WO2017068805A1 - Saliva secretion promoter, and oral composition and drinkable composition containing same - Google Patents

Saliva secretion promoter, and oral composition and drinkable composition containing same Download PDF

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Publication number
WO2017068805A1
WO2017068805A1 PCT/JP2016/065047 JP2016065047W WO2017068805A1 WO 2017068805 A1 WO2017068805 A1 WO 2017068805A1 JP 2016065047 W JP2016065047 W JP 2016065047W WO 2017068805 A1 WO2017068805 A1 WO 2017068805A1
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composition
dry powder
yamabushitake
extract
mass
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PCT/JP2016/065047
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French (fr)
Japanese (ja)
Inventor
丸山　真達
求 尾島
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ライオン株式会社
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Priority to JP2017546417A priority Critical patent/JPWO2017068805A1/en
Publication of WO2017068805A1 publication Critical patent/WO2017068805A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a salivary secretion-promoting agent that exhibits a high salivary secretion-promoting effect, an oral composition and a beverage composition containing the same.
  • Saliva is a secretory fluid in the oral cavity that greatly affects the quality of life.
  • wetting action in the oral cavity digestion action of saliva components by amylase, self-cleaning action as circulating fluid in the oral cavity, antibacterial action by antibacterial ingredients, buffering action to neutralize acid causing caries Etc. are known. Therefore, a decrease in salivary secretion is an indirect risk, such as increased risk of oral problems such as caries, periodontal disease, bad breath, and thirst, difficulty in speaking, difficulty in eating, and inability to eat deliciously. It can also cause a direct decline in quality of life.
  • Patent Documents 1 and 2 a method for improving the wettability in the oral cavity using a water-soluble polymer substance having high water retention
  • Patent documents 3 to 5 a method for promoting salivary secretion by using various natural products and organic acids
  • the method of simply moistening the oral cavity is not limited to the improvement of the moistening action, and cannot fully replace all the functions of saliva, and there is a problem that a stickiness derived from a water-soluble polymer substance occurs. .
  • JP 2007-084501 A JP 2014-189524 A JP 2005-162633 A International Publication No. 05/049050 Japanese Patent Application Laid-Open No. 07-101856 JP 2013-237699 A JP 2012-051897 A JP 2007-001961 A
  • the present invention has been made in view of the above circumstances, and an object thereof is to provide a saliva secretion-promoting agent that exhibits a high salivary secretion-promoting effect, an oral composition and a beverage composition containing the same.
  • the present inventors have found that (A) dried powder of Herbium (Herium erinaceus) and / or an extract thereof has a high salivary secretion promoting effect, and a salivary secretion promoter. As a result, it has been found that it can be suitably blended in a composition for oral cavity.
  • (B) sugar alcohol and (C) crystalline cellulose are used in combination with (A) dry powder of Yamabushitake and / or its extract in an oral composition, the salivary secretion promoting effect of component (A) is obtained. It has been found that it has an improved saliva secretion promoting effect, gives a good feeling of good taste by suppressing the appearance of nasty taste, and can suppress the discoloration of the preparation over time and stabilize the appearance of the preparation.
  • Yamabushitake extract has antibacterial properties against oral bacteria, and oral compositions containing this are known (Patent Documents 6 to 8; JP2013-237699A, JP2012051897A). JP, 2007-001961, A).
  • the dried powder of Yamabushitake or its extract is not an antibacterial action against non-pathogenic resident bacteria in the oral cavity, but selectively activates its growth to promote growth and promote oral bacterial flora.
  • the present inventors have newly found that the dried powder of Yamabushitake or an extract thereof has an excellent effect of promoting salivation, and have made the present invention.
  • the salivary secretion promoter comprising (A) a dried powder of Yamabushitake or an extract thereof preferably exhibits an excellent salivary secretion promoting effect when formulated as a liquid preparation or solid preparation for oral cavity.
  • the component (A) is blended with an oral preparation, particularly a solid formulation, a unique taste unique to the component (A) is strongly expressed and the taste is lowered, and the formulation is discolored over time. .
  • the present inventors further investigated, when the (B) and (C) component was used in combination, the salivary secretion promoting action of the (A) component was improved.
  • a mouthwash or a mouse spray containing a saliva secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the dry powder has a 90% cumulative particle size of 30 ⁇ m
  • a saliva secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the dry powder has a 90% cumulative particle size of 30 ⁇ m
  • an excellent saliva secretion promoting effect could be imparted by the oral composition having a 50% cumulative particle size of 15 ⁇ m or less.
  • composition for beverages containing a saliva secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the 90% cumulative particle size of the dry powder is 30 ⁇ m or less, 50
  • An excellent saliva secretion promoting effect could be imparted by the beverage composition having a% cumulative particle size of 15 ⁇ m or less.
  • component (A) when (D) inosinic acid and / or a salt thereof is further added to the above composition, the taste of component (A) is further suppressed, the taste is improved, and the saliva secretion promoting effect is further improved. Furthermore, by further blending (E) dry powder of Camellia sinensis and / or its extract, the taste of component (A) was further suppressed and the taste could be further improved.
  • the present invention provides the following saliva secretion promoter, oral composition and beverage composition.
  • a salivary secretion promoter comprising a dried powder of Yamabushitake (Hericium erinaceus) and / or an extract thereof.
  • An oral composition comprising the salivary secretion promoter according to [1] or [2].
  • (B) The composition for oral cavity according to [4], wherein the component is one or more sugar alcohols selected from sorbitol, xylitol, maltitol and reduced palatinose.
  • the content of the component (A) is 1 to 40% by mass in terms of dry powder of Yamabushitake, the content of the component (B) is 25 to 90% by mass, and the content of the component (C) is 5 to 30% by mass.
  • composition for oral cavity according to any one of [7].
  • solid preparation is a tablet, granule or chewing gum.
  • a beverage composition containing a salivary secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the dry powder has a 90% cumulative particle size of 30 ⁇ m or less and a 50% cumulative particle size of 15 ⁇ m.
  • a beverage composition characterized by the following: [16] [15] The beverage composition according to [15], wherein the content of component (A) is 0.05 to 2% by mass in terms of dry powder equivalent of Yamabushitake. [17] The beverage composition according to [15] or [16], further comprising (D) 0.001 to 0.5% by mass of inosinic acid and / or a salt thereof.
  • a dry powder of Camellia sinensis and / or an extract thereof is contained in an amount of 0.1 to 2% by mass in terms of the dry powder of the tea tree, [15] to [17] Beverage composition.
  • the present invention it is possible to provide a saliva secretion promoter and a composition for oral cavity that have a high saliva secretion promoting effect. Furthermore, it is possible to provide an oral composition having an excellent salivary secretion promoting effect, a good taste and a stable formulation appearance. ADVANTAGE OF THE INVENTION According to this invention, the composition for drinks which is excellent in the saliva secretion promotion effect and good in taste can also be provided.
  • the saliva secretion-promoting agent of the present invention comprises (A) dried powder of Herbium erinaceus and / or an extract thereof as an active ingredient.
  • Yamabushitake As a dried powder of Yamabushitake or an extract thereof, those prepared by a known method using a fruit body and / or mycelium of Yamabushitake (Hericium erinaceus) as a raw material can be used. In this case, it is possible to use either the fruit body of Yamabushitake, the mycelium, or both as the raw material, but it is preferable to use the fruit body of Yamabushitake that is safe and has food experience.
  • the dry powder of Yamabushitake is not particularly limited in its preparation method, and can be obtained by employing a usual method, and is obtained by freeze-drying or heat-drying the raw material fruit bodies and / or mycelium and then pulverizing them. Dry ground powder can be used.
  • the conditions for freeze-drying and heat-drying may be the same as in the conventional method, and the physical properties such as the particle size of the dry powder are not particularly limited as long as they can be blended in the oral preparation.
  • Yamabushitake dry powders include “Yamabushitake dry powder” (manufactured by Hokuto), Gokayama Yamabushitake powder (manufactured by Isoyama Hayashi Co., Ltd.), Yamabushi mochi “dry powder” (manufactured by Aso Biotech Co., Ltd.), Sango Yamabushitake Powders (manufactured by Shinshu Mushroom Studio) and the like are sold, and these can be used as they are or after being pulverized and further adjusted in particle size.
  • the extract of Yamabushitake can be directly extracted from the fruit body and / or mycelium of the raw Yamabushitake, but what is extracted from the dried powder of Yamabushitake is preferable.
  • the method for obtaining the extract is not particularly limited, and a known method can be adopted.
  • the extraction solvent include water, alcohols (for example, lower alcohols having 1 to 3 carbon atoms such as methanol, absolute ethanol, and ethanol, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), and ketones such as acetone.
  • esters such as diethyl ether, dioxane, acetonitrile, and ethyl acetate, polar solvents such as xylene, benzene, and chloroform, and nonpolar solvents. These can be used alone or in combination of two or more as a mixed solution.
  • polar solvents such as xylene, benzene, and chloroform
  • nonpolar solvents such as xylene, benzene, and chloroform
  • nonpolar solvents such as xylene, benzene, and chloroform.
  • the obtained extract can be prepared by arbitrarily drying, concentrating or diluting depending on the dosage form and form of the preparation to be applied. In many cases, it can be used as it is, but if necessary, it may be further subjected to purification treatment such as deodorization and decoloration within the range that does not affect its efficacy, or it may be filtered with a sterilization filter.
  • purification treatment such as deodorization and decoloration within the range that does not affect its efficacy, or it may be filtered with a sterilization filter.
  • the usual means generally applied to an object can be arbitrarily selected and performed.
  • a dry pulverized powder of Yamabushitake fruit body or an aqueous extract thereof particularly a dry pulverized powder of Yamabushitake fruit body.
  • a sufficient effect can be exhibited at a lower concentration than the extract.
  • the dry powder of Yamabushitake as component (A) or an extract thereof preferably has a 90% cumulative particle size (D90, volume basis) of 200 ⁇ m or less, more preferably 100 ⁇ m or less, particularly 30 ⁇ m or less. In particular, it is 25 ⁇ m or less, more preferably 0.1 ⁇ m or more, particularly 0.5 ⁇ m or more.
  • D90, volume basis 90% cumulative particle size
  • the 50% cumulative particle diameter (D50, volume basis) is preferably 100 ⁇ m or less, more preferably 50 ⁇ m or less, particularly 15 ⁇ m or less, especially 12 ⁇ m or less, still more preferably 0.01 ⁇ m or more, particularly preferably 0.00. 1 ⁇ m or more.
  • the particle diameter can be measured by a known particle size distribution measuring instrument, for example, using a laser diffraction particle size distribution measuring apparatus (Microtrack MT3000II, manufactured by Nikkiso Co., Ltd.).
  • the particle size of the dried yamabushitake powder As for the particle size of the dried yamabushitake powder, a known pulverization method is used so that the fruit body and / or mycelium of the raw material is freeze-dried or heat-dried, or a commercially available dried yamabushitake powder has a predetermined particle size. Can be adjusted.
  • the pulverization method is not particularly limited, and dry pulverization or wet pulverization can be employed.
  • pulverizers such as a stone mill, a pin mill, a hammer mill, a jet mill, a roller mill, a colloid mill, a planetary mill, a vibration mill, a rotating mill, an attritor, a bead mill, an ultrasonic ball mill, and a high-pressure homogenizer can be used.
  • these pulverization methods can be performed a plurality of times, or a plurality of pulverization methods can be combined.
  • the salivary secretion-promoting agent of the present invention preferably has a dose of 1 to 1,000 mg, more preferably 5 to 500 mg, still more preferably 10 to 200 mg in terms of dry powder of Yamabushitake. It is preferable to prepare a preparation by adjusting the concentration of the dried powder of Yamabushitake or an extract thereof so that the dose per time is within the above range. Saliva secretion can be effectively promoted within the above range. If the concentration is too high, the unique taste of Yamabushitake may become strong and difficult to use, but if it is 1,000 mg or less, this can be sufficiently prevented.
  • the above dry powder equivalent amount is the amount used when using dry powder, and in the extract, it is the dry powder mass of Yamabushitake necessary to obtain the pure extract amount (extract amount excluding the solvent). .
  • a dried powder of Yamabushitake or an extract thereof according to the present invention can be blended in an oral composition as a salivary secretion promoter. Specifically, it is prepared in the form of solid, liquid (some or all of the ingredients are dispersed or suspended without being solubilized, the same applies hereinafter), paste, gel, etc.
  • Various types of tablets such as disintegrating tablets, chewable tablets, troches, candies, etc., granules such as granules, chewing gum, gummi, toothpaste, liquid toothpaste, liquid toothpaste, toothpaste such as toothpaste, mouthwash, mouth spray, etc. Can be used in dosage form.
  • the saliva secretion-promoting agent of the present invention is suitable as a liquid formulation or a solid formulation.
  • a solid formulation because the dry powder does not dissolve in water.
  • it can be suitably prepared as a solid preparation such as a tablet, granule or chewing gum, among others as a tablet or granule.
  • a tablet tablets for disintegration or dissolution in the oral cavity such as orally disintegrating tablets, chewable tablets, troches, and candies are suitable, and granular agents that can be disintegrated or dissolved in the oral cavity are also suitable.
  • the amount of dry powder of Yamabushitake or the extract thereof is 1 to 40% (mass%, the same applies hereinafter) in terms of dry powder with respect to the entire composition. )), More preferably 5 to 30%, still more preferably 5 to 25%.
  • the blending amount the higher the saliva secretion promoting effect, and if it is 1% or more, a sufficient saliva secretion promoting effect can be imparted. 40% or less is suitable for suppressing the appearance of off-taste and preventing discoloration of the preparation over time.
  • the amount of Yamabushitake dry powder or extract thereof is preferably 0.05 to 2%, more preferably 0.1 to 1%, in terms of dry powder, relative to the entire composition. More preferably, it is 0.2 to 0.8%.
  • the greater the blending amount the greater the salivary secretion promoting effect. However, it is preferable not to add too much to suppress the expression of off-flavors and maintain the taste satisfactorily.
  • a dried powder of Yamabushitake or an extract thereof according to the present invention can be blended in a beverage composition as a saliva secretion promoter. Specifically, it can be prepared in a solid or liquid form, and the saliva secretion promoter can be dispersed and suspended in water and used as a beverage.
  • the blended amount of the dried powder of Yamabushitake or the extract thereof with respect to the entire beverage composition is dried within the range of the dose in a single use (the use per mouthful is about 10 mL as a beverage) as described above. It is preferably 0.05 to 2% (administration concentration) in terms of powder, more preferably 0.1 to 1%, and still more preferably 0.2 to 0.8%.
  • the liquid preparation for oral cavity is a mouthwash or mouse spray containing the saliva secretion promoter, and (A) 90% cumulative particle size of dry powder of Yamabushitake, which is a saliva secretion promoter, 50 It is preferable that the% cumulative particle diameter is 15 ⁇ m or less from the viewpoint of the salivary secretion promoting effect, taste, and dispersibility.
  • the beverage composition contains the salivary secretion promoter, and is a beverage composition that is used by being dispersed, suspended, or dissolved in water, and is a saliva secretion promoter.
  • the 90% cumulative particle diameter of the powder is preferably 30 ⁇ m or less, and the 50% cumulative particle diameter is preferably 15 ⁇ m or less from the viewpoint of the salivary secretion promoting effect, taste, and dispersibility.
  • the oral composition of the present invention preferably further contains (B) a sugar alcohol and (C) crystalline cellulose in combination, thereby obtaining a sufficient taste improving effect and a discoloration suppressing effect of the preparation. It is done.
  • component (B) or component (C) is absent, discoloration of the preparation over time may not be sufficiently suppressed, particularly in solid preparations.
  • sugar alcohols include erythritol, xylitol, sorbitol, maltitol, isomaltitol, lactitol, reduced palatinose, maltotriitol, isomatotriitol, panitol, oligosaccharide alcohol, reduced starch syrup, and reduced maltose starch syrup.
  • sorbitol, xylitol, maltitol, reduced palatinose, mannitol, and erythritol are preferable, and sorbitol, xylitol, maltitol, and reduced palatinose are more preferable.
  • the blending amount of the sugar alcohol as the component (B) is preferably 25 to 90%, more preferably 30 to 90%, still more preferably 45 to 85%, particularly preferably 50 to 80% of the entire composition.
  • the greater the amount the more the taste derived from the component (A) can be suppressed and the taste can be improved. If the amount is 25% or more, the taste can be sufficiently improved, and more suitable for suppressing discoloration of the preparation. If too much is added, discoloration of the preparation may not be suppressed even when component (C) is added, and 90% or less is suitable for suppressing discoloration of the preparation.
  • the sugar alcohol of (B) component can be used also as an excipient
  • Crystalline cellulose is obtained by hydrolyzing and purifying cellulose of pulp obtained from a fibrous plant with an acid, and a commercially available product can be used.
  • Component (C) is preferably 5 to 30%, more preferably 10 to 25% of the total composition of crystalline cellulose. 5 to 30% can sufficiently suppress the discoloration of the preparation.
  • discoloration suppressing action increases as the blending amount increases, but if blending too much, the blending amount of the component (B) must be relatively reduced, which may be disadvantageous for taste improvement and discoloration suppression. .
  • the ratio (A) / (B) indicating the proportion of the components (A) and (B) is preferably 0.01 to 1.5, more preferably 0.05 to 0.7. More preferably, it is 0.07 to 0.6, and particularly preferably 0.07 to 0.5.
  • the ratio is within the above range, the saliva secretion promoting effect is more excellent, and the taste improving effect and the discoloration suppressing effect of the preparation are further enhanced. If (A) / (B) is less than 0.01, the salivary secretion promoting effect may not be sufficiently obtained. When it exceeds 1.5, the taste improving effect and the discoloration suppressing effect of the preparation may not be obtained satisfactorily.
  • (A) / (C) which indicates the ratio of the blended amounts of the components (A) and (C), is preferably 0.1 to 8, more preferably 0.25 to 2.5 as a mass ratio. It is.
  • the blending ratio is within the above range, the saliva secretion promoting effect is more excellent, and the taste improving effect and the discoloration suppressing effect of the preparation are further enhanced. If (A) / (C) is less than 0.1, the salivary secretion promoting effect may not be sufficiently obtained. If it exceeds 8, the taste improving effect and the discoloration inhibiting effect of the preparation may not be obtained satisfactorily.
  • (B) / (C) indicating the ratio of the blending amounts of the components (B) and (C) can be 1 to 18 as a mass ratio, but is preferably 2 to 8.
  • the blending ratio is within the above range, the taste improving effect and the discoloration suppressing effect of the preparation are more excellent.
  • the blending ratio of (A) / (B) and / or the blending ratio of (A) / (C) is preferably within the above ranges, respectively, and all of the above blending ratios are within the above ranges. Is particularly preferred. It is preferable to mix
  • (D) inosinic acid and / or a salt thereof can be further added to the composition for oral cavity and beverage composition according to the present invention.
  • the off-flavor derived from the component (A) is sufficiently suppressed, the taste is further improved, and the salivary secretion promoting action is also improved, and the saliva secretion promoting effect is excellent under a pleasant taste. Can be granted.
  • the inosinic acid of component (D) used in the present invention is a generic name for inosine phosphoric acid, and examples include inosine-2′-phosphoric acid, inosine-3′-phosphoric acid, and inosine-5′-phosphoric acid.
  • inosine-2′-phosphoric acid Inosine-2′-phosphoric acid
  • inosine-3′-phosphoric acid Inosine-5′-phosphoric acid.
  • inosine-5′-phosphoric acid One kind may be used alone or two kinds may be used in combination, but inosine-5′-phosphate is particularly preferable.
  • the salt include a sodium salt and a potassium salt, and a sodium salt is preferable.
  • An inosinic acid sodium salt is an umami component, and an extract containing inosinic acid such as bonito or a chemically synthesized one can also be used.
  • Inosinic acid is solid at room temperature, but can be used by dissolving in water.
  • the blending amount is preferably 0.001 to 0.5% (administration concentration) of the whole composition, more preferably 0.01 to 0.2%. It is. Within this range, the taste is sufficiently improved. In addition, when mix
  • the oral composition and beverage composition according to the present invention may further contain (E) dried tea tree powder and / or an extract thereof.
  • the off-flavor derived from the component (A) is sufficiently suppressed, the taste is further improved, and an excellent saliva secretion promoting effect can be imparted under a pleasant taste.
  • powdered tea obtained by pulverizing tea leaves and / or powdered tea produced in the production process of tea leaves can be used, but powdered tea capable of adjusting the particle size is preferable.
  • the average particle size of the powdered tea obtained by pulverizing tea leaves is not particularly limited, but is preferably 0.1 to 100 ⁇ m, more preferably 1 to 80 ⁇ m.
  • the average particle size was measured using a laser diffraction particle size distribution measuring device (Microtrack MT3000II, manufactured by Nikkiso Co., Ltd.) (the same applies hereinafter).
  • the tea leaf water extract can be dried by freeze-drying or spray-drying.
  • green tea or hojicha powder obtained by spray drying a commercially available tea leaf extract can be used.
  • the blended amount of dry powder of chanoki and / or its extract is preferably 0.1-2% (administration concentration), more preferably 0.3%, in terms of dry powder with respect to the whole composition. ⁇ 1%. Within this range, the taste is sufficiently improved. In addition, when mix
  • oral solid preparations such as tablets and granules preferably contain the component (B) and the component (C) together with the component (A) from the viewpoint of the salivary secretion promoting effect, taste, and formulation appearance.
  • the particle size of the component (A) is not particularly limited, but the 90% cumulative particle size is preferably 100 ⁇ m or less, particularly preferably 50 ⁇ m or less, and in particular, the 90% cumulative particle size is 30 ⁇ m or less and the 50% cumulative particle size. When it is 15 ⁇ m or less, the salivary secretion promoting effect is more excellent. Furthermore, when (D) component and / or (E) component are contained, a taste improves more.
  • oral liquid preparations and beverage compositions such as mouthwashes, mouse sprays, etc., which are used in the mouth, are liquid (A) and (D) and / or (E).
  • the component (A) has a 90% cumulative particle size of 30 ⁇ m or less and a 50% cumulative particle size of 15 ⁇ m or less from the viewpoint of the salivary secretion promoting effect, taste, and dispersibility of the component (A). .
  • composition for oral cavity of the present invention generally known components for oral composition can be appropriately blended as necessary within the range not impairing the effects of the present invention.
  • optional components that can be blended in solid preparations, particularly tablets, include taste-masking agents, excipients, binders, disintegrants, and lubricants.
  • Examples of the corrigent include sweeteners, sour agents, and flavoring agents.
  • Examples of the sweetening agent include aspartame, acesulfame potassium, saccharin sodium, sucralose, stevia, thaumatin, sugarcane extract, heated palatinose, licorice, etc. Among them, aspartame, acesulfame potassium, sucralose and stevia are preferable.
  • the content of the sweetening agent is preferably from 0.1 to 3%, more preferably from 0.3 to 1.5% of the whole composition.
  • Examples of the sour agent include citric acid, tartaric acid, malic acid, succinic acid, fumaric acid and the like, and citric acid is particularly preferable.
  • the content of the sour agent is preferably 0.1 to 10%, more preferably 0.5 to 5% of the whole composition.
  • flavoring agents include monoterpenes such as l-menthol, camphor, borneol and limonene, and essential oils containing them.
  • Other flavoring agents include anise oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, cardamom oil, coriander oil, mandarin oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway Natural fragrances such as oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, peppermint oil, Iris concrete, absolute rose, orange flower, and processing of these natural fragrances Perfumes that have been processed (front cut, rear cut, fractional distillation, liquid-liquid extraction, essence, powder, etc.); peppermint, grapefruit, lemon, cassis, yogurt, lime, spearmint, mango, vanilla, apple, Grape, lychee, peach, spearmint, elda Natural fragrances such
  • fragrances of the examples it is not limited to the fragrances of the examples.
  • menthol essential oils such as peppermint oil, peppermint oil, spearmint oil, etc.
  • limonene range oil, etc.
  • the content of the flavoring agent is preferably 0.01 to 5%, more preferably 0.1 to 3% of the entire composition.
  • starch and derivatives thereof can be blended in addition to (B) sugar alcohol and (C) crystalline cellulose.
  • Specific examples include hydroxypropyl starch.
  • the content of the excipient is preferably 10 to 99%, more preferably 20 to 90% of the whole composition including the components (B) and (C).
  • binder examples include hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, ethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, gelatin, dextrin, starch, pregelatinized starch and the like.
  • the content of the binder is preferably 0.5 to 20%, more preferably 1 to 10%, based on the entire composition.
  • disintegrant examples include carmellose, carmellose calcium, croscarmellose sodium, low-substituted hydroxypropyl cellulose, low-substituted carboxymethyl starch sodium, crospovidone, and the like.
  • the content of the disintegrant is preferably 0.5 to 20%, more preferably 1 to 10% of the entire composition.
  • Lubricants include magnesium stearate, calcium stearate, sucrose fatty acid ester, glycerin fatty acid ester, anhydrous silicic acid, light anhydrous silicic acid, sodium stearyl fumarate and the like.
  • the content of the lubricant is preferably 0.01 to 5%, more preferably 0.1 to 3% of the entire composition.
  • beverage composition according to the present invention known components generally used for beverage compositions can be appropriately blended in a normal amount as needed within the range not impairing the effects of the present invention.
  • specific examples include sweeteners, acidulants, seasonings, food materials, fruit juices, fragrances, antioxidants, preservatives, and water.
  • % means “% by mass” unless otherwise specified.
  • the particle size (90% cumulative particle size, 50% cumulative particle size) was measured using a laser diffraction particle size distribution analyzer (Microtrack MT3000II, manufactured by Nikkiso Co., Ltd.).
  • Example 1 As Yamabushitake dry powder, "Yamabushitake dry powder" (manufactured by Hokuto Co., Ltd.) was used and pulverized with a beads mill (Ultra Apex Mill UAM-15, Hiroshima Metal & Machinery Co., Ltd.) to obtain a predetermined particle size. .
  • the salivary secretion promoting effect was evaluated by the following method. Evaluation method of salivary secretion promoting effect Saliva secretion amount was measured by the following method for 8 subjects complaining of thirst due to intense exercise etc. on the day before the test.
  • Yamabushitake dry powder manufactured by Hokuto Co., Ltd.
  • the secreted saliva was kept in the mouth so as not to be swallowed.
  • the retained saliva was discharged into the container every 5 minutes and the mass was measured to determine the amount of saliva secreted.
  • the measurement was carried out at 5-minute intervals until 30 minutes after the mouthwash.
  • concentration shown in Table 1 was used, and distilled water was used as control.
  • an aqueous solution of sodium polyglutamate (Na) was similarly evaluated.
  • the time course of saliva secretion is shown in FIG.
  • a saliva secretion promoting effect the accumulated saliva secretion amount for 30 minutes is shown in Table 1.
  • Yamabushitake dry powder has a high salivary secretion promoting effect.
  • the salivary secretion promoting effect of Yamabushitake mushroom dry powder (concentration 0.1%) was also measured by sodium polyglutamate ( It was found to be useful as a salivary secretion promoter.
  • Example 2 The salivary secretion promoting effect of an oral composition (tablet) containing Yamabushitake dry powder (uses 90% cumulative particle size of 100 ⁇ m and 50% cumulative particle size of 25 ⁇ m as in Experimental Example 1) was evaluated by the following method. .
  • the powder mixture having the composition shown in Tables 2 and 3 is compressed directly by a conventional tableting method using a hydraulic single-punch tableting machine, and a tablet is prepared. This is used as an oral composition for the following evaluation. Using.
  • the tablet had a diameter of 7 mm and a mass of 140 mg, and the tableting pressure was 1,000 to 2,000 kgf.
  • the following tests were performed on the obtained tablets. The results are shown in Tables 2 and 3.
  • Saliva secretion amount before and after ingestion of oral composition was measured for 8 subjects complaining of thirst due to intense exercise etc. on the day before the test.
  • the amount of saliva secreted is retained in the oral cavity so as not to swallow the secreted saliva, and the retained saliva is discharged into the container every 5 minutes, and this is repeated 6 times, and the weight of saliva secreted in 30 minutes is calculated. It was measured and this was taken as salivary secretion.
  • the oral composition (tablet) was ingested after being dissolved in the oral cavity without being chewed.
  • the salivary secretion promoting effect was calculated for 8 subjects with the amount of saliva before intake of the oral composition of each subject as 100%, and the ratio (%) of the amount of saliva after intake.
  • the average value (average rate of change in saliva volume) of 8 persons was determined and determined based on the following criteria. The judgment results of “ ⁇ ” and “ ⁇ ” were considered to be acceptable because of their high salivary secretion promoting effect. Criteria ⁇ : 150% ⁇ average change rate of saliva amount ⁇ : 120% ⁇ average change rate of saliva amount ⁇ 150% ⁇ : 100% ⁇ average change rate of saliva volume ⁇ 120% X: Average rate of change in saliva volume ⁇ 100%
  • Score standard 4 The taste of dried Yamabushitake is sufficiently suppressed and can be used without any problems 3: The taste of dried Yamabushitake is suppressed and can be used 2: The taste of dried Yamabushitake is almost suppressed It is difficult to use 1: The taste of dried Yamatake mushroom powder is not suppressed and cannot be used Judgment criteria ⁇ : Average value is 3.5 to 4 points ⁇ : Average value is 3 to 3 points Less than 5 points ⁇ : Average value is 2 or more and less than 3 points ⁇ : Average value is 1 or more and less than 2 points
  • Example 4 Beverage compositions having the compositions shown in Tables 4 to 6 were prepared by conventional methods, and liquid oral compositions (mouthwashes) having the compositions shown in Table 7 were prepared by conventional methods. About these compositions, the taste (taste improvement effect) was evaluated by the following method. In addition, the salivary secretion promoting effect of these beverage compositions and liquid oral compositions was evaluated (Except for measuring the amount of saliva secreted after ingestion or mouthwash in the same manner as the taste evaluation method, It was measured and evaluated in the same manner. The results are shown in the table.
  • Yamabushitake dry powder was pulverized with a bead mill (Ultra Apex Mill UAM-15, manufactured by Hiroshima Metal & Machinery Co., Ltd.) to give a predetermined particle size.
  • the powdered green tea used was an average particle size (measurement method is the same as described above), 30 ⁇ m, manufactured by Shizuokaen.
  • As the powdered roasted tea, manufactured by Kogetsuen Co., Ltd. an average particle size (measurement method is the same as above) of 10 ⁇ m was used.
  • the inosine salt used was inosine-5′-phosphate disodium (manufactured by Wako Pure Chemical Industries, Ltd.).
  • Yamabushitake extract and powdered green tea extract were prepared by preparing a 5% aqueous suspension of dry powder (90% cumulative particle size 100 ⁇ m, 50% cumulative particle size 25 ⁇ m) at 80 ° C. Extraction was performed by heating for about 1 hour, and then the supernatant obtained by centrifugation at 10,000 G for 10 minutes was prepared by filtration through a sterile filter having a hole diameter of 0.22 ⁇ m. This 10% extraction liquid blend corresponds to 0.5% (5% aqueous suspension x 10/100 (blending amount)) in terms of dry powder.
  • Powdered tea (adjusted by adding 100 mL of hot water or water) Yamabushitake dry powder 0.2g (90% cumulative particle size 25 ⁇ m, 50% cumulative particle size 12 ⁇ m) 0.8g powdered roasted tea Total 1.0g

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Abstract

Provided are: a saliva secretion promoter that is highly effective at promoting saliva secretion, said saliva secretion promoter being made from (A) a dry powder and/or an extract of Hericium erinaceus; an oral composition that contains the saliva secretion promoter and preferably also contains (B) sugar alcohol and (C) crystalline cellulose; and the aforementioned oral composition, additionally containing (D) inosinic acid or a salt thereof and (E) a dry powder and/or an extract of Camellia sinensis. Also provided is a drinkable composition that contains the saliva secretion promoter and preferably also contains (D) inosinic acid or a salt thereof and (E) a dry powder and/or an extract of Camellia sinensis.

Description

唾液分泌促進剤、これを含有する口腔用組成物及び飲料用組成物Salivary secretion promoter, oral composition and beverage composition containing the same
　本発明は、高い唾液分泌促進効果を奏する唾液分泌促進剤、これを含有する口腔用組成物及び飲料用組成物に関する。 The present invention relates to a salivary secretion-promoting agent that exhibits a high salivary secretion-promoting effect, an oral composition and a beverage composition containing the same.
　唾液は、生活の質に大きく関与する口腔内の分泌液である。唾液の機能として口腔内の湿潤作用や唾液成分のアミラーゼによる消化作用、更には、口腔内の循環液としての自浄作用や抗菌成分による抗菌作用、う蝕の原因となる酸を中和する緩衝作用などが知られている。そのため、唾液分泌量の低下は、う蝕や歯周病、口臭などの口腔内トラブルのリスク向上、更には、口の渇き、話しにくさ、食べにくさ、美味しく食べられなくなるなど、間接的、直接的に生活の質を大きく低下する原因にもなる。 Saliva is a secretory fluid in the oral cavity that greatly affects the quality of life. As a function of saliva, wetting action in the oral cavity, digestion action of saliva components by amylase, self-cleaning action as circulating fluid in the oral cavity, antibacterial action by antibacterial ingredients, buffering action to neutralize acid causing caries Etc. are known. Therefore, a decrease in salivary secretion is an indirect risk, such as increased risk of oral problems such as caries, periodontal disease, bad breath, and thirst, difficulty in speaking, difficulty in eating, and inability to eat deliciously. It can also cause a direct decline in quality of life.
　そこで、保水性の高い水溶性高分子物質を用いた口腔内の湿潤性を改善する方法（特許文献１，２）や、各種天然物や有機酸を併用することで唾液分泌を促進させる方法（特許文献３～５）が検討されてきた。
　しかし、単に口腔内を湿潤させる方法では、湿潤作用の改善に留まり、唾液の機能の全てを十分に代替できるものではなく、また、水溶性高分子物質に由来するネバツキが生じるという問題があった。また、天然物や有機酸による唾液分泌促進効果には改良の余地があった。 Therefore, a method for improving the wettability in the oral cavity using a water-soluble polymer substance having high water retention (Patent Documents 1 and 2) and a method for promoting salivary secretion by using various natural products and organic acids ( Patent documents 3 to 5) have been studied.
However, the method of simply moistening the oral cavity is not limited to the improvement of the moistening action, and cannot fully replace all the functions of saliva, and there is a problem that a stickiness derived from a water-soluble polymer substance occurs. . Moreover, there is room for improvement in the salivary secretion promoting effect of natural products and organic acids.
特開２００７－０８４５０１号公報JP 2007-084501 A 特開２０１４－１８９５２４号公報JP 2014-189524 A 特開２００５－１６２６３３号公報JP 2005-162633 A 国際公開第０５／０４９０５０号International Publication No. 05/049050 特開平０７－１０１８５６号公報Japanese Patent Application Laid-Open No. 07-101856 特開２０１３－２３７６９９号公報JP 2013-237699 A 特開２０１２－０５１８９７号公報JP 2012-051897 A 特開２００７－００１９６１号公報JP 2007-001961 A
　従って、優れた唾液分泌促進効果を与える新たな技術の開発が望まれた。 Therefore, the development of a new technology that gives an excellent salivary secretion promoting effect has been desired.
　本発明は、上記事情に鑑みなされたもので、高い唾液分泌促進効果を奏する唾液分泌促進剤、これを含有する口腔用組成物及び飲料用組成物を提供することを目的とする。 The present invention has been made in view of the above circumstances, and an object thereof is to provide a saliva secretion-promoting agent that exhibits a high salivary secretion-promoting effect, an oral composition and a beverage composition containing the same.
　本発明者らは、上記目的を達成するため鋭意検討を行った結果、（Ａ）ヤマブシタケ（Ｈｅｒｉｃｉｕｍ　ｅｒｉｎａｃｅｕｓ）の乾燥粉末及び／又はその抽出物が、高い唾液分泌促進効果を奏し、唾液分泌促進剤として、口腔用組成物に好適に配合し得ることを見出した。また、（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物に、（Ｂ）糖アルコール及び（Ｃ）結晶セルロースを併用して口腔用組成物に配合すると、（Ａ）成分の唾液分泌促進効果が向上して優れた唾液分泌促進効果を奏し、また、異味の発現を抑えて味の良い良好な使用感を与え、経時における製剤の変色を抑制して製剤外観も安定化できることを見出した。 As a result of intensive investigations to achieve the above object, the present inventors have found that (A) dried powder of Herbium (Herium erinaceus) and / or an extract thereof has a high salivary secretion promoting effect, and a salivary secretion promoter. As a result, it has been found that it can be suitably blended in a composition for oral cavity. In addition, when (B) sugar alcohol and (C) crystalline cellulose are used in combination with (A) dry powder of Yamabushitake and / or its extract in an oral composition, the salivary secretion promoting effect of component (A) is obtained. It has been found that it has an improved saliva secretion promoting effect, gives a good feeling of good taste by suppressing the appearance of nasty taste, and can suppress the discoloration of the preparation over time and stabilize the appearance of the preparation.
　ヤマブシタケ抽出物が口腔細菌に対して抗菌性を有し、これを配合した口腔用組成物は知られている（特許文献６～８；特開２０１３－２３７６９９号公報、特開２０１２－０５１８９７号公報、特開２００７－００１９６１号公報）。また、出願人は、ヤマブシタケの乾燥粉末又はその抽出物が、口腔内の非病原性常存菌に対しては抗菌作用ではなく、その増殖を選択的に活性化して生育を促進し口腔細菌叢を改善する作用があることを見出し、これを用いた非病原性口腔内常在菌の生育促進剤又は口腔内の菌叢改善剤、及び口腔用組成物を提案した（ＰＣＴ／ＪＰ２０１５／０７５５７４号明細書）。
　これに対して、本発明者らは、ヤマブシタケの乾燥粉末又はその抽出物に、唾液分泌を促進する優れた作用があることを新たに見出し、本発明をなすに至ったものである。 Yamabushitake extract has antibacterial properties against oral bacteria, and oral compositions containing this are known (Patent Documents 6 to 8; JP2013-237699A, JP2012051897A). JP, 2007-001961, A). The applicant also stated that the dried powder of Yamabushitake or its extract is not an antibacterial action against non-pathogenic resident bacteria in the oral cavity, but selectively activates its growth to promote growth and promote oral bacterial flora. Has been found to have an action to improve the growth rate of the non-pathogenic oral resident bacteria or oral flora improving agent using the same, and a composition for oral cavity (PCT / JP2015 / 075754) Specification).
On the other hand, the present inventors have newly found that the dried powder of Yamabushitake or an extract thereof has an excellent effect of promoting salivation, and have made the present invention.
　また、本発明において、（Ａ）ヤマブシタケの乾燥粉末又はその抽出物からなる唾液分泌促進剤は、好ましくは口腔用の液体製剤又は固体製剤として製剤化すると優れた唾液分泌促進効果を発揮するものであるが、（Ａ）成分を口腔用製剤、特に固体製剤に配合すると、（Ａ）成分に特有の異味が強く発現して味が低下し、また、経時で製剤が変色するという問題が生じた。そこで、かかる問題を解消するため、本発明者らが更に検討を進めたところ、（Ｂ）及び（Ｃ）成分を併用して配合することによって、（Ａ）成分の唾液分泌促進作用が向上し、固体製剤として調製しても前記味、製剤の変色といった問題を生じさせることなく、優れた唾液分泌促進効果を付与することができた。この場合、（Ａ）成分に特有の異味は糖類の甘味によってマスキングされるものの前記製剤の変色は抑制できず、糖類として乳糖などを不適切に添加すると経時による変色が顕著になったが、（Ｂ）及び（Ｃ）成分を併用して添加すると、意外にも、両成分が相互作用して特異的に経時における製剤の変色が抑制され、製剤が本来持つ色調を維持することが可能となり、上記格別な作用効果を付与できた。 In the present invention, the salivary secretion promoter comprising (A) a dried powder of Yamabushitake or an extract thereof preferably exhibits an excellent salivary secretion promoting effect when formulated as a liquid preparation or solid preparation for oral cavity. However, when the component (A) is blended with an oral preparation, particularly a solid formulation, a unique taste unique to the component (A) is strongly expressed and the taste is lowered, and the formulation is discolored over time. . Then, in order to eliminate such a problem, when the present inventors further investigated, when the (B) and (C) component was used in combination, the salivary secretion promoting action of the (A) component was improved. Even when prepared as a solid preparation, it was possible to impart an excellent salivary secretion promoting effect without causing problems such as taste and discoloration of the preparation. In this case, although the unique taste of the component (A) is masked by the sweetness of saccharides, discoloration of the preparation cannot be suppressed, and discoloration over time became prominent when lactose or the like was added inappropriately as saccharides. When the components B) and (C) are added in combination, unexpectedly, both components interact to specifically suppress discoloration of the preparation over time, and maintain the original color tone of the preparation. The above-mentioned special effect was able to be given.
　加えて、本発明では、（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤を含有する洗口剤又はマウススプレーであって、前記乾燥粉末の９０％積算粒子径が３０μｍ以下、５０％積算粒子径が１５μｍ以下である口腔用組成物によって、優れた唾液分泌促進効果を付与できた。
　また、本発明では、（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤を含有する飲料用組成物であって、前記乾燥粉末の９０％積算粒子径が３０μｍ以下、５０％積算粒子径が１５μｍ以下である飲料用組成物によって、優れた唾液分泌促進効果を付与できた。 In addition, in the present invention, (A) a mouthwash or a mouse spray containing a saliva secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the dry powder has a 90% cumulative particle size of 30 μm Hereinafter, an excellent saliva secretion promoting effect could be imparted by the oral composition having a 50% cumulative particle size of 15 μm or less.
In the present invention, (A) a composition for beverages containing a saliva secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the 90% cumulative particle size of the dry powder is 30 μm or less, 50 An excellent saliva secretion promoting effect could be imparted by the beverage composition having a% cumulative particle size of 15 μm or less.
　本発明においては、前記組成物に、更に（Ｄ）イノシン酸及び／又はその塩を配合すると、（Ａ）成分の異味が更に抑制されて味が改善し、唾液分泌促進効果もより向上する。また、更に（Ｅ）チャノキ（Ｃａｍｅｌｌｉａ　ｓｉｎｅｎｓｉｓ）の乾燥粉末及び／又はその抽出物を配合することで、（Ａ）成分の異味を更に抑制して味をより改善できた。 In the present invention, when (D) inosinic acid and / or a salt thereof is further added to the above composition, the taste of component (A) is further suppressed, the taste is improved, and the saliva secretion promoting effect is further improved. Furthermore, by further blending (E) dry powder of Camellia sinensis and / or its extract, the taste of component (A) was further suppressed and the taste could be further improved.
　従って、本発明は、下記の唾液分泌促進剤、口腔用組成物及び飲料用組成物を提供する。
〔１〕
　（Ａ）ヤマブシタケ（Ｈｅｒｉｃｉｕｍ　ｅｒｉｎａｃｅｕｓ）の乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤。
〔２〕
　１回使用における投与量が、ヤマブシタケの乾燥粉末換算で１～１，０００ｍｇである〔１〕記載の唾液分泌促進剤。
〔３〕
　〔１〕又は〔２〕記載の唾液分泌促進剤を含有してなることを特徴とする口腔用組成物。
〔４〕
　（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤、（Ｂ）糖アルコール、及び（Ｃ）結晶セルロースを含有してなることを特徴とする口腔用組成物。
〔５〕
　（Ｂ）成分が、ソルビトール、キシリトール、マルチトール及び還元パラチノースから選ばれる１種又は２種以上の糖アルコールである〔４〕記載の口腔用組成物。
〔６〕
　（Ａ）／（Ｂ）が質量比として０．０１～１．５である〔４〕又は〔５〕記載の口腔用組成物。
〔７〕
　（Ａ）／（Ｃ）が質量比として０．１～８である〔４〕～〔６〕のいずれかに記載の口腔用組成物。
〔８〕
　（Ａ）成分の含有量がヤマブシタケの乾燥粉末換算量で１～４０質量％、（Ｂ）成分の含有量が２５～９０質量％、（Ｃ）成分の含有量が５～３０質量％である〔４〕～〔７〕のいずれかに記載の口腔用組成物。
〔９〕
　固体製剤である〔４〕～〔８〕のいずれかに記載の口腔用組成物。
〔１０〕
　固体製剤が、錠剤、粒状剤又はチューインガムである〔９〕記載の口腔用組成物。
〔１１〕
　（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤を含有する洗口剤又はマウススプレーであって、前記乾燥粉末の９０％積算粒子径が３０μｍ以下、５０％積算粒子径が１５μｍ以下であることを特徴とする口腔用組成物。
〔１２〕
　（Ａ）成分の含有量がヤマブシタケの乾燥粉末換算量で０．０５～２質量％である〔１１〕記載の口腔用組成物。
〔１３〕
　更に、（Ｄ）イノシン酸及び／又はその塩を０．００１～０．５質量％含有する〔３〕～〔１２〕のいずれかに記載の口腔用組成物。
〔１４〕
　更に、（Ｅ）チャノキ（Ｃａｍｅｌｌｉａ　ｓｉｎｅｎｓｉｓ）の乾燥粉末及び／又はその抽出物を、チャノキの乾燥粉末換算量で０．１～２質量％含有する〔３〕～〔１３〕のいずれかに記載の口腔用組成物。
〔１５〕
　（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤を含有する飲料用組成物であって、前記乾燥粉末の９０％積算粒子径が３０μｍ以下、５０％積算粒子径が１５μｍ以下であることを特徴とする飲料用組成物。
〔１６〕
　（Ａ）成分の含有量がヤマブシタケの乾燥粉末換算量で０．０５～２質量％である〔１５〕記載の飲料用組成物。
〔１７〕
　更に、（Ｄ）イノシン酸及び／又はその塩を０．００１～０．５質量％含有する〔１５〕又は〔１６〕記載の飲料用組成物。
〔１８〕
　更に、（Ｅ）チャノキ（Ｃａｍｅｌｌｉａ　ｓｉｎｅｎｓｉｓ）の乾燥粉末及び／又はその抽出物を、チャノキの乾燥粉末換算量で０．１～２質量％含有する〔１５〕～〔１７〕のいずれかに記載の飲料用組成物。
〔１９〕
　水に分散又は溶解して飲料を調製する製剤形態である、〔１５〕～〔１８〕のいずれかに記載の飲料用組成物。
〔２０〕
　固体製剤である〔１９〕記載の飲料用組成物。 Therefore, the present invention provides the following saliva secretion promoter, oral composition and beverage composition.
[1]
(A) A salivary secretion promoter comprising a dried powder of Yamabushitake (Hericium erinaceus) and / or an extract thereof.
[2]
[1] The salivary secretion promoter according to [1], wherein the dose in a single use is 1 to 1,000 mg in terms of Yamabushitake dry powder.
[3]
An oral composition comprising the salivary secretion promoter according to [1] or [2].
[4]
(A) A saliva secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, (B) a sugar alcohol, and (C) a crystalline cellulose.
[5]
(B) The composition for oral cavity according to [4], wherein the component is one or more sugar alcohols selected from sorbitol, xylitol, maltitol and reduced palatinose.
[6]
The oral composition according to [4] or [5], wherein (A) / (B) is 0.01 to 1.5 in terms of mass ratio.
[7]
The oral composition according to any one of [4] to [6], wherein (A) / (C) is 0.1 to 8 in terms of mass ratio.
[8]
The content of the component (A) is 1 to 40% by mass in terms of dry powder of Yamabushitake, the content of the component (B) is 25 to 90% by mass, and the content of the component (C) is 5 to 30% by mass. [4] The composition for oral cavity according to any one of [7].
[9]
The oral composition according to any one of [4] to [8], which is a solid preparation.
[10]
The composition for oral cavity according to [9], wherein the solid preparation is a tablet, granule or chewing gum.
[11]
(A) A mouthwash or mouse spray containing a saliva secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the dry powder has a 90% cumulative particle size of 30 μm or less and a 50% cumulative particle size Is a composition for oral cavity, wherein the composition is 15 μm or less.
[12]
The composition for oral cavity according to [11], wherein the content of the component (A) is 0.05 to 2% by mass in terms of dry powder of Yamabushitake.
[13]
The oral composition according to any one of [3] to [12], further comprising (D) 0.001 to 0.5% by mass of inosinic acid and / or a salt thereof.
[14]
Furthermore, (E) a dry powder of Camellia sinensis and / or an extract thereof is contained in an amount of 0.1 to 2% by mass in terms of dry powder of tea tree, [3] to [13] Oral composition.
[15]
(A) A beverage composition containing a salivary secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the dry powder has a 90% cumulative particle size of 30 μm or less and a 50% cumulative particle size of 15 μm. A beverage composition characterized by the following:
[16]
[15] The beverage composition according to [15], wherein the content of component (A) is 0.05 to 2% by mass in terms of dry powder equivalent of Yamabushitake.
[17]
The beverage composition according to [15] or [16], further comprising (D) 0.001 to 0.5% by mass of inosinic acid and / or a salt thereof.
[18]
Furthermore, (E) a dry powder of Camellia sinensis and / or an extract thereof is contained in an amount of 0.1 to 2% by mass in terms of the dry powder of the tea tree, [15] to [17] Beverage composition.
[19]
The beverage composition according to any one of [15] to [18], which is a preparation form in which a beverage is prepared by dispersing or dissolving in water.
[20]
[19] The beverage composition according to [19], which is a solid preparation.
　本発明によれば、高い唾液分泌促進効果を奏する唾液分泌促進剤及び口腔用組成物を提供できる。更に、唾液分泌促進効果が優れ、また、味が良く製剤外観も安定な口腔用組成物を提供できる。本発明によれば、唾液分泌促進効果が優れ、味が良い飲料用組成物を提供することもできる。 According to the present invention, it is possible to provide a saliva secretion promoter and a composition for oral cavity that have a high saliva secretion promoting effect. Furthermore, it is possible to provide an oral composition having an excellent salivary secretion promoting effect, a good taste and a stable formulation appearance. ADVANTAGE OF THE INVENTION According to this invention, the composition for drinks which is excellent in the saliva secretion promotion effect and good in taste can also be provided.
実験例１で用いた各評価サンプルにおける、経時での唾液分泌量の変化を示すグラフである。It is a graph which shows the change of the amount of saliva secretion with time in each evaluation sample used in example 1 of an experiment.
　以下、本発明につき更に詳述する。本発明の唾液分泌促進剤は、（Ａ）ヤマブシタケ（Ｈｅｒｉｃｉｕｍ　ｅｒｉｎａｃｅｕｓ）の乾燥粉末及び／又はその抽出物を有効成分とする。 Hereinafter, the present invention will be described in further detail. The saliva secretion-promoting agent of the present invention comprises (A) dried powder of Herbium erinaceus and / or an extract thereof as an active ingredient.
　ヤマブシタケの乾燥粉末又はその抽出物としては、ヤマブシタケ（Ｈｅｒｉｃｉｕｍ　ｅｒｉｎａｃｅｕｓ）の子実体及び／又は菌糸体を原料として用い、公知の方法によって調製したものを使用できる。
　この場合、原料としては、ヤマブシタケの子実体、菌糸体のいずれか一方だけ、あるいは両方を使用可能であるが、食経験があり安全なヤマブシタケの子実体の使用が好適である。 As a dried powder of Yamabushitake or an extract thereof, those prepared by a known method using a fruit body and / or mycelium of Yamabushitake (Hericium erinaceus) as a raw material can be used.
In this case, it is possible to use either the fruit body of Yamabushitake, the mycelium, or both as the raw material, but it is preferable to use the fruit body of Yamabushitake that is safe and has food experience.
　ヤマブシタケの乾燥粉末は、その調製方法に特に制限はなく通常の方法を採用して得ることができ、原料の子実体及び／又は菌糸体を凍結乾燥又は加熱乾燥した後、粉砕することによって得られる乾燥粉砕粉末を使用できる。なお、凍結乾燥、加熱乾燥の条件も常法と同様でよく、また、乾燥粉末の粒径等の物性は、口腔用製剤に配合可能であれば特に限定されない。ヤマブシタケ乾燥粉末としては、「ヤマブシタケ乾燥粉末」（ホクト（株）製）、五箇山ヤマブシタケ粉末（（株）祖山林産製）、山伏茸「乾燥粉末」（（株）阿蘇バイオテック製）、さんごヤマブシタケ粉末（信州きのこ工房製）などが販売されており、これらをそのまま、あるいは粉砕して、更には粒度調整して使用することができる。 The dry powder of Yamabushitake is not particularly limited in its preparation method, and can be obtained by employing a usual method, and is obtained by freeze-drying or heat-drying the raw material fruit bodies and / or mycelium and then pulverizing them. Dry ground powder can be used. The conditions for freeze-drying and heat-drying may be the same as in the conventional method, and the physical properties such as the particle size of the dry powder are not particularly limited as long as they can be blended in the oral preparation. Yamabushitake dry powders include “Yamabushitake dry powder” (manufactured by Hokuto), Gokayama Yamabushitake powder (manufactured by Isoyama Hayashi Co., Ltd.), Yamabushi mochi “dry powder” (manufactured by Aso Biotech Co., Ltd.), Sango Yamabushitake Powders (manufactured by Shinshu Mushroom Studio) and the like are sold, and these can be used as they are or after being pulverized and further adjusted in particle size.
　また、ヤマブシタケの抽出物は、原料のヤマブシタケの子実体及び／又は菌糸体から直接抽出し得るが、ヤマブシタケの乾燥粉末から抽出したものが好適である。
　抽出物を得る方法は特に限定されず、公知の方法を採用できる。
　抽出溶媒としては、水や、アルコール類（例えば、メタノール、無水エタノール、エタノール等の炭素数１～３の低級アルコール、プロピレングリコール、１，３－ブチレングリコール等の多価アルコール）、アセトン等のケトン類、ジエチルエーテル、ジオキサン、アセトニトリル、酢酸エチルエステル等のエステル類、キシレン、ベンゼン、クロロホルムなどの極性溶媒、非極性溶媒が挙げられる。これらは、１種類を単独で又は２種類以上を任意に組み合わせて混液として使用できる。なお、異なる溶媒によって抽出したものを組み合わせて溶媒抽出物として使用することもできる。上記溶媒の中では、特にヒトに用いるものであることを考慮して安全性の面から水及び／又はエタノールが好ましい。
　なお、原料に対する溶媒の使用量、抽出温度や抽出時間は特に制限されず、適宜調整できる。
　得られた抽出物は、応用する製剤の剤型、形態により乾燥、濃縮、あるいは希釈などを任意に行って調製することができる。なお、多くの場合は、そのままの状態で利用できるが、必要に応じて、その効力に影響のない範囲で更に脱臭、脱色などの精製処理を加えたり、滅菌フィルターで濾過してもよく、抽出物に一般的に適用される通常の手段を任意に選択して行うことができる。 Further, the extract of Yamabushitake can be directly extracted from the fruit body and / or mycelium of the raw Yamabushitake, but what is extracted from the dried powder of Yamabushitake is preferable.
The method for obtaining the extract is not particularly limited, and a known method can be adopted.
Examples of the extraction solvent include water, alcohols (for example, lower alcohols having 1 to 3 carbon atoms such as methanol, absolute ethanol, and ethanol, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), and ketones such as acetone. And esters such as diethyl ether, dioxane, acetonitrile, and ethyl acetate, polar solvents such as xylene, benzene, and chloroform, and nonpolar solvents. These can be used alone or in combination of two or more as a mixed solution. In addition, what was extracted with a different solvent can also be combined and used as a solvent extract. Among these solvents, water and / or ethanol are preferable from the viewpoint of safety considering that they are particularly used for humans.
In addition, the usage-amount of the solvent with respect to a raw material, extraction temperature, and extraction time are not restrict | limited in particular, It can adjust suitably.
The obtained extract can be prepared by arbitrarily drying, concentrating or diluting depending on the dosage form and form of the preparation to be applied. In many cases, it can be used as it is, but if necessary, it may be further subjected to purification treatment such as deodorization and decoloration within the range that does not affect its efficacy, or it may be filtered with a sterilization filter. The usual means generally applied to an object can be arbitrarily selected and performed.
　本発明では、特にヤマブシタケ子実体の乾燥粉砕粉末又はその水抽出物、とりわけヤマブシタケ子実体の乾燥粉砕粉末を用いることが好ましい。乾燥粉砕粉末を用いると、抽出物よりも低い濃度で十分な効果を発現させることができる。 In the present invention, it is particularly preferable to use a dry pulverized powder of Yamabushitake fruit body or an aqueous extract thereof, particularly a dry pulverized powder of Yamabushitake fruit body. When dry pulverized powder is used, a sufficient effect can be exhibited at a lower concentration than the extract.
　また、本発明において、（Ａ）成分のヤマブシタケの乾燥粉末又はその抽出物は、９０％積算粒子径（Ｄ９０、体積基準）が２００μｍ以下であることが好ましく、より好ましくは１００μｍ以下、特に３０μｍ以下、とりわけ２５μｍ以下であり、更に好ましくは０．１μｍ以上、特に０．５μｍ以上である。微粒化するほど、唾液分泌促進機能がより高まり、より低い濃度で十分な効果を発現させることができ、また、分散性も向上する。
　更に、５０％積算粒子径（Ｄ５０、体積基準）は、１００μｍ以下であることが好ましく、より好ましくは５０μｍ以下、特に１５μｍ以下、とりわけ１２μｍ以下であり、更に好ましくは０．０１μｍ以上、特に０．１μｍ以上である。
　上記粒子径の測定は公知の粒度分布測定機器により測定することができ、例えば、レーザー回折式粒度分布測定装置（マイクロトラックＭＴ３０００ＩＩ、日機装（株）製）を用いて測定することができる。 In the present invention, the dry powder of Yamabushitake as component (A) or an extract thereof preferably has a 90% cumulative particle size (D90, volume basis) of 200 μm or less, more preferably 100 μm or less, particularly 30 μm or less. In particular, it is 25 μm or less, more preferably 0.1 μm or more, particularly 0.5 μm or more. The smaller the atomization, the higher the salivary secretion promoting function, and the sufficient effect can be expressed at a lower concentration, and the dispersibility is also improved.
Further, the 50% cumulative particle diameter (D50, volume basis) is preferably 100 μm or less, more preferably 50 μm or less, particularly 15 μm or less, especially 12 μm or less, still more preferably 0.01 μm or more, particularly preferably 0.00. 1 μm or more.
The particle diameter can be measured by a known particle size distribution measuring instrument, for example, using a laser diffraction particle size distribution measuring apparatus (Microtrack MT3000II, manufactured by Nikkiso Co., Ltd.).
　ヤマブシタケ乾燥粉末の粒子径は、原料の子実体及び／又は菌糸体を凍結乾燥又は加熱乾燥したものを、あるいは市販のヤマブシタケ乾燥粉末を、所定の粒子径になるように公知の粉砕方法を採用して調整することができる。
　粉砕方法としては、特に限定されるものではないが、乾式粉砕又は湿式粉砕を採用できる。例えば、石臼、ピンミル、ハンマーミル、ジェットミル、ローラーミル、コロイドミル、遊星ミル、振動ミル、回転ミル、アトライター、ビーズミル、超音波ボールミル、高圧ホモジナイザー等の粉砕装置を使用することができる。粉砕は、これら粉砕方法を複数回行うこともでき、また、複数の粉砕方法を組み合わせることもできる。
　また、市販の乾燥粉末を、篩等を用いて所定の粒子径に調整してもよい。 As for the particle size of the dried yamabushitake powder, a known pulverization method is used so that the fruit body and / or mycelium of the raw material is freeze-dried or heat-dried, or a commercially available dried yamabushitake powder has a predetermined particle size. Can be adjusted.
The pulverization method is not particularly limited, and dry pulverization or wet pulverization can be employed. For example, pulverizers such as a stone mill, a pin mill, a hammer mill, a jet mill, a roller mill, a colloid mill, a planetary mill, a vibration mill, a rotating mill, an attritor, a bead mill, an ultrasonic ball mill, and a high-pressure homogenizer can be used. For pulverization, these pulverization methods can be performed a plurality of times, or a plurality of pulverization methods can be combined.
Moreover, you may adjust commercially available dry powder to a predetermined particle diameter using a sieve.
　本発明の唾液分泌促進剤は、１回使用における投与量が、ヤマブシタケの乾燥粉末換算で１～１，０００ｍｇであることが好ましく、より好ましくは５～５００ｍｇ、更に好ましくは１０～２００ｍｇである。１回当たりの投与量が上記範囲内になるようにヤマブシタケの乾燥粉末又はその抽出物の濃度を調整して製剤化することが好ましい。上記範囲内であると、唾液分泌を効果的に促進することができる。なお、あまり高濃度になりすぎるとヤマブシタケ特有の異味が強くなり使用困難になる場合があるが、１，０００ｍｇ以下であるとこれを十分に防止できる。
　上記乾燥粉末換算量は、乾燥粉末を使用する場合はその使用量であり、抽出物においては、その抽出純分量（溶媒を除いた抽出物量）を得るために必要なヤマブシタケの乾燥粉末質量である。 The salivary secretion-promoting agent of the present invention preferably has a dose of 1 to 1,000 mg, more preferably 5 to 500 mg, still more preferably 10 to 200 mg in terms of dry powder of Yamabushitake. It is preferable to prepare a preparation by adjusting the concentration of the dried powder of Yamabushitake or an extract thereof so that the dose per time is within the above range. Saliva secretion can be effectively promoted within the above range. If the concentration is too high, the unique taste of Yamabushitake may become strong and difficult to use, but if it is 1,000 mg or less, this can be sufficiently prevented.
The above dry powder equivalent amount is the amount used when using dry powder, and in the extract, it is the dry powder mass of Yamabushitake necessary to obtain the pure extract amount (extract amount excluding the solvent). .
　本発明にかかわる（Ａ）ヤマブシタケの乾燥粉末又はその抽出物は、唾液分泌促進剤として口腔用組成物に配合することができる。具体的には、固体、液体（配合成分の一部又は全部が可溶化せずに分散、懸濁したものも含む。以下、同様。）、ペースト状、ゲル状などの形態に調製し、口腔内崩壊錠、チュアブル錠、トローチ、キャンディー等の錠剤、顆粒等の粒状剤、チューインガム、グミ、練歯磨、液体歯磨、液状歯磨、潤製歯磨等の歯磨剤、洗口剤、マウススプレー等の各種剤型で使用し得る。
　本発明の唾液分泌促進剤は、液体製剤又は固体製剤として好適であり、特にヤマブシタケ乾燥粉末を用いる場合には、前記乾燥粉末が水に溶けないことから、固体製剤に調製することが好ましい。例えば錠剤、粒状剤、チューインガム等の固体製剤として、中でも錠剤、粒状剤として好適に調製し得る。錠剤としては、口腔内崩壊錠、チュアブル錠、トローチ、キャンディー等の口腔内で崩壊又は溶解させるための錠剤が好適であり、また、口腔内で崩壊又は溶解させ得る粒状剤も好適である。 (A) A dried powder of Yamabushitake or an extract thereof according to the present invention can be blended in an oral composition as a salivary secretion promoter. Specifically, it is prepared in the form of solid, liquid (some or all of the ingredients are dispersed or suspended without being solubilized, the same applies hereinafter), paste, gel, etc. Various types of tablets such as disintegrating tablets, chewable tablets, troches, candies, etc., granules such as granules, chewing gum, gummi, toothpaste, liquid toothpaste, liquid toothpaste, toothpaste such as toothpaste, mouthwash, mouth spray, etc. Can be used in dosage form.
The saliva secretion-promoting agent of the present invention is suitable as a liquid formulation or a solid formulation. In particular, when a Yamabushitake dry powder is used, it is preferable to prepare a solid formulation because the dry powder does not dissolve in water. For example, it can be suitably prepared as a solid preparation such as a tablet, granule or chewing gum, among others as a tablet or granule. As the tablet, tablets for disintegration or dissolution in the oral cavity such as orally disintegrating tablets, chewable tablets, troches, and candies are suitable, and granular agents that can be disintegrated or dissolved in the oral cavity are also suitable.
　この場合、口腔用組成物全体に対するヤマブシタケの乾燥粉末又はその抽出物の配合量は、１回使用における投与量が上記範囲内になるように調整することが好ましく、口腔用組成物の形態、剤型等に応じて適宜調整することができる。
　具体的には、錠剤、粒状剤等の固体製剤の場合、ヤマブシタケの乾燥粉末又はその抽出物の配合量は、組成物全体に対して、乾燥粉末換算で１～４０％（質量％、以下同様。）が好ましく、より好ましくは５～３０％、更に好ましくは５～２５％である。配合量が多いほど唾液分泌促進効果が高まり、１％以上であると十分な唾液分泌促進効果を付与できる。４０％以下であることが、異味の発現を抑え、経時での製剤の変色を防止するには好適である。
　また、液体製剤の場合、ヤマブシタケの乾燥粉末又はその抽出物の配合量は、組成物全体に対して、乾燥粉末換算で０．０５～２％が好ましく、より好ましくは０．１～１％、更に好ましくは０．２～０．８％である。配合量が多いほど唾液分泌促進効果が高まるが、多く配合しすぎないほうが、異味の発現を抑え、味を良好に維持するには好適である。 In this case, it is preferable to adjust the blending amount of the dried powder of Yamabushitake or the extract thereof with respect to the whole oral composition so that the dose in a single use is within the above range, and the form and agent of the oral composition It can adjust suitably according to a type | mold etc.
Specifically, in the case of solid preparations such as tablets and granules, the amount of dry powder of Yamabushitake or extract thereof is 1 to 40% (mass%, the same applies hereinafter) in terms of dry powder with respect to the entire composition. )), More preferably 5 to 30%, still more preferably 5 to 25%. The greater the blending amount, the higher the saliva secretion promoting effect, and if it is 1% or more, a sufficient saliva secretion promoting effect can be imparted. 40% or less is suitable for suppressing the appearance of off-taste and preventing discoloration of the preparation over time.
In the case of a liquid preparation, the amount of Yamabushitake dry powder or extract thereof is preferably 0.05 to 2%, more preferably 0.1 to 1%, in terms of dry powder, relative to the entire composition. More preferably, it is 0.2 to 0.8%. The greater the blending amount, the greater the salivary secretion promoting effect. However, it is preferable not to add too much to suppress the expression of off-flavors and maintain the taste satisfactorily.
　本発明にかかわる（Ａ）ヤマブシタケの乾燥粉末又はその抽出物は、唾液分泌促進剤として飲料用組成物に配合することができる。具体的には、固体又は液体の形態に調製でき、前記唾液分泌促進剤を水に分散、懸濁して飲料として用いることができる。
　この場合、飲料用組成物全体に対するヤマブシタケの乾燥粉末又はその抽出物の配合量は、上記と同様に１回使用（一口あたりの使用は、飲料として約１０ｍＬ）における投与量の範囲内において、乾燥粉末換算で０．０５～２％（投与濃度）が好ましく、より好ましくは０．１～１％、更に好ましくは０．２～０．８％である。配合量が多いほど唾液分泌促進効果が高まるが、多く配合しすぎないほうが、異味の発現を抑え、味を良好に維持するには好適である。飲料としての投与濃度が上記範囲内になるように調整することが望ましい。 (A) A dried powder of Yamabushitake or an extract thereof according to the present invention can be blended in a beverage composition as a saliva secretion promoter. Specifically, it can be prepared in a solid or liquid form, and the saliva secretion promoter can be dispersed and suspended in water and used as a beverage.
In this case, the blended amount of the dried powder of Yamabushitake or the extract thereof with respect to the entire beverage composition is dried within the range of the dose in a single use (the use per mouthful is about 10 mL as a beverage) as described above. It is preferably 0.05 to 2% (administration concentration) in terms of powder, more preferably 0.1 to 1%, and still more preferably 0.2 to 0.8%. The greater the blending amount, the greater the salivary secretion promoting effect. However, it is preferable not to add too much to suppress the expression of off-flavors and maintain the taste satisfactorily. It is desirable to adjust the administration concentration as a beverage within the above range.
　なお、口腔用の液体製剤は、前記唾液分泌促進剤を含有する洗口剤、マウススプレーであって、唾液分泌促進剤である（Ａ）ヤマブシタケの乾燥粉末の９０％積算粒子径３０μｍ以下、５０％積算粒子径１５μｍ以下であることが、唾液分泌促進効果、更には味、分散性の点から、好ましい。
　また、飲料用組成物は、前記唾液分泌促進剤を含有し、特に水に分散、懸濁、あるいは溶解して用いる飲料用組成物であって、唾液分泌促進剤である（Ａ）ヤマブシタケの乾燥粉末の９０％積算粒子径３０μｍ以下、５０％積算粒子径１５μｍ以下であることが、唾液分泌促進効果、更には味、分散性の点から、好ましい。 The liquid preparation for oral cavity is a mouthwash or mouse spray containing the saliva secretion promoter, and (A) 90% cumulative particle size of dry powder of Yamabushitake, which is a saliva secretion promoter, 50 It is preferable that the% cumulative particle diameter is 15 μm or less from the viewpoint of the salivary secretion promoting effect, taste, and dispersibility.
The beverage composition contains the salivary secretion promoter, and is a beverage composition that is used by being dispersed, suspended, or dissolved in water, and is a saliva secretion promoter. (A) Drying of Yamabushitake The 90% cumulative particle diameter of the powder is preferably 30 μm or less, and the 50% cumulative particle diameter is preferably 15 μm or less from the viewpoint of the salivary secretion promoting effect, taste, and dispersibility.
　本発明の口腔用組成物には、更に、（Ｂ）糖アルコール及び（Ｃ）結晶セルロースを併用して配合することが好ましく、これにより、十分な味の改善効果及び製剤の変色抑制効果が得られる。（Ｂ）成分又は（Ｃ）成分を欠くと、特に固体製剤において、経時での製剤の変色を十分に抑制することができない場合がある。 The oral composition of the present invention preferably further contains (B) a sugar alcohol and (C) crystalline cellulose in combination, thereby obtaining a sufficient taste improving effect and a discoloration suppressing effect of the preparation. It is done. When component (B) or component (C) is absent, discoloration of the preparation over time may not be sufficiently suppressed, particularly in solid preparations.
　（Ｂ）糖アルコールとしては、エリスリトール、キシリトール、ソルビトール、マルチトール、イソマルチトール、ラクチトール、還元パラチノース、マルトトリイトール、イソマルトトリイトール、パニトール、オリゴ糖アルコール、還元水飴、還元麦芽糖水飴等が挙げられ、１種単独で又は２種以上を組み合わせて使用し得る。中でも、ソルビトール、キシリトール、マルチトール、還元パラチノース、マンニトール、エリスリトールが好ましく、より好ましくはソルビトール、キシリトール、マルチトール、還元パラチノースである。 (B) Examples of sugar alcohols include erythritol, xylitol, sorbitol, maltitol, isomaltitol, lactitol, reduced palatinose, maltotriitol, isomatotriitol, panitol, oligosaccharide alcohol, reduced starch syrup, and reduced maltose starch syrup. Can be used singly or in combination of two or more. Of these, sorbitol, xylitol, maltitol, reduced palatinose, mannitol, and erythritol are preferable, and sorbitol, xylitol, maltitol, and reduced palatinose are more preferable.
　（Ｂ）成分の糖アルコールの配合量は、組成物全体の２５～９０％が好ましく、３０～９０％がより好ましく、更に好ましくは４５～８５％、特に好ましくは５０～８０％である。配合量が多いほど、（Ａ）成分由来の異味を抑制し、味を改善でき、２５％以上であると味を十分に改善でき、製剤の変色抑制にもより好適である。多く配合しすぎると、（Ｃ）成分を添加しても製剤の変色を抑制できない場合があり、９０％以下であることが製剤の変色抑制には好適である。なお、（Ｂ）成分の糖アルコールは、トローチ錠等の錠剤の賦形剤としても用いることができる。 The blending amount of the sugar alcohol as the component (B) is preferably 25 to 90%, more preferably 30 to 90%, still more preferably 45 to 85%, particularly preferably 50 to 80% of the entire composition. The greater the amount, the more the taste derived from the component (A) can be suppressed and the taste can be improved. If the amount is 25% or more, the taste can be sufficiently improved, and more suitable for suppressing discoloration of the preparation. If too much is added, discoloration of the preparation may not be suppressed even when component (C) is added, and 90% or less is suitable for suppressing discoloration of the preparation. In addition, the sugar alcohol of (B) component can be used also as an excipient | filler of tablets, such as a troche tablet.
　（Ｃ）結晶セルロースは、繊維性植物から得たパルプのセルロースを酸で加水分解し精製したものであり、市販品を使用し得る。
　（Ｃ）成分の結晶セルロースの配合量は、組成物全体の５～３０％が好ましく、より好ましくは１０～２５％である。５～３０％で製剤の変色を十分に抑制できる。なお、配合量が多いほど変色抑制作用が高まるが、多く配合しすぎると相対的に（Ｂ）成分の配合量を少なくせざるを得なくなるため、味改善や変色抑制に不利になる場合がある。 (C) Crystalline cellulose is obtained by hydrolyzing and purifying cellulose of pulp obtained from a fibrous plant with an acid, and a commercially available product can be used.
Component (C) is preferably 5 to 30%, more preferably 10 to 25% of the total composition of crystalline cellulose. 5 to 30% can sufficiently suppress the discoloration of the preparation. In addition, discoloration suppressing action increases as the blending amount increases, but if blending too much, the blending amount of the component (B) must be relatively reduced, which may be disadvantageous for taste improvement and discoloration suppression. .
　本発明では、（Ｂ）、（Ｃ）成分を配合する場合、下記に示す配合比率の範囲内で配合することが、より好ましい。
　（Ａ）、（Ｂ）成分の配合量の割合を示す（Ａ）／（Ｂ）は、質量比として０．０１～１．５であることが好ましく、より好ましくは０．０５～０．７、更に好ましくは０．０７～０．６、特に好ましくは０．０７～０．５である。配合比率が上記範囲内であると唾液分泌促進効果がより優れ、味の改善効果、製剤の変色抑制効果もより高まる。（Ａ）／（Ｂ）が０．０１に満たないと、唾液分泌促進効果が十分に得られない場合がある。１．５を超えると味の改善効果、製剤の変色抑制効果が満足に得られない場合がある。 In this invention, when mix | blending (B) and (C) component, it is more preferable to mix | blend within the range of the compounding ratio shown below.
The ratio (A) / (B) indicating the proportion of the components (A) and (B) is preferably 0.01 to 1.5, more preferably 0.05 to 0.7. More preferably, it is 0.07 to 0.6, and particularly preferably 0.07 to 0.5. When the blending ratio is within the above range, the saliva secretion promoting effect is more excellent, and the taste improving effect and the discoloration suppressing effect of the preparation are further enhanced. If (A) / (B) is less than 0.01, the salivary secretion promoting effect may not be sufficiently obtained. When it exceeds 1.5, the taste improving effect and the discoloration suppressing effect of the preparation may not be obtained satisfactorily.
　更に、（Ａ）、（Ｃ）成分の配合量の割合を示す（Ａ）／（Ｃ）は、質量比として０．１～８であることが好ましく、より好ましくは０．２５～２．５である。配合比率が上記範囲内であると唾液分泌促進効果がより優れ、味の改善効果、製剤の変色抑制効果もより高まる。（Ａ）／（Ｃ）が０．１に満たないと、唾液分泌促進効果が十分に得られない場合がある。８を超えると味の改善効果、製剤の変色抑制効果が満足に得られない場合がある。 Furthermore, (A) / (C), which indicates the ratio of the blended amounts of the components (A) and (C), is preferably 0.1 to 8, more preferably 0.25 to 2.5 as a mass ratio. It is. When the blending ratio is within the above range, the saliva secretion promoting effect is more excellent, and the taste improving effect and the discoloration suppressing effect of the preparation are further enhanced. If (A) / (C) is less than 0.1, the salivary secretion promoting effect may not be sufficiently obtained. If it exceeds 8, the taste improving effect and the discoloration inhibiting effect of the preparation may not be obtained satisfactorily.
　なお、（Ｂ）、（Ｃ）成分の配合量の割合を示す（Ｂ）／（Ｃ）は、質量比として１～１８とすることができるが、好ましくは２～８である。配合比率が上記範囲内であると、味の改善効果、製剤の変色抑制効果がより優れる。 In addition, (B) / (C) indicating the ratio of the blending amounts of the components (B) and (C) can be 1 to 18 as a mass ratio, but is preferably 2 to 8. When the blending ratio is within the above range, the taste improving effect and the discoloration suppressing effect of the preparation are more excellent.
　本発明では、特に（Ａ）／（Ｂ）の配合比率、及び／又は（Ａ）／（Ｃ）の配合比率がそれぞれ上記範囲内であることが好ましく、上記配合比率の全てがそれぞれ上記範囲内であることが、とりわけ好ましい。
　（Ｂ）、（Ｃ）成分は、固体製剤に配合することが好ましい。 In the present invention, in particular, the blending ratio of (A) / (B) and / or the blending ratio of (A) / (C) is preferably within the above ranges, respectively, and all of the above blending ratios are within the above ranges. Is particularly preferred.
It is preferable to mix | blend (B) and (C) component with a solid formulation.
　また、本発明にかかわる口腔用組成物、飲料用組成物には、更に、（Ｄ）イノシン酸及び／又はその塩を配合できる。（Ｄ）成分を添加すると、（Ａ）成分由来の異味が十分に抑制されて味がより改善し、更に唾液分泌の促進作用も向上し、心地良い味のもとで優れた唾液分泌促進効果を付与できる。 In addition, (D) inosinic acid and / or a salt thereof can be further added to the composition for oral cavity and beverage composition according to the present invention. When the component (D) is added, the off-flavor derived from the component (A) is sufficiently suppressed, the taste is further improved, and the salivary secretion promoting action is also improved, and the saliva secretion promoting effect is excellent under a pleasant taste. Can be granted.
　本発明に使用される（Ｄ）成分のイノシン酸とは、イノシンリン酸の総称であり、イノシン－２’－リン酸、イノシン－３’－リン酸、イノシン－５’－リン酸が挙げられ、１種単独で又は２種を併用してもよいが、中でもイノシン－５’－リン酸が好ましい。また、塩としては、ナトリウム塩、カリウム塩等があるが、好ましくはナトリウム塩である。イノシン酸のナトリウム塩は、旨味成分であり、かつお節等のイノシン酸を含む抽出物や化学的合成したものを用いることもできる。市販品としては、キリン協和フーズ社製（リポタイド（登録商標））、味の素（株）製（Ａｊｉｔｉｄｅ（登録商標）　ＩＭＰ）、和光純薬工業（株）製などが挙げられ、これらを使用し得る。
　なお、イノシン酸は、常温では固体であるが、水に溶解して使用できる。 The inosinic acid of component (D) used in the present invention is a generic name for inosine phosphoric acid, and examples include inosine-2′-phosphoric acid, inosine-3′-phosphoric acid, and inosine-5′-phosphoric acid. One kind may be used alone or two kinds may be used in combination, but inosine-5′-phosphate is particularly preferable. Examples of the salt include a sodium salt and a potassium salt, and a sodium salt is preferable. An inosinic acid sodium salt is an umami component, and an extract containing inosinic acid such as bonito or a chemically synthesized one can also be used. Examples of commercially available products include Kirin Kyowa Foods (Lipotide (registered trademark)), Ajinomoto Co. (Ajide (registered trademark) IMP), Wako Pure Chemical Industries, Ltd., and the like. .
Inosinic acid is solid at room temperature, but can be used by dissolving in water.
　（Ｄ）イノシン酸及び／又はその塩を配合する場合、その配合量は、組成物全体の０．００１～０．５％（投与濃度）が好ましく、より好ましくは０．０１～０．２％である。この範囲内であると、味が十分に改善する。なお、飲料用組成物に配合する場合は、飲料としての投与濃度が上記範囲内になるように調整することが望ましい。 (D) When inosinic acid and / or a salt thereof is blended, the blending amount is preferably 0.001 to 0.5% (administration concentration) of the whole composition, more preferably 0.01 to 0.2%. It is. Within this range, the taste is sufficiently improved. In addition, when mix | blending with the composition for drinks, it is desirable to adjust so that the administration concentration as a drink may be in the said range.
　本発明にかかわる口腔用組成物、飲料用組成物には、更に、（Ｅ）チャノキの乾燥粉末及び／又はその抽出物を配合できる。（Ｅ）成分を添加すると、（Ａ）成分由来の異味が十分に抑制されて味がより改善し、心地良い味のもとで優れた唾液分泌促進効果を付与できる。 The oral composition and beverage composition according to the present invention may further contain (E) dried tea tree powder and / or an extract thereof. When the component (E) is added, the off-flavor derived from the component (A) is sufficiently suppressed, the taste is further improved, and an excellent saliva secretion promoting effect can be imparted under a pleasant taste.
　（Ｅ）チャノキの乾燥粉末及び／又はその抽出物としては、ツバキ属植物のチャノキ（学名：Ｃａｍｅｌｌｉａ　ｓｉｎｅｎｓｉｓ）に属する樹木の生葉、もしくは、それを加工して得られる不発酵茶、半発酵茶、発酵茶、後発酵茶の粉砕物や抽出液であれば、特に限定されずに用いることができる。具体的には、抹茶、緑茶、煎茶、深蒸し茶、玉露、茎茶、かぶせ茶、玉緑茶、ほうじ茶、番茶、玄米茶、釜炒り茶、ウーロン茶などから選ばれる１種又は２種以上が使用できる。特に、ヤマブシタケ乾燥粉末の味覚のマスキング効果の点から、抹茶、緑茶、ほうじ茶が好ましい。 (E) As a dry powder of chanoki and / or an extract thereof, raw leaves of a tree belonging to Camellia plant genus (scientific name: Camellia sinensis), or unfermented tea, semi-fermented tea obtained by processing it, Any fermented tea or post-fermented tea pulverized product or extract can be used without particular limitation. Specifically, one or more types selected from matcha, green tea, sencha, deep-steamed tea, gyokuro, stem tea, kabuse tea, tama green tea, roasted tea, bancha, brown rice tea, kettle roasted tea, oolong tea, etc. are used. it can. In particular, matcha, green tea, and roasted tea are preferred from the viewpoint of the taste masking effect of the dried Yamabushitake powder.
　チャノキの乾燥粉末としては、茶葉を粉砕した粉末茶及び／又は茶葉の生産過程で生じる粉茶が使用できるが、粒子径の調整が可能な粉末茶が好ましい。茶葉を粉砕した粉末茶の平均粒子径は特に限定されないが０．１～１００μｍが好ましく、より好ましくは１～８０μｍである。なお、平均粒子径はレーザー回折式粒度分布測定装置（マイクロトラックＭＴ３０００ＩＩ、日機装（株）製）を用いて測定した（以下、同様。）。
　また、茶葉抽出物を粉末とするには、公知の乾燥方法を用いることができ、具体的には茶葉の水抽出物を凍結乾燥やスプレードライを採用して乾燥することができる。
具体的には、市販の茶葉抽出物をスプレードライした緑茶、ほうじ茶の粉末などが使用できる。 As the dried tea powder, powdered tea obtained by pulverizing tea leaves and / or powdered tea produced in the production process of tea leaves can be used, but powdered tea capable of adjusting the particle size is preferable. The average particle size of the powdered tea obtained by pulverizing tea leaves is not particularly limited, but is preferably 0.1 to 100 μm, more preferably 1 to 80 μm. The average particle size was measured using a laser diffraction particle size distribution measuring device (Microtrack MT3000II, manufactured by Nikkiso Co., Ltd.) (the same applies hereinafter).
Moreover, in order to make a tea leaf extract into a powder, a well-known drying method can be used, and specifically, the tea leaf water extract can be dried by freeze-drying or spray-drying.
Specifically, green tea or hojicha powder obtained by spray drying a commercially available tea leaf extract can be used.
　（Ｅ）チャノキの乾燥粉末及び／又はその抽出物の配合量は、組成物全体に対して乾燥粉末換算で、好ましくは０．１～２％（投与濃度）であり、より好ましくは０．３～１％である。この範囲内であると、味が十分に改善する。なお、飲料用組成物に配合する場合は、飲料としての投与濃度が上記範囲内になるように調整することが望ましい。 (E) The blended amount of dry powder of chanoki and / or its extract is preferably 0.1-2% (administration concentration), more preferably 0.3%, in terms of dry powder with respect to the whole composition. ~ 1%. Within this range, the taste is sufficiently improved. In addition, when mix | blending with the composition for drinks, it is desirable to adjust so that the administration concentration as a drink may be in the said range.
　本発明において、錠剤、粒状剤等の口腔用固体製剤は、（Ａ）成分と共に（Ｂ）成分及び（Ｃ）成分を含有することが、唾液分泌促進効果、味、製剤外観の点から好ましい。この場合、（Ａ）成分の粒子径は特に限定されないが、９０％積算粒子径が１００μｍ以下、特に５０μｍ以下であることが好ましく、とりわけ９０％積算粒子径が３０μｍ以下、５０％積算粒子径が１５μｍ以下であると、唾液分泌促進効果がより優れる。更に、（Ｄ）成分及び／又は（Ｅ）成分を含有すると、味がより改善する。
　また、本発明において、口内での使用形態が液体である、洗口剤、マウススプレー等の口腔用液体製剤や飲料用組成物は、（Ａ）成分と共に（Ｄ）成分及び／又は（Ｅ）成分を含有し、（Ａ）成分は９０％積算粒子径３０μｍ以下、５０％積算粒子径１５μｍ以下であることが、唾液分泌促進効果、味、更には（Ａ）成分の分散性の点から好ましい。 In the present invention, oral solid preparations such as tablets and granules preferably contain the component (B) and the component (C) together with the component (A) from the viewpoint of the salivary secretion promoting effect, taste, and formulation appearance. In this case, the particle size of the component (A) is not particularly limited, but the 90% cumulative particle size is preferably 100 μm or less, particularly preferably 50 μm or less, and in particular, the 90% cumulative particle size is 30 μm or less and the 50% cumulative particle size. When it is 15 μm or less, the salivary secretion promoting effect is more excellent. Furthermore, when (D) component and / or (E) component are contained, a taste improves more.
Further, in the present invention, oral liquid preparations and beverage compositions such as mouthwashes, mouse sprays, etc., which are used in the mouth, are liquid (A) and (D) and / or (E). The component (A) has a 90% cumulative particle size of 30 μm or less and a 50% cumulative particle size of 15 μm or less from the viewpoint of the salivary secretion promoting effect, taste, and dispersibility of the component (A). .
　本発明の口腔用組成物には、本発明の効果を損なわない範囲で、口腔用組成物用として一般的な公知成分を必要に応じて適宜、配合し得る。具体的に固体製剤、特に錠剤に配合し得る任意成分としては、矯味剤、賦形剤、結合剤、崩壊剤、滑沢剤などが挙げられる。 In the composition for oral cavity of the present invention, generally known components for oral composition can be appropriately blended as necessary within the range not impairing the effects of the present invention. Specific examples of optional components that can be blended in solid preparations, particularly tablets, include taste-masking agents, excipients, binders, disintegrants, and lubricants.
　矯味剤としては、甘味剤、酸味剤、香味剤等が挙げられる。
　甘味剤としては、アスパルテーム、アセスルファムカリウム、サッカリンナトリウム、スクラロース、ステビア、ソーマチン、サトウキビ抽出物、パラチノース加熱物、カンゾウ等が挙げられ、中でも、アスパルテーム、アセスルファムカリウム、スクラロース、ステビアが好ましい。甘味剤の含有量は組成物全体の０．１～３％が好ましく、０．３～１．５％がより好ましい。
　酸味剤としては、クエン酸、酒石酸、リンゴ酸、コハク酸、フマル酸等が挙げられ、中でもクエン酸が好ましい。酸味剤の含有量は組成物全体の０．１～１０％が好ましく、０．５～５％がより好ましい。 Examples of the corrigent include sweeteners, sour agents, and flavoring agents.
Examples of the sweetening agent include aspartame, acesulfame potassium, saccharin sodium, sucralose, stevia, thaumatin, sugarcane extract, heated palatinose, licorice, etc. Among them, aspartame, acesulfame potassium, sucralose and stevia are preferable. The content of the sweetening agent is preferably from 0.1 to 3%, more preferably from 0.3 to 1.5% of the whole composition.
Examples of the sour agent include citric acid, tartaric acid, malic acid, succinic acid, fumaric acid and the like, and citric acid is particularly preferable. The content of the sour agent is preferably 0.1 to 10%, more preferably 0.5 to 5% of the whole composition.
　香味剤としては、ｌ－メントール、カンフル、ボルネオール、リモネン等のモノテルペン類、それらを含有する精油が挙げられる。その他の香味剤としては、アニス油、ウィンターグリーン油、カシア油、クローブ油、タイム油、セージ油、カルダモン油、コリアンダー油、マンダリン油、ラベンダー油、ローズマリー油、ローレル油、カモミル油、キャラウェイ油、マジョラム油、ベイ油、レモングラス油、オリガナム油、パインニードル油、ネロリ油、ローズ油、ジャスミン油、ハッカ油、イリスコンクリート、アブソリュートローズ、オレンジフラワー等の天然香料、及びこれら天然香料の加工処理（前溜部カット、後溜部カット、分留、液液抽出、エッセンス化、粉末香料化等）した香料；ペパーミント、グレープフルーツ、レモン、カシス、ヨーグルト、ライム、スペアミント、マンゴー、バニラ、アップル、グレープ、ライチ、ピーチ、スペアミント、エルダーベリー、ストロベリー、巨峰、マスカット、プラム、ソーダ、オレンジ、バナナ、バター、フルーツミックス、トロピカルフルーツミックス等の天然香料、及びこれら天然香料の加工処理（前溜部カット、後溜部カット、分留、液液抽出、エッセンス化、粉末香料化等）した香料；メントール、カルボン、アネトール、シネオール、サリチル酸メチル、シンナミックアルデヒド、オイゲノール、３－ｌ－メントキシプロパン－１，２－ジオール、チモール、リナロール、リナリールアセテート、リモネン、メントン、メンチルアセテート、Ｎ－置換－パラメンタン－３－カルボキサミド、ピネン、オクチルアルデヒド、メンソフラン、シトラール、ヌートカトン、γ－ウンデカラクトン、γ－デカラクトン、γ－ノナラクトン、δ－デカラクトン、バニリン、エチルバニリン、ベンズアルデヒド、プレゴン、カルビールアセテート、アニスアルデヒド、エチルアセテート、エチルブチレート、アリルシクロヘキサンプロピオネート、メチルアンスラニレート、エチルメチルフェニルグリシデート、ヘキサナール、エチルアルコール、プロピルアルコール、ブタノール、イソアミルアルコール、ヘキセノール、ジメチルサルファイド、シクロテン、フルフラール、トリメチルピラジン、エチルラクテート、メチルラクテート、エチルチオアセテート等の単品香料；並びに調合香料等、チュアブル錠に用いられる公知の香料素材を使用することができ、実施例の香料に限定されない。中でも、メントール（精油としてはハッカ油、ペパーミント油、スペアミント油等）、リモネン（オレンジ油等）等が好ましい。香味剤の含有量は組成物全体の０．０１～５％が好ましく、０．１～３％がより好ましい。 Examples of flavoring agents include monoterpenes such as l-menthol, camphor, borneol and limonene, and essential oils containing them. Other flavoring agents include anise oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, cardamom oil, coriander oil, mandarin oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway Natural fragrances such as oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, peppermint oil, Iris concrete, absolute rose, orange flower, and processing of these natural fragrances Perfumes that have been processed (front cut, rear cut, fractional distillation, liquid-liquid extraction, essence, powder, etc.); peppermint, grapefruit, lemon, cassis, yogurt, lime, spearmint, mango, vanilla, apple, Grape, lychee, peach, spearmint, elda Natural fragrances such as berry, strawberry, kyoho, muscat, plum, soda, orange, banana, butter, fruit mix, tropical fruit mix, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, Liquid-liquid extraction, essence, powder fragrance, etc.); menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-diol, thymol, linalool, Linarel acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, mensofuran, citral, nootkatone, γ-undecalactone, γ-decalactone, γ-nonalactone, δ-decalact , Vanillin, ethyl vanillin, benzaldehyde, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, hexanal, ethyl alcohol, propyl alcohol, Single flavors such as butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethylthioacetate; and known flavor materials used for chewable tablets such as blended flavors may be used. Yes, it is not limited to the fragrances of the examples. Of these, menthol (essential oils such as peppermint oil, peppermint oil, spearmint oil, etc.), limonene (orange oil, etc.) and the like are preferable. The content of the flavoring agent is preferably 0.01 to 5%, more preferably 0.1 to 3% of the entire composition.
　賦形剤としては、（Ｂ）糖アルコールや（Ｃ）結晶セルロースの他に、スターチ及びその誘導体等を配合することができる。具体的には、ヒドロキシプロピルスターチ等が挙げられる。賦形剤の含有量は、（Ｂ）、（Ｃ）成分を含めて組成物全体の１０～９９％が好ましく、２０～９０％がより好ましい。 As the excipient, starch and derivatives thereof can be blended in addition to (B) sugar alcohol and (C) crystalline cellulose. Specific examples include hydroxypropyl starch. The content of the excipient is preferably 10 to 99%, more preferably 20 to 90% of the whole composition including the components (B) and (C).
　結合剤としては、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、メチルセルロース、エチルセルロース、ポリビニルアルコール、ポリビニルピロリドン、ゼラチン、デキストリン、デンプン、アルファー化デンプン等が挙げられる。結合剤の含有量は組成物全体の０．５～２０％が好ましく、１～１０％がより好ましい。 Examples of the binder include hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, ethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, gelatin, dextrin, starch, pregelatinized starch and the like. The content of the binder is preferably 0.5 to 20%, more preferably 1 to 10%, based on the entire composition.
　崩壊剤としては、カルメロース、カルメロースカルシウム、クロスカルメロースナトリウム、低置換度ヒドロキシプロピルセルロース、低置換度カルボキシメチルスターチナトリウム、クロスポビドン等が挙げられる。崩壊剤の含有量は組成物全体の０．５～２０％が好ましく、１～１０％がより好ましい。 Examples of the disintegrant include carmellose, carmellose calcium, croscarmellose sodium, low-substituted hydroxypropyl cellulose, low-substituted carboxymethyl starch sodium, crospovidone, and the like. The content of the disintegrant is preferably 0.5 to 20%, more preferably 1 to 10% of the entire composition.
　滑沢剤としては、ステアリン酸マグネシウム、ステアリン酸カルシウム、ショ糖脂肪酸エステル、グリセリン脂肪酸エステル、無水ケイ酸、軽質無水ケイ酸、フマル酸ステアリルナトリウム等が挙げられる。滑沢剤の含有量は組成物全体の０．０１～５％が好ましく、０．１～３％がより好ましい。 Lubricants include magnesium stearate, calcium stearate, sucrose fatty acid ester, glycerin fatty acid ester, anhydrous silicic acid, light anhydrous silicic acid, sodium stearyl fumarate and the like. The content of the lubricant is preferably 0.01 to 5%, more preferably 0.1 to 3% of the entire composition.
　本発明にかかわる飲料用組成物には、本発明の効果を損なわない範囲で、飲料用組成物用として一般的な公知成分を必要に応じて適宜、通常量で配合し得る。具体的には甘味料、酸味料、調味料、食品材料、果汁、香料、酸化防止剤、保存料、水などが挙げられる。 In the beverage composition according to the present invention, known components generally used for beverage compositions can be appropriately blended in a normal amount as needed within the range not impairing the effects of the present invention. Specific examples include sweeteners, acidulants, seasonings, food materials, fruit juices, fragrances, antioxidants, preservatives, and water.
　以下、実験例、実施例及び比較例、処方例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。なお、下記の例において％は特に断らない限りいずれも質量％を示す。粒子径（９０％積算粒子径、５０％積算粒子径）は、レーザー回折式粒度分布測定装置（マイクロトラックＭＴ３０００ＩＩ、日機装（株）製）を用いて測定した。 Hereinafter, although an experimental example, an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified. The particle size (90% cumulative particle size, 50% cumulative particle size) was measured using a laser diffraction particle size distribution analyzer (Microtrack MT3000II, manufactured by Nikkiso Co., Ltd.).
　［実験例１］
　ヤマブシタケ乾燥粉末として、「ヤマブシタケ乾燥粉末」（ホクト（株）製）を使用し、ビーズミル（ウルトラアペックスミル　ＵＡＭ－１５、（株）広島メタル＆マシナリー製）にて粉砕し、所定の粒子径とした。唾液分泌促進効果は下記方法で評価した。
唾液分泌促進効果の評価方法
　試験前日に激しい運動等をしたことで口渇状態を主訴する８名の被験者について、以下の方法で唾液分泌量を測定した。即ち、ヤマブシタケ乾燥粉末（ホクト（株）製）を評価サンプルとして用い、評価サンプル２０ｍＬで３０秒間洗口した後、分泌されてくる唾液を飲み込まないように口腔内に保持した。保持した唾液は５分毎に容器に吐出し、質量を計測することで唾液分泌量とした。測定は洗口の３０分後まで５分間隔で実施した。なお、評価サンプルとしては、表１に示す濃度のヤマブシタケ乾燥粉末の水懸濁液を用い、コントロールとしては蒸留水を用いた。また、比較のためポリグルタミン酸ナトリウム（Ｎａ）の水溶液についても同様に評価した。
　唾液分泌の経時変化を図１に示した。また、唾液分泌促進効果として、３０分間の累積唾液分泌量を表１に示した。 [Experimental Example 1]
As Yamabushitake dry powder, "Yamabushitake dry powder" (manufactured by Hokuto Co., Ltd.) was used and pulverized with a beads mill (Ultra Apex Mill UAM-15, Hiroshima Metal & Machinery Co., Ltd.) to obtain a predetermined particle size. . The salivary secretion promoting effect was evaluated by the following method.
Evaluation method of salivary secretion promoting effect Saliva secretion amount was measured by the following method for 8 subjects complaining of thirst due to intense exercise etc. on the day before the test. That is, Yamabushitake dry powder (manufactured by Hokuto Co., Ltd.) was used as an evaluation sample, and after mouthwashing with 20 mL of the evaluation sample for 30 seconds, the secreted saliva was kept in the mouth so as not to be swallowed. The retained saliva was discharged into the container every 5 minutes and the mass was measured to determine the amount of saliva secreted. The measurement was carried out at 5-minute intervals until 30 minutes after the mouthwash. In addition, as an evaluation sample, the water suspension of the Yamabushitake dry powder of the density | concentration shown in Table 1 was used, and distilled water was used as control. For comparison, an aqueous solution of sodium polyglutamate (Na) was similarly evaluated.
The time course of saliva secretion is shown in FIG. In addition, as a saliva secretion promoting effect, the accumulated saliva secretion amount for 30 minutes is shown in Table 1.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
　図１に示す結果から、ヤマブシタケ乾燥粉末には、高い唾液分泌促進効果があることがわかった。
　また、表１に示すように、３０分間で分泌された唾液量及びコントロールに対する比率（％）で見ても、ヤマブシタケ乾燥粉末（濃度０．１％）の唾液分泌促進効果は、ポリグルタミン酸ナトリウム（濃度１％）を超えて高く、唾液分泌促進剤として有用であることがわかった。 From the results shown in FIG. 1, it was found that Yamabushitake dry powder has a high salivary secretion promoting effect.
In addition, as shown in Table 1, the salivary secretion promoting effect of Yamabushitake mushroom dry powder (concentration 0.1%) was also measured by sodium polyglutamate ( It was found to be useful as a salivary secretion promoter.
　［実験例２］
　ヤマブシタケ乾燥粉末（実験例１と同様の９０％積算粒子径１００μｍ、５０％積算粒子径２５μｍのものを使用。）を配合した口腔用組成物（錠剤）の唾液分泌促進効果を下記方法で評価した。
　表２、３に示す組成の粉体混合物を油圧式単発打錠機にて直接打錠法で、通常の方法によって打錠し、錠剤を調製し、これを口腔用組成物として、下記評価に用いた。なお、錠剤の大きさは直径７ｍｍ、質量１４０ｍｇであり、打錠圧は１，０００～２，０００ｋｇｆとした。得られた錠剤について、以下の試験を行った。結果を表２、３に併記した。 [Experiment 2]
The salivary secretion promoting effect of an oral composition (tablet) containing Yamabushitake dry powder (uses 90% cumulative particle size of 100 μm and 50% cumulative particle size of 25 μm as in Experimental Example 1) was evaluated by the following method. .
The powder mixture having the composition shown in Tables 2 and 3 is compressed directly by a conventional tableting method using a hydraulic single-punch tableting machine, and a tablet is prepared. This is used as an oral composition for the following evaluation. Using. The tablet had a diameter of 7 mm and a mass of 140 mg, and the tableting pressure was 1,000 to 2,000 kgf. The following tests were performed on the obtained tablets. The results are shown in Tables 2 and 3.
唾液分泌促進効果の評価方法
　試験前日に激しい運動等をしたことで口渇状態を主訴する８名の被験者について、口腔用組成物（錠剤）の摂取前後の唾液分泌量を測定した。唾液分泌量は、分泌されてくる唾液を飲み込まないように口腔内に保持し、保持した唾液を５分毎に容器に吐出し、これを６回繰り返し、３０分間で分泌された唾液の重量を計測し、これを唾液分泌量とした。口腔用組成物（錠剤）の摂取は、噛まずに口腔内で溶解させて舐めて摂取した。
　唾液分泌促進効果は、被験者８名について、各被験者の口腔用組成物摂取前の唾液量を１００％とし、摂取後の唾液量の比率（％）を算出した。８名の平均値（唾液量の平均変化率）を求め、下記の基準に基づき判定した。判定結果が◎及び○のものを、唾液分泌促進効果が高く合格であるとした。
　判定基準
　　◎：１５０％≦唾液量の平均変化率
　　○：１２０％≦唾液量の平均変化率＜１５０％
　　△：１００％＜唾液量の平均変化率＜１２０％
　　×：唾液量の平均変化率≦１００％ Evaluation Method of Salivary Secretion Promoting Effect Saliva secretion amount before and after ingestion of oral composition (tablet) was measured for 8 subjects complaining of thirst due to intense exercise etc. on the day before the test. The amount of saliva secreted is retained in the oral cavity so as not to swallow the secreted saliva, and the retained saliva is discharged into the container every 5 minutes, and this is repeated 6 times, and the weight of saliva secreted in 30 minutes is calculated. It was measured and this was taken as salivary secretion. The oral composition (tablet) was ingested after being dissolved in the oral cavity without being chewed.
The salivary secretion promoting effect was calculated for 8 subjects with the amount of saliva before intake of the oral composition of each subject as 100%, and the ratio (%) of the amount of saliva after intake. The average value (average rate of change in saliva volume) of 8 persons was determined and determined based on the following criteria. The judgment results of “◎” and “○” were considered to be acceptable because of their high salivary secretion promoting effect.
Criteria ◎: 150% ≦ average change rate of saliva amount ○: 120% ≦ average change rate of saliva amount <150%
Δ: 100% <average change rate of saliva volume <120%
X: Average rate of change in saliva volume ≦ 100%
　［実験例３］
　実験例２と同様の口腔用組成物（錠剤）について、以下の試験を行った。結果を表２、３の下部に併記した。 [Experiment 3]
The following test was conducted on the same oral composition (tablet) as in Experimental Example 2. The results are shown at the bottom of Tables 2 and 3.
（１）味覚（味の改善効果）の評価方法
　口腔用組成物（錠剤）を通常の方法で舐めて摂取した後、その味覚について、被験者８名が下記の評点基準に基づき官能評価した。８名の平均値を求め、下記の基準に基づき判定した。判定結果が◎及び○のものを合格であるとした。
　評点基準
　　４：ヤマブシタケ乾燥粉末の異味が十分に抑えられ、問題なく使用でき
　　　　る
　　３：ヤマブシタケ乾燥粉末の異味が抑えられ、使用することが可能であ
　　　　る
　　２：ヤマブシタケ乾燥粉末の異味がほとんど抑えられておらず、使用は
　　　　困難である
　　１：ヤマブシタケ乾燥粉末の異味が抑えられておらず、使用できない
　判定基準
　　◎：平均値が３．５点以上４点以下
　　○：平均値が３点以上３．５点未満
　　△：平均値が２点以上３点未満
　　×：平均値が１点以上２点未満 (1) Evaluation Method of Taste (Taste Improvement Effect) After the oral composition (tablet) was licked and ingested by a normal method, eight subjects were subjected to sensory evaluation on the taste based on the following rating criteria. The average value of 8 persons was calculated | required and it determined based on the following reference | standard. Judgment results of ◎ and ○ were considered acceptable.
Score standard 4: The taste of dried Yamabushitake is sufficiently suppressed and can be used without any problems 3: The taste of dried Yamabushitake is suppressed and can be used 2: The taste of dried Yamabushitake is almost suppressed It is difficult to use 1: The taste of dried Yamatake mushroom powder is not suppressed and cannot be used Judgment criteria ◎: Average value is 3.5 to 4 points ○: Average value is 3 to 3 points Less than 5 points Δ: Average value is 2 or more and less than 3 points ×: Average value is 1 or more and less than 2 points
（２）変色（製剤の変色抑制効果）の評価方法
　口腔用組成物（錠剤）を非密封のプラスチックケースに入れ、４℃又は室温で１ヶ月間保存後に取り出し、４℃保存品と比較した室温保存品の色を下記基準に基づき評価した。
　評価基準
　　◎：殆ど変色を認めず、使用上問題ない
　　○：やや変色を認めるが、使用上問題ない
　　△：変色を認め、使用上問題となる可能性がある
　　×：明らかな変色を認め、使用上問題となる (2) Evaluation method of discoloration (discoloration-suppressing effect of the preparation) The oral composition (tablet) is placed in an unsealed plastic case, taken out after storage at 4 ° C or room temperature for 1 month, and room temperature compared with 4 ° C stored product. The color of the preserved product was evaluated based on the following criteria.
Evaluation criteria ◎: Almost no discoloration and no problem in use ○: Some discoloration is recognized, but no problem in use △: Discoloration is recognized and may cause a problem in use ×: Clear discoloration is recognized and used It becomes a problem
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
　［実験例４］
　表４～６に示す組成の飲料用組成物を常法によって調製し、また、表７に示す組成の液体口腔用組成物（洗口剤）を常法によって調製した。これら組成物について、下記方法で味覚（味の改善効果）を評価した。なおまた、これら飲料用組成物、液体口腔用組成物の唾液分泌促進効果を評価（味覚の評価方法と同様にして摂取又は洗口した後の唾液分泌量を測定した以外は、実験例２と同様の方法で測定、評価）した。結果を表に併記した。 [Experimental Example 4]
Beverage compositions having the compositions shown in Tables 4 to 6 were prepared by conventional methods, and liquid oral compositions (mouthwashes) having the compositions shown in Table 7 were prepared by conventional methods. About these compositions, the taste (taste improvement effect) was evaluated by the following method. In addition, the salivary secretion promoting effect of these beverage compositions and liquid oral compositions was evaluated (Except for measuring the amount of saliva secreted after ingestion or mouthwash in the same manner as the taste evaluation method, It was measured and evaluated in the same manner. The results are shown in the table.
　ヤマブシタケ乾燥粉末は、ビーズミル（ウルトラアペックスミル　ＵＡＭ－１５、（株）広島メタル＆マシナリー製）にて粉砕し、所定の粒子径とした。
　粉末緑茶は、合資会社静岡園製、平均粒子径（測定法は上記と同様。）３０μｍを使用した。
　粉末ほうじ茶は、（株）香月園製、平均粒子径（測定法は上記と同様。）１０μｍを使用した。
　イノシン酸塩は、イノシン－５’－リン酸２ナトリウム（和光純薬工業（株）製）を使用した。 Yamabushitake dry powder was pulverized with a bead mill (Ultra Apex Mill UAM-15, manufactured by Hiroshima Metal & Machinery Co., Ltd.) to give a predetermined particle size.
The powdered green tea used was an average particle size (measurement method is the same as described above), 30 μm, manufactured by Shizuokaen.
As the powdered roasted tea, manufactured by Kogetsuen Co., Ltd., an average particle size (measurement method is the same as above) of 10 μm was used.
The inosine salt used was inosine-5′-phosphate disodium (manufactured by Wako Pure Chemical Industries, Ltd.).
（１）味覚（味の改善効果）の評価方法
　表に記載の飲料用組成物の場合は１００ｍＬを摂取、洗口剤の場合は１０ｍＬを３０秒洗口した後の味について、上記実験例３の味覚の評価方法と同様にして、同様の評点基準、判定基準で判定した。判定結果が◎及び○のものを合格であるとした。 (1) Evaluation Method of Taste (Taste Improvement Effect) In the case of the beverage composition shown in the table, 100 mL was ingested, and in the case of the mouthwash, the taste after 10 mL was rinsed for 30 seconds, the above Experimental Example 3 In the same manner as the taste evaluation method, the same evaluation criteria and evaluation criteria were used. Judgment results of ◎ and ○ were considered acceptable.
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000007
 ＊、＊＊；表７中、ヤマブシタケ抽出物、粉末緑茶抽出物は、乾燥粉末（９０％積算粒子径１００μｍ、５０％積算粒子径２５μｍ）の５％水懸濁液を調製し、８０℃で約１時間加熱することで抽出を行った後、１０，０００Ｇで１０分間遠心することで得た上清を、穴径０．２２μｍの滅菌フィルターで濾過することによって調製した。この抽出液１０％配合は、乾燥粉末換算で０．５％（５％水懸濁液×１０／１００（配合量））に相当する。
Figure JPOXMLDOC01-appb-T000007
 *, **: In Table 7, Yamabushitake extract and powdered green tea extract were prepared by preparing a 5% aqueous suspension of dry powder (90% cumulative particle size 100 μm, 50% cumulative particle size 25 μm) at 80 ° C. Extraction was performed by heating for about 1 hour, and then the supernatant obtained by centrifugation at 10,000 G for 10 minutes was prepared by filtration through a sterile filter having a hole diameter of 0.22 μm. This 10% extraction liquid blend corresponds to 0.5% (5% aqueous suspension x 10/100 (blending amount)) in terms of dry powder.
　［処方例１］粉末茶（お湯又は水１００ｍＬを加えて調整する。）
ヤマブシタケ乾燥粉末　　　　　　　　　　　　　　　　　　０．４ｇ
（９０％積算粒子径１００μｍ、５０％積算粒子径２５μｍ）
イノシン酸塩　　　　　　　　　　　　　　　　　　　　　　０．０５ｇ
塩化ナトリウム　　　　　　　　　　　　　　　　　　　　　０．２ｇ
塩化カリウム　　　　　　　　　　　　　　　　　　　　　　０．６ｇ　
合計　　　　　　　　　　　　　　　　　　　　　　　　　　１．２５ｇ [Prescription Example 1] Powdered tea (adjusted by adding 100 mL of hot water or water)
Yamabushitake dry powder 0.4g
(90% cumulative particle size 100 μm, 50% cumulative particle size 25 μm)
Inosinate 0.05g
Sodium chloride 0.2g
Potassium chloride 0.6g
Total 1.25g
　［処方例２］粉末茶（お湯又は水１００ｍＬを加えて調整する。）
ヤマブシタケ乾燥粉末　　　　　　　　　　　　　　　　　　０．４ｇ
（９０％積算粒子径２５μｍ、５０％積算粒子径１２μｍ）
うま味だしハイミー　　　　　　　　　　　　　　　　　　　０．２ｇ
（味の素（株）製、イノシン酸４％含有）
塩化カリウム　　　　　　　　　　　　　　　　　　　　　　０．６ｇ
合計　　　　　　　　　　　　　　　　　　　　　　　　　　１．２ｇ [Prescription Example 2] Powdered tea (adjusted by adding 100 mL of hot water or water)
Yamabushitake dry powder 0.4g
(90% cumulative particle size 25 μm, 50% cumulative particle size 12 μm)
Umami Dashi Hime 0.2g
(Ajinomoto Co., Inc., containing 4% inosinic acid)
Potassium chloride 0.6g
Total 1.2g
　［処方例３］粉末茶（お湯又は水１００ｍＬを加えて調整する。）
ヤマブシタケ乾燥粉末　　　　　　　　　　　　　　　　　　０．２ｇ
（９０％積算粒子径２５μｍ、５０％積算粒子径１２μｍ）
粉末緑茶　　　　　　　　　　　　　　　　　　　　　　　　１．０ｇ
合計　　　　　　　　　　　　　　　　　　　　　　　　　　１．２ｇ [Formulation Example 3] Powdered tea (adjusted by adding 100 mL of hot water or water)
Yamabushitake dry powder 0.2g
(90% cumulative particle size 25 μm, 50% cumulative particle size 12 μm)
Powdered green tea 1.0g
Total 1.2g
　［処方例４］粉末茶（お湯又は水１００ｍＬを加えて調整する。）
ヤマブシタケ乾燥粉末　　　　　　　　　　　　　　　　　　０．２ｇ
（９０％積算粒子径２５μｍ、５０％積算粒子径１２μｍ）
粉末ほうじ茶　　　　　　　　　　　　　　　　　　　　　　０．８ｇ
合計　　　　　　　　　　　　　　　　　　　　　　　　　　１．０ｇ [Prescription Example 4] Powdered tea (adjusted by adding 100 mL of hot water or water)
Yamabushitake dry powder 0.2g
(90% cumulative particle size 25 μm, 50% cumulative particle size 12 μm)
0.8g powdered roasted tea
Total 1.0g

Claims (20)

  1. 　（Ａ）ヤマブシタケ（Ｈｅｒｉｃｉｕｍ　ｅｒｉｎａｃｅｕｓ）の乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤。 (A) A salivary secretion promoter composed of a dry powder of Herbium erinaceus and / or an extract thereof.
  2. 　１回使用における投与量が、ヤマブシタケの乾燥粉末換算で１～１，０００ｍｇである請求項１記載の唾液分泌促進剤。 The salivary secretion promoter according to claim 1, wherein the dose in a single use is 1 to 1,000 mg in terms of Yamabushitake dry powder.
  3. 　請求項１又は２記載の唾液分泌促進剤を含有してなることを特徴とする口腔用組成物。 An oral composition comprising the salivary secretion promoter according to claim 1 or 2.
  4. 　（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤、（Ｂ）糖アルコール、及び（Ｃ）結晶セルロースを含有してなることを特徴とする口腔用組成物。 (A) A composition for oral cavity comprising a salivary secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, (B) a sugar alcohol, and (C) crystalline cellulose.
  5. 　（Ｂ）成分が、ソルビトール、キシリトール、マルチトール及び還元パラチノースから選ばれる１種又は２種以上の糖アルコールである請求項４記載の口腔用組成物。 The oral composition according to claim 4, wherein the component (B) is one or more sugar alcohols selected from sorbitol, xylitol, maltitol and reduced palatinose.
  6. 　（Ａ）／（Ｂ）が質量比として０．０１～１．５である請求項４又は５記載の口腔用組成物。 The composition for oral cavity according to claim 4 or 5, wherein (A) / (B) is 0.01 to 1.5 as a mass ratio.
  7. 　（Ａ）／（Ｃ）が質量比として０．１～８である請求項４～６のいずれか１項記載の口腔用組成物。 The composition for oral cavity according to any one of claims 4 to 6, wherein (A) / (C) is 0.1 to 8 in terms of mass ratio.
  8. 　（Ａ）成分の含有量がヤマブシタケの乾燥粉末換算量で１～４０質量％、（Ｂ）成分の含有量が２５～９０質量％、（Ｃ）成分の含有量が５～３０質量％である請求項４～７のいずれか１項記載の口腔用組成物。 The content of the component (A) is 1 to 40% by mass in terms of dry powder of Yamabushitake, the content of the component (B) is 25 to 90% by mass, and the content of the component (C) is 5 to 30% by mass. The oral composition according to any one of claims 4 to 7.
  9. 　固体製剤である請求項４～８のいずれか１項記載の口腔用組成物。 The oral composition according to any one of claims 4 to 8, which is a solid preparation.
  10. 　固体製剤が、錠剤、粒状剤又はチューインガムである請求項９記載の口腔用組成物。 The composition for oral cavity according to claim 9, wherein the solid preparation is a tablet, a granule or a chewing gum.
  11. 　（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤を含有する洗口剤又はマウススプレーであって、前記乾燥粉末の９０％積算粒子径が３０μｍ以下、５０％積算粒子径が１５μｍ以下であることを特徴とする口腔用組成物。 (A) A mouthwash or mouse spray containing a saliva secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the dry powder has a 90% cumulative particle size of 30 μm or less and a 50% cumulative particle size Is a composition for oral cavity, wherein the composition is 15 μm or less.
  12. 　（Ａ）成分の含有量がヤマブシタケの乾燥粉末換算量で０．０５～２質量％である請求項１１記載の口腔用組成物。 The composition for oral cavity according to claim 11, wherein the content of component (A) is 0.05 to 2% by mass in terms of dry powder equivalent of Yamabushitake.
  13. 　更に、（Ｄ）イノシン酸及び／又はその塩を０．００１～０．５質量％含有する請求項３～１２のいずれか１項記載の口腔用組成物。 The oral composition according to any one of claims 3 to 12, further comprising (D) 0.001 to 0.5 mass% of inosinic acid and / or a salt thereof.
  14. 　更に、（Ｅ）チャノキ（Ｃａｍｅｌｌｉａ　ｓｉｎｅｎｓｉｓ）の乾燥粉末及び／又はその抽出物を、チャノキの乾燥粉末換算量で０．１～２質量％含有する請求項３～１３のいずれか１項記載の口腔用組成物。 The oral cavity according to any one of claims 3 to 13, further comprising (E) 0.1 to 2% by mass of a dry powder of Camellia sinensis and / or an extract thereof in terms of a dry powder of tea tree. Composition.
  15. 　（Ａ）ヤマブシタケの乾燥粉末及び／又はその抽出物からなる唾液分泌促進剤を含有する飲料用組成物であって、前記乾燥粉末の９０％積算粒子径が３０μｍ以下、５０％積算粒子径が１５μｍ以下であることを特徴とする飲料用組成物。 (A) A beverage composition containing a salivary secretion promoter comprising a dried powder of Yamabushitake and / or an extract thereof, wherein the dry powder has a 90% cumulative particle size of 30 μm or less and a 50% cumulative particle size of 15 μm. A beverage composition characterized by the following:
  16. 　（Ａ）成分の含有量がヤマブシタケの乾燥粉末換算量で０．０５～２質量％である請求項１５記載の飲料用組成物。 The beverage composition according to claim 15, wherein the content of component (A) is 0.05 to 2% by mass in terms of dry powder equivalent of Yamabushitake.
  17. 　更に、（Ｄ）イノシン酸及び／又はその塩を０．００１～０．５質量％含有する請求項１５又は１６記載の飲料用組成物。 The beverage composition according to claim 15 or 16, further comprising (D) 0.001 to 0.5 mass% of inosinic acid and / or a salt thereof.
  18. 　更に、（Ｅ）チャノキ（Ｃａｍｅｌｌｉａ　ｓｉｎｅｎｓｉｓ）の乾燥粉末及び／又はその抽出物を、チャノキの乾燥粉末換算量で０．１～２質量％含有する請求項１５～１７のいずれか１項記載の飲料用組成物。 The beverage according to any one of claims 15 to 17, further comprising (E) a dry powder of Camellia sinensis and / or an extract thereof in an amount of 0.1 to 2% by mass in terms of dry powder of the tea tree. Composition.
  19. 　水に分散又は溶解して飲料を調製する製剤形態である、請求項１５～１８のいずれか１項記載の飲料用組成物。 The beverage composition according to any one of claims 15 to 18, which is a preparation form in which a beverage is prepared by dispersing or dissolving in water.
  20. 　固体製剤である請求項１９記載の飲料用組成物。 20. The beverage composition according to claim 19, which is a solid preparation.
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