TWI490208B - 乙炔基衍生物 - Google Patents
乙炔基衍生物 Download PDFInfo
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- TWI490208B TWI490208B TW102137560A TW102137560A TWI490208B TW I490208 B TWI490208 B TW I490208B TW 102137560 A TW102137560 A TW 102137560A TW 102137560 A TW102137560 A TW 102137560A TW I490208 B TWI490208 B TW I490208B
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- Prior art keywords
- compound
- formula
- phenylethynyl
- disease
- morpholin
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- 150000001875 compounds Chemical class 0.000 claims description 65
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- LBLXFRRQZJVWJO-UHFFFAOYSA-N [5-[2-(3-chlorophenyl)ethynyl]pyridin-2-yl]-morpholin-4-ylmethanone Chemical compound ClC1=CC=CC(C#CC=2C=NC(=CC=2)C(=O)N2CCOCC2)=C1 LBLXFRRQZJVWJO-UHFFFAOYSA-N 0.000 claims description 5
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| EP3353161B1 (en) * | 2015-09-25 | 2021-07-21 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Triazole derivatives as p2y14 receptor antagonists |
| RS62517B1 (sr) | 2017-12-08 | 2021-11-30 | Boehringer Ingelheim Int | Derivati imidazopiridina i njihova upotreba kao leka |
| EA202191014A1 (ru) * | 2018-10-17 | 2021-11-09 | Бёрингер Ингельхайм Интернациональ Гмбх | Производные 4-пиразин-2-илметил-морфолина и их применение в качестве лекарственного средства |
| TW202035396A (zh) | 2018-10-17 | 2020-10-01 | 德商百靈佳殷格翰國際股份有限公司 | 4-吡啶基甲基-嗎啉衍生物及其作為藥物之用途 |
| CN112888684B (zh) * | 2018-10-17 | 2023-10-10 | 勃林格殷格翰国际有限公司 | 4-嘧啶-5-基甲基-吗啉衍生物及其作为药物的用途 |
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| WO2013049255A1 (en) * | 2011-09-26 | 2013-04-04 | Vanderbilt University | Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors |
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| CN101795689A (zh) * | 2007-06-03 | 2010-08-04 | 范德比尔特大学 | 苯甲酰胺mGluR5正性变构调节剂和制备与使用所述调节剂的方法 |
| CN102596909A (zh) * | 2009-10-27 | 2012-07-18 | 霍夫曼-拉罗奇有限公司 | 正变构调节剂(pam) |
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