TWI494138B - Method for preparing antibacterial non-woven fabric - Google Patents

Description

Antibacterial non-woven fabric preparation method

The present invention relates to a method for preparing an antibacterial nonwoven fabric, and more particularly to a method for preparing an antibacterial nonwoven fabric having the growth and reproduction of bacteria and microorganisms on wound gauze.

According to the skin, the skin is the largest tissue structure of the human body. It not only has the function of regulating body temperature and regulating the water balance in the body, but also the first line of defense against the invasion of external pathogens. When the skin is injured in a large area, it may cause imbalance of body function. Organs are seriously dysfunctional and even die; in general, skin wounds are still in contact with clothing or the outside world after being treated with drugs. If they are accidentally caught, they may be damaged by dust or bacteria in the air. The situation.

Therefore, in order to avoid exposure of the wound to the air, people usually cover the wound with a straight stretch or wrap the wound with gauze and tape to protect the wound; however, the general OK stretch or gauze, only With the effect of isolating the wound to avoid contact with the outside world, when the gauze is accidentally wetted by water or the coating is too long to be replaced, the gauze is easy to breed bacteria and become a hotbed of bacteria, causing the wound to continue to be infected by bacteria and causing more serious damage. Inflammatory response.

Nowadays, the inventor is still in the light of the insatiable spirit of the above-mentioned existing wound gauze, and it is improved by the rich professional knowledge and years of practical experience. And based on this, the present invention was developed.

SUMMARY OF THE INVENTION A primary object of the present invention is to provide a method for preparing an antibacterial nonwoven fabric having the growth and reproduction of bacteria and microorganisms on wound gauze.

In order to achieve the above-mentioned purposes, the inventors have developed the following implementation techniques, first mixing a first excipient, a nano-silver porous composite, and a first polysaccharide, heating and stirring until the first The saccharide is completely dissolved to form a substrate; then, the substrate is uniformly screen printed on the fibrous non-woven fabric by screen coating, and the moisture is completely removed to form a dry and specific thickness antibacterial. Not woven.

The antibacterial nonwoven fabric preparation method as described above, wherein the first excipient is selected from the group consisting of starch, mannitol, lactose, sorbitol, and polyethylene glycol; preferably, the first excipient is selected from the group consisting of Yamanashi alcohol.

The antibacterial nonwoven fabric preparation method as described above, wherein the first polysaccharide system has a functional group of a carboxyl group; preferably, the first polysaccharide system is sodium alginate.

The antibacterial non-woven fabric preparation method as described above, wherein a humectant is further added to the preparation of the substrate, and the humectant is selected from the group consisting of sorbitol, hyaluronic acid stock solution, vegetable glycerin, vitamin B5, allantoin, urea, and the like. The group of the mixture; thereby, to maintain the wound surface moisture, thereby reducing wound pain and accelerating the healing of the wound surface.

The antibacterial non-woven fabric preparation method as described above, wherein in the preparation of the substrate, a thickener may be further added, and the thickener may be selected from the group consisting of alginic acid, polyglutamic acid, polyvinyl alcohol, chitosan, and the like. a group of mixtures.

Thereby, the antibacterial substrate formed by mixing the sodium alginate and the nano silver porous composite material, the nano silver porous composite material can isolate the external bacteria, and the sodium alginate is used to promote the regeneration of the wound new tissue. Achieve anti-infection and promote wound healing speed, thereby reducing the chance of wound infection and the number of patients changing dressings.

In addition, in the present invention, the antibacterial substrate is screen printed on the fibrous non-woven fabric by a screen printing method, and the texture structure and the capillary pores of the non-woven fabric are finer, and the touch is softer when it comes into contact with the wound. When connecting with the wound, it is only necessary to add a small amount of water to separate the non-woven fabric from the wound, and solve the problem that the traditional to tear off the OK stretch or gauze is not only painful, but also tears the wound which is healed or crusted again.

Furthermore, the present invention utilizes a screen printing and screen printing method to uniformly screen the antibacterial substrate on the fibrous non-woven fabric, and the screen printing method is different from the traditional dipping method, the spray method or the plate scraping method. The method and the like enable the present invention to accurately control the thickness of the nonwoven fabric.

The object of the present invention and its structural and functional advantages will be explained in conjunction with the specific embodiments according to the structure shown in the following drawings, so that the reviewing committee can have a more in-depth and specific understanding of the present invention.
First, please refer to the first figure, which is a flow chart of a preferred embodiment of the method for preparing an antibacterial nonwoven fabric of the present invention, which comprises the following steps:

Step 1 (S1): mixing a first excipient, a nano-silver porous composite and a first polysaccharide, heating and stirring until the first polysaccharide is completely dissolved to form a substrate; The first polysaccharide system has a carboxyl group functional group. Preferably, the first polysaccharide system is alginate, wherein the alginate acid is an insoluble colloidal acid obtained from brown seaweed. For a group of D-mannuronic acid and L-guluronic acid polymers containing different ratios, these uronic acids are α-1,4 and β-1, The 4-bond is a linear polymer with a molecular weight of about 240,000. The sodium salt is soluble in water and the calcium salt is insoluble in water. It is worth noting that the preparation method of the above nano-silver porous composite is suitable for the applicant of the present invention. Application for the Republic of China invention patent on April 16 (application number 10111) No. 3509), the content of the "Preparation method of nano-silver porous antibacterial composite material" is the reference material of this case;

Step 2 (S2): the substrate is uniformly screen printed on the fibrous non-woven fabric by a screen printing method, and the moisture is completely removed, thereby forming a dry and specific thickness antibacterial non-woven fabric; wherein, the filter mesh Press-coating screen printing method is to apply the substrate to a special size filter screen, and then screen printing on the fibrous non-woven fabric under appropriate pressure;

Furthermore, the first excipient may be selected from the group consisting of starch, mannitol, lactose, sorbitol, and polyethylene glycol (PEG); preferably, An excipient is selected from the group consisting of sorbitol.

In addition, in the above step (S1), a moisturizing agent may be further added, and the moisturizing agent is selected from the group consisting of sorbitol, hyaluronic acid stock solution, vegetable glycerin, vitamin B5, allantoin, urea ( Urea) and the group of its mixture.

Further, when the first step (S1) is performed, a thickener may be further added, and the thickener may be selected from the group consisting of alginate, poly(gamma-glutamic acid), A group consisting of polyvinyl alcohol, chitosan, and mixtures thereof.

In addition, the scope of the invention may be further demonstrated by the following practical embodiments, but is not intended to limit the scope of the invention in any way:

First, 20 g of silver nitrate crystals were dissolved in 80 g of deionized water and placed in a 20% by weight silver nitrate solution; then 37.8 mL of silver nitrate solution was dissolved in 500 mL of deionized water to prepare a solution A; then, 10 g was obtained. The gelatin is dissolved in 300 mL of deionized water, and the temperature is maintained at 40 ° C. Stirring is continued to dissolve the gelatin uniformly; then, the solution A is poured and continuously stirred to prepare a solution B; 0.2 g of sodium borohydride is dissolved. In 100 mL of deionized water, and adding Solution B, the silver ions in Solution B can be reduced to silver particles to prepare Solution C, and the chemical reaction formula of the silver ions which can be reduced to silver particles is as follows:

Next, the alkali made of sodium hydroxide is dropped into the solution C, the pH of the solution C is adjusted to 6, and the temperature is maintained at 40 degrees Celsius to prepare the solution D; then, 40 g of sodium citrate is dissolved. 500mL deionized water, stirred to dissolve evenly, to obtain an alkaline solution E; 10mL of hydrochloric acid was added to 300ml of deionized water to prepare an acid solution to prepare a solution F; the solution F was quickly poured into the solution E, and rapidly stirred The pH of the solution is rapidly lowered to about 1.5 to prepare a strongly acidic solution G. Then, the solution G is slowly dropped into the alkali solution prepared by using sodium hydroxide to adjust the pH to 6 to obtain a weak acidity. Solution H; finally, the solution D is quickly poured into the solution H, and mixed to obtain a nano-silver porous composite of silver-yttria complex, that is, the silver particles can be coated on the porous cerium oxide rubber. In the structure.

Next, 8 g of deionized water and 2 g of sorbitol solution were uniformly mixed, and 0.01 g of the nano silver porous composite material was added thereto, and uniformly dispersed by ultrasonic vibration, and then 1 g of sodium alginate was added thereto, and heated to 100 ° C and continuous stirring until completely dissolved, configure a substrate containing 3000 ppm of silver; followed by a special size and thickness of the screen to screen the substrate at a suitable pressure (for example, 1.5 atm) on the fiber On the non-woven fabric, heat to 80 ° C and maintain for 1 hour, so that the moisture is completely removed, that is, a dry and specific thickness of the antibacterial non-woven fabric; when used, can be used to cut the size directly to the wound, to solve the traditional wound gauze susceptible bacteria It becomes a hotbed of bacteria, which causes the wound to continue to be infected by bacteria. It is worth noting that the size of the mesh grid determines the thickness of the substrate film. Generally, the porosity of the mesh may be between 500 μm and 100 μm.

It can be seen from the above preparation method and implementation description of the antibacterial non-woven fabric that the present invention has the following advantages:

1. The invention comprises an antibacterial substrate formed by mixing a sodium alginate and a nano silver porous composite material, wherein the nano silver porous composite material isolates external bacteria, and the sodium alginate is used to promote regeneration of wound new tissue. Anti-infection and promote the speed of wound healing, thereby reducing the chance of wound infection and the number of patients changing dressings.
2. In the invention, the antibacterial substrate is screen printed on the fibrous non-woven fabric by the screen printing method, and the texture structure and the capillary pores of the non-woven fabric are finer, and the touch is softer when in contact with the wound, and if the wound is wounded When connecting, it is only necessary to add a small amount of water to separate the non-woven fabric from the wound. It can solve the problem that the traditional to tear off the OK stretch or gauze is not only painful, but also tears the wound which is healed or crusted again.
3. The invention utilizes the method of screen coating by pressure screen printing to uniformly screen the antibacterial substrate on the fibrous non-woven fabric, and the screen printing method is different from the traditional dipping method, the spraying method or the plate scraping method. This makes it possible to accurately control the thickness of the nonwoven fabric.
4. The antibacterial non-woven fabric preparation method of the present invention can maintain the wound surface moisture by the addition of a moisturizing agent, thereby reducing wound pain and accelerating the healing of the wound surface.

In summary, the preparation method of the antibacterial non-woven fabric of the present invention can achieve the intended use efficiency by the above-mentioned disclosed embodiments, and the present invention has not been disclosed before the application, and has completely complied with the provisions of the patent law. Claim.爰Issuing an application for a patent for invention in accordance with the law, and asking for a review, and granting a patent, is truly sensible.

The illustrations and descriptions of the present invention are merely preferred embodiments of the present invention, and are not intended to limit the scope of the present invention; those skilled in the art, which are characterized by the scope of the present invention, Equivalent variations or modifications are considered to be within the scope of the design of the invention.

(S1). . . step one

(S2). . . Step two

First Figure: Flow chart of the preparation method of the present invention

(S1). . . step one

(S2). . . Step two

Claims (7)

An antibacterial non-woven fabric preparation method comprises the following steps: Step 1: mixing a first excipient, a nano-silver porous composite and a first polysaccharide, heating and stirring until the first plurality The saccharide is completely dissolved and becomes a substrate, wherein the nano-silver porous composite is a composite material having silver particles which can be coated in the porous cerium oxide structure; and step 2: adding the sieve plate The substrate is uniformly screen printed on the fibrous nonwoven fabric by press coating, and the moisture is completely removed to form an antibacterial nonwoven fabric which is dry and has a specific thickness. The antibacterial non-woven fabric preparation method according to claim 1, wherein the first excipient is selected from the group consisting of starch, mannitol, lactose, sorbitol, and polyethylene glycol. , PEG) group of people. The antibacterial nonwoven fabric preparation method according to claim 2, wherein the first excipient is selected from the group consisting of sorbitol. The antibacterial nonwoven fabric preparation method according to claim 1, wherein the first polysaccharide system has a carboxyl group functional group. The antibacterial nonwoven fabric preparation method according to claim 4, wherein the first polysaccharide system is alginate. The antibacterial non-woven fabric preparation method according to claim 1, wherein in the step 1, a moisturizing agent is further added, which is selected from the group consisting of sorbitol, hyaluronic acid stock solution, vegetable glycerin, vitamin B5, Allantoin (allantoi a group of n), urea (urea), and mixtures thereof. The method for preparing an antibacterial non-woven fabric according to claim 1, wherein a thickener is further added to the step 1, the thickener is selected from the group consisting of alginic acid and polyglutamic acid (poly(γ). - glutamic acid)), a group of polyvinyl alcohol, chitosan, and the like.