TWI647224B - 激酶抑制劑化合物的多晶型、含其的藥物組合物及其製備方法和應用 - Google Patents
激酶抑制劑化合物的多晶型、含其的藥物組合物及其製備方法和應用 Download PDFInfo
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
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| ZA (1) | ZA201901717B (enExample) |
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| EA201990688A1 (ru) * | 2016-09-29 | 2019-08-30 | Эквинокс Сайенсиз, Ллк. | Полиморфные формы соединения, представляющего собой ингибитор киназ, содержащая их фармацевтическая композиция, способ их получения и их применение |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| EP3884929B1 (en) | 2020-03-25 | 2023-06-14 | Ocular Therapeutix, Inc. | Ocular implant containing a tyrosine kinase inhibitor |
| CA3191463A1 (en) | 2020-09-14 | 2022-03-17 | Said Saim | Bioerodible ocular drug delivery insert and therapeutic method |
| CN117157294A (zh) * | 2021-03-16 | 2023-12-01 | 怡诺安有限公司 | 作为蛋白激酶抑制剂的杂环化合物的结晶形式 |
| JP7138982B1 (ja) | 2021-09-24 | 2022-09-20 | 東海物産株式会社 | アンセリンの結晶及びその製造方法 |
| US20250205152A1 (en) | 2022-03-11 | 2025-06-26 | EyePoint Pharmaceuticals, Inc. | Method of preventing age-related macular degeneration by administering an ocular drug delivery insert |
| TW202400143A (zh) | 2022-03-11 | 2024-01-01 | 美商視點製藥有限公司 | 用於治療眼睛病況之持續給藥方案 |
| TW202345804A (zh) | 2022-03-11 | 2023-12-01 | 美商視點製藥有限公司 | 治療濕性老年黃斑部病變(Wet Age-related Macular Degeneration)之方法 |
| IL322360A (en) | 2023-04-11 | 2025-09-01 | Ocular Therapeutix Inc | Intraocular implant containing axitinib iv polymorph |
| CN117143083A (zh) * | 2023-08-30 | 2023-12-01 | 沈阳药科大学 | VEGFR抑制剂Vorolanib的合成方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003031438A1 (en) * | 2001-10-10 | 2003-04-17 | Sugen, Inc. | 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors |
| CN101553482A (zh) * | 2006-09-15 | 2009-10-07 | 艾科睿制药公司 | 激酶抑制剂化合物 |
| CN102272124A (zh) * | 2008-11-13 | 2011-12-07 | 力奇制药公司 | 舒尼替尼苹果酸盐的新晶形 |
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| US20110026367A1 (en) * | 2007-05-07 | 2011-02-03 | Baumer Electric Ag | Acoustic Transducer |
| US20100256392A1 (en) * | 2007-11-21 | 2010-10-07 | Teva Pharmaceutical Industries Ltd. | Polymorphs of sunitinib base and processes for preparation thereof |
| CA2720943A1 (en) * | 2008-04-16 | 2009-10-22 | Natco Pharma Limited | Novel polymorphic forms of sunitinib base |
| KR101375156B1 (ko) | 2008-05-23 | 2014-03-18 | 쟝수 치아타이 티안큉 파마수티컬 주식회사 | 디하이드로인돌리논 유도체들 |
| EP2264027A1 (en) * | 2009-05-27 | 2010-12-22 | Ratiopharm GmbH | Process for the preparation of N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
| CN106928114B (zh) * | 2015-12-31 | 2020-07-28 | 韶远科技（上海)有限公司 | 含有脲基的环状手性氨基类化合物及其可放大工艺和用途 |
| EA201990688A1 (ru) * | 2016-09-29 | 2019-08-30 | Эквинокс Сайенсиз, Ллк. | Полиморфные формы соединения, представляющего собой ингибитор киназ, содержащая их фармацевтическая композиция, способ их получения и их применение |
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2021
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- 2023-03-28 JP JP2023052465A patent/JP7763203B2/ja active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003031438A1 (en) * | 2001-10-10 | 2003-04-17 | Sugen, Inc. | 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors |
| CN101553482A (zh) * | 2006-09-15 | 2009-10-07 | 艾科睿制药公司 | 激酶抑制剂化合物 |
| CN102272124A (zh) * | 2008-11-13 | 2011-12-07 | 力奇制药公司 | 舒尼替尼苹果酸盐的新晶形 |
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