TWI602510B - Oral lozenge and its preparation method - Google Patents

Description

Buccal tablet and preparation method thereof

The invention relates to a buccal tablet, in particular to a buccal tablet which has the advantages of simple preparation method, short production time and the like, and is suitable for industrial production and a preparation method thereof.

A buccal tablet is a compressed tablet that is slowly dissolved in the oral cavity and can be used as a medicine or as a food. When the buccal tablet is used as a medicine, it can produce long-lasting effects on the oral cavity and the pharynx for local anti-inflammatory, disinfection and the like. When used as food, it can mask bad breath and clean teeth.

As a buccal tablet for use as a medicine, a medicinal active ingredient is generally considered, and mainly includes a Chinese medicinal material or a pharmaceutical compound as a raw material, for example, a grass coral lozenge, a watermelon cream lozenge, a Huasu tablet, a lysozyme lozenge, and the like. The buccal tablet as a food is generally prepared by using a drug-drinking substance as a raw material, for example, a mint-containing tablet, a fruit-flavored lozenge, a tea lozenge, and the like.

Whether as a medicine or a food, the buccal tablet is generally prepared by pulverizing the raw material and then preparing the tablet. The general preparation process is to prepare the raw material into a concentrated liquid, a concentrated paste or a lyophilized powder, and after being sieved, mixed with the auxiliary material. After granulation and drying, it is then tableted.

At present, the prior art generally adopts a gas phase instantaneous high pressure process for tableting, which not only has a large number of steps and strict process parameters, but also has a high crushing rate of the tablet sample when the above process is used, resulting in a low daily productivity of the buccal tablet.

The object of the present invention is to provide a buccal tablet and a preparation method thereof. The preparation method of the buccal tablet provided by the invention is simple and the production time is short, and is suitable for industrial production.

The present invention provides a buccal tablet comprising filter paper and a material encapsulated in the filter paper, the material comprising a medicinal material and/or an edible material. In a preferred embodiment, the material is a dry material, and the materials include licorice, mint, tea, tangerine peel, clove, cinnamon, mountain plant, mangosteen, bergamot, ebony, ginseng, medlar, sea, lemon, chrysanthemum, coffee One or more of cocoa, vitamin C, vitamin B6, vitamin B12, taurine, guarana and folic acid.

Further, the above materials further comprise pharmaceutically or foodly acceptable excipients having a particle size of from 7 mesh to 20 mesh and a weight of the filter paper of from 15 g/m2 to 25 g/m2.

The present invention also provides a method for preparing a buccal tablet comprising the steps of: encapsulating the above material in the filter paper to form a buccal tablet. Wherein, the above materials include medicinal materials and/or food materials.

In a preferred embodiment, the material has a particle size of 7 mesh to 20 mesh, and the material is prepared according to the following method: the raw material of the above material is pulverized at 2 ° C to 10 ° C and passed through a 7 mesh to 20 mesh sieve. Make the above materials. Further, the temperature of the above package is 145 ° C to 155 ° C, the weight of the above-mentioned mouth piece is 0.2 g / piece to 1.5 g / piece, and the speed of the above package is 35 pieces / minute - 45 pieces / minute.

Compared with the prior art, the invention directly encapsulates the medicinal material and/or the food material into the filter paper as a buccal tablet, does not need to pass the tableting procedure, has the advantages of simple preparation method and short production time, and is more suitable for industrial production.

In addition, when the buccal tablet provided by the invention is contained in the oral cavity or the pharynx, the aroma and related components of the material in the filter paper are gradually released, and the filter paper is applied to the oral cavity or the pharynx, thereby exerting the efficacy, only in the absence of corresponding taste or Discard the filter paper when aroma.

The invention adopts the inlet of the buccal tablet made of the filter paper packaging material, not only the fragrance is released quickly, but also the aroma lasts longer. From the experimental results, it was found that the release time of the aroma of the 1 gram/tablet tablet produced by the present invention in the oral cavity was 5 minutes or more.

In order to facilitate further understanding and understanding of the structure, the use and the features of the present invention, the preferred embodiments are described in detail below. The present invention provides a mouth piece comprising a filter paper and a package. The material in the above filter paper. Wherein, the above materials include medicinal materials and/or food materials.

The above-mentioned materials are substances which can be used as medicines or as foods to achieve the functions of masking oral odor and cleaning teeth, and are materials including medicines, food materials or medicines. The medicinal material may be a Chinese medicinal material, an effective part of a Chinese medicinal material, a Chinese medicinal material extract, and a pharmaceutical compound, and the above-mentioned foodstuff may be a plant, an effective part of a plant, a plant extract, a food additive, or the like.

The above materials are not particularly limited, and those skilled in the art can select specific materials to prepare corresponding buccal tablets according to needs, for example, licorice and/or mint can be selected to prepare a buccal tablet having a masking oral odor, or a grass coral can be selected. , watermelon cream, etc. to prepare a buccal tablet having an anti-inflammatory effect.

In the present invention, the above materials may further include licorice, mint, tea, tangerine peel, clove, cinnamon, hawthorn, mangosteen, bergamot, ebony, ginseng, medlar, sea, lemon, chrysanthemum, coffee, cocoa, vitamin C, vitamin B6. One or more of substances such as vitamin B12, taurine, guarana and folic acid.

Further, the above material is a powdery dry material, that is, when the above material is a single raw material, it is a powder; when the above material is a mixed raw material, it is a mixed powder. When the above material is a single raw material, the single raw material can be pulverized without need of wetting, tableting, etc.; when the above materials are mixed raw materials, the raw materials are pulverized and then uniformly mixed, and no need to be carried out. Wetting, tableting, etc. The particle size range of the above materials is 7 mesh to 20 mesh, and the preferred range is 10 mesh to 15 mesh.

In the present invention, in addition to the medicinal material and/or the food material as an active ingredient, the above materials further include pharmaceutically acceptable excipients and/or food-acceptable excipients, and the specific types of the above-mentioned excipients of the present invention There is no particular limitation, and the corresponding substances well known to those skilled in the art may be used.

Wherein, the above pharmaceutically acceptable excipients may include fillers, flavors, sweeteners, flavors and the like, and the above-mentioned food-acceptable excipients include flavors, sweeteners, flavors and the like.

In addition, the buccal sheet provided by the present invention further comprises a filter paper for encapsulating the above materials, and the filter paper encapsulates the materials to form a buccal tablet. The filter paper has the function of encapsulating the powdery material, so that the buccal tablet can be produced without a procedure such as tableting.

In practical applications, the weight of the filter paper ranges from 15 g/m 2 to 25 g/m 2 , and more preferably ranges from 20 g/m 2 to 22 g/m 2 . The material of the filter paper of the present invention is not particularly limited, and a preferred material is a filter paper made of softwood pulp and/or hemp pulp.

Since the invention directly encapsulates the medicinal material and/or the food material into the filter paper as a buccal tablet, it does not need to go through a tableting process, and therefore has the advantages of simple preparation method and short production time, and is more suitable for industrial production. When the buccal tablet provided by the invention is contained in the oral cavity or the pharynx, the aroma and related components of the material in the filter paper are gradually released, and the filter paper acts on the oral cavity or the pharynx, thereby exerting the efficacy, only when there is no corresponding taste or aroma. Discard the filter paper.

The invention also provides a method for preparing a buccal tablet, comprising the steps of: encapsulating a material in a filter paper to form a buccal tablet. Wherein, the above materials include medicinal materials and/or food materials.

In the present invention, the above-mentioned materials refer to substances which can exert effects as medicines or as foods to mask oral odor and clean teeth, and include materials for medicinal materials, food materials or medicines. Among them, the medicinal materials can be Chinese herbal medicines, effective parts of Chinese medicinal materials, extracts of Chinese medicinal materials, and pharmaceuticals. The composition may be a plant having a corresponding action, an effective part of a plant, a plant extract, a food additive, or the like.

The above materials are not particularly limited, and those skilled in the art can select specific materials to prepare corresponding buccal tablets according to needs, for example, licorice and/or mint can be selected to prepare a buccal tablet having a masking oral odor, or a grass coral can be selected. A mouthwash containing an anti-inflammatory effect is prepared from a watermelon cream or the like.

In the present invention, the above materials may further include licorice, mint, tea, tangerine peel, clove, cinnamon, hawthorn, mangosteen, bergamot, ebony, ginseng, medlar, sea, lemon, chrysanthemum, coffee, cocoa, vitamin C, vitamin B6. One or more of substances such as vitamin B12, taurine, guarana and folic acid.

In the present invention, the above material is a powdery dry material, that is, when the above material is a single raw material, it is a powder; when the above material is a mixed raw material, it is a mixed powder. When the above materials are a single raw material, the above single raw materials may be pulverized without need of wetting, tableting, etc.; when the above materials are mixed raw materials, the raw materials may be pulverized and uniformly mixed, and no need to be carried out. Wetting, tableting, etc. The particle size range of the above materials is 7 mesh to 20 mesh, and the preferred range is 10 mesh to 15 mesh.

In the present invention, in addition to the medicinal material and/or the food material as an active ingredient, the above materials further include pharmaceutically acceptable excipients and/or food-acceptable excipients, and the specific types of the above-mentioned excipients of the present invention There is no particular limitation, and the corresponding substances well known to those skilled in the art may be used.

Wherein, the above pharmaceutically acceptable excipient may include a filler, a flavor, a sweetener, a flavoring agent and the like, and the above-mentioned food-acceptable excipients include a flavor, a sweetener, a flavoring agent and the like.

In the present invention, the above materials are preferably prepared by pulverizing the raw materials of the above materials at 2 ° C to 10 ° C and passing through a 7 mesh to 20 mesh sieve to prepare the above materials. The invention is in the range of 2 ° C ~ 10 ° C The raw materials of the above materials are pulverized at a low temperature to better maintain the flavor of the materials. The pulverization temperature is 3 ° C to 8 ° C. The raw materials of the above materials can be made into a dry material after being pulverized and passed through a 7 mesh to 20 mesh sieve.

Before the pulverization process of the raw materials of the above materials, the pretreatment of the raw materials of the above materials is further included, and the pretreatment includes: a process of removing impurities and sterilizing the raw materials of the materials.

In the present invention, the above-mentioned cleaning procedure is to remove foreign matter such as eggs, stones, and metals in the raw materials of the above materials, followed by a sterilization procedure. In a preferred embodiment, the sterilization procedure is radiation sterilization and the radiation dose ranges from 3KGy to 5KGy.

The invention utilizes the above filter paper to encapsulate the above materials to form a buccal tablet. The filter paper has a function of encapsulating the above-mentioned materials in a powder form, so that a buccal tablet can be produced without a procedure such as tableting. In practical applications, the weight of the filter paper ranges from 15 g/m 2 to 25 g/m 2 , and preferably ranges from 20 g/m 2 to 22 g/m 2 . The material of the filter paper of the present invention is not particularly limited, and a preferred material is a filter paper made of softwood pulp and/or hemp pulp.

According to the present invention, the above materials can be packaged in the above filter paper by using a packaging machine to form a buccal tablet. In practical applications, the temperature range of the above package is 145 ° C ~ 155 ° C, the weight of the above-mentioned mouth piece is 0.2 g / piece ~ 1.5 g / piece, and the speed range of the above package is 35 pieces / minute ~ 45 pieces / minute.

After the package is completed, the prepared buccal piece is subjected to ultraviolet sterilization and then packaged. In a preferred embodiment, the sterilization method is irradiation under ultraviolet light for 15 minutes to 30 minutes.

The preparation process provided by the invention is simple, and not only the fragrance is released quickly after the mouth piece is prepared, but also the aroma lasts for a long time. From the experimental results, it was found that the release time of the aroma of the 1 gram/tablet tablet produced by the present invention in the oral cavity was 5 minutes or more.

In order to further illustrate the present invention, the buccal tablets provided by the present invention and the preparation method thereof are described below in conjunction with the examples, and the scope of the present invention is not limited by the following examples.

Example 1

The mint leaves were tested for pesticide residues and heavy metals, and the foreign eggs such as eggs, stones and metals in the raw materials meeting the test standards were removed, followed by 3KGy radiation treatment, and the irradiated mint leaves were pulverized at 5 ° C. The pulverized material was passed through a 10-mesh sieve, and then 10 g of sieved mint leaves, 0.5 g of sweetener, and 0.5 g of flavor were mixed for 30 minutes to prepare a mixture.

The mixture was packaged in filter paper at a temperature of 150 ° C using a packaging machine and packaged into a 1 g piece/tablet tablet, and the package speed was set to 35 bags/min.

The above-mentioned buccal tablet may be irradiated under ultraviolet light for 15 minutes.

The buccal tablet is contained in the mouth, and there is still a minty aroma after 5 minutes. After 15 minutes, the mint aroma is no longer obvious, and the buccal tablet can be discarded.

Example 2

The licorice is tested for pesticide residues and heavy metals, and the foreign matter such as eggs, stones and metals in the raw materials meeting the testing standards are removed, followed by 3KGy radiation treatment, and the irradiated licorice is pulverized at 10 ° C, and The pulverized material was passed through a 5-mesh sieve, and then 10 g of sieved licorice, 0.3 g of sweetener and 0.2 g of flavor were mixed for 40 minutes to prepare a mixture.

The mixture was packaged in a filter paper at a temperature of 145 ° C using a packaging machine, and packaged into a buccal sheet having a specification of 0.5 g/piece, and the package speed was set to 45 bags/min.

The above-mentioned buccal tablet may be irradiated under ultraviolet light for 20 minutes.

The buccal tablet is contained in the oral cavity, and the licorice aroma is still present after 5 minutes. After 13 minutes, the licorice aroma is no longer obvious, and the buccal tablet can be discarded.

Example 3

Pesticide residues and heavy metal indicators were detected on mint leaves and licorice, and foreign eggs such as eggs, stones and metals in the raw materials meeting the test standards were removed, followed by 3KGy radiation treatment, and the irradiated licorice and mint were respectively treated. The leaves were comminuted at 10 ° C, and the pulverized material was passed through a 5 mesh sieve, followed by mixing 5 g of sifted licorice, 5 g of sieved mint leaves, 0.3 g of sweetener and 0.2 g of flavor for 40 minutes. Made into a mixture.

The mixture was packaged in filter paper at a temperature of 155 ° C using a packaging machine, and packaged into a 1.5 g/piece mouth piece, and the package speed was set to 45 bags/min.

The above-mentioned buccal tablet was irradiated under ultraviolet light for 18 minutes.

The buccal tablet is contained in the mouth. After 8 minutes, there is still a licorice aroma and a mint aroma. After 20 minutes, the licorice aroma and the mint aroma are no longer obvious, and the buccal tablet can be discarded.

Comparative example 1

Pesticide residues and heavy metal indicators were detected on the mint leaves, and foreign eggs such as eggs, stones and metals in the raw materials meeting the test standards were removed, followed by water extraction at 80 ° C, the ratio of feed water was 1:10, and extraction was performed 3 times. . The prepared extracts were combined and passed through a 60 mesh sieve, and then the extract was concentrated under vacuum at a temperature of 50 ° C and a vacuum of 80 KPa to prepare a concentrate.

10 g of the concentrate was mixed with 0.03 g of ethanol and 0.03 g of polyvinyl alcohol to form wet granules, and the wet granules were passed through a 20 mesh sieve, and dried at a temperature of 50 ° C for 5 hours, followed by 10 g of dried particles and 0.03 g of the lubricant and 0.02 g of the release agent were mixed and then tableted to prepare a 1 g/tablet buccal tablet, and finally the above-mentioned buccal tablet was irradiated under ultraviolet light for 18 minutes.

The buccal tablets were contained in the mouth, and after 3 minutes, the buccal tablets were completely melted, and after 5 minutes, there was no mint aroma in the mouth.

The above embodiments are intended to be illustrative only, and are not intended to limit the scope of the present invention. It is included in the scope of the following patent application.

Claims (6)

A mouth piece comprising a filter paper and a dry powdery material encapsulated in the filter paper, the powdery material comprising licorice, mint, tea, dried tangerine peel, clove, cinnamon, yam, mangosteen, bergamot, ebony, ginseng, medlar, inflated At least one of sea, lemon, chrysanthemum, coffee, and cocoa, and the powdery material has a particle size of 7 mesh to 20 mesh. When the filter paper is contained in the oral cavity or the pharynx, the aroma of the material inside the filter paper is gradually released. The buccal tablet according to claim 1, wherein the above material further comprises one or more of vitamin C, vitamin B6, vitamin B12, taurine, guarana and folic acid. The buccal tablet of claim 1, wherein the above material further comprises a pharmaceutically or foodly acceptable excipient. The buccal tablet according to claim 1, wherein the filter paper has a weight of 15 g/m 2 to 25 g/m 2 . The invention discloses a preparation method of a buccal tablet, comprising the steps of: removing and sterilizing a material of the material, sterilizing the sterilizing by irradiation, and irradiating the dose is 3KGy~5KGy; pulverizing the raw material of the material at 2° C. to 10° C. The powdery material having a particle size of 7 mesh to 20 mesh is obtained through a 7 mesh to 20 mesh sieve; the powdery material is encapsulated in a filter paper to form a buccal tablet, and the powdery material comprises at least a medicinal material or a food material using a dry material. one of them. The preparation method according to claim 5, wherein the temperature of the package is 145 ° C to 155 ° C, the weight of the buccal tablet is 0.2 g / piece to 1.5 g / piece, and the speed of the package is 35 pieces. /min ~ 45 pieces / minute.