TWI461219B - Reduces the rough composition of the skin - Google Patents
Reduces the rough composition of the skin Download PDFInfo
- Publication number
- TWI461219B TWI461219B TW099131491A TW99131491A TWI461219B TW I461219 B TWI461219 B TW I461219B TW 099131491 A TW099131491 A TW 099131491A TW 99131491 A TW99131491 A TW 99131491A TW I461219 B TWI461219 B TW I461219B
- Authority
- TW
- Taiwan
- Prior art keywords
- glutamic acid
- skin
- sds
- present
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 56
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 claims description 75
- 229930182847 D-glutamic acid Natural products 0.000 claims description 71
- 206010013786 Dry skin Diseases 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 7
- 235000013305 food Nutrition 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 35
- 210000003491 skin Anatomy 0.000 description 27
- 238000011282 treatment Methods 0.000 description 26
- 238000009472 formulation Methods 0.000 description 18
- 238000000034 method Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 230000000694 effects Effects 0.000 description 13
- 229940024606 amino acid Drugs 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 11
- 150000001413 amino acids Chemical class 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 9
- 239000013642 negative control Substances 0.000 description 9
- -1 amine salt Chemical class 0.000 description 8
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- 235000011194 food seasoning agent Nutrition 0.000 description 7
- 235000013557 nattō Nutrition 0.000 description 7
- 230000008591 skin barrier function Effects 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000000855 fermentation Methods 0.000 description 6
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- 235000015429 Mirabilis expansa Nutrition 0.000 description 5
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- 235000013536 miso Nutrition 0.000 description 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 4
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- 229930195713 D-glutamate Natural products 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
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- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
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- 125000004185 ester group Chemical group 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
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- 229910052751 metal Inorganic materials 0.000 description 2
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- 238000002156 mixing Methods 0.000 description 2
- LPUQAYUQRXPFSQ-AENDTGMFSA-M monosodium D-glutamate Chemical compound [Na+].[O-]C(=O)[C@H]([NH3+])CCC([O-])=O LPUQAYUQRXPFSQ-AENDTGMFSA-M 0.000 description 2
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- 125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
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- ZDXPYRJPNDTMRX-GSVOUGTGSA-N D-glutamine Chemical compound OC(=O)[C@H](N)CCC(N)=O ZDXPYRJPNDTMRX-GSVOUGTGSA-N 0.000 description 1
- 229930195715 D-glutamine Natural products 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
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- 239000004793 Polystyrene Substances 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
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- 239000011425 bamboo Substances 0.000 description 1
- 150000003939 benzylamines Chemical class 0.000 description 1
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- HBGGXOJOCNVPFY-UHFFFAOYSA-N diisononyl phthalate Chemical compound CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C HBGGXOJOCNVPFY-UHFFFAOYSA-N 0.000 description 1
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- 235000013345 egg yolk Nutrition 0.000 description 1
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- 229920002223 polystyrene Polymers 0.000 description 1
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- 239000002994 raw material Substances 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 235000021108 sauerkraut Nutrition 0.000 description 1
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- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/24—Organic nitrogen compounds
- A21D2/245—Amino acids, nucleic acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/50—Soya sauce
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/60—Salad dressings; Mayonnaise; Ketchup
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Birds (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- General Preparation And Processing Of Foods (AREA)
Description
本發明係關於減輕肌膚粗糙之經口組合物及預防肌膚粗糙之經口組合物，其含有選自由D-麩胺酸與其衍生物及/或鹽所組成之群中之1種或2種以上之化合物；以及減輕肌膚粗糙之方法及預防肌膚粗糙之方法，其包括投予上述化合物之步驟。
於發生肌膚粗糙之皮膚中，經皮水分蒸散量(TEWL)增加，因此一般認為皮膚屏障功能降低係肌膚粗糙之原因之一。
非專利文獻1：標準皮膚科學 第7版(醫學書院)
先前之肌膚粗糙之減輕及/或預防用組合物係皮膚外用而具有幫助皮膚保濕之作用，並非藉由經口投予來抑制皮膚屏障功能降低。
因此，需要開發出一種可作用於皮膚屏障功能而減輕及/或預防肌膚粗糙的穩定且安全之經口組合物。
本發明提供一種減輕肌膚粗糙之經口組合物，其含有選自由D-麩胺酸與其衍生物及/或鹽所組成之群中之1種或2種以上之化合物。
本發明提供一種預防肌膚粗糙之經口組合物，其含有選自由D-麩胺酸與其衍生物及/或鹽所組成之群中之1種或2種以上之化合物。
本發明提供一種醫藥品組合物，其含有本發明之減輕肌膚粗糙之經口組合物或預防肌膚粗糙之經口組合物。
本發明提供一種食品組合物，其含有本發明之減輕肌膚粗糙之經口組合物或預防肌膚粗糙之經口組合物。
本發明提供一種減輕肌膚粗糙之方法，其包括投予減輕肌膚粗糙之經口組合物之步驟，該經口組合物含有選自由D-麩胺酸與其衍生物及/或鹽所組成之群中之1種或2種以上之化合物。
本發明提供一種預防肌膚粗糙之方法，其包括投予預防肌膚粗糙之經口組合物之步驟，該經口組合物含有選自由D-麩胺酸與其衍生物及/或鹽所組成之群中之1種或2種以上之化合物。
於本發明之減輕肌膚粗糙之方法及/或預防肌膚粗糙之方法中，存在上述減輕肌膚粗糙之經口組合物及/或預防肌膚粗糙之經口組合物為醫藥品組合物之情形。
於本發明之減輕肌膚粗糙之方法及/或預防肌膚粗糙之方法中，存在上述減輕肌膚粗糙之經口組合物及/或預防肌膚粗糙之經口組合物為食品組合物之情形。
本說明書中，所謂「肌膚粗糙」，係一種皮膚病，係指定義為肌膚表面乾燥、皮溝、皮丘的肌理紊亂狀態。發生肌膚粗糙之皮膚表面因肌理紊亂而產生皮屑，在光學上變得不規則，因而藉由目視可見該肌理紊亂。
本說明書中，所謂「皮膚屏障功能」，係將皮膚保持在正常狀態之功能，係指防止異物侵入體內或水分自體內喪失之功能。
本說明書中，所謂D-麩胺酸之「鹽」，係指於無損D-麩胺酸之肌膚粗糙改善效果的條件下包括金屬鹽、胺鹽等中之任一種鹽。上述金屬鹽存在包括鹼金屬鹽、鹼土類金屬鹽等之情形。上述胺鹽存在包括三乙胺鹽、苄胺鹽等之情形。
本說明書中，所謂D-麩胺酸之「衍生物」，係指於無損D-麩胺酸之肌膚粗糙改善效果的條件下，D-麩胺酸分子於胺基、羧基、側鏈中之任一者上與任一原子團共價鍵結而成者。上述任一原子團包括：N-苯基乙醯基、4,4'-二甲氧基三苯甲基(DMT)等保護基，蛋白質、肽、糖、脂質、核酸等生物大分子(biomacromolecule)，聚苯乙烯、聚乙烯(Polyethylene)、聚乙烯(Polyvinyl)、聚酯等合成高分子(synthetic macromolecular)，酯基等官能基，但並不限定於該等。上述酯基存在包括例如甲酯、乙酯等脂肪族酯或芳香族酯之情形。
胺基酸存在L-體與D-體之光學異構物，天然蛋白質係L-胺基酸與肽鍵結而成者，除去細菌之細胞壁等例外，由於僅L-胺基酸被利用，因此可認為以人類為代表的哺乳類體內僅存在L-胺基酸，僅利用L-胺基酸。根據(木野內忠稔等人，蛋白質、核酸、酶，50：453-460(2005)，Lehninger Principles of Biochemistry[上]第2版，pp132-147(1993)，廣川書店，Harper's Biochemistry，原文書22版，pp21-30(1991)，丸善)可知，先前無論於學術上亦或工業上，胺基酸基本上僅使用L-胺基酸。
作為例外地使用D-胺基酸之實例，於用作由細菌產生之抗生素之原料時，以及化學合成胺基酸時，為了省去自等量獲得之L-胺基酸與D-胺基酸之混合物中僅分離取得L-胺基酸所耗費的成本，而有直接以DL-胺基酸混合物之形式使用D-胺基酸的食品添加物之例。但是，先前尚無在產業上僅使用D-胺基酸作為具有生理活性之物質的例子。
D-絲胺酸或D-天冬胺酸由於D-體之比率較高，故而對其進行比較研究。現已明確，D-絲胺酸局部存在於大腦、海馬中，係腦內NMDA(N-甲基-D-天冬胺酸，N-methyl-D-aspartic acid)受體之調節因子。D-天冬胺酸可見局部存在於精巢或松果體中，顯示參與控制激素分泌(日本專利特開2005-3558號公報)。但是，D-麩胺酸之減輕肌膚粗糙之效果尚不明確。
以下之實施例所揭示之D-麩胺酸之減輕肌膚粗糙之效果先前尚不為人知。因此，含有D-麩胺酸之本發明之經口組合物為新穎發明。
近年來有報告指出，令ddY小鼠自由攝取10 mM之D-胺基酸水溶液2週之後，測定各器官中之D-胺基酸濃度，結果於松果體之每1腺體中的濃度為3~1000 pmol；於每1克濕重之腦組織中的濃度為2~500 nmol(Morikawa，A.等人，Amino Acids,32: 13-20(2007))。根據所述內容，算出下文說明之本發明之組合物所含之D-麩胺酸的每天攝取量的下限。
如以下之實施例所示，本發明之D-麩胺酸於1~10 mM之水溶液濃度之經口組合物中，對小鼠具有減輕肌膚粗糙之效果。因此，本發明之改善肌膚粗糙之經口組合物及食品組合物所含之D-麩胺酸的量，於D-麩胺酸被送至生物體皮膚組織之條件下，可為任何含量。於本發明之組合物為內服劑之情形時，D-麩胺酸之含量為0.00001重量%~100重量%之範圍即可。於本發明之組合物為內服劑之情形時，D-麩胺酸之含量較理想為0.00002重量%~80重量%，最理想為0.0002重量%~60重量%。再者，本發明之組合物所含的D-麩胺酸之每天攝取量的下限為平均1 kg體重0.01 ng即可，較佳為0.1 ng，更佳為1 ng。
本發明之醫藥品組合物有時不僅含有D-麩胺酸、D-麩胺酸之鹽及/或可於生物體內藉由藥物代謝酶等釋放D-麩胺酸的衍生物，而且於無損D-麩胺酸之減輕肌膚粗糙之效果之條件下更包含1種或2種以上之藥學上所容許之添加物。上述添加物包括：稀釋劑及發泡劑、黏合劑及接著劑、潤滑劑、流動促進劑、塑化劑、崩解劑、載劑、緩衝劑、著色料、香料、甜味料、防腐劑及穩定劑、吸附劑、以及業者所知之其他醫藥品添加劑，但並不限定於該等。
本發明之食品組合物有時不僅含有D-麩胺酸、D-麩胺酸之鹽及/或可於生物體內藉由藥物代謝酶等釋放D-麩胺酸的衍生物，而且於無損D-麩胺酸之改善肌膚粗糙效果之條件下更含有調味料、著色料、保存料等食品所容許之成分。
本發明之食品組合物只要為例如糖果、小甜餅、味噌、法式沙拉醬、蛋黃醬、法式麵包、醬油、酸乳酪、外撒料、調味料/納豆之佐料、納豆、未過濾黑醋等先前用於食品組合物者則可為任意，但並不限定於上述例示。
以下所說明之本發明之實施例僅為例示，並非限定本發明之技術範圍者。本發明之技術範圍僅由申請專利範圍所記載之內容限定。
本說明書中所言及之全部文獻係藉由引用將其全文併入本說明書中。
以下之實施例所說明之實驗係依據美國國家衛生研究所(National Institutes of Health(NIH))之準則且由資生堂研究中心之倫理委員會批准後實施。
短期投予D-麩胺酸所獲得之減輕肌膚粗糙之效果
方法
實驗動物
小鼠係將HR-1無毛小鼠(雄性，7週齡，星野試驗動物飼育所股份有限公司)供於實驗。每個實驗條件使用7~8隻小鼠。
投予胺基酸
為了調查胺基酸對肌膚粗糙之效果，對小鼠給水投予1 mM或10 mM之D-麩胺酸。將不含D-麩胺酸之飲用水作為陰性對照。
肌膚粗糙實驗
於開始投予D-麩胺酸後第10天及第11天，將滲入有10%之SDS(sodium dodecyl sulfate，十二烷基硫酸鈉)溶液之不織布接觸麻醉下之小鼠之背部之一側5分鐘(以下稱為「SDS處理」)。SDS處理次數有時為2~5次，直至引起肌膚粗糙為止。本實施例中，將開始投予D-麩胺酸後第10天及第11天之SDS處理分別稱為第1次及第2次SDS處理。又，於以下之經皮水分蒸散量之測定中，將已實施SDS處理之部位稱為「SDS處理部位」，將未實施SDS處理之相反側部位稱為「SDS非處理部位」。
經皮水分蒸散量之定量
為了對肌膚粗糙狀態進行定量，而使用水分蒸散量測定裝置(Tewameter TM-300，Courage+Khazaka公司製造)並依據製造商之說明書確定第1次SDS處理開始前(SDS處理前)、與第1次及第2次SDS處理2小時後之經皮水分蒸散量。此處，將自SDS處理部位之經皮水分蒸散量減去SDS非處理部位之經皮水分蒸散量而獲得之測定值設為「TEWLΔ值」。
結果
圖1表示調查經口投予D-麩胺酸11天對SDS處理小鼠之效果而獲得之實驗結果。各實驗條件之誤差槓表示於同一條件下反覆進行7~8次而獲得之實驗結果之測定值之標準偏差。又，星號(*)表示進行Dunnett檢定時p未達5%。
關於第1次SDS處理開始前(SDS處理前)之TEWLΔ值，陰性對照為0.7 g/m2
/h，投予1 mM之D-麩胺酸為0.4 g/m2
/h，投予10 mM之D-麩胺酸為0.1 g/m2
/h。關於第1次SDS處理2小時後(第1次處理)之TEWLΔ值，陰性對照為2.2 g/m2
/h，投予1 mM之D-麩胺酸為1.5 g/m2
/h，投予10 mM之D-麩胺酸為1.2 g/m2
/h。關於第2次SDS處理2小時後(第2次SDS處理)之TEWLΔ值，陰性對照為7.0 g/m2
/h，投予1 mM之D-麩胺酸為3.2 g/m2
/h，投予10 mM之D-麩胺酸為3.8 g/m2
/h。關於第2次SDS處理2小時後之TEWLΔ值，投予1 mM及10 mM之D-麩胺酸與陰性對照相比可見顯著差異。以上結果顯示：反覆進行SDS處理，小鼠會出現肌膚粗糙，藉由預先投予D-麩胺酸可預防及/或減輕肌膚粗糙。
長期投予D-麩胺酸所獲得之減輕肌膚粗糙之效果
方法
胺基酸之投予、肌膚粗糙實驗及經皮水分蒸散量之定量係使用上述HR-1無毛小鼠並藉由與實施例1相同之方式進行。胺基酸係使用10 mM之L-或D-麩胺酸、或者L-或D-麩醯胺。將不含胺基酸之飲用水作為陰性對照。SDS處理係於開始投予上述胺基酸後第27天及第28天進行。本實施例中，分別將開始投予上述胺基酸後第27天及第28天之SDS處理稱為第1次及第2次SDS處理。經皮水分蒸散量之測定係於第2次SDS處理2小時後進行。
結果
圖2表示調查經口投予D-麩胺酸28天對SDS處理小鼠之效果而獲得之實驗結果。各實驗條件之誤差槓表示於同一條件下反覆進行5次而獲得之實驗結果之測定值之標準偏差。又，星號(*)表示進行Dunnett檢定時p未達5%。
關於第2次SDS處理2小時後(第2次SDS處理)之TEWLΔ值，陰性對照為2.4 g/m2
/h，投予D-麩胺酸為0.9 g/m2
/h，投予L-麩胺酸為1.1 g/m2
/h，投予D-麩醯胺為3.3 g/m2
/h，投予L-麩醯胺為2.3 g/m2
/h。關於第2次SDS處理2小時後之TEWLΔ值，投予10 mM之D-麩胺酸與陰性對照相比可見顯著差異，另一方面，投予L-麩胺酸、L-麩醯胺及D-麩醯胺與陰性對照相比未見顯著差異。以上之結果顯示：於SDS處理前長期投予D-麩胺酸之情形時，可顯著預防及/或減輕肌膚粗糙。因此提示：持續攝取D-麩胺酸可有效地維持及/或促進皮膚屏障功能。
根據本發明，將含有D-麩胺酸之錠劑、軟膠囊、顆粒、飲料劑、糖果、小甜餅、味噌、法式沙拉醬、蛋黃醬、法式麵包、醬油、酸乳酪、外撒料、調味料/納豆之佐料、納豆及未過濾黑醋之調配例示於下文。該等之調配例係於例示之目的下列舉者，並非意在限定本發明之技術範圍。
調配例1(錠劑)
調配例2(錠劑)
調配例3(軟膠囊)
調配例4(軟膠囊)
調配例5(顆粒)
調配例6(飲料)
調配例7(糖果)
調配例8(小甜餅)
調配例8(小甜餅)之製造方法
一面攪拌黃油一面緩慢添加精製細砂糖，添加雞蛋、D-麩胺酸鈉及香料並進行攪拌。充分混合之後，添加均勻篩選之低筋麵粉並低速攪拌，製成塊狀並放置於冰箱中。其後，進行成型，於170℃下烘烤15分鐘製成小甜餅。
調配例9(味噌)
調配例9(味噌)之製造方法
將米麹與鹽充分混合。將已洗浄之大豆於3倍量之水中浸泡一晚後除去水分，一面新添加水一面熬煮，倒出至竹簍中。收集煮出之湯汁(種水)，以成為10%w/v之方式溶解D-麩胺酸。立即將已煮熟之大豆磨碎，添加混有鹽之米麹，一面添加上述溶解有D-麩胺酸之種水一面均勻地混合直至達到近似黏土之硬度。將其揉成團子狀並裝滿整個桶直至無間隙為止，將表面撫平並用保鮮膜覆蓋密封。3個月後，更換容器，將表面撫平並用保鮮膜覆蓋。再者，亦可使用會大量產生D-麩胺酸之米麹，來代替向種水中添加D-麩胺酸。為獲得該米麹，可藉由日本專利特開2008-185558所記載之方法對D-麩胺酸進行定量，藉此進行挑選。又，亦可向市售之味噌中添加D-麩胺酸或其鹽。
調配例10(法式沙拉醬)
調配例10(法式沙拉醬)之製造方法
向醋中添加氯化鈉及D-麩胺酸之後，充分攪拌溶解。添加沙拉油，充分攪拌並添加胡椒。
調配例11(蛋黃醬)
調配例11(蛋黃醬)之製造方法
向蛋黃(室溫)中添加醋、氯化鈉、D-麩胺酸及胡椒，利用攪蛋器充分攪拌。逐次少量添加沙拉油，同時繼續攪拌，而製成乳液。最後添加砂糖並攪拌。
調配例12(法式麵包)
調配例12(法式麵包)之製造方法
向溫水中添加1 g砂糖及乾酵母進行預備醱酵。向盆中添加高筋麵粉、低筋麵粉、氯化鈉、5 g砂糖及D-麩胺酸鈉，並向其中添加經預備醱酵之酵母。充分揉捏之後製成球狀，並於30℃下進行一次醱酵。再次揉捏生麵，醒麵後修整為適當形狀，使用電子醱酵機進行最終醱酵。將其切開並於220℃之烘箱中烘烤30分鐘。
調配例13(醬油)
調配例13(醬油)之製造方法
向市售之醬油中添加D-麩胺酸鈉並充分攪拌。又，亦可使用會大量產生D-麩胺酸之麹來釀造醬油，而代替添加D-麩胺酸或其鹽。為獲得該種麹，可藉由日本專利特開2008-185558所記載之方法對D-麩胺酸進行定量，藉此進行挑選。
調配例14(酸乳酪)
調配例14(酸乳酪)之製造方法
於40℃~45℃下進行醱酵。可使用其他市售之種菌，亦可向市售之酸乳酪中添加D-麩胺酸鈉。又，亦可使用會大量產生D-麩胺酸之菌，來代替添加D-麩胺酸或其鹽。為獲得該菌，可藉由日本專利特開2008-185558所記載之方法對D-麩胺酸進行定量，藉此進行挑選。
調配例15(外撒料)
調配例16(調味料/納豆之佐料)
調配例17(納豆)
調配例17(納豆)之製造方法
亦可使用會大量產生D-麩胺酸之菌來製造納豆，而代替添加D-麩胺酸或其鹽。為獲得該菌，可藉由日本專利特開2008-185558所記載之方法對D-麩胺酸進行定量，藉此進行挑選。
調配例18(未過濾黑醋)
調配例18(未過濾黑醋)之製造方法
亦可使用會大量產生D-麩胺酸之菌來製造醋、黑醋、未過濾黑醋，而代替添加D-麩胺酸或其鹽。為獲得該菌，可藉由日本專利特開2008-185558所記載之方法對D-麩胺酸進行定量，藉此進行挑選。
圖1係表示經口投予D-麩胺酸11天對SDS處理小鼠之皮膚屏障功能之效果的圖表。
圖2係表示經口投予D-麩胺酸28天對SDS處理小鼠之皮膚屏障功能之效果的圖表。
(無元件符號說明)
Claims (4)
- 一種選自由D-麩胺酸及其鹽所組成之群中之1或2種以上之化合物於製造減輕肌膚粗糙之經口組合物的用途。
- 一種選自由D-麩胺酸及其鹽所組成之群中之1或2種以上之化合物於製造預防肌膚粗糙之經口組合物的用途。
- 如請求項1或2之用途，其中經口組合物為醫藥品組合物。
- 如請求項1或2之用途，其中經口組合物為食品組合物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009226075 | 2009-09-30 | ||
| PCT/JP2010/065198 WO2011040185A1 (ja) | 2009-09-30 | 2010-09-06 | 肌あれ軽減経口組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201117831A TW201117831A (en) | 2011-06-01 |
| TWI461219B true TWI461219B (zh) | 2014-11-21 |
Family
ID=43826013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW099131491A TWI461219B (zh) | 2009-09-30 | 2010-09-16 | Reduces the rough composition of the skin |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120165408A1 (zh) |
| EP (1) | EP2484357A4 (zh) |
| JP (1) | JP5636370B2 (zh) |
| KR (1) | KR20120080164A (zh) |
| CN (1) | CN102686224B (zh) |
| TW (1) | TWI461219B (zh) |
| WO (1) | WO2011040185A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6060456B2 (ja) * | 2013-03-26 | 2017-01-18 | 福山黒酢株式会社 | 食酢の製造方法 |
| EP3603612A4 (en) * | 2017-03-24 | 2020-08-12 | Ajinomoto Co., Inc. | AGENT IMPROVING THE FUNCTIONS OF THE CORNEAL LAYER |
| JP7467138B2 (ja) | 2020-01-30 | 2024-04-15 | 株式会社 資生堂 | 腸管バリア改善剤 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009215268A (ja) * | 2008-03-12 | 2009-09-24 | Shiseido Co Ltd | グルタミン酸誘導体、不全角化抑制剤、毛穴縮小剤、肌荒れ防止・改善剤及び皮膚外用組成物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091171B2 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
| JP4643800B2 (ja) * | 2000-06-16 | 2011-03-02 | エム・ディジャパン株式会社 | プロテアーゼ阻害剤 |
| AU3946402A (en) * | 2000-11-01 | 2002-05-27 | Sention Inc | Methods and compositions for regulating memory consolidation |
| JP3439199B2 (ja) * | 2001-05-07 | 2003-08-25 | 憲司 中村 | 保湿組成物 |
| EP1521735A2 (en) * | 2001-05-25 | 2005-04-13 | Ceremedix, Inc | Single amino acid based compounds for counteracting effects of reactive oxygen species and free radicals |
| JP4291967B2 (ja) * | 2001-11-08 | 2009-07-08 | 雪印乳業株式会社 | 皮膚コラーゲン産生促進剤 |
| JP2005041861A (ja) * | 2003-07-09 | 2005-02-17 | Takeda Chem Ind Ltd | 皮膚角層水分量低下抑制剤 |
| JP4838537B2 (ja) * | 2005-05-25 | 2011-12-14 | 株式会社 資生堂 | 不全角化抑制剤、毛穴縮小剤又は肌荒れ防止・改善剤及び皮膚外用組成物 |
| KR100628413B1 (ko) * | 2005-12-29 | 2006-09-26 | 주식회사 바이오리더스 | 폴리감마글루탐산―비타민ｃ 복합체를 함유하는 콜라게나제저해제 및 그 용도 |
| JP2008285472A (ja) * | 2007-04-16 | 2008-11-27 | Sapporo Breweries Ltd | 細胞外マトリックス分解酵素阻害剤 |
-
2010
- 2010-09-06 KR KR1020127005294A patent/KR20120080164A/ko active Search and Examination
- 2010-09-06 WO PCT/JP2010/065198 patent/WO2011040185A1/ja active Application Filing
- 2010-09-06 US US13/261,200 patent/US20120165408A1/en not_active Abandoned
- 2010-09-06 EP EP10820305.0A patent/EP2484357A4/en not_active Withdrawn
- 2010-09-06 CN CN201080043067.3A patent/CN102686224B/zh not_active Expired - Fee Related
- 2010-09-06 JP JP2011534160A patent/JP5636370B2/ja active Active
- 2010-09-16 TW TW099131491A patent/TWI461219B/zh not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009215268A (ja) * | 2008-03-12 | 2009-09-24 | Shiseido Co Ltd | グルタミン酸誘導体、不全角化抑制剤、毛穴縮小剤、肌荒れ防止・改善剤及び皮膚外用組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102686224A (zh) | 2012-09-19 |
| KR20120080164A (ko) | 2012-07-16 |
| EP2484357A4 (en) | 2013-11-20 |
| US20120165408A1 (en) | 2012-06-28 |
| WO2011040185A1 (ja) | 2011-04-07 |
| JP5636370B2 (ja) | 2014-12-03 |
| TW201117831A (en) | 2011-06-01 |
| JPWO2011040185A1 (ja) | 2013-02-28 |
| CN102686224B (zh) | 2014-07-16 |
| EP2484357A1 (en) | 2012-08-08 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |