CN102459283B - C-met 蛋白激酶的氨基吡唑三唑并噻二唑抑制剂 - Google Patents

C-met 蛋白激酶的氨基吡唑三唑并噻二唑抑制剂 Download PDF

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Publication number
CN102459283B
CN102459283B CN201080028334.XA CN201080028334A CN102459283B CN 102459283 B CN102459283 B CN 102459283B CN 201080028334 A CN201080028334 A CN 201080028334A CN 102459283 B CN102459283 B CN 102459283B
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compound
cancer
formula
compounds
pharmaceutically acceptable
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Expired - Fee Related
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Chinese (zh)
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CN102459283A (zh
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D·劳弗
李磐
K·麦金蒂
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080028334.XA 2009-05-28 2010-05-27 C-met 蛋白激酶的氨基吡唑三唑并噻二唑抑制剂 Expired - Fee Related CN102459283B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18178609P 2009-05-28 2009-05-28
US61/181,786 2009-05-28
PCT/US2010/036312 WO2010138665A1 (en) 2009-05-28 2010-05-27 Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase

Publications (2)

Publication Number Publication Date
CN102459283A CN102459283A (zh) 2012-05-16
CN102459283B true CN102459283B (zh) 2014-11-12

Family

ID=42346870

Family Applications (1)

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CN201080028334.XA Expired - Fee Related CN102459283B (zh) 2009-05-28 2010-05-27 C-met 蛋白激酶的氨基吡唑三唑并噻二唑抑制剂

Country Status (25)

Country Link
EP (1) EP2435443B1 (OSRAM)
JP (1) JP5686796B2 (OSRAM)
KR (1) KR20120030110A (OSRAM)
CN (1) CN102459283B (OSRAM)
AR (1) AR076617A1 (OSRAM)
AU (1) AU2010254055B2 (OSRAM)
BR (1) BRPI1012037A2 (OSRAM)
CA (1) CA2762190A1 (OSRAM)
CL (1) CL2011002946A1 (OSRAM)
DK (1) DK2435443T3 (OSRAM)
ES (1) ES2433090T3 (OSRAM)
HR (1) HRP20130986T1 (OSRAM)
IL (1) IL216581A (OSRAM)
MX (1) MX2011012521A (OSRAM)
NZ (1) NZ596616A (OSRAM)
PL (1) PL2435443T3 (OSRAM)
PT (1) PT2435443E (OSRAM)
RS (1) RS53011B (OSRAM)
RU (1) RU2552993C2 (OSRAM)
SG (1) SG176574A1 (OSRAM)
SI (1) SI2435443T1 (OSRAM)
TW (1) TWI491614B (OSRAM)
UA (1) UA106082C2 (OSRAM)
WO (1) WO2010138665A1 (OSRAM)
ZA (1) ZA201108655B (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011012522A (es) * 2009-05-28 2012-02-08 Vertex Pharma Inhibidores de pirazol sustituido de proteina cinasa c-met.
JP2013527195A (ja) * 2010-05-27 2013-06-27 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−Ｍｅｔプロテインキナーゼのアミノピラゾールトリアゾロチアジアゾールインヒビター
TR201113223A2 (tr) * 2011-12-29 2012-06-21 Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem.
KR101373912B1 (ko) 2012-03-26 2014-03-13 중앙대학교 산학협력단 Ｓｈｐ－2의 활성을 특이적으로 저해하는 조성물 및 이의 제조방법
CN106924260B (zh) * 2015-12-31 2018-05-25 北京浦润奥生物科技有限责任公司 化合物在制备用于治疗脑胶质瘤的药物中的用途
CN109897054B (zh) * 2017-12-08 2021-12-10 中国药科大学 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
CN1863780A (zh) * 2002-08-14 2006-11-15 沃泰克斯药物股份有限公司 蛋白激酶抑制剂及其应用
US7122548B2 (en) * 2003-07-02 2006-10-17 Sugen, Inc. Triazolotriazine compounds and uses thereof
JO2629B1 (en) * 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
ZA200804681B (en) * 2005-11-30 2009-11-25 Vertex Pharma Inc Inhibitors of C-Met and uses thereof
JP5144532B2 (ja) * 2005-11-30 2013-02-13 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−Ｍｅｔ阻害剤及び用法
NL2000613C2 (nl) * 2006-05-11 2007-11-20 Pfizer Prod Inc Triazoolpyrazinederivaten.
WO2008144767A1 (en) * 2007-05-21 2008-11-27 Sgx Pharmaceuticals, Inc. Heterocyclic kinase modulators
BRPI0921509A2 (pt) * 2008-11-19 2016-03-08 Vertex Pharma inibidor triazolotiadiazol de proteína quinase c-met
MX2011012522A (es) * 2009-05-28 2012-02-08 Vertex Pharma Inhibidores de pirazol sustituido de proteina cinasa c-met.

Also Published As

Publication number Publication date
BRPI1012037A2 (pt) 2016-05-17
SI2435443T1 (sl) 2013-12-31
NZ596616A (en) 2013-05-31
CL2011002946A1 (es) 2012-07-27
AR076617A1 (es) 2011-06-22
PT2435443E (pt) 2013-10-31
ES2433090T3 (es) 2013-12-09
IL216581A0 (en) 2012-02-29
EP2435443A1 (en) 2012-04-04
PL2435443T3 (pl) 2014-01-31
MX2011012521A (es) 2012-01-30
AU2010254055B2 (en) 2016-01-14
SG176574A1 (en) 2012-01-30
DK2435443T3 (da) 2013-10-28
CN102459283A (zh) 2012-05-16
WO2010138665A1 (en) 2010-12-02
RU2552993C2 (ru) 2015-06-10
RS53011B (sr) 2014-04-30
RU2011153613A (ru) 2013-07-10
KR20120030110A (ko) 2012-03-27
HRP20130986T1 (hr) 2013-11-22
TWI491614B (zh) 2015-07-11
TW201100436A (en) 2011-01-01
EP2435443B1 (en) 2013-07-31
ZA201108655B (en) 2013-01-30
JP2012528186A (ja) 2012-11-12
CA2762190A1 (en) 2010-12-02
JP5686796B2 (ja) 2015-03-18
HK1169105A1 (en) 2013-01-18
AU2010254055A1 (en) 2011-12-15
UA106082C2 (uk) 2014-07-25
IL216581A (en) 2014-02-27

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