TWI628180B - 作為ＰＩ３Ｋ抑制劑的吡啶并［１，２－ａ］嘧啶酮類似物 - Google Patents

作為ＰＩ３Ｋ抑制劑的吡啶并［１，２－ａ］嘧啶酮類似物 Download PDF

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Publication number
TWI628180B
TWI628180B TW104119646A TW104119646A TWI628180B TW I628180 B TWI628180 B TW I628180B TW 104119646 A TW104119646 A TW 104119646A TW 104119646 A TW104119646 A TW 104119646A TW I628180 B TWI628180 B TW I628180B
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TW
Taiwan
Prior art keywords
compound
alkyl
reaction
acid
pyrido
Prior art date
Application number
TW104119646A
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English (en)
Chinese (zh)
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TW201625612A (zh
Inventor
吳成德
Chengde Wu
于濤
Tao Yu
陳曙輝
Shuhui Chen
Original Assignee
正大天晴藥業集團股份有限公司
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54934872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI628180(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CN201410271282.9A external-priority patent/CN105461711B/zh
Application filed by 正大天晴藥業集團股份有限公司, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. filed Critical 正大天晴藥業集團股份有限公司
Publication of TW201625612A publication Critical patent/TW201625612A/zh
Application granted granted Critical
Publication of TWI628180B publication Critical patent/TWI628180B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
TW104119646A 2014-06-17 2015-06-17 作為ＰＩ３Ｋ抑制劑的吡啶并［１，２－ａ］嘧啶酮類似物 TWI628180B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201410271282.9 2014-06-17
CN201410271282.9A CN105461711B (zh) 2014-06-17 2014-06-17 作为PI3K抑制剂的吡啶并[1,2-a]嘧啶酮类似物
CN201510324348 2015-06-12
CN201510324348.0 2015-06-12

Publications (2)

Publication Number Publication Date
TW201625612A TW201625612A (zh) 2016-07-16
TWI628180B true TWI628180B (zh) 2018-07-01

Family

ID=54934872

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104119646A TWI628180B (zh) 2014-06-17 2015-06-17 作為ＰＩ３Ｋ抑制劑的吡啶并［１，２－ａ］嘧啶酮類似物

Country Status (11)

Country Link
US (1) US9856256B2 (cg-RX-API-DMAC7.html)
EP (1) EP3159341B8 (cg-RX-API-DMAC7.html)
JP (1) JP6680774B2 (cg-RX-API-DMAC7.html)
KR (1) KR102495840B1 (cg-RX-API-DMAC7.html)
CN (1) CN106470992B (cg-RX-API-DMAC7.html)
AU (1) AU2015276699B2 (cg-RX-API-DMAC7.html)
CA (1) CA2951971C (cg-RX-API-DMAC7.html)
EA (1) EA032642B1 (cg-RX-API-DMAC7.html)
ES (1) ES2754264T3 (cg-RX-API-DMAC7.html)
TW (1) TWI628180B (cg-RX-API-DMAC7.html)
WO (1) WO2015192760A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3395817B1 (en) * 2015-12-16 2022-02-23 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pyrido[1,2-a]pyrimidone analog, crystal form thereof, intermediate thereof and preparation method therefor
CN110386932A (zh) 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
US12325695B2 (en) * 2019-01-24 2025-06-10 Jiangsu Aosaikang Pharmaceutical Co., Ltd. 5-(4-pyridyloxy)pyrazole compounds serving as TGF-βR1 kinase inhibitor
CA3162166A1 (en) 2019-12-02 2021-06-10 Storm Therapeutics Limited Polyheterocyclic compounds as mettl3 inhibitors
AU2021218925A1 (en) * 2020-02-10 2022-09-29 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Use of pyrido[1,2-a]pyrimidinone compound in treating lymphoma
WO2021180111A1 (zh) 2020-03-10 2021-09-16 正大天晴药业集团股份有限公司 包括吡啶并[1,2-a]嘧啶酮化合物的药物组合
US20230321104A1 (en) * 2020-09-15 2023-10-12 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Use of pyrido[1,2-a]pyrimidinone compound in treating peripheral t cell lymphoma
WO2022121929A1 (zh) * 2020-12-08 2022-06-16 正大天晴药业集团股份有限公司 吡啶并[1,2-a]嘧啶酮化合物的治疗妇科肿瘤的用途
WO2023169488A1 (zh) * 2022-03-09 2023-09-14 正大天晴药业集团股份有限公司 包括吡啶并[1,2-a]嘧啶酮化合物和EGFR抑制剂的药物组合

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120010192A1 (en) * 2010-07-02 2012-01-12 Gilead Sciences, Inc. Fused Heterocyclic Compounds as Ion Channel Modulators
WO2012037108A1 (en) * 2010-09-13 2012-03-22 Glaxosmithkline Llc Aminoquinoline derivatives as antiviral agents
TW201443037A (zh) * 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
TW201602107A (zh) * 2014-06-17 2016-01-16 南京明德新藥研發股份有限公司 作為ｍＴＯＲ／ＰＩ３Ｋ抑制劑的吡啶并［１，２－ａ］嘧啶酮類似物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0415185A (pt) * 2003-10-10 2006-11-28 Pfizer Prod Inc 2h-[1,2,4]triazol[4,3-a]pirazinas substituìdas como inibidores da gsk-3
CN101541783B (zh) * 2006-06-30 2014-10-01 苏尼西斯制药有限公司 吡啶酮基pdk1抑制剂
EP2211615A4 (en) * 2007-10-22 2010-10-13 Glaxosmithkline Llc PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS
WO2009155121A2 (en) * 2008-05-30 2009-12-23 Amgen Inc. Inhibitors of pi3 kinase
WO2013071698A1 (zh) * 2011-11-17 2013-05-23 山东轩竹医药科技有限公司 三环类PI3K和/或mTOR抑制剂
CN103539777B (zh) 2012-07-13 2016-03-02 广东东阳光药业有限公司 Pi3激酶调节剂及其使用方法和用途
WO2014022128A1 (en) * 2012-07-29 2014-02-06 Calitor Sciences, Llc Pi3 kinase modulators and methods of use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120010192A1 (en) * 2010-07-02 2012-01-12 Gilead Sciences, Inc. Fused Heterocyclic Compounds as Ion Channel Modulators
WO2012037108A1 (en) * 2010-09-13 2012-03-22 Glaxosmithkline Llc Aminoquinoline derivatives as antiviral agents
TW201443037A (zh) * 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
TW201602107A (zh) * 2014-06-17 2016-01-16 南京明德新藥研發股份有限公司 作為ｍＴＯＲ／ＰＩ３Ｋ抑制劑的吡啶并［１，２－ａ］嘧啶酮類似物

Also Published As

Publication number Publication date
EP3159341A4 (en) 2018-05-16
US20170137420A1 (en) 2017-05-18
CN106470992B (zh) 2018-11-06
KR20170016465A (ko) 2017-02-13
JP6680774B2 (ja) 2020-04-15
WO2015192760A1 (zh) 2015-12-23
AU2015276699B2 (en) 2019-10-10
EA032642B1 (ru) 2019-06-28
EP3159341B8 (en) 2020-01-08
EP3159341B1 (en) 2019-08-21
EA201790016A1 (ru) 2017-06-30
KR102495840B1 (ko) 2023-02-03
EP3159341A1 (en) 2017-04-26
TW201625612A (zh) 2016-07-16
AU2015276699A1 (en) 2017-01-19
CA2951971A1 (en) 2015-12-23
JP2017519821A (ja) 2017-07-20
US9856256B2 (en) 2018-01-02
CN106470992A (zh) 2017-03-01
CA2951971C (en) 2024-09-10
ES2754264T3 (es) 2020-04-16

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