TWI276466B - Multifunctional multireactor chemical synthesis instrument - Google Patents

Abstract

A stand alone instrument for enhancing chemical and physical reactions on the ""bench"" level by providing a single instrument capability of performing a variety of functions on a plurality of reaction vessels at the same time (in parallel), includes heating, cooling and five other functional capabilities, and more particularly to such instruments that provide the matrix or plural functions and plural reaction vessels, with the further ability of providing real time energy balance data on each reactor. Thus, the instruments provide for any or all of heating, cooling, reflux, inert gas blanketing, vacuuming, stirring and evaporation at each reactor. (The words ""reactor"", ""microreactor"", ""reaction vessel"" and ""vessel"" are used interchangeably herein, and generally refer to bench scale flasks, beakers and other reactors used by bench chemists, biochemists, physicists, biologists, research doctors, and the like.) In some embodiments, the instruments include cooling units which uniquely rely upon phase change coolant injections. In other embodiments, the instruments include cofinger stoppers. The instruments may include both the phase change coolant systems and the cofinger stopper arrangements.

Description

1276466 IX. Description of the Invention: [Technical Fields of the Invention] The present invention relates to a multifunctional parallel independent multi-reaction tank chemical synthesizer, in particular to perform multiple functions simultaneously (in parallel) in multiple reaction tanks. A single instrument that includes the ability to heat, cool, and up to five other functions; it is specifically about such a device with a cooling device that can uniquely rely on phase change coolant injection. The apparatus may further comprise a unique porous reflux microreactor stopper for the reaction vessel to enhance processing efficiency and provide a plurality of inlets and outlets that do not interfere with each other. This instrument also includes programmable features and a secondary system. [Prior Art] • For the prior art of various types of padded/cooled reaction tanks (reactors), the following patents are available: US Patent No. 2,472,362 (issued to Herber L Bamebey et al.) discloses a use. The method for continuously heating and cooling the contents of the reaction vessel by the fluid medium comprises the following steps: enclosing the evaporative fluid into the wall of the reaction vessel and the auxiliary condensation surface, forming a heated gas at the bottom and the periphery thereof In a closed confined space; maintaining a portion of the evaporative fluid in a liquid state as a pool contacting the bottom of the reaction vessel; first applying an external heat to the liquid and transferring heat from the hydrothermal fluid through the reaction vessel wall Heating the reaction vessel and its contents, and condensing the vapor thereof, then, stopping the application of external heat to the liquid, and finally, by boiling the liquid pool in contact with the bottom of the reaction tank to externally cool the auxiliary condensation surface The reaction vessel and its contents are cooled and the vapor obtained on the condensation surface is condensed. U.S. Patent No. 2,739,221 (issued to GH Morey) discloses a reaction-slot heater which, as described in claim 2, includes a first valve and a second valve, the first valve being connected to a non-flammability And a non-combustible gaseous support fluid supply source to adjust the amount of entry of the fluid to cover the heating element and thereby to vent the combustible product adjacent to the heating element. The second valve is connected to a non-combustible and non-combustible liquid support fluid supply to adjust the incoming amount of the fluid to effectively cool the reaction vessel. " 6 1276466 一美=Patent No. 2,894,881 (issued to Clinton Μ·Wolston et al.) Uncovered, =, species tested to use the steam test device 'The device has a condenser tank, a flask, a b-support heating device Through the condenser tube and the light diffusing plate, and the modified ΐϊ 凝 condensing groove has a concave portion. The concave portion is provided with a shielding screen, and the adjustable shelf is placed on the shielding plate to support the flask, and the condenser tank is provided under the condenser groove. a conduit, wherein the discharge end of the valve = guide is located below the inlet of the condenser and protrudes outwardly from the recess i, and is configured to be discharged forward and backward against the shelf. No. 3, 143, 167 (issued to Α · vie — - a kind of temperature control, double, package 3, the first metal cover wall surrounding the cover space, and the cover wall can be used to a heating device for raising the temperature of the casing, a cooling device for lowering the temperature of the casing by the second gold wall and the outer wall of the heating device, and the temperature of the casing can be heated to contact with the temperature of the metal wall The component, the outer wall can be in contact with the H temperature element in a temperature-controlled manner, and is connected to the second temperature sensing element disk upper/if cooling device to selectively activate the heating and cooling device to generate the inside of the casing The desired temperature control (four) way. The circuit comprises a bridge, a switch device connecting the heating device to the power source, and the first temperature sensing start cooling device and the second temperature sensing component are connected to the bridge to start the heating device ^ _ ^ Country Township No. 3,239,432 (issued to C Chinchi et al.) reveals the operation of a distillation column and determines the product from the first distillation column, the control device of the heterogeneity, the device includes : A device for sampling a product of a mixed liquid from the first stage - a test tower component , a vertical interval of 5 is placed in the test liquid, the liquid sample storage capacity 11 is located at the bottom of the bottom of the test tower ,ίίΐί, used to connect the ^, the product sample of the sister and will be scheduled The volume of the woman's storage container = the receiving device's use of the liquid sample in the storage capacity H to break the if vaporized gas from the lower part of the test tower upward through the test tower internal ΐ ΐ ΐ ί ( 四 四 四 四 四 四New riser, connected to the upper end of the test to condense the condensing device of the most dangerous part of the rising gas 7 1276466, used to return the condensate to the uppermost returning device of the receiving plate, and the pressure of the test tower is During the operation, the pressure of the constant pressure is maintained, and the liquid holding device that maintains the liquid level on the tray at the pre-filled liquid level is used to detect the temperature to generate the temperature of the equilibrium evaporation gas indicating the receiving tray on the test tray. a temperature sense of the signal for receiving the temperature signal and correlating the sensed temperature with a distillation characteristic of a known product sample having approximately the same composition as the sample of the operation a receiving device corresponding to the output #, and a receiving device for receiving the output signal and adjusting the control parameters of the first distillation column according to the output signal. US Patent No. 3,473,387 (issued to Charles Meriam) reveals A fluid property measuring instrument II for tilting/inclining/pressure phase, which can be used to directly read the volume, weight or speed of a fluid, or cross-flow a measuring hole, a nozzle, a tube or a layer The differential pressure of the flow element, or directly read the hydrostatic head, the speed difference or the total fluid head. There is also an adjuster to calibrate the measured condition of the fluid with the measurement, the measured value, including: Measure the temperature, density, viscosity, pressure, humidity, fluid mixture, etc. of the fluid, the temperature of the fluid used in the fluid pressure gauge, etc. Further, U.S. Patent No. 3,479,252 5 (issued to Kurt Anders et al.) discloses a device for degreasing an article by using a boiling solvent or steam derived from the solvent, the device having a double wall and a cooling device being attached to the double Between the walls. The cold device 10 includes a water spray device, and a ventilation device for the wire flow _ double money and sputum. Thus, the circulating air has the dual function of pumping solvent vapor and cooling the walls of the device. U.S. Patent No. 4,019,365 (issued to Leon Woo) discloses that a thermal deformation transformer is suitable for measuring the stress or strain of a sample material, which is based on a flat modulus with a known elastic modulus. _^The lion is connected: the axis of displacement to measure. The connection connects the test sample in parallel with the spring, ie the two f are equally displaced. The transducer senses the axial displacement of the shaft such that the displacement of the crucible is related to the stress paste of the sample. The sample is susceptible to temperature changes during the test exposure. 1276466 U.S. Patent No. 314, issued to Maf Frcderiek Strehle, r) discloses a device and method for protecting biological materials, whereby the biological material is cooled to a temperature close to freezing point at a substantially linear rate, and at a relatively constant temperature. The liquid is changed from liquid to body and then cooled to a final temperature at a substantially linear rate. # The material is cooled to the temperature of the beam ~ (freezing point) or when the liquid phase is slightly higher than the freezing point, the environment surrounding the material is rapidly dependent on the phase change of the cooling element and the minimum supercooling (4), and then Warm to the freezing point temperature or the pin is slightly colder than the freezing point to reduce the temperature at the completion phase to a minimum. The device also considers pre-rate, phase change time, and end temperature, among other things. U.S. Patent No. 4,043,762 (issued to George Milt〇n 〇lds> discloses a test tube and its analog-like coupling device that can connect a test tube to other objects or devices for various purposes, for example, for support purposes. In one embodiment of the invention, the coupling device includes a flexible tubular body portion at both ends (four), and is peripherally wrapped around a conventional tubular test tube that is slidably tightly closed at the end. 4, the % knot device also includes a flange portion formed by a flexible elastic and integral opening along the circumferential direction, the edge portion protruding longitudinally and outwardly from one end of the tube body portion, and An opening is formed near the end of the self to support a matching member such as a conventional funnel, a branch, a thermometer, or other tilting, and the money is connected to the test tube. In an embodiment, the coupling device is connected to the tube of the test tube. Partially integrated. US 4,117,881 (issued to Thomas Ε WiUams et al. A cold tissue tissue for blood cells, bone marrow and other similar biological tissues is placed in contact with each other in _ pair heating The second one = cold. The bag Cooling with the biological tissue "ί ' cooling rate. The bag, therefore also contains the life of the bag compared to the time programmed value of the tissue temperature, and derives a mistake, the error is The temperature of the biological tissue: the value of the demand. The tissue is heated to compensate for the cold chilling of the chilled gas. The _ _ the degree of cooling 'heating n back should be the error signal and then restart 1276466, and from the organization In addition to the latent heat of melting, the organization undergoes a phase change from the liquid phase. " US Patent No. 4,276,264 (issued to jury V. Redikultser et al.) discloses a device for sterilizing aqueous liquid media. The utility model comprises a sterilization container having an inlet and outlet connection for introducing and deriving a liquid medium, and a heating device is arranged at a lower portion of the container, and a condenser is arranged on the upper part of the container. The container is also provided with a coaxial transmission unit. A gas riser with a diffuser on the heater - 0 US Patent No. 4, 3, J54 (issued to Leland A. Imig et al.) discloses a cyclic heating and cooling of the sample. Fatigue test The heating and cooling are performed. The cryogenic refrigerating fluid flows through the block 10 holding the sample 11 to cool the block, and the replaceable heating body 13 passes through the block 10 to The block and the sample 11 are heated to a very high temperature. The settings of the control devices 36 and 46 are used to interact with the cooling and heating modes so that the heating and cooling are very hot and very cold. The temperature is cyclically performed. The block 10 is constructed to have a minimum mass to facilitate rapid temperature changes. U.S. Patent No. 4,480,682 (issued to Hiroshi Kaneta et al.) discloses a device that is more than (four), sperm, etc., has The heat conducting base block is formed under the heat insulating peripheral wall having a cooling passage through which the coolant can flow. The base block is provided with a base temperature sensing element, and the base block is connected by a heat and edge connecting member. Provided with an upper secret guiding member, the upper heat conducting member is shaped & = for the coolant to circulate above the cooling passage. A temperature control heater, an upper block body=兀, a plurality of top end openings, and the base block is used as a base member of the upright pipe, and the air is disposed between the insulating peripheral wall and the upper block To make it straight into the space, the lower end of the stand can be cooled by the base block, and accommodate the slowness of the solution contained in the tubes, and the solution is cooled; the east object, such as the god, the sperm secret analog The upper part of the If is cooled. The buffer solution in the tube can be used to control the cooling of the lower buffer by the base block, and the upper block can be used to control the cooling of the buffer solution containing the contents of the upper buffer solution without the contents. 1276466 U.S. Patent No. 4,489,569 (issued to Helmuth Sitte) discloses a cooling device that uses liquid nitrogen to cool a sample to a temperature range of -100 ° C to 195 t, in a propylene, _ hydrocarbon, isopentane, or other cooling Conducted under the media.

The cooling of the cooling tank vessel and/or the liquefier by liquid ammonia is only in the initial configuration, and the freezing of the cooling medium can be avoided; but when the temperature of the cooling tank reaches the required temperature, the liquid nitrogen level is lowered. Below the height of the protective casing, the result is only indirect, further solid-to-solid contact and further cooling of the gas phase. The temperature of the cooling bath can be ensured by the constant temperature control system. At the same time, the standby operation of the fault-free operation can be ensured by the automatic replenishment system of liquid nitrogen and the system for controlling the liquid nitrogen level. There are also treatments for safe disposal of waste cooling media that may be flammable and/or toxic. U.S. Patent No. 4,502,531 (issued to peter petersen) discloses an apparatus and method for heating a bottom having a trough bottom and at least one trough, the invention including a furnace body suitable for a trough, the furnace body There is a furnace bottom and at least one furnace body side wall. There is also a heating mechanism disposed on the bottom of the furnace and the side wall of the furnace body for heating the storage tank, and is configured to be adapted to the bottom of the tank and the groove, and the heat is disposed around the furnace body ==== It has a temperature-sensing 11 that can be used in contact with the miscellaneous tank. + US Patent No. 4,548,259 (issued to 3_(^池) reveals - a kind of mobile tank with a nano-mix solution, surrounded by a lion electric heater, The electric heating person has the isothermal frame of the heat capacity 1 and is used as the cooling source to lighten the isothermal frame. The thermal retardation plate is set in the flow, and the temperature of the isothermal frame is lower than the test. The sample solution will be held at the predetermined temperature = 嫌 峨峨 七 七 七 美国 US US 4,563,883 (issued to Hellmuth Sitte) shake dry to soak the sample in the cool cooling liquid, the sample Note that person H, the rib accelerates the injector to a predetermined speed into the liquid 11 1276466 but in the liquid, and before the end of the vertical movement or at the end of the moment, the injector is rotated to promote heat conduction from the sample. Various means for causing the injector to produce a rotational motion. U.S. Patent No. 4,578,963 (issued to this 11111111±3丨廿6) discloses a device for cryogenically solidifying a sample, the device comprising: a storage tank adapted to accommodate a cold gas medium having an upper boundary and an atmosphere connected outside the storage tank, and a cooling provided in the storage tank The upper surface of the cooling device is movable between a lower position and a lower position than the upper boundary. The upper portion is maintained at the upper position for a period of time for the sample to be applied thereto, and then lowered to the lower position.

U.S. Patent No. 4,667,730 (issued to George Zemp) discloses a temperature regulating apparatus for a laboratory reaction tank apparatus comprising: a reaction tank and a heat chamber for a fluid heat exchange medium, the heat chamber being at least A portion of the reaction vessel surrounds the reaction vessel, and at least a portion of the reaction vessel jacket surrounds the heat chamber and has at least one inlet for fluid heat exchange medium. The at least one inlet is configured to extend along the reaction tank jacket and extend into the heat, and at least one inlet region is provided with a nozzle. The nozzle has an outlet at a month and is disposed in the at least one inlet region to allow fluid to pass through the nozzle after the fluid has flowed through the nozzle, and to cause the fluid hot out of the outlet to flow into the chamber. U.S. Patent No. 4,846,257 (issued to Terry A. Wallace et al.) discloses a device for keeping food hot and/or cold. The device includes a body that is isolated by heavy rural materials. There are separate portions for the hot food and the cold food, and the cold food is cooled by the ice chamber provided in the bottom concave portion and the gas cooler provided above the concave portion, and the hot food is electrically disposed at the bottom of the concave portion. The coil and the solar heating plate above are used for insulation. > U.S. Patent No. 4,966,469 (issued to Douglas S. Fraser et al. to disclose a positioning device for positioning a temperature sensor on a freeze-dried flask, the device comprising a near central position The opening is usually a circular plastic plug, j is fixed at the top of the test in a quick joint manner. Caitong f is _ j ..., the galvanic couple is wound into a coil and supported by a ring tube, so the thermocouple is Formation · 12 1276466 by state and at the center of the flask, so that the thermocouple is retractable, so it can be used for flasks of various lengths. US Patent No. 5,123,477 (issued to Jonathan M. Tyler) reveals a thermal reaction a tank and a method of operating the heat reaction tank. The reaction tank comprises: a reaction chamber, wherein the chamber is thermally insulated by the chilled air circulating in the wall of the reaction chamber, and the sample bottle tray is held in the reaction chamber; An air supply device for discharging air from the room; a heating device for heating the air supplied to the room; a temperature sensor for sensing the temperature of the air and the sample bottle supplied to the room; and in accordance with Sensing

The temperature of the sample vial and air in the chamber is used to activate the heater to maintain the temperature of the sample bottle at the desired level. US Patent No. 5,139,079 (issued to [(±8611^66邙&11:)) discloses an improved invention of the characteristics of a dynamic mechanical analyzer that utilizes a modified radiant furnace to provide convective heat transfer. The device measures mechanical and rheological properties to reduce the tropics. US Patent No. 5,154,067 (issued to Takashi Tonizawa) reveals a kind of mobile cooling, which is related to the heat absorption and chemical release of chemical reactions. The middle of the reaction chamber surrounded by the inner wall and the outer wall and the working medium 'working medium storage member are disposed in the inner wall of the reaction chamber for the medium to be stored therein, and the working wire member is separated from the outer wall provided by the agent. The suction and the suction are used to make the suction, and at least a part of the outer wall constitutes a heat radiation portion. _ US Patent No. 5,171,538 (issued to Edward Tremmel et al.): -J academic analyzer system The reagent is supplied purely, and the system comprises: a stagnation on the wall of the η丨 space and the reagent contained in the space facing the end face; the seal=2 is a 13 1276466 stop plug. One is sent to Danie with the f core i D. Revealing the cool green including (4) transfer to the irr bio-matology enchanting van _ step, (6) the solution of the decision _ coffee from the petals ^ =

/ The steps. According to the defrosting system, the system includes: for: pre-touching the storage unit in the enclosure, and the multi-room room is used to exchange the thieves independently of other temperature changes. There is also a servo mechanism for putting the sample selected from the storage unit back and back, the sample is placed in each pair of financial offices, and the control (4) is operatively connected to the heat exchange thief and the servo lining to operate the hot (4) Come to (4) The temperature change in the financial room and the Kailin ship agency to transfer the bribe unit to each of the unwinding rooms. U.S. Patent No. 5, 2G3, 2G3 (issued to William L., et al.) discloses a device for measuring the viscosity of a fluid in a sealed container in the field, the device comprising - loading the container in any fluid Formed inside the container - the component ^ sphere. The device also includes a core made of a material and a composite sphere made of a different material surrounding a layered multi-layered surface covering the surface of the core. The container may also be supported by a support member having a degree of visibility so that the sphere within the volume II can roll in the fluid at a particular speed. An inductor is provided along the wall of the container to sense the velocity of the sphere, the sensor comprising - sensors positioned at known distances to sense when the sphere is provided by each sensor, The speed at which this fluid is measured can be used to determine the viscosity of the fluid. U.S. Patent No. 5,337,806 (issued to: fQSef Trunner) discloses a solution bedding tank for supplying a liquid for immersing a heated or cooled ruthenium flask into the liquid. The heating or cooling device is disposed at the bottom of the supply tank, and the liquid is transported by an immersion pump through the liquid supply pipe and the opening provided at the bottom of the storage tank. The liquid level of the liquid in the sump is adjusted by means of a slide which overflows back into the supply tank when it is full. When the pump is turned off, the liquid in the sump flows back into the supply tank. U.S. Patent No. 5,447,374 (issued to Douglas S. Frast et al.) discloses a method and apparatus for positioning a probe, such as a temperature sensor, in a flask. The stopper is provided with a hole adapted to be fixed to the open end of the flask, and an extension pipe extends through the hole. A jaw mechanism is coupled to the tube for securing the probe to the stop. The clamping mechanism includes: a first flange and a second opposite flange, which are slightly spaced apart

, set. The 0-type sealing ring is sleeved on the flange so that the flange can be deformed to the shouting and the probe is fixed between the flanges. U.S. Patent No. 5,489,532 (issued to Stanley E. Charm) discloses an automatic test device for determining a test method for an antimicrobial drug, the device package having a device for inserting a test container The heating block, and the sub-tf Ξ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ 雏 第 第 第 第 第 第 第 第 第 。 。 。 。 。 The test device includes a timing signal present therein to emit a scent. The test device is adapted to heat and cool sequential test solids of one or more test containers containing the sample. Ί, 689, 895 (issued to David T. S叻herland et al. - probe, such as temperature sensing 11 positioned in the flask for use with 3 ίΐίί 'the device includes an open end adapted to be attached to the flask The central hole and at least one of the central holes are radially spaced apart from each other and the ====== is not passed through the needle conduit, so that the inner and outer sides of the flask are substantially in position of the tube. Needle _ in the relative dryness of the guide Kang ^===_, Lai _ by the cold 15 1276466 (10) if the patent No. 5,947,343 (issued to Klaus Ho on the ann) reveals one: =-- 'Operation to make the cover element It is guaranteed to be driven, operated, easily opened and closed by an uncomplicated and financial mechanism. The spring element uses a spring elastic diaphragm to connect the cover member to the cover. US Patent No. 6'95,356 (issued to Miriam Rits) reveals a ventilator that has a base body and a body having a base end and a terminal end and a pass-like side wall extending from the base end of the first and second support plates to the end, the two special plates Forming at a base end portion of the cover body and having a plurality of apertures penetrating the cover body, a filter assembly comprising: a first lower portion having a first porosity, a second upper diaphragm having a second porosity, and a radiation absorbing material disposed on the first. US Patent No. 6,502,456 Bl ( Issued to Yaosheng Chen) discloses a method and apparatus for measuring the dryness, temperature, flow rate, total pressure|force, dynamic pressure of steam at the bottom of the well, and the wet steam is turbulent in the well. The apparatus includes a A series of fiber optic sensors disposed in a plurality of sections of the outer casing assembly. The descent enters the well to reach different downhole locations to measure various steam parameters at various locations and degrees, and the resulting data is stored. Recording plate ± for subsequent analysis when the device is lifted from the well to the ground. "Μ The device is extremely reliable, accurate and extremely durable in harsh environments. US Patent No. 6, 615, 914 (issued to Li Y〇ung, the inventor of the present invention, discloses a reaction tank system comprising: a reaction tank; a cooling unit functionally connected to the reaction tank for controlled cooling; functionally connecting the reaction tank Controllable plus a heating element for heating; and connecting to the cooling unit and the secret unit, so as to programmatically and automatically control at least the opening/closing flow of the cooled single mosquito and the opening/closing heating of the control heating unit and The heating rate is 16 1276466. The wire is placed in the controlled weaving. The material is included in the proximity, like the θ-order component, the cooling element has at least one port for injecting the phase-change cold: agent. The heat absorbing zone and at least _: to turn the phase change coolant, ir: f is provided with an injector for injecting a liquid phase change coolant from the inlet into the embodiment, the control device comprises a software, and the system comprises The control device is configured to cycle open/close its control actions to establish a predetermined temperature sequence and a programmable temperature level. The S used in the present invention is an inert material to the environment, which absorbs heat during evaporation and has a temperature of ίf. This material may be selected from an inert gas, and the dioxide is shown as ΐϋίί ΐ f shed 965 A2 (issued to K〇nd〇_ (4) Jie 2 -: - a glass tube shaped iii body having an opening at the end of the bottle body, having a 苐-heating element surrounding and supporting the tubular bottle. The tubular bottle is exposed above the block and exposed to the outside. One is in the application of i: The cover of the cover (4) Lai σ, the cover body and the cover body; the seal: the position of the opening miscellaneous I丨, +, Chu Yiyi exit, and a heating 兀And a temperature control circuit for controlling the heating element: the control circuit controls the temperature of the bottle of the bottle that maintains the upper portion of the crucible and the lid that is in contact with the bottle mouth, and the reagent is Adding to the tube to dissolve the reagent causes the reagent to react with the sample 'and complete the reagent or from the === skill, the invention is neither derived from its inspiration, nor can it be [invention], the invention is related to Provided at the same time in multiple reaction tanks (ie, at the same time as the sputum Ability to enhance or enhance the independence of the chemical and physical reactions on the desktop. According to the above various functions: heating, ϋ 17 1276466 ^.. 忐 忐 abilities. Especially related to one can provide multi-function and multiple The above-mentioned apparatus for further real-time energy balance data of each reaction tank can be provided by the reaction, and the apparatus of the present invention can provide heating, cooling, f, inert gas protection, vacuuming, and each of the reaction tanks. Any one or part of the energy of the lining and evaporation materials (referred to as "reaction tank", "microreactor" and "reactor" as used herein, generally referred to as the so-called chemist and biochemist engaged in the experiment. , the material scientist, the researcher, the flask, the reactor, the reactor, etc. In some embodiments, the apparatus of the present invention also includes a unique cooling device to cool the cold person. Implementation of the invention, the present invention

The instrument includes a porous shout. Gamma can also include both phase change cooling (four) systems and multi-hole return stop plugs. The apparatus of the present invention has a phase change coolant capability, one or more reaction tank zones, and, in other words, a "workstation" includes a cooling group functionally connected to the workstation (so that the reaction tank can be applied Controlled cooling is connected to the reaction tank to reduce the controllable heating (device); and - connecting the cooling group and heating, and so that the surface program can automatically control the cooling group and the control group of the heating group , at least the species of the on/off flow path (flow) and flow rate of the cooling group, and at least the control of the on/off heating and the addition of the control plus, and includes a device capable of planning the program. Cooling groups, heating groups, control devices, etc. are described above and below in a single representative, but it must be understood that each individual workstation may contain multiple components 'such as ^ or more cooling and ^ or The heating group does not exceed the scope of the present invention. The cooling group includes: a cooling element disposed adjacent to the reaction tank and having at least one H-into-cold (four) population, a absorbing zone, and one for discharging the intersecting Export of cold agent; and note The device is configured to verify the phase of the cooling element. In a preferred embodiment, the control device includes a software body, including a physical controller of the injection device, for cycling on/off to control its motion = with her _It can be used to regulate the temperature level. It is used for the cooling of this month. It is an environmentally inert material that absorbs when it is evaporated. It is 18 1276466 and has a temperature below atmospheric at atmospheric pressure (ie less than 24). °C), and may be selected from the group consisting of inert gas, such as a gas barrier and nitrogen. It is preferably provided with a remote storage tank containing a phase change coolant in a liquid state under dust. This system also includes At least one, and preferably two, temperature sensors are coupled to the reaction vessel and fed back to the microprocessor for automatic temperature control adjustment. In these embodiments, the invention includes a porous reflux plug and a microreactor, and The backstop itself. Here, the "stop" means _ wire (plug inside the plug microreactor ^ opening) or external stopper (cover outside the opening σ of the microreactor). The reactor has a touch The mouth and the fine volume of the towel are used for the chemical t process, The venting port is usually of the type _. The porous reflux stopper comprises: a) a portion of the main plug body of the cylindrical peripheral wall, and b) a peripheral wall of the main plug which is connected to the plug to the microreaction The opening of the crucible (or the opening of any extension member of the open part of the reaction cassette). The main plug body (1) part one or two of the AT upper gas top penetrates to the bottom, the central hole faces the top / the center k, and includes - the return finger member; and iff four of the plurality of peripheral holes are set in the center On the periphery of the hole, each periphery penetrates to the bottom. Preferably, the outer hole is made up of four female outer peripherals: ίίΓ is a concentric component containing at least two tubes, each of which has a upper and a lower end and a lower end, so-called "concentric: inner;; Or asymmetry. refers to; component mode. In some real;; there; ij; =: even in its mixed application, the finger member contains the lower end of the opening, and the other has the upper end and The lower end, the straight center, the first one of the two I, the concentric components, each tube surrounds the inner f, the outer; the bottom end of the opening and the outer tube material such as: cold correction ί has the lower end. The flow through the outer space of the two tubes is in contact. 3 ports..., liquid or gas will not be in the microreactor, for example, within the burning range 19 1276466 - in the case of only the male, the sealing device will be the main body The side wall (peripheral wall) is formed in the neck of the micro-reactive micro-reaction. In other embodiments, the H device has at least one ring-shaped seal ring disposed on the main plug body. For the purpose of a cool connection reactor (or its extension) and the non-sanding of the sand, the Γΐ Γΐ , , , , , , , , The peripheral wall of the plug body can also have a tapered peripheral wall having a tapered peripheral wall diameter. Alternatively, the soil α /, has upper & and lower section, and the upper section has a larger diameter than the lower section. The fact that the upper section does not even have to be Cylindrical, so the segment is not inserted into the ΐϋ 1 shot. Thus, the upper segment can form any bottom size or shape, hair: In other words, the 'the & body usually forms a cylindrical shape should be referenced' at least to the microreactor The stopper portion in the neck portion should be formed in the shape of the opening of the main plug body of the present invention, such as: Lai, square ^ micro = part of the shape, when the stopper For the external stop plug; the square shaped reaction device of the open shape is preferably connected to the square outer stop. In some embodiments, the finger member of the device is a concentric component containing a soil outer tube. At least one inner tube has an elbow-shaped section extending outward from the outer tube tooth. The elbow-shaped section may be disposed in the outer portion of the main plug body extending outside the outer tube. Alternatively, the elbow may be set at the main button = The main body continues to extend outward. Therefore, the elbow segment will enter the interior of the microreactor, and the wire is arranged on the side wall of the microreactor to open the sigma. The hole can be selected from the group consisting of: metal, Lai, rubber, It is made of materials in a group of plastic materials. For example, the choice of steel is selected as steel. The pipe can be made with a plug, or a hard glass, a metal compound or a cast, but typically Even ^ 1276466 flexible plastic tube, hard py C tube, copper tube or a fixed or flexible tube such as a similar tube. Some fields i holes and peripheral holes can be used for a variety of different functions, in a certain === In other words, the physical characteristics are =

Refers to the tube structure 2 5 ίί: closed entrance. In some embodiments, the peripheral apertures and the device, and the two of the three cover gases (eg, the inert gas that protects the reaction) the delivery tube member includes a blanket gas storage, wherein at least one of the members may include physical properties The measuring device may be characterized by including temperature, pressure, dryness, ρ Η value and hot material rate. The device of the present invention may further comprise a mounting jig to connect the above-mentioned under-protection to the micro-reaction. The extension member may also or separately comprise an extension member disposed between the microreactor and the stopper. The present invention includes a control device for controlling all functions of each workstation. In other words, the #-workstation may be unrelated. All other workstations are individually controlled. In a preferred embodiment, the control relies on state control of one or more internal microprocessors and/or CPUs for the user to monitor, plan, and adjust any or all. ^ Workstation. For this reason, the device is additionally equipped with a keyboard, a touchpad, a sound-sensing voice control or other input device, which can be integrally constructed on the instrument casing, or Remote (distance or number) setting, and by wire or wireless connection & I. In a preferred embodiment, the instrument of the present invention has a built-in touchpad, signal display, cpu, microchip And an energy balance reading, storage and report printer for each workstation. An example of such an instrument of the present invention, having seven workstations and providing the aforementioned seven functions, therefore, this unique combination of professional seven The function is a multi-functional parallel independent multi-reaction tank synthesis reaction instrument 21 1276466 [Embodiment] ^ Reference _ The specific embodiment of the invention is described in detail as follows: The rot of the genus 2 is used in the same - Time (ie, parallel) implements independent operation control of each of the plurality of anti-air tanks: such as the above-mentioned device "% includes a unique reaction tank with a finger micro-reactor stopper to strengthen the treatment of different injection (input) mouth and discharge (Output) and mutual pre-regulation of the private, although the independent control of the invention of the instrument of the present invention includes the work of the reaction tank system: micro == ^ cut · material - plus m 'Ling should be based on this system can be automatically achieved , these needs Including, for example, the cooling sequence of the second enthalpy, reflux, evaporation, cold, and other tests, when the heat absorption zone is set, for example, === t, the heat is absorbed from the reaction tank and the base is emitted. The use of the reaction tank used in the evaporation and gas form discharge can be any form of heat transfer of the reaction tank to add or remove heat. Thus: j temperature calculators, for example: In the upper part of the reaction tank = the lower part. The temperature is connected to the financial sense - the program can be set to reverse the electric fine, micro-processing H. His known device is used as the towel core, the control unit of the component is added to the group ii yuan) a type of heating device that can be ordered (four) or heat (ίί rate) to control 'or both control and automatic (four). Addition or subtraction can be transmitted to the sheep) 22 1276466 Convection, radiation, direct or indirect, for example: by heat exchanger, or The combined heating mechanism 'but usually a heating element of the Wei heating element or the electric heating element type applies heat convection. 1. The above heating group of Warhammer can be a flat plate, a reaction tank with a nested member, a heterogeneous component of a reaction tank, a her member, a health tube or any other miscellaneous, and the reaction tank is connected to the reaction tank to at least In part, for example, the lower part is twisted. The tank (four) μ she should, the invention of the cooling group 'as the corresponding heating group - the cooling group can be: - with the population of cooling elements and two: mouth or a number of these components containing one or more One. The cooling group also includes a control device for controlling the injection of the main inlet rib. A variety of the invention is manufactured and sold without a phase change coolant for "setting". The supply of coolant is preferred. For example, a machine or other coolant may be added to produce, compress or store. Device. A house - or a raft is a coil or molded, mechanically processed or otherwise formed into a near reaction tank itself ', 'i Valley promises a phase change coolant, and preferably a paste m 奂a, the open area of the cooling element is enclosed, for example, a material is formed. The phase change coolant is injected from the injection port. ',, ^, and the heat is absorbed from the reactor and the heat is taken. The cooling is done at room temperature 'for example, preferably below 24 ° c, and the most can be fine; the material: the box is now r-like', then set the supply device as described above. This tear:: times: 23 1276466 Environmentally sound rings are commercially available to produce a net heat absorption conversion effect and are a dissipative inert substance, including the current commercial phase === the phase change coolant r as described above. The inert gas, the carbon dioxide gas, and the apricots are divided into apricots - not limited to this, liquid,. Easy to use to adjust very close to the chamber boundary point at atmospheric pressure. 'It is best to use pressurized liquid carbon dioxide. / Dish (in some %, there are also small diameter tubes or injection ports, and this nozzle = use as a nozzle to use, There is no need to add additional hardware. The valve mechanism can be a flap valve, a free-standing plate/_, or a controllable opening (^ rate control) such as a rod valve or a gate valve. The magnetic tube or switch or other sputum device can be used to control the sputum. The smashing control paste can be opened and closed by the ridge suit or the lifting device. In the more complicated system, the above two types are opened. /Closed valve and flow rate control valve can be used to provide two ways of control in the system. The control device can be used with any programmable device, such as: manual control, dial, button, lever, etc. A sensor (sensor) for feedback, with appropriate software or sequential input, external input, and a computer or microprocessor connected to the cooling group to the hot group and preferably to the reaction tank. More specifically, A programmable device can be provided to the user For outputting information, for example, the microprocessor may have a display including a reading and typing program. For example, the device may have a plurality of buttons, input devices, selection devices, switchers, keyboards, etc., and may also include : "Sequence (SEQUENCE NUMBER)", "Temperature (TEMPERAT YES ^ ^ΓΒΚΤΙΜΕ), ^ ITM programmed temperature for a specific time, when it uses the heating group and when it uses the cooling group. "Time (TIME) The input can be completed after the required time or the actual timing starts and ends 24 1276466. ί Compared to the embodiment, the additional description, control, input, icon,

W ^ (HEATING ϋΝίΤ) and "Cold (C00LING Ride)" = 1 "' _ The two groups of units can be _ or _ or two ways users need to use other (four) input / output devices, as appropriate It is very obvious to the technicians of this area. In another embodiment, the donor can also control the flow, from the "'predetermined selection of group tolerances and other participations. The programmable programming device can also have, and can be implemented between heating and/or cooling sequences; ^ ^ ίί^ ίί Γ 可由 熟悉 熟悉 在 在 在 在 在 在 在 不 不 不 不 不 或 或 或 或 或 半 半 半 半Depending on the reaction tank, it is only covered by the main casing (outer casing). ί In the example, the reaction tank itself can be removed from the other scales of the system, in order to take out the reaction product and clear the system, only to understand the space _ does not touch the inter-type table instead of the i-arm condensing tube And the cooling group can be connected thereto, and the design is not in the scope of the present invention according to the first to the eighth. The following is a specific embodiment of the phase change cooling system. Referring first to the first and second figures, the injection rate of the second * / cooling group is used to modulate the coolant injection. The reaction tank described above has a temperature-time sequence of the reaction tank of 丄=Fig. - and the two diagrams _ specific for the cooling group, but for this 25 1276466 X Ming ^ heating group, words, similar description and control technology are equally applicable. “The fourth figure shows a schematic diagram of a reaction tank system that can be heated and cooled.

The crucible I has a crucible cooling zone 5 and a heating zone 7. The person σ 9 can supply the coolant from the injection control G 1 to the cooling group 13. The cooling group 13 encloses and communicates with the cooling zone of the reaction tank 3 to transfer heat from the zone 5 to the coolant of the cooling group 13. The outlet 29 is used to discharge the vaporized coolant from the cooling group 13 to the atmosphere. The phase change coolant supply source 15 is connected to the cooling unit via a conduit 17 to cool the group.

The heating group 19 is shown in the heating zone 7 of the reaction tank 3, and the heating group surrounds and connects the heating zone 7 of the reaction tank 3 so as to transfer heat to the reaction tank when necessary to control the chemical reaction caused in the reaction tank 3. . The microprocessor 21, which can be programmed, is a control device of the reaction tank system, which is connected to the coolant injection controller by a cable 23 and to the heating group 19 by a cable 25 to control the temperature required for the reaction tank. The cycle, and the program can be programmed to the microprocessor 21 for control. A heating chamber 7 is provided in the heating zone 7 in the reaction tank. The fifth drawing shows a perspective view of a first embodiment of a reaction tank system 60. The reaction tank 61 has a cooling zone 69 and a heating zone 79. The cooling zone 69 surrounding the reaction tank 61 is provided with a phase change coolant inlet β5 and The cooling group 63 of the phase change coolant outlet 。. The heating group 71 is disposed around the heating zone 79 of the reaction tank 61. The sixth figure shows a perspective view of the second embodiment of the reaction tank system 101. 103 is provided with an upper part m of the cooling group 1〇5, and the cooling group 1〇5 has a phase change coolant inlet 107 and an outlet 109. The bottom heating zone 113 of the reaction tank 1〇3 is also shown surrounded by the heating group 115. A magnetron operated agitating device 丨17 is disposed inside the reaction tank 103. The magnetron operation scramble device 117 is used in a preferred embodiment of the reaction tank system to facilitate occurrence in a reaction tank controlled by a cooling and heating auxiliary system. The chemical reaction. The magnetron operation scramble device 117 is driven by an electromagnetic drive mechanism (not shown) provided in the heating zone 113 of the heating zone 115 in the reaction zone 1〇3. 26 1276466 Stirring in a specific reaction time Device required The cycle is controlled by the programmable controller 21 (see the fourth figure). The above is a description of the preferred embodiment of the invention, and the fourth, fifth and sixth figures each represent the upper reaction tank cooling group and the lower reaction. The construction of the tank heating set, but this configuration may also be upside down, and may include multiple heating and/or cooling groups in any useful configuration without departing from the scope of the invention. Likewise, any heating/cooling or cooling / The heating sequence, or the reverse, reverse or even simultaneous heating and cooling can also achieve the effect of the invention. As mentioned above, the heating and cooling group of the apparatus of the invention can also directly or indirectly conduct heat and be connected to the reaction tank. It may include, for example, a bath, such as an oil bath, a water bath or a gel bath, etc.; other heats such as a flowing gas, or a solid or a combination thereof. In an embodiment of the invention without phase change cooling The cooling group can be used with any conventional cooling secrets, such as: liquid cooling, and any conventional addition such as: convection heating or resistance heating. ...... w ί 7 to 17 Porous The embodiment of the flow stop plug tank (i.e., the microreactor) is described in detail, and the technique of the main flow stop plug is described as follows. The following figures detail the characteristics of the cooling and/or return plug. & 柯频 - coherent dry sign ΐ ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί ί The structure of the back plug. The main body 4 of the back side #6, the side portion 8 and the bottom portion 28, the central portion of the main plug body 4 from the center to the bottom portion 28 is provided with a plurality of outer holes. (peripheral hole) 16, 18, 20, 22, 243? r center of the bottom 28. & 24 and 26 also from the top 6 through the central hole ^ ^ 本 hair _ stop 2 longitudinal section view, the middle of the 1 ϋ a a another by the external officer 12 and the inner tube 14 constitute a tongue, you say α τ pieces. In this embodiment, the inner and outer tubes 14 and 12 each have a configuration of 27 1276466 which can be used to simultaneously add two different components to the center of the reaction solution. In another case, this configuration can be used to maintain a fixed volume within the desired water range by adding or discharging the feedstock. For other uses, it is obvious to those skilled in the art that the reflux plug 2 has a slanted (tapered) circumference and can be slightly elastic or continuously applied, so that it can be inserted into the opening neck of the microreactor to reach Press fit to use the microreactor in combination. Further, the central hole 10 is shown in the central portion in the seventh and eighth figures, but it is not necessary to have a center hole. Similarly, the outer holes need not be equally spaced or spaced from the center. Although the symmetrical arrangement is aesthetically pleasing, it is not critical to the function of the present invention. The ancestral canopy can be used to inject a reactant, a lam, a thin or other material into a solid, liquid or gas. Alternatively, any of the holes in the outer hole will also be slightly reacted to discharge its internal material. External air can also be used to sense such things as temperature, thermal conductivity, pressure, dryness, and electrical resistance by inserting a person or j. The outer hole can also be used to introduce inert or reactive gas to the exhaust. The outer apertures can also be used in combinations of the various functions described above, either continuously or continuously or in other desired manners. , the eve inserting the central scorpion sharing fingerboard member' can be used to achieve either of the above purposes. The white bottom is closed at the bottom end. Therefore, hot or cold liquid or gas can flow through a group of people* to heat or cool the contents of the microprocessor. When used, it is used for cooling. Or heating is ideal. 3 shows the hair, the flow stop plug 5Q. An embodiment, this stopper 2 . For example, the return plug 2 has different features. In detail, the stop plug has a top portion 54, a peripheral wall 58, and a bottom portion 6. And the above, - the finger == 3⁄4 a lai ^ the heart of the seal ring ^ = before =:. Qing 28 I276466 The tenth embodiment shows a further embodiment of the recirculation stop plug of the present invention. The stopper 1 includes a main plug body 102 having a top portion 104 and a bottom portion 106, the peripheral wall of which forms a top portion 108. And the shape of the two sections of the lower section 11,, and the diameter of the upper section 1〇8 is larger than that of the lower section τ, such as a beaker, a flask or other open reactor neck of a microreactor, and borrows a double The sealing ring 112 is 19 Π ml and is internally sealed. The central hole 116 is inserted into the finger member formed by the outer tube 118 and the inner tube f. In addition, a plurality of (at least four) different sizes are provided, and the outer side holes are represented by symbols 126 and 128. In the embodiment, the inner tube 12G has an elbow portion 122 that passes through the outer tube. The U8^ main plug body 102 has a peripheral wall upper portion 1〇8 as shown. Duan Qiu's instrument of the invention has an embodiment of a stopper 151 having an upper section 153 and a lower jaw 157. The stopper 151 is provided with a central side and is provided with a diffuser 161 connected to the outside by a duct 163. This constitutes a usable port. Further, the output duct 165 and the control valve are called. Peripheral production of the central hole 157 can be used in the paste, sputum pressure of the week of use. Yes, if necessary, other connected bodies or liquids or two rows of 157 can also be connected to the pumping device to the gas - Included = = 1 indicates a reflow stop 170 of the present invention. This stopper factory is 177. The pipe structure and the cookware f have a central hole 175 and six outer holes - which can generate pressure or pressure, measure the production port of the county, or add any combination of these functions. The discharge member σ, a tapered member 19_; the extension member (10) has a neck portion, and has a wider ((4)) "co-insertion microprocessor (not shown) under the opening dust condition m) The portion 193 is configured to hold the backflow stop at the backflow stop = the switch can be attached to the microprocessor for fixing the return stop to the microprocessor 29 17276466 under pressure. Turning to a specific perspective view of still another embodiment of the apparatus of the present invention, the neck of the instrument is inserted into the microreactor 201 to form a return stop as shown in the seventh figure. There is a right %^^1C) Φ hunting duct connected to an outer hole to guide the person to cover the gas, and second, r outer f cover (four). Thermoelectric sensation iHitt can be opened outside the 215. ===== The clamped return stop 211 can be positioned in the rear position of the microreactor 210. An example of an apparatus of the present invention is shown in the following. This instrument _ includes -; Γ 3 Γ, 1 extension 305, fixture and return stop _ the seventeenth figure shows the same as the one shown in the sixteenth figure, the other is the other three Related composition. In the figure, all the same components are: In this embodiment, the microprocessor 301 is disposed on the insulating cylinder 341. The H-shaped cylinder 341 has an inner portion 343 which is provided with a base heating and cooling mechanism 34. In addition, there is also an electromagnetic lion device 347 and a controller 349. 5 Features The overall shape of the instrument of the present invention and its ship, the following will be invented in its structure and ^8 chart forest invention multi-function parallel, vertical multi-reaction tank chemical instrument II The ρ station is mounted on the stereogram of the reaction tank' and the nineteenth diagram shows the same instrument 401 reaction tank cover in the positioning of the stereo®. In the second picture, the components of the general system are marked with the same payment. The instrument 401 includes: a main casing 4〇3, a pressure control crying, and a microprocessor programming touchpad with an optical pen booth. The main external ^ 1276466 has a central processing unit (cpu) inside to control each work individually. The touchpad 407 is used to set the temperature, the gas flow rate, the coolant flow rate, and the like. (4) The specific setting of the person 1 or the desired parameter of the (4) parameter includes: heating, cooling, reflow and giving instructions are available. Made of metal or a combination of materials, and Jin Weng another: material selection. m In the apparatus of the present invention shown in Fig. 18, the main casing 4〇3 further includes a top plate 415' and a stepped intermediate plate 417 and an upper plate 419 at the rear. In each of the embodiments, there are seven workstations 425, 427, 429 = ^, 433, 435, 437 on the top panel 415 of the instrument 401; the upper layer 419 is provided with water supply to each of the above workstations 425 ... 437 Seven water supply fittings 445, 447, 449, 45:1, 453, 455, 457 ' control the water supply to the above-mentioned workstations on/off valves 4 Yang, 邳 7, 4, 47 473, 475, 477 ' The gas supply to each of the above workstations is 4:5, 487, 489, 49, 493, 495, 497; the middle plate 417 is provided with drainage joints 5〇5, 5〇7, 5 respectively for each of the above workstations. 〇9, 5ii, 513, Qiao, Catch, exhaust pipe joints 525, 527, Na, 535, 537' respectively from each workstation exhaust thermocouples for each workstation to install thermocouple = 45, 547, 549 55, 553, 555, 557; middle plate 417 front = with / knife do not buckle the grip of the fixtures set up in each workstation, 567, which, 573, 575, 577. In this way, 'multiple workstations 425...437 and corresponding water supply, A, drainage, control and other components are all concentrated on the main housing) 4G3 to form a simple, compact and easy to operate tube = the nineteenth figure shows the first In the eighteenth embodiment, the reaction tank positions of the workstations of the instrument tree of the present invention are respectively provided with reaction tank insulating covers 519, 521, 523, 53g, and 559. Du ί ί ΐ 头 445, 447 · · · 457 can be used to pass the coolant through the return pipe member or, he read the corresponding reaction tank of the person's station, and can also be used with the 31 1276466 agent system Or use it without a phase change coolant assist system. The joints 485, 487, . . . 497 can be used to supply miscellaneous covering gas, cooling or adding or inverting the body 'surface often' to create a reactive atmosphere above the reactants. The twentieth diagram shows the instrument of the invention shown in the eighteenth figure. The main reason is 0' but with other features of the shed members, such components include ··············································································· 587. The other components and functions of the same symbols as those shown in Fig. 18 are the same as those described above, and will not be further described herein. VIII. A reaction tank for reflux type reaction and related various circuit connections And the assembly of the reflow stop plug, the assembly is suitable for the second aspect of the present invention, and the reaction tube 589 is disposed on the neck 591 of the reaction state 1005, and is disposed on the extension tube. The lower end of the upper 597 and the lower yoke are inserted into the returning stop 599 of the upper end of the extension pipe and ΐ1, 广, 605, 607 '609, connected to the return stop 599 and open to the inlet pipe 611 of the reaction tank. 2, 13th, 13th, 3, 615b, the end of the water pipe The head 617', the second tenth figure "the same as the payee, the member of the _, will be further described here.", the younger one of the twelve figures shows the main Zhao placed in the instrument of the present invention, the middle level 417 And the partial enlarged surface of each component on the upper layer 419 is illustrated by a single workstation in the figure. The instrument if there is a water supply pipe joint 445 in the upper layer of the middle layer, control _465 485, and the drainage concentrated in the middle layer Pipe joint 5Q5, hot head 52+5, clamp arm brace 565 in front of the middle layer. i 545 and milk line official connection. Figure 12 shows the invention crying/ini in combination with the 20th to 22nd drawings. Symbols are marked, and their descriptions are omitted to avoid repetition. Figure = the same Μ I, 别不本发明仪器4〇1 32 1276466 In addition to the above-mentioned components and components, 'a fixture 619 is also included for the disaster holding reaction tank 1005 'The clamp 619 is connected at the base end to support the free end of the cool arm 621 of the buckle seat 565, and the reaction tank cover 519 is divided into a semi-circular left and right half bodies 519a, 519b, and the return stop 599 has The finger member 623 extends downward, and the relationship and function of the other members are as described above. 'The twenty-fourth chart The apparatus of the present invention shown in Fig. 18 has placed the auxiliary systems of the three reaction tanks 1007, 1009, and 1011 in perspective view. In this embodiment, for example, one reaction tank can be used for inertness. The reaction is carried out at room temperature under gas coverage, the other reaction tank is used for reaction at room temperature without gas coverage, and the other reaction tank is used for high temperature reaction. The twenty-fifth figure shows the same as the twenty-fourth figure. The apparatus of the present invention is shown in FIG. 4, but in addition to the two reaction tanks 1', the sub-9, and the ship, a reaction sample 1017 is added, for example, for the concentrated volatilization process of the solvent. Figure 26 shows the apparatus of the present invention which is identical to the apparatus of the twenty-fifth figure, tearing the reaction I, 5, 1013, 1G15, and can be used to carry out a reflux reaction, which is a recirculation system, and the composition is suitable for In the inert gas ring i*: nff: and enthalpy temperature gas sensitive reaction. The recirculation system includes: - the main pipe = the same number of vacuum manifolds as the reaction tank (this example only shows the Γ ί 岐 岐 961 961 of the pipe joint 959. As for the main body of the instrument 1 401 does not carelessly (4) 鄕 right to three Cheto Ching and the illustrator are the same or better than the twenty-sixth figure. ί Zhongfan and the eighteenth figure. It is shown in the twenty-seventh figure, and its position is omitted and the relevant pipeline is properly attacked = In the figure, the reaction tanks have been fixed. The half bodies 519a and 519b have been closed together; in the figure, it can be seen that the left and right sides of the reaction tank cover are above the reaction tank, and the neck of the reaction tank is 1〇〇5. 33 1276466 is clamped and positioned by the clamp 619. One end of the clamp 619 is supported by the clamp 565 by the clamp arm 621. The resistance heater 581, the stirring drive motor 583, the timing dial 585 and the control are arranged under the reaction tank 1〇〇5. The twenty-eighth figure shows a partial detail of the portion of the reaction tank 1007 of the twenty-sixth figure + which corresponds to the twenty-seventh figure. A resistance heater 631 is provided below the reaction tank 1〇07. The driving motor 633, the timing dial 635 and the controller 637. The neck 591 of the reaction tank is fastened by one end by the arm 641 to the buckle seat 567. The clamp 643 is clamped and positioned. The opening neck of the reaction tank 1007 is plugged with a return stop plug 5 having a plurality of holes 647, and the two holes are respectively passed through the inert gas introduction pipe 651 and the exhaust gas discharge pipe 653. The air inlet 487 and the air outlet 527 are connected. The two tubes 651 and 653 are bundled in the back bend by the bundle tube 655. The first nineteenth figure of the wood indicates the phase of the other reaction tank 1009 in the twenty-sixth figure. A partial detail of the twenty-seventh figure. Below the reaction tank 1009, a resistance heater, that is, a stirring drive motor 663, a timing dial 665 and a controller 667 are provided. The neck 591 of the reaction tank lj is borrowed from one end. The arm 669 is clamped and held by the clamp 68ι of the buckle seat 569. One of the holes 673 of the return stopper 671 is inserted with a thermocouple 675, and the pipeline 677 is connected to the thermocouple socket 549. The twentieth diagram shows the second In the sixteenth figure, the other part of the reaction tank 1〇11 is equivalent to the partial detail of the first seventeenth figure. Below the reaction tank 1011, a resistance heater 691, a stirring drive motor 693, a timing dial 695 and control are provided. The head 591 of the reaction tank 10^ is held by the clamp 701 of the buckle seat 571 by the arm 699 at one end. One of the holes 705 of the clamp return IL stopper 703 is provided with a thermocouple (not shown), and the pipeline is connected to the thermocouple socket 551. Among the plugs 7〇3, & = to the water supply pipe joint 451, In addition, the stopper 7_face is connected to the outlet outlet 511', and the top surface is connected to the exhaust gas f 713a, to the exhaust gas, and the symbol 715 is a cluster tube for concentrating the above tubes into bundles. Representing the phase in the twenty-sixth figure - the phase of the reaction cell 1G13 = a partial detail of the seventeenth figure. The ', . , 72 of the reaction tank 1 〇 13 is a mixing drive motor 723, a timing dial, and a controller. Reaction port 34 1276466 The neck of the groove 1013 is held by a clamp 731 which is fastened to the buckle seat 573 by the arm 729 at one end. The upper three holes 735 of the return stop 733 are connected to the thermocouple line 737, respectively. The air supply pipe 739 and the exhaust pipe 741 are respectively connected to the corresponding thermocouple pipe joint 553, the air supply pipe joint 493, and the exhaust pipe joint 533, and the above pipes are bundled by the cluster pipe 743. The thirty-second diagram shows a partial detail of a portion of the reaction tank 1015 in the twenty-sixth embodiment which is equivalent to the twenty-seventh diagram. Below the reaction tank 1015, a resistance heater 751, a stirring drive motor 753, a timing dial 755, and a controller 757 are provided. The neck of the slot 1015 is held by one end by the arm 759 at the clamp 761^φ position of the buckle 575. The upper two holes 765 of the return plug 763 are connected to the thermocouple line 769 and the air supply pipe 767 are connected to the thermocouple socket 555 and the air supply pipe joint 495, respectively. Further, a hole above the return stopper 763 is connected to the vacuum branch pipe 967 to be connected to the vacuum control valve 969 of the vacuum manifold 961 supported by the support groove 951. The thirty-third figure shows a partial detail of the phase of the other reaction tank 1017 in the twenty-sixth diagram. Below the reaction tank 1017, a resistor heater 771, a stirring drive motor 773, a timing dial 775, and a controller 777 are provided. The neck of the reaction tank ^017 is held by one end of the clamp 781 of the buckle seat 577 by the arm 779. The two holes 785 on the upper side of the return plug 783 are respectively connected to a vacuum branch pipe %3 and an air supply pipe 787 and are respectively connected to a vacuum control valve 969 and a gas supply pipe joint 497 of the vacuum manifold 961 supported by the support groove 951. The joint portion of the vacuum manifold 961 and the main vacuum tube 957 is held by a fork-shaped jig 979. _ * Thirty-fourth represents the embodiment of the reaction tank configuration of the apparatus of the present invention. A perspective view of the twenty-sixth embodiment. In this figure, the reaction tanks 1021 and 1023 are sequentially connected to perform a two-step reaction. The instrument 4〇1 is basically the same as the foregoing, and only the two return plugs 979 and 981 on the counter-disc 1021, 1023 are connected by a gas supply pipe 975, a connecting pipe 973, a vacuum branch pipe 971 and a vacuum control valve 977 to be common. jobs. Thus, the user can perform different steps in the different reaction tanks by the apparatus 401 of the present invention to complete the multi-step reaction. It will be apparent to those skilled in the art that more than two reaction vessels can be interconnected in a manner similar to that described above to achieve multiple reactions. 35 1276466 As in the predecessor, due to the above-mentioned various points and effects, the various synthetic reactions and methods can be carried out simultaneously on the same instrument, or individually. The lower wire shows the reaction of the specific L? compound of the above reaction tank. The actual reaction is represented by the chemical structure w in the thirty-fifth to forty-secondth figures. Table 1005 1007 1009 1011 1013 1015 1017 Reaction mechanism generation map twenty-seventh figure twenty-eighth figure twenty-ninth figure thirty-thth thirty-first figure thirty-two figure thirty-third figure mutual response裎 缉 缉 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三 第三The time sequence 1 representing the various characteristics of the apparatus of the present invention is used to indicate the cooling charge used in conjunction with the second ordering characteristic of the first graph S. The first figure shows the completion of the cooling temperature of the second figure, the sequence of the cooling injector, and the opening and closing cycle of the cooling injector. The cooling injector is opened and closed. The fourth figure shows the reaction system of the present invention. Block Diagram 36 1276466 The fifth and sixth figures respectively show a schematic representation of two representative reaction tanks of the reaction system of the fourth diagram. View f Seven graph, a top view of an embodiment of the porous reflow stop of the present invention. f Eight Diagrams Fig. 7 is a longitudinal sectional side view showing the porous reflux stopper of the present invention. Ninth aspect of the present invention is a longitudinal cross-sectional side view of another embodiment of the porous reflow stop shown in the present invention. FIG. 11 is a longitudinal sectional side of the first embodiment of the present invention. Figure 12 is a perspective view showing the arrangement of the porous reflux stopper of the present invention and its attached finger tube, respectively. Figure 13 is a schematic view showing an embodiment of an extension member of the present invention. Figure 14 is a plan view showing an embodiment of a jig used in the present invention. Fig. 15 is a perspective view showing a configuration example of a connecting line of three different functions of the microreactor of the apparatus of the present invention. Fig. 16 is a perspective view showing the apparatus of the present invention having an extension member and five pipe connection holes for different functions. Fig. 17 is a perspective view showing an example of a configuration in which the microreactor shown in Fig. 16 is further added with a power line. Eighteenth®, showing a multi-functional multi-reaction tank chemical synthesis apparatus of the present invention, is not yet provided with a perspective view of an embodiment of the reaction vessel and the overall appearance of the piping. The nineteenth chart is not shown in the eighteenth figure. The instrument n of the present invention has been mounted on the overall perspective of the positioning.豕 视图 第二 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图 图Perspective view. The table is transferred to the enchantment of the present invention - the main unit portion. The twenty-third figure shows an exploded view of the combination of the twentieth to twenty-two diagrams in combination with the component groups 37 1276466. The twenty-fourth figure shows that the fineness of the present invention shown in the eighteenth figure has three reaction tanks to assist the green separable_the room temperature reaction under the cover of the gas atmosphere under the cover of the gas atmosphere and the reverse reaction at high temperature Red - the example is transparent. The twenty-fifth diagram shows a perspective view of the reaction tank assisting system of the present invention as shown in the twenty-fourth embodiment, but with the addition of a solvent evaporation concentration process. The tenth, the figure shows the same as the present invention shown in the twenty-fifth figure, but a further perspective view of the gas-sensitive reaction for reflux reaction and room temperature reaction under an inert gas is carried out.

The seventeenth to the twenty-third map shows the instruments of the present invention shown in the twenty-sixth figure. Should it be slotted? A partially enlarged perspective view of the configuration relationship and detailed construction. The twenty-fourth chart is a perspective view of a plurality of steps in a single-process in which two reverse-strands are interconnected to sequentially perform in different reaction tanks. The thirty-fifth to the fortieth-towings have made the financial losses a chemical change in the course of various physical and physical reactions. [Explanation of main component symbols] 1,60,101 Reaction system 3, 61,103, 301,1005,1007,1_,ion,1〇13,1()15, dish 7,1〇21 1023, reaction tank (reactor) 150, 200, 300, 401 Instrument 5, 69, 111 Cooling zone 7, 79, 113 Heating zone 9, 65, 107 Inlet 29, 67, 109 Outlet 11 Injector (injection controller) 13, 63, 105 Cooling group 15 Coolant supply 38 1276466 17,163,165, 219, 321,323, 677, 707, 769, 973 conduit (pipeline) 19, 71,115 heating group 21, 31, 301 microprocessor (planable controller) 23,25 cable 27,117, 347 agitator 2, 50, 100, 151, 170, 211, 309, 599, 645, 671, 703, 733, 763, 783, 979, 981 4, 52, 102 6, 54,104 8, 58,108, 110 28, 60, 106 Backflow plug main plug body top wall (top) Peripheral wall (circumferential side Department) bottom 10, 61, 157, 175, 213 central hole 14, 16, 18, 20, 22, 24, 26, 64, 66, 126, 128, 159, 177, 215, 601, 60 3, 605, 607, 609, 673, 705, 735 , 765, 785 Outer holes (holes, holes) 12, 70,118,183 14, 72,120,185 32, 34 68,181,213, 623 62,112,114 108,153,171 110,157,173 74,122 76, 617 161,217 167 190, 305, 573 191 193 195, 643, 701 Outer tube inner tube bottom end finger tube seal ring peripheral wall upper section peripheral wall lower section elbow joint joint gas diffuser control valve extension member (extension) bottom end neck top Neck clamp 39 1276466 203, 303, 591 open neck 221,675 sensor (thermocouple) 230, 307, 619, 643, 681, 731, 761, 781 fixture

341 Insulation Cylinder 343 Insulated Bottom 345 Heating and Cooling Mechanism 349 Controller 403 Main Enclosure 405 Pressure Controller. 407 Touch Panel 409 Photoelectric Pen 413 Panel 411 Indicator 415 Top Panel 417 Middle Plate 419 Upper Plate

425, 427, 429, 431, 433, 435, 437 445, 447, 449, 451, 453, 455, 457 465, 467, 469, 471, 473, 475, 477 485, 487, 489, 491, 493, 495 , 497 505, 507, 509, 511, 513, 515, 517 525, 527, 529, 531, 533, 535, 537 545, 547, 549, 551, 553, 555, 557 565, 567, 569, 571, 573 , 575, 577 519, 521, 523, 539, 541, 543, 559 519a, 519b 581, 631, 661, 691, 721, 751, 771 583, 633, 663, 693, 723, 753, 773 585, 653 695, 725, 755, 775 workstation water supply pipe joint opening/closing valve (control valve) air supply pipe joint (air inlet) drain pipe joint exhaust pipe joint (exhaust port) thermocouple socket clamp arm seat buckle reaction Slot insulation cover (reaction tank cover) Insulation cover half body resistance heater motor timing dial 1276466 587, 637, 667, 697, 727, 757, 777 controller 589 agitator block 595 lower yoke 597 upper light 611,709 inlet pipe 613a, 613b, 711a, 711b Outlet pipes 615a, 615b, 653, 713a, 713b, 741 Exhaust pipes 621, 641, 669, 699, 729, 759, 787, 975 Clamping arms 651, 739, 767 655, 715, 743 951 953 955 957 959 961 963, 967, 971 9 65, 969, 977 979 Gas inlet pipe (air supply pipe) Cluster pipe Support groove Bracket Pillar Main vacuum pipe Pipe joint Vacuum manifold Vacuum branch pipe Vacuum control valve Fork clamp 41

Claims (1)

1276466 X. Patent application scope: 1. A multifunctional parallel independent multi-reaction tank chemical synthesis instrument, comprising: (a) a main casing having at least three independent workstations, each workstation being adapted to receive a reaction tank; (b) at least one cooling group functionally coupled to one of the at least three independent workstations for controlled cooling thereof, each of the cooling groups comprising: (i) a cooling element disposed adjacent each of said at least three independent workstations and having an inlet for injecting a phase change coolant, a heat absorption zone and an outlet for discharging said phase change coolant; And (ii) / main mushroom for injecting the liquid phase change coolant into the cooling element via the inlet; / (c) at least one heating group functionally connected to the at least three independent workstations Each of them is controlled to be heated; (d) at least one stirring mechanism is connected to each of the at least three independent workstations (8) control means, each cooling group and each heating group are connected for automatic control The above injectors respectively control at least one of the following: 'control each feeding mechanism separately, the force includes a programmable component; the workbench contains a 1 body> and the system includes a filling Device, the entity's control device, is used to periodically turn on/off its control action to establish a preset temperature change of different programmable temperature ranges, and the instrument of item 1, Instrument II progress - further comprising: H = _ a tank, connected to the line by each - of the injection device and human population, with pressurized contents of the liquid phase-change refrigerant. ^ T child storage tank 3. ^ Ming Qi 2 of the diligent 'where the phase change cooling ship material, will absorb heat during evaporation and at atmospheric pressure 42 !276466 》. 4. Apparatus according to claim 3, wherein the phase change cools carbon dioxide and nitrogen.匕3 r月性乱体5·In accordance with the instrument of item 1, the instrument further includes (Q at least one reflow mechanism for each of the above independent workstations) - an inert gas protection mechanism for each An instrument according to the request item, wherein the scale-side standing station ^ generating device and the device for generating a vacuum pressure function on the reaction tank. ' 7. According to the apparatus of claim 1, wherein each of the independent units Forming, and each cooling group is connected to each of the corresponding upper portions, and each of the cooling groups comprises: (0) a cooling element near the upper portion of the reaction tank, having a gamma agent, a heat absorbing region, and a 1 σ rib Discharge the above phase (ii), the population injector is adapted to apply the coolant to the cooling element. And (in) connect the phase change coolant supply of the injection device, i press the liquid phase change coolant ; , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Including: can be independent workstations can be regulated The ability to program a program to preset a plurality of required temperature settings for the required temperature setting; at least one function - a temperature sensor for the reaction tank; and a sufficient software to identify the temperature And controlling the above-mentioned ageing and the above-mentioned cooling group to achieve the setting of the ^= degree and the required time to go back and forth within a predetermined acceptable range of tolerance. The apparatus according to claim 1, wherein the control device The main peripheral includes an input mechanism connected to the control device. The g-grain private element 43 1276466 10. According to the claim 9, the 绮 其 绮 绮 绮 绮 绮 绮 绮 绮 绮Independent on/off indicator of function. A workstation indicates a multi-wei parallel independent multi-reaction synthesis, the instrument includes: (4) The main housing 'has at least three standing stations, each of which accommodates a reaction tank And (b) at least one cooling group functionally coupled to each of the at least three independent workstations for controlled cooling thereof, each of the cooling groups comprising: (I) a cooling element, Proximate to the at least three separate workstations of each of And having an inlet for injecting a phase change coolant, a heat absorption zone and an outlet for discharging the phase change coolant; and a μ (II) injection state for passing the liquid phase change coolant The inlet is injected into the cooling element; (C) at least one, a heating group, functionally coupled to each of the at least three independent workstations for controlled heating thereof; (d) at least one agitation mechanism, Connecting each of the at least three independent workstations; (e) at least one of the workstations, wherein a microreactor reaction tank is contained therein, the reaction tank having a cylindrical open neck and a predetermined volume storage area (a) a porous reflux stopper, functionally inserted into the neck of the reaction tank, the porous reflux stopper having: (i) a stopper body having a top wall and a bottom wall and The outer side wall is provided with a central hole extending from the top wall through the bottom wall, the central hole is located at a central portion of the top wall, and includes a regulating hole, and a plurality of the same top is also arranged around the central hole a through hole outside the bottom wall; (ϋ) a sealing member disposed on the outer side wall of the stopper body so that the stopper can closely contact the opening of the reaction tank; (g) the control device 'connects each cooling group and each a heating group and each of 44 1276466 agitating mechanisms for programmatically and automatically controlling the injectors to respectively control at least one of an on/off process and a flow rate thereof, respectively controlling at least one of on/off heating and heating rates One, and separately controlling each of the two stirring mechanisms, wherein the control device comprises a programmable component; wherein the control device comprises a software, and the system comprises an injector, a physical control device for periodically switching on/off its control action Establish at least one package & various preset temperature sequences for different programmable temperature ranges. 12. The apparatus according to claim η, wherein the finger member of the stopper is at least two, a set of concentric tubes, each tube having an upper end and a lower end, wherein the ends are open, and each tube is functional Ground to the end of the instrument ^ L. The brain of the 13^^ item ^, wherein the finger f is a group containing two inner and outer branches, each f has an upper end and a lower end, wherein the inner tube has a utm and the outer smear has a closed lower end. 14. The apparatus of claim n, wherein the apparatus further comprises: a pipeline connected to each of the upper jaws and the inlet vessel; wherein the reservoir is filled with pressurized liquid phase change coolant. 15 & ϋ, where the phase change coolant is an environmentally inert room temperature. In the case of the absorption of heat, there is an instrument 15' in which the point of the Buddha is lower than the 16^τ item ^_15 at atmospheric pressure, wherein the phase change coolant is selected from the group consisting of inert gas, carbon dioxide and nitrogen.曰^ r “生^,隋性气保':,上: Each standing 17· According to the instrument of claim 11, the instrument further includes · (8)▼ 1 · (b) The work station includes: vacuum reduction pressure function 1δ· According to the apparatus of claim 11, wherein each of the helium pressure volatilization functions generates a crack and generates 45 1276466 for the reaction tank, and the towel county-_red gamma has an upper portion )t) into a concave portion, and Each cooling group is connected to an upper portion of each of the corresponding stations, each of the cooling groups including (1) a cooling element adjacent to the upper portion of the reaction tank, having an inlet for injecting a phase change coolant, a heat absorption region, and an outlet for discharging the phase change coolant; (··), the inlet of the ten inlets, suitable for programmable control injection of the phase change coolant to the cooling element; (10) connecting the injection device The phase change coolant supply source has a liquid phase change coolant under pressure; the solid heat group is connected to each program station to program and control the application of heat. I week is 2 〇 production Request for the ceremonies of item 11, The control (4) includes: can be independent: - the ability of a workstation to plan the program, a set of multiple required, field, setting and corresponding to the temperature setting of the S, the two functions, connection - reaction The temperature sensor of the tank; 2 = discriminates from the temperature of the tank, and responds by controlling the above-mentioned plus 2 = upper acceptance deviation range.