TWI254639B - External preparations for enhancing cell activity - Google Patents

Abstract

This invention relates to external preparations for enhancing cell activity which comprise polysaccharides dissolved in an aqueous Solution; based on the total weight, 1 to 50% of xyloglucan, 1 to 50% of laminaran and 1 to 50% of krestin are added. The aqueous solution having the polysaccharides dissolved therein further contains, based on the total weight, 1 to 50% of pectin, 1 to 30% of dextran, 1 to 30% of glucose, 1 to 40% of pullulan, 1 to 30% of lentinan, 1 to 50% of cyclodextrin and 1 to 50% of trehalose. These preparations enhance the immune resistance and healing capacity of cell tissues in the oral cavity, nasal mucosa, etc. without any side effect. Thus, they are applicable not only to pollenosis and stomatitis but also to various diseases of cellular level over a wide scope including the skin and scalp.

Description

1254639 (1) Field of the Invention The present invention relates to an agent for promoting cell activity, which has an effect of improving various diseases mainly such as hay fever or endophthalmitis, and at the same time, an electrolyte for cells can be applied. Balance and osmotic pressure balance activate cells, thereby improving various diseases caused by decreased cell function of skin cells. Prior Art In the past, inorganic salts such as sodium chloride, natural sugars such as glucose, and plasma have been widely used as a compounding agent for various cosmetic or pharmaceutical external preparations. For example, a cream containing soft skin such as sodium chloride is described in USP 3 5 74 8 5 4, and on the other hand, an application for a skin cleansing product containing mineral salts has been applied in West Germany. Patent Publication No. 3 3 27 840 is described in the specification. Further, an application for a sugar component in which a mixture of glucose and a skin is lubricated is described in U.S. Patent No. 3,859,436. Further, an application for an aqueous solution of a dextrin for shaving has been described in U.S. Patent No. 3, 7,775,978. However, these past external preparations can achieve the purpose of skin sterilization and skin protection, but it is difficult to improve skin diseases caused by skin capillary circulation and function reduction, and pigmentation, athlete's foot, femoral hernia, hair trout, and body odor. Various diseases caused by a decrease in skin cell division function such as alopecia, dandruff, and itching. Therefore, the present inventors have found that in order to activate skin cells and improve various diseases caused by a decrease in cell function of skin cells, it is a skin potassium chloride in the skin surface -6-(4) 1254639 〇. 1 to 1%. The method for solving the problem. The various symptoms of pigmentation, pigmentation, and hair loss on human skin are related to various factors such as ultraviolet rays and chemical substances, and are limited to cell-level changes. Specifically, salt is a mitochondria of one of the small organs in the cell. In terms of membrane or cell membrane barrier. That is, the membrane disorder of the mitochondria causes intracellular respiratory obstruction, which in turn reduces the production of ATP (adenosine triphosphate) which is a source of cellular power. Because of this, the lack of ATP causes a decrease in the energy transport function of the cell membrane, and reduces the ability of material transport between cells and interstitial fluid. As a result, insufficient nutrients such as glucose in the cells are generated, and blood circulation caused by a decrease in the acidity of ATP is caused. There are many reasons for the above-mentioned changes at the cell level, and particularly for cells such as the oral cavity or the nasal mucosa, the interstitial fluid is increased by osmotic pressure, and the cells at the disease site are activated. Further, it has been found that the addition of xyloglucan, laminarin, and polysaccharide K can improve the immunity or epidemic power of cell tissues such as the oral cavity or nasal mucosa. EMBODIMENT OF THE INVENTION The present invention is basically formulated as a preparation for promoting cell activity by dissolving a polysaccharide in an aqueous solution, and adding xyloglucan in a weight ratio of 1 to 5 % by weight to 1 to 50 % of laminarin, With 1 to 5 % of the polysaccharide K (krestin). Xyloglucan is a constituent sugar chain that is ubiquitous in the cell wall (primary wall) of elongated and hypertrophic plant cells. The specificity of the plant species is due to the xylose or fucose-galactose linkage of the xylose residue. The galactose residue-9-(7) 1254639 The so-called aqueous phase component (pure water) is an oil-free state produced only by pure water, and is completely free of water-soluble petroleum products used in the preparation of general external preparations such as cosmetics. Surfactant and the like. Therefore, when the aqueous phase components of these components are mixed, it is necessary to completely dissolve the components and carry out at 50 to 100 °C. Table 1 Number of patients with disease name Validity (dot) Effectiveness (%) Male type hair loss 60 118 98 Physical and mental hair loss 50 60 60 Acne 3 0 5 8 97 Red face 60 66 5 5 Foot 癣 50 95 95 Lipid leakage skin Yan 100 197 99 Atopic dermatitis 100 98 4 9 Endophthalmitis 50 100 100 Hay fever 100 196 98 Table 1 shows the results obtained by the pharmacological test of Formulation Example 1. In the case of the use of the external preparation of the present invention, no change is a defect, and the change is 1 point, and the effect is confirmed to be 2 points, and the total point of each person is added, and the validity is calculated by the following formula. In addition, in this test, it is necessary to confirm the healing effect of hay fever, and the efficiency is calculated for 100 patients. [Equation 1] Effectiveness = Total point - Target person X 100 -12- (9) 1254639 As a result, when the concentration of xyloglucan is increased to the prescription 2 or higher, there is a phenomenon of separation after dissolution, which is improper. Prescription. Further, in addition to xyloglucan, any of the laminarin polysaccharide and the polysaccharide K must exhibit a potency at a concentration of at least 丨% or more, and when the concentration exceeds 50%, it cannot be a place. [Effects of the Invention]

The present invention is to add a weight ratio of 1 to 50% of xyloglucan, 1 to 5 % of laminarin, and 1 to 5 % of polysaccharide K (kre st in ). Among the components of the aqueous phase, the immunity or healing power of cell tissues such as the oral cavity or the nasal mucosa can be improved, and the disease can also be treated for diseases such as hay fever.

In addition, while improving the immunity or healing power of the cell tissue, the same environment as the interstitial fluid of the skin cells can be produced, and the intracellular respiratory disorder caused by the membrane disorder of the mitochondria or the ATP of the cell activity source can be prevented ( Reduced production of adenosine triphosphate), can maintain electrolyte balance, osmotic pressure balance, and promote the normalization of barrier cells in the surface of skin cells or mucosal cells, and difficult for male hair loss or hemorrhoids, athlete's foot, lipid leakage dermatitis, etc. The disease of treatment is extremely useful. The significance of the present invention greatly contributes to humans. -14 -

Claims (1)

1254639 -- i .::: .' one: . i....- ...-: -n. . . . , .,.. . V .1 . a... 捡, patent application scope 9 2 1 0 3 5 4 Patent Application No. 9 Amendment to the Chinese Patent Application Scope of the Republic of China, February 17, 1995 曰 Amendment 1. An agent for promoting cell activity, which is characterized by dissolving a polysaccharide in an aqueous solution to promote cell activity. The total weight ratio is 1 to 50% xyloglucan, 1 to 50% of laminarin', and i to 50% of polysaccharide K (krestin). 2. The agent for promoting cell activity according to the first aspect of the patent application, wherein the aqueous solution in which the polysaccharide is dissolved contains, in total, 1 to 50% by weight of pectin and 1 to 30% of oligosaccharide. Sugar, 1 to 30% glucose, 1 to 40% amylopectin (pululan), 1 to 30% lentinan (leutinan), 1 to 50% cyclodextrin and 1 to 50% trehalose. 3. The agent for promoting cell activity according to the first or second aspect of the patent application, wherein the aqueous solution in which the polysaccharide is dissolved is added to the whole weight ratio of 氯化·1 to 1% of sodium chloride, 0.1 to 1% of calcium chloride, and 〇·1 to 1% of potassium chloride.