TWI653237B - 磷酸鉑（ｐｈｏｓｐｈａｐｌａｔｉｎ）化合物之合成與純化方法及其用途 - Google Patents
磷酸鉑（ｐｈｏｓｐｈａｐｌａｔｉｎ）化合物之合成與純化方法及其用途 Download PDFInfo
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- TWI653237B TWI653237B TW106122720A TW106122720A TWI653237B TW I653237 B TWI653237 B TW I653237B TW 106122720 A TW106122720 A TW 106122720A TW 106122720 A TW106122720 A TW 106122720A TW I653237 B TWI653237 B TW I653237B
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- Prior art keywords
- dach
- complex
- substituted
- diamine
- platinum
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- 238000000034 method Methods 0.000 title claims abstract description 98
- YPGLWPWPVJBCEM-UHFFFAOYSA-K [Pt+3].[O-]P([O-])([O-])=O Chemical compound [Pt+3].[O-]P([O-])([O-])=O YPGLWPWPVJBCEM-UHFFFAOYSA-K 0.000 title abstract description 6
- 150000001875 compounds Chemical class 0.000 title description 13
- 230000002194 synthesizing effect Effects 0.000 title description 3
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- 239000007787 solid Substances 0.000 claims description 43
- ZZMFAAPZGBNYRP-UHFFFAOYSA-J phosphonato phosphate platinum(4+) Chemical compound [Pt+4].[O-]P([O-])(=O)OP([O-])([O-])=O ZZMFAAPZGBNYRP-UHFFFAOYSA-J 0.000 claims description 39
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 25
- 238000001953 recrystallisation Methods 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 21
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 20
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- 150000004982 aromatic amines Chemical class 0.000 claims description 6
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- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 claims description 4
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- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 claims description 4
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- 238000010438 heat treatment Methods 0.000 claims description 2
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- 238000012360 testing method Methods 0.000 description 4
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- 238000004294 195Pt NMR spectroscopy Methods 0.000 description 1
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- KPDXSGZQDXNAHJ-UHFFFAOYSA-I [O-]P([O-])(=O)OP(=O)([O-])OP(=O)([O-])[O-].[Pt+5] Chemical class [O-]P([O-])(=O)OP(=O)([O-])OP(=O)([O-])[O-].[Pt+5] KPDXSGZQDXNAHJ-UHFFFAOYSA-I 0.000 description 1
- RBQCRIWVHHAARW-UHFFFAOYSA-J [O-]P([O-])(=O)OP(=O)([O-])[O-].[Pt+2].NC1(CCCCC1)N.[Pt+2] Chemical compound [O-]P([O-])(=O)OP(=O)([O-])[O-].[Pt+2].NC1(CCCCC1)N.[Pt+2] RBQCRIWVHHAARW-UHFFFAOYSA-J 0.000 description 1
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- YMHQVDAATAEZLO-UHFFFAOYSA-N cyclohexane-1,1-diamine Chemical compound NC1(N)CCCCC1 YMHQVDAATAEZLO-UHFFFAOYSA-N 0.000 description 1
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- VKKIJPPZWGZEFC-UHFFFAOYSA-J tetrasodium phosphonato phosphate tetrahydrate Chemical compound O.O.O.O.[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O VKKIJPPZWGZEFC-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN109310663B (zh) * | 2016-04-06 | 2022-05-31 | 弗斯普拉廷治疗有限公司 | 磷铂液体制剂 |
| WO2018129257A1 (en) * | 2017-01-06 | 2018-07-12 | Phosplatin Therapeutics Llc | Phosphaplatin compounds as therapeutic agents for treatment of bone blood cancers |
| ES2971716T3 (es) * | 2017-09-08 | 2024-06-06 | Promontory Therapeutics Inc | Compuestos de fosfaplatino como agentes inmunomoduladores y usos terapéuticos de los mismos |
| CN113861036B (zh) * | 2021-11-08 | 2024-04-02 | 合肥工业大学 | 一种乙二胺高氯酸铜配合物的制备及用途 |
| US11673904B1 (en) | 2021-12-09 | 2023-06-13 | L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude | Low pressure process for synthesis of Pt(PF3)4 involving a soluble intermediate and storage of obtained Pt(PF3)4 |
| CN119822568B (zh) * | 2025-02-19 | 2025-08-19 | 扬州宏鑫环保科技有限公司 | 一种高效纯化水制备装置及制备方法 |
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| ZA200806748B (en) * | 2006-01-30 | 2010-01-27 | Platco Technologies Proprietar | Preparation of platinum (II) complexes |
| TW200902091A (en) * | 2007-05-18 | 2009-01-16 | Tti Ellebeau Inc | Systems, devices, and methods for passive transdermal delivery of active agents to a biological interface |
| SI2173337T1 (sl) * | 2007-08-06 | 2014-10-30 | Ohio University | Fosfaplatini in njihova uporaba pri zdravljenju vrst raka, odpornih proti cisplatinu in karboplatinu |
| PH12012502394A1 (en) * | 2010-06-04 | 2013-02-04 | Univ Ohio | Phosphaplatins and their use for treatment of cancers |
| EP2763537B1 (en) * | 2011-10-05 | 2018-01-10 | Rathindra N. Bose | Efficient processes for large scale preparation of phosphaplatins antitumor agents |
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