelis JM, and Sjoerd H. Van Der Burg. "Immunotherapy of established (pre) malignant disease by synthetic long peptide vaccines." Nature Reviews Cancer 8.5 (2008): 351-360. *
Naylor PH. et al., "Peptide Based Vaccine Approaches for Cancer-A Novel Approach Using a WT-1 Synthetic Long Peptide and the IRX-2 Immunomodulatory Regimen." Cancers (Basel)., 2011 Oct 25, 3(4), 3991-4009. *

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TWI609879B (zh) 2018-01-01
TW201422635A (zh) 2014-06-16
WO2014010231A1 (en) 2014-01-16
US20170196956A1 (en) 2017-07-13
JP6259983B2 (ja) 2018-01-17
EP2872530A1 (en) 2015-05-20
TW201803584A (zh) 2018-02-01
US10172926B2 (en) 2019-01-08
US20150190489A1 (en) 2015-07-09
JP2015524788A (ja) 2015-08-27
TW201840581A (zh) 2018-11-16
TWI636791B (zh) 2018-10-01
TW201925220A (zh) 2019-07-01
US9561265B2 (en) 2017-02-07
EP2872530A4 (en) 2016-04-06
US20190060433A1 (en) 2019-02-28

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