CN108181210A - A kind of blood cell analyzer and its reaction tank temperature control equipment - Google Patents
A kind of blood cell analyzer and its reaction tank temperature control equipment Download PDFInfo
- Publication number
- CN108181210A CN108181210A CN201611124163.6A CN201611124163A CN108181210A CN 108181210 A CN108181210 A CN 108181210A CN 201611124163 A CN201611124163 A CN 201611124163A CN 108181210 A CN108181210 A CN 108181210A
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- reaction tank
- heater
- shielding case
- temperature
- reagent
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 101
- 210000000601 blood cell Anatomy 0.000 title claims description 6
- 210000004369 blood Anatomy 0.000 claims abstract description 13
- 239000008280 blood Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 6
- 238000007789 sealing Methods 0.000 claims abstract description 6
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 30
- 238000012544 monitoring process Methods 0.000 abstract description 3
- 238000004159 blood analysis Methods 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 description 10
- 229910000838 Al alloy Inorganic materials 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000004820 blood count Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 238000005338 heat storage Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
- G05D23/20—Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/016—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Automation & Control Theory (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of blood analyser and its reaction tank temperature control equipments, and including reaction tank, reaction tank shielding case, heater and controller, the reaction tank is mounted in reaction tank shielding case, and shielding case protecgulum is provided on the reaction tank shielding case；The shielding case protecgulum forms a closed cavity with reaction tank shielding case；The heater is mounted in reaction tank shielding case, and shielding case inner sealing cavity and reaction tank are heated；Realize that constant temperature controls near reaction tank in shielding case by the heating power for changing heater.The temperature of reagent of addition is impacted in itself the invention avoids reaction tank, reagent reaction is maintained and is carried out in the range of one steady temperature, so as to make blood analysis more accurate.In addition, heater output power is set according to the ambient temperature value of instrument monitoring, control method is simple.
Description
Technical field
The present invention relates to a kind of blood analyser more particularly to a kind of blood cell analyzer and its reaction tank temperature
Control device.
Background technology
Clinical examination instrument, such as cellanalyzer, more particularly to a kind of white blood cell count(WBC) and leukocyte differential count test are common
With the cellanalyzer of a reaction tank.In leukocyte differential count test, need to locate blood in advance under normal circumstances
Reason, is reacted using specific reagent with blood, while to ensure that reaction fully, can be carried out reliably, is needed to reaction
Place provides a stable isoperibol.Widely used (30~40 DEG C) reactions of realization reagent constant temperature in cellanalyzer
Method to be preheated to reagent, reagent is made to reach required temperature before reaction tank is added in.Such as patent CN201320862224
The preheating device for reagent mentioned includes regenerative block, reagent container, heater element, cover board, air locking etc., and reagent container is located at
Among regenerative block, air locking is sleeved on the both ends of reagent container, and outer wall, heat storage pool and the cover board of reagent container squeeze close jointly
The sealing that device realizes liquid is sealed, can ensure that reagent is preheated to required temperature before reaction tank is added in.But aforesaid way is deposited
In following problem, i.e., when the reagent of preheating is added to reaction tank, since the temperature of reaction tank is different from temperature of reagent, can cause
The temperature of the warmed-up reagent added in generates variation, particularly instrument at low ambient temperatures in use, reaction tank and addition
Temperature of reagent differs greatly, and the temperature of reagent added in can be caused to decline apparent, and the temperature change of reagent can exceed pretreatment at this time
Required steady temperature range is reacted, influences the stability of apparatus measures.Therefore, it is necessary to a kind of thermostatic control modes to maintain
Reaction tank is in the temperature environment of constant (30~40 DEG C), and avoiding reaction tank, (particularly less than 25 DEG C of room temperature) is tried adding in itself
The temperature of agent impacts.
There is not any scheme at present for carrying out thermostatic control to the reaction tank of such cellanalyzer, be only related to
To preheating device for reagent.
As for a kind of blood isothermal reaction system and method that patent CN201110215582 is mentioned is that reagent is preheated
Journey and it is preheated after the process reacted of reagent carried out in same ontology, the ontology is small using thermal conductivity factor and to correlation
The corrosion-resistant preferable titanium alloy of effect of reagent makes, and the preheating flow channel of reagent is built in ontology, and reagent flow is preheated
Channel is heated, although can achieve the purpose that reagent preheating and reaction environment constant temperature, the integrated preheating device are needle
The reaction tank of leukocyte differential count is designed, it is impossible to be used as leukocytoreaction with counting with the pond of two kinds of functions, it is impossible to
Applied to the Highgrade integration in such cellanalyzer, being unfavorable for realizing instrument；And preheating channel is made using titanium alloy,
Processing difficulties, device is complicated, of high cost.For another example the leukocyte differential count incubating device that patent CN201610025457 is mentioned is one
Formula preheats incubating device, and the ontology is made of aluminium alloy, is machined with pipe laying groove on ontology, is given in a manner of being embedded to pipeline
The small reagent of dosage directly preheats, and front preheating process is carried out to the big reagent of dosage.In addition the heat preservation of 5mm thickness is used outside incubating device
Cotton coats, and reduces external heat loss.Although being easier to process than aforementioned patent ontology, device is equally complicated, can not be simultaneous
Hold for white blood cell count(WBC) function.All such integral type reagent preheating incubating devices cannot be compatible with white blood cell count(WBC) function,
It is unfavorable for the Highgrade integration of instrument, and apparatus structure is complicated, it is of high cost.
Therefore, the prior art has yet to be improved and developed.
Invention content
The purpose of the present invention is to provide a kind of blood cell analyzer and its reaction tank temperature control equipments, it is intended to solve
The problem of existing blood analyser does not control reaction tank temperature.
Technical scheme is as follows：
A kind of reaction tank temperature control equipment of blood analyser, including reaction tank, reaction tank shielding case, heater and
Controller, the reaction tank are mounted in reaction tank shielding case, and shielding case protecgulum is provided on the reaction tank shielding case；Institute
It states shielding case protecgulum and forms a closed cavity with reaction tank shielding case；The heater is mounted in shielding case, the control
Device is connect with heater point, and the heater is used to heat shielding case inner sealing cavity；The controller for changing
The temperature of the heating power control heater of heater, realizes the constant temperature control of reaction tank.Preferably, the reaction tank screen
It covers cover to be made of metal material with shielding case protecgulum, such as corrosion-resistant stainless steel, aluminium alloy material can be used to make.
Preferably, the calandria installing plate is made of the big material of thermal conductivity factor, general that thermal conductivity factor is selected to be more than
Copper product making such as can be used in 200W/m.K, it is possible to use aluminium alloy.
Preferably, the heater installation site is not contacted close to the reaction tank with the reaction tank.
The temperature controlled method of reaction tank of the blood analyser is to be placed in heater and the same shielding of reaction tank
It covers and is heated in the enclosure space formed, according to environment temperature, the output power of heater is controlled, so as to maintain reaction tank institute
Shielding case formed space in constant temperature.The environment temperature can be passed by the temperature at the other positions of monitoring instrument
Sensor obtains.The output power of the heater is controlled according to the environment temperature monitor value, and environment temperature is relatively low and shadow
When ringing to reaction effect, start heater output power, and according to the demand temperature objectives of reaction tank in shielding case, regulation heating
The output power of body reaches the demand constant temperature in the shielding case inner sealing space where reaction tank, not by extraneous low temperature
It influences.
Preferably, the environment temperature is detected by reading temperature of reagent outside instrument environments temperature monitoring sensor value and machine
Sensor obtains.
A kind of blood cell analyzer, including the reaction tank temperature control equipment in above-mentioned.
Beneficial effects of the present invention：The present invention maintains reaction tank temperature to keep constant by a kind of simple mode；It uses
Heater heats shielding case inner sealing space where reaction tank, keeps constant reaction tank temperature, so as to be reaction tank
The reaction of interior reagent provides constant temperature place.Using heater, the use of combination temperature controller is not needed to, it is anti-according to Instrument sensor
The ambient temperature value of feedback sets heater output power, makes reaction tank temperature maintenance nearby in shielding case constant, control method letter
It is single.
Description of the drawings
Fig. 1 is the reaction tank shielding case structure schematic diagram with heater of cellanalyzer in the present invention.
Fig. 2 is the band heater mounting structure schematic diagram of cellanalyzer in the present invention.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, clear and definite, develop simultaneously embodiment pair referring to the drawings
The present invention is further described.
Referring to Fig. 1 and Fig. 2, provided by the present invention for the reaction tank thermostatically-controlled equipment of cellanalyzer, including anti-
Pond 3, reaction tank shielding case 2, heater 4 and heater installing plate 5 are answered, shielding case is provided on the reaction tank shielding case 2
Protecgulum 1.Reaction tank is positioned in the reaction tank shielding case 2, an enclosure space is formed around reaction tank at this time, using described
Heater 4 heats the enclosure space, according to the variation of ambient temperature, controls the output power of heater 4, you can
Reach environment temperature in control reaction tank shielding case 2 in the ranges such as required, it is simple in structure, it is easy to control.Further include a control
Device processed, the controller are connect with heater point, for controlling the calorific value of heater.
Wherein, the shielding case protecgulum 1 forms a closed cavity with reaction tank shielding case 2；The heater 4 is mounted on
It is positioned on heater installing plate 5 in reaction tank shielding case 2, realizes that temperature controls by the output power for changing heater 4, make
Reaction tank shielding case 2 remains constant with the empty cavity temperature that shielding case protecgulum 1 is formed, and is maintained so as to fulfill the temperature of reaction tank 3
It is constant.
In preferred embodiment provided by the invention:
Reaction tank shielding case 2 and shielding case protecgulum 1 are made of metal material；In the present embodiment, use stainless steel or
Person's aluminum alloy materials make.
Reaction tank 3 is positioned on reaction tank shielding case 2, and shielding case protecgulum 1 forms a closing sky with reaction tank shielding case 2
Chamber；Heater 4 is mounted on heater installing plate 5, is placed in the closing sky that shielding case protecgulum 1 is formed with reaction tank shielding case 2
Intracavitary, heater 4 do not need to contact with reaction tank 3 close to reaction tank 3.
In the present embodiment, the devices such as resistance-type calandria or semiconductor calandria, heater peace may be used in heater 4
Loading board 5 is made of the big material of thermal conductivity factor, the general material that thermal conductivity factor is selected to be more than 200W/m.K, in the present embodiment,
It uses aluminum material to make, to ensure the heat of more effectively conduction heater 4 conduction, so as to more effectively be shielded to reaction tank
The enclosure space that cover 2 is formed with shielding case protecgulum 1 is heated；In addition to ensure heat transfer efficiency, pacify in heater 4 and heater
Heat-conducting silicone grease is coated between loading board 5, to reduce interface resistance, improves heat conduction efficiency.
The control method of reaction tank isoperibol is：The temperature value of instrument environments temperature sensor monitors is read, for phase
The environment temperature answered changes the output power of heater 4, to control the calorific value of heater 4, reaches control shielding case temperature
Constant purpose, under normal circumstances, the temperature in shielding case are consistent with environment temperature.
In the present embodiment, when environment temperature is less than the target temperature needed for reaction tank, heater 4 starts, to ensure low
Reaction tank shielding case temperature is stably maintained at target temperature value under warm environment.When environment temperature detected value is in target temperature model
When enclosing interior, heater 4 stops output power.
By the above-mentioned output power for the presetting heater 4 of temperature environment detected value, realize under various circumstances, certainly
The calorific value of dynamic control heater 4, the shielding case internal temperature where keeping reaction tank remain unchanged in constant target value.
The heater mentioned in said program is not limited to general resistance-type calandria, refers to all with voltage, electric current
The heater of driving.The present invention also provides a kind of blood analyser, above-mentioned reaction tank temperature control is installed in the analyzer
Device processed.
The invention has the advantages that：1st, the prior art does not control the temperature of reaction tank, a kind of letter of the invention
Single mode maintains reaction tank temperature to keep constant；2nd, heating element structure is simple, principle is unrestricted, therefore, design freedom
Greatly, it is at low cost；3rd, the small range closed area formed using heater heating reaction tank shielding case, is efficiently utilized heater
Heat, maintain reaction tank constant temperature in a certain range；4th, the control method of heater, according to the variation of environment temperature, control
The output power of heater processed makes the neighbouring constant temperature of reaction tank, control method in shielding case simple.
It should be understood that the application of the present invention is not limited to the above, it for those of ordinary skills, can
To be improved or converted according to the above description, all these modifications and variations should all belong to the guarantor of appended claims of the present invention
Protect range.
Claims (5)
1. a kind of reaction tank temperature control equipment of blood analyser, which is characterized in that including reaction tank, reaction tank shielding case,
Heater and controller, the reaction tank are mounted in reaction tank shielding case, and shielding is provided on the reaction tank shielding case
Cover protecgulum；The shielding case protecgulum forms a closed cavity with reaction tank shielding case；The heater is mounted in shielding case,
The controller is connect with heater point, and the heater is used to heat shielding case inner sealing cavity；The controller
For changing the temperature of the heating power control heater of heater, the constant temperature control of reaction tank is realized.
2. the reaction tank temperature control equipment of blood analyser according to claim 1, which is characterized in that further include a hair
Hot body installing plate, the heater are mounted on calandria installing plate and are positioned in reaction tank shielding case.
3. the reaction tank temperature control equipment of blood analyser according to claim 1, which is characterized in that further include a use
In the external temperature that the temperature detector of sensing reaction tank shielding case external temperature, the controller are detected according to temperature detector
Degree controls the output power of heater, to control the calorific value of heater.
4. the reaction tank temperature control equipment of blood analyser according to claim 3, which is characterized in that specific controlling party
Method is：When the environment temperature detected value target temperature constant less than reaction tank, heater output power is set, works as environment temperature
When detected value is in target temperature range, heater stops output power.
5. a kind of blood cell analyzer, which is characterized in that including the reaction tank temperature described in claim 1-4 any one
Control device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611124163.6A CN108181210A (en) | 2016-12-08 | 2016-12-08 | A kind of blood cell analyzer and its reaction tank temperature control equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611124163.6A CN108181210A (en) | 2016-12-08 | 2016-12-08 | A kind of blood cell analyzer and its reaction tank temperature control equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108181210A true CN108181210A (en) | 2018-06-19 |
Family
ID=62544936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611124163.6A Pending CN108181210A (en) | 2016-12-08 | 2016-12-08 | A kind of blood cell analyzer and its reaction tank temperature control equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108181210A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112444619A (en) * | 2019-08-30 | 2021-03-05 | 深圳迈瑞生物医疗电子股份有限公司 | Impedance method counting device and blood cell analyzer |
| CN112881718A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Blood analyzer, heating assembly and assembly seat |
| CN112912734A (en) * | 2018-12-27 | 2021-06-04 | 株式会社日立高新技术 | Automatic analyzer |
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| CN101799467A (en) * | 2009-02-05 | 2010-08-11 | 深圳迈瑞生物医疗电子股份有限公司 | Particle analyzer, constant-temperature reaction system and constant-temperature reaction method |
| CN202351117U (en) * | 2011-11-04 | 2012-07-25 | 深圳市普康电子有限公司 | Pre-heating device of blood cell analyzer |
| CN203455345U (en) * | 2013-07-26 | 2014-02-26 | 深圳理邦实验生物电子有限公司 | Novel blood cell sample reaction tank device |
| CN105486573A (en) * | 2016-01-13 | 2016-04-13 | 广州埃克森生物科技有限公司 | Leucocyte classification incubation device |
| CN205280724U (en) * | 2015-10-10 | 2016-06-01 | 嘉兴凯实生物科技有限公司 | Heating element and heating device of thrombelastogram appearance |
| CN206270209U (en) * | 2016-12-08 | 2017-06-20 | 深圳市帝迈生物技术有限公司 | A kind of blood cell analyzer and its reaction tank temperature control equipment |
-
2016
- 2016-12-08 CN CN201611124163.6A patent/CN108181210A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101799467A (en) * | 2009-02-05 | 2010-08-11 | 深圳迈瑞生物医疗电子股份有限公司 | Particle analyzer, constant-temperature reaction system and constant-temperature reaction method |
| CN202351117U (en) * | 2011-11-04 | 2012-07-25 | 深圳市普康电子有限公司 | Pre-heating device of blood cell analyzer |
| CN203455345U (en) * | 2013-07-26 | 2014-02-26 | 深圳理邦实验生物电子有限公司 | Novel blood cell sample reaction tank device |
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| CN206270209U (en) * | 2016-12-08 | 2017-06-20 | 深圳市帝迈生物技术有限公司 | A kind of blood cell analyzer and its reaction tank temperature control equipment |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112912734A (en) * | 2018-12-27 | 2021-06-04 | 株式会社日立高新技术 | Automatic analyzer |
| CN112444619A (en) * | 2019-08-30 | 2021-03-05 | 深圳迈瑞生物医疗电子股份有限公司 | Impedance method counting device and blood cell analyzer |
| CN112444619B (en) * | 2019-08-30 | 2023-12-19 | 深圳迈瑞动物医疗科技股份有限公司 | Impedance method counting device and blood cell analyzer |
| CN112881718A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Blood analyzer, heating assembly and assembly seat |
| CN112881718B (en) * | 2019-11-30 | 2024-04-12 | 深圳市帝迈生物技术有限公司 | Blood analyzer, heating element and assembly seat |
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