TWI491614B - Ｃ－ｍｅｔ蛋白質激酶之胺基吡唑三唑并噻二唑抑制劑 - Google Patents
Ｃ－ｍｅｔ蛋白質激酶之胺基吡唑三唑并噻二唑抑制劑 Download PDFInfo
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- TWI491614B TWI491614B TW099117257A TW99117257A TWI491614B TW I491614 B TWI491614 B TW I491614B TW 099117257 A TW099117257 A TW 099117257A TW 99117257 A TW99117257 A TW 99117257A TW I491614 B TWI491614 B TW I491614B
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- acceptable salt
- cancer
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18178609P | 2009-05-28 | 2009-05-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201100436A TW201100436A (en) | 2011-01-01 |
| TWI491614B true TWI491614B (zh) | 2015-07-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW099117257A TWI491614B (zh) | 2009-05-28 | 2010-05-28 | Ｃ－ｍｅｔ蛋白質激酶之胺基吡唑三唑并噻二唑抑制劑 |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP2435443B1 (OSRAM) |
| JP (1) | JP5686796B2 (OSRAM) |
| KR (1) | KR20120030110A (OSRAM) |
| CN (1) | CN102459283B (OSRAM) |
| AR (1) | AR076617A1 (OSRAM) |
| AU (1) | AU2010254055B2 (OSRAM) |
| BR (1) | BRPI1012037A2 (OSRAM) |
| CA (1) | CA2762190A1 (OSRAM) |
| CL (1) | CL2011002946A1 (OSRAM) |
| DK (1) | DK2435443T3 (OSRAM) |
| ES (1) | ES2433090T3 (OSRAM) |
| HR (1) | HRP20130986T1 (OSRAM) |
| IL (1) | IL216581A (OSRAM) |
| MX (1) | MX2011012521A (OSRAM) |
| NZ (1) | NZ596616A (OSRAM) |
| PL (1) | PL2435443T3 (OSRAM) |
| PT (1) | PT2435443E (OSRAM) |
| RS (1) | RS53011B (OSRAM) |
| RU (1) | RU2552993C2 (OSRAM) |
| SG (1) | SG176574A1 (OSRAM) |
| SI (1) | SI2435443T1 (OSRAM) |
| TW (1) | TWI491614B (OSRAM) |
| UA (1) | UA106082C2 (OSRAM) |
| WO (1) | WO2010138665A1 (OSRAM) |
| ZA (1) | ZA201108655B (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2435444A1 (en) * | 2009-05-28 | 2012-04-04 | Vertex Pharmaceuticals Incorporated | Substituted pyrazole inhibitors of c-met protein kinase |
| US8263777B2 (en) | 2010-05-27 | 2012-09-11 | Vertex Pharmaceuticals Incorporated | Aminopyrazole triazolothiadiazole inhibitor of c-Met protein kinase |
| TR201113223A2 (tr) * | 2011-12-29 | 2012-06-21 | Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. | Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem. |
| KR101373912B1 (ko) | 2012-03-26 | 2014-03-13 | 중앙대학교 산학협력단 | Ｓｈｐ－2의 활성을 특이적으로 저해하는 조성물 및 이의 제조방법 |
| CN106924260B (zh) * | 2015-12-31 | 2018-05-25 | 北京浦润奥生物科技有限责任公司 | 化合物在制备用于治疗脑胶质瘤的药物中的用途 |
| CN109897054B (zh) * | 2017-12-08 | 2021-12-10 | 中国药科大学 | 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2008144767A1 (en) * | 2007-05-21 | 2008-11-27 | Sgx Pharmaceuticals, Inc. | Heterocyclic kinase modulators |
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| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| CN1863780A (zh) * | 2002-08-14 | 2006-11-15 | 沃泰克斯药物股份有限公司 | 蛋白激酶抑制剂及其应用 |
| US7122548B2 (en) * | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| JO2629B1 (en) * | 2004-08-19 | 2012-06-24 | افينتيس فارما سوتيكالز انك | Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon |
| CA2630884A1 (en) * | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
| ZA200804681B (en) * | 2005-11-30 | 2009-11-25 | Vertex Pharma Inc | Inhibitors of C-Met and uses thereof |
| NL2000613C2 (nl) * | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| CN102216309B (zh) * | 2008-11-19 | 2014-05-07 | 沃泰克斯药物股份有限公司 | C-met蛋白激酶的三唑并噻二唑抑制剂 |
| EP2435444A1 (en) * | 2009-05-28 | 2012-04-04 | Vertex Pharmaceuticals Incorporated | Substituted pyrazole inhibitors of c-met protein kinase |
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2010
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- 2010-05-27 NZ NZ596616A patent/NZ596616A/xx not_active IP Right Cessation
- 2010-05-27 BR BRPI1012037A patent/BRPI1012037A2/pt not_active IP Right Cessation
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008144767A1 (en) * | 2007-05-21 | 2008-11-27 | Sgx Pharmaceuticals, Inc. | Heterocyclic kinase modulators |
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| Publication number | Publication date |
|---|---|
| CA2762190A1 (en) | 2010-12-02 |
| PT2435443E (pt) | 2013-10-31 |
| WO2010138665A1 (en) | 2010-12-02 |
| KR20120030110A (ko) | 2012-03-27 |
| AU2010254055B2 (en) | 2016-01-14 |
| PL2435443T3 (pl) | 2014-01-31 |
| ZA201108655B (en) | 2013-01-30 |
| RS53011B (sr) | 2014-04-30 |
| HRP20130986T1 (hr) | 2013-11-22 |
| AR076617A1 (es) | 2011-06-22 |
| JP2012528186A (ja) | 2012-11-12 |
| SI2435443T1 (sl) | 2013-12-31 |
| CL2011002946A1 (es) | 2012-07-27 |
| NZ596616A (en) | 2013-05-31 |
| TW201100436A (en) | 2011-01-01 |
| RU2011153613A (ru) | 2013-07-10 |
| DK2435443T3 (da) | 2013-10-28 |
| CN102459283A (zh) | 2012-05-16 |
| AU2010254055A1 (en) | 2011-12-15 |
| BRPI1012037A2 (pt) | 2016-05-17 |
| SG176574A1 (en) | 2012-01-30 |
| ES2433090T3 (es) | 2013-12-09 |
| HK1169105A1 (en) | 2013-01-18 |
| IL216581A0 (en) | 2012-02-29 |
| EP2435443A1 (en) | 2012-04-04 |
| RU2552993C2 (ru) | 2015-06-10 |
| CN102459283B (zh) | 2014-11-12 |
| IL216581A (en) | 2014-02-27 |
| JP5686796B2 (ja) | 2015-03-18 |
| EP2435443B1 (en) | 2013-07-31 |
| MX2011012521A (es) | 2012-01-30 |
| UA106082C2 (uk) | 2014-07-25 |
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