TWI556834B - 用於含鋅組成物之表面活化劑系統 - Google Patents
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- TWI556834B TWI556834B TW102142177A TW102142177A TWI556834B TW I556834 B TWI556834 B TW I556834B TW 102142177 A TW102142177 A TW 102142177A TW 102142177 A TW102142177 A TW 102142177A TW I556834 B TWI556834 B TW I556834B
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- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- IPGANOYOHAODGA-UHFFFAOYSA-N dilithium;dimagnesium;dioxido(oxo)silane Chemical compound [Li+].[Li+].[Mg+2].[Mg+2].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O IPGANOYOHAODGA-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910001506 inorganic fluoride Inorganic materials 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229940068917 polyethylene glycols Drugs 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/068108 WO2014088575A1 (en) | 2012-12-06 | 2012-12-06 | Surfactant systems for zinc containing compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201438753A TW201438753A (zh) | 2014-10-16 |
| TWI556834B true TWI556834B (zh) | 2016-11-11 |
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| TW102142177A TWI556834B (zh) | 2012-12-06 | 2013-11-20 | 用於含鋅組成物之表面活化劑系統 |
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|---|---|
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| EP (1) | EP2928441B1 (enExample) |
| KR (1) | KR20150094676A (enExample) |
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| AR (1) | AR093791A1 (enExample) |
| AU (1) | AU2012396297B2 (enExample) |
| BR (1) | BR112015012959B1 (enExample) |
| CA (1) | CA2890686C (enExample) |
| HK (1) | HK1215161A1 (enExample) |
| IL (1) | IL238842B (enExample) |
| IN (1) | IN2015DN03993A (enExample) |
| MX (1) | MX354873B (enExample) |
| PH (1) | PH12015501070A1 (enExample) |
| RU (1) | RU2622022C2 (enExample) |
| TW (1) | TWI556834B (enExample) |
| WO (1) | WO2014088575A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015014900B1 (pt) | 2012-12-19 | 2019-05-14 | Colgate-Palmolive Company | Dentifrício compreendendo um complexo haleto de aminoácidozinco e uso de uma fonte de íon de zinco junto com um aminoácido |
| AU2012398399B2 (en) * | 2012-12-24 | 2015-11-19 | Colgate-Palmolive Company | Oral care composition |
| CA2892557C (en) * | 2012-12-24 | 2020-09-15 | Colgate-Palmolive Company | Dentifrice compositions comprising abrasive silica, calcium carbonate and zinc compounds |
| CN112315834A (zh) * | 2013-12-19 | 2021-02-05 | 高露洁-棕榄公司 | 抗恶臭口腔护理组合物 |
| CN104721063B (zh) * | 2013-12-19 | 2018-05-08 | 高露洁-棕榄公司 | 包含氧化锌和柠檬酸锌的洁齿剂组合物 |
| CN104721226B (zh) * | 2013-12-19 | 2019-12-24 | 高露洁-棕榄公司 | 口腔护理组合物 |
| CN106794121B (zh) * | 2014-10-15 | 2020-12-18 | 高露洁-棕榄公司 | 包含锌、精氨酸和丝氨酸的口腔护理组合物 |
| CN107106422B (zh) | 2014-12-15 | 2021-04-09 | 高露洁-棕榄公司 | 高盐牙膏及其使用方法 |
| WO2016105389A1 (en) | 2014-12-23 | 2016-06-30 | Colgate-Palmolive Company | Oral care compositions |
| RU2681525C2 (ru) | 2014-12-26 | 2019-03-07 | Колгейт-Палмолив Компани | Композиции для личной гигиены с фосфатом цинка в качестве активного вещества |
| MY182599A (en) * | 2014-12-26 | 2021-01-26 | Colgate Palmolive Co | Oral care compositions and methods of use |
| WO2016105429A1 (en) | 2014-12-26 | 2016-06-30 | Colgate-Palmolive Company | Zinc phosphate complex |
| BR112017012807B1 (pt) | 2014-12-26 | 2020-09-15 | Colgate-Palmolive Company | Composição para higiene bucal e uso de um complexo solúvel de polifosfato de zinco na preparação da mesma |
| BR112017012806B1 (pt) | 2014-12-26 | 2020-11-17 | Colgate-Palmolive Company | complexo de polifosfato de zinco solúvel e método de produção de polifosfato de zinco |
| RU2017128410A (ru) * | 2015-07-01 | 2019-02-12 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта и способы их применения |
| WO2017079962A1 (en) * | 2015-11-13 | 2017-05-18 | The Procter & Gamble Company | Dentifrice compositions with anti-tartar and anti-bacterial benefits |
| US10179038B2 (en) | 2015-12-30 | 2019-01-15 | Colgate-Palmolive Company | Oral care device with sacrificial electrode |
| CN107969115B (zh) | 2016-06-24 | 2021-12-24 | 高露洁-棕榄公司 | 口腔护理组合物及使用方法 |
| WO2018118161A1 (en) | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| US10058493B2 (en) * | 2016-12-21 | 2018-08-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| KR102337307B1 (ko) * | 2017-04-10 | 2021-12-09 | (주)아모레퍼시픽 | 저자극성 구강용 조성물 |
| CN111032001A (zh) * | 2017-08-31 | 2020-04-17 | 高露洁-棕榄公司 | 口腔护理组合物 |
| MX383559B (es) | 2018-03-29 | 2025-03-14 | Procter & Gamble | Composiciones para el cuidado bucal para promover la salud de las encias |
| JP7058341B2 (ja) | 2018-03-29 | 2022-04-21 | ザ プロクター アンド ギャンブル カンパニー | 歯肉健康を促進するための口腔ケア組成物 |
| CN111989083B (zh) | 2018-03-29 | 2024-02-13 | 宝洁公司 | 用于促进牙龈健康的口腔护理组合物 |
| MX385755B (es) | 2018-03-29 | 2025-03-18 | Procter & Gamble | Composiciones para el cuidado bucal para promover la salud de las encias |
| AU2019414295A1 (en) * | 2018-12-26 | 2021-06-24 | Colgate-Palmolive Company | Methods of shifting biofilm in the oral cavity from pathogenic to healthy biofilm |
| MX2022002255A (es) * | 2019-08-27 | 2022-03-22 | Colgate Palmolive Co | Composiciones para el cuidado oral con produccion de espuma aumentada y metodos para las mismas. |
| WO2021062631A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| JP7377963B2 (ja) | 2019-09-30 | 2023-11-10 | ザ プロクター アンド ギャンブル カンパニー | ホップベータ酸及び金属イオンを含む口腔ケア組成物 |
| JP7414973B2 (ja) | 2019-09-30 | 2024-01-16 | ザ プロクター アンド ギャンブル カンパニー | 歯科バイオフィルムの処置のための歯磨剤組成物 |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
| CN114746068A (zh) * | 2019-12-10 | 2022-07-12 | 高露洁-棕榄公司 | 含有锌化合物和精氨酸的粘度稳定的不含sls的牙膏 |
| WO2021168696A1 (en) * | 2020-02-26 | 2021-09-02 | The Procter & Gamble Company | Oral care compositions for gum health |
| WO2021168684A1 (en) * | 2020-02-26 | 2021-09-02 | The Procter & Gamble Company | Oral care compositions for gum health |
| US20230042261A1 (en) * | 2020-04-27 | 2023-02-09 | Mahnaz Rashti | Aqueous oral care compositions |
| CN117045527A (zh) * | 2022-05-07 | 2023-11-14 | 好来化工(中山) 有限公司 | 一种包含茶氨酸和双锌的口腔护理组合物及茶氨酸的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008145475A1 (en) * | 2007-05-31 | 2008-12-04 | Unilever Plc | Oral care composition |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3980767A (en) | 1968-07-23 | 1976-09-14 | Beecham Group Limited | Gel toothpastes |
| US3966863A (en) | 1974-12-04 | 1976-06-29 | Beecham Group Limited | Oral hygiene compositions |
| EP0007170B1 (en) | 1978-07-12 | 1981-06-17 | Beecham Group Plc | Method of inhibiting corrosion of aluminium tubes by toothpastes |
| US4358437A (en) | 1978-11-29 | 1982-11-09 | Beecham Group Limited | Compositions |
| US5855870A (en) * | 1990-03-22 | 1999-01-05 | Ultradent Products, Inc. | Method for treating sensitive teeth |
| US5330748A (en) * | 1993-05-19 | 1994-07-19 | Church & Dwight Co., Inc. | Dentifrices containing zinc oxide particles |
| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| US20080267891A1 (en) * | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
| US20090053267A1 (en) * | 2007-08-20 | 2009-02-26 | Depierro Karen | Dentifrice composition containing silicone oil beads |
| BRPI0821860B1 (pt) * | 2008-02-08 | 2016-11-01 | Colgate Palmolive Co | composição para cuidado oral, e, usos de uma composição e de um aminoácido básico, em forma livre ou de sal |
| RU2471475C2 (ru) * | 2008-02-08 | 2013-01-10 | Колгейт-Палмолив Компани | Продукт для ухода за полостью рта и способы его применения и получения |
| CA2707085C (en) * | 2008-02-08 | 2013-11-26 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| US20090238769A1 (en) * | 2008-03-21 | 2009-09-24 | Colgate-Palmolive Company | Compositions Comprising Nonionic And Zwittterionic Surfactants |
| JP5600346B2 (ja) * | 2009-05-26 | 2014-10-01 | コルゲート・パーモリブ・カンパニー | 歯磨剤組成物 |
| TWI455728B (zh) * | 2010-01-14 | 2014-10-11 | Colgate Palmolive Co | 牙劑組成物 |
| AU2010363052B2 (en) * | 2010-10-27 | 2014-11-20 | Colgate-Palmolive Company | Oral care composition comprising arginine and calcium carbonate |
-
2012
- 2012-12-06 BR BR112015012959-5A patent/BR112015012959B1/pt active IP Right Grant
- 2012-12-06 AU AU2012396297A patent/AU2012396297B2/en active Active
- 2012-12-06 RU RU2015121349A patent/RU2622022C2/ru active
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- 2012-12-06 CN CN201280077523.5A patent/CN104822360B/zh active Active
- 2012-12-06 KR KR1020157018043A patent/KR20150094676A/ko not_active Withdrawn
- 2012-12-06 MX MX2015007010A patent/MX354873B/es active IP Right Grant
- 2012-12-06 IN IN3993DEN2015 patent/IN2015DN03993A/en unknown
- 2012-12-06 US US14/649,557 patent/US20150297500A1/en not_active Abandoned
- 2012-12-06 WO PCT/US2012/068108 patent/WO2014088575A1/en not_active Ceased
- 2012-12-06 HK HK16103093.2A patent/HK1215161A1/zh unknown
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2013
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- 2013-12-04 AR ARP130104488A patent/AR093791A1/es unknown
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2015
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- 2015-05-14 PH PH12015501070A patent/PH12015501070A1/en unknown
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2022
- 2022-02-18 US US17/675,409 patent/US20220168212A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008145475A1 (en) * | 2007-05-31 | 2008-12-04 | Unilever Plc | Oral care composition |
Non-Patent Citations (1)
| Title |
|---|
| J Clin Dent 2012; 23(2):40-7之摘要 * |
Also Published As
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|---|---|
| CN104822360A (zh) | 2015-08-05 |
| US20150297500A1 (en) | 2015-10-22 |
| CA2890686A1 (en) | 2014-06-12 |
| KR20150094676A (ko) | 2015-08-19 |
| AU2012396297A1 (en) | 2015-05-28 |
| BR112015012959A2 (pt) | 2017-07-11 |
| MX354873B (es) | 2018-03-23 |
| CN104822360B (zh) | 2017-11-14 |
| IL238842B (en) | 2020-04-30 |
| AU2012396297B2 (en) | 2015-08-20 |
| EP2928441B1 (en) | 2018-07-11 |
| TW201438753A (zh) | 2014-10-16 |
| PH12015501070B1 (en) | 2015-08-03 |
| AR093791A1 (es) | 2015-06-24 |
| IN2015DN03993A (enExample) | 2015-10-02 |
| CA2890686C (en) | 2020-03-31 |
| MX2015007010A (es) | 2015-09-28 |
| EP2928441A1 (en) | 2015-10-14 |
| PH12015501070A1 (en) | 2015-08-03 |
| US20220168212A1 (en) | 2022-06-02 |
| RU2015121349A (ru) | 2017-01-13 |
| WO2014088575A1 (en) | 2014-06-12 |
| RU2622022C2 (ru) | 2017-06-08 |
| HK1215161A1 (zh) | 2016-08-19 |
| BR112015012959B1 (pt) | 2018-12-11 |
| IL238842A0 (en) | 2015-06-30 |
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