TWI253346B - Manufacturing method of nano compound collagen - Google Patents

Manufacturing method of nano compound collagen Download PDF

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Publication number
TWI253346B
TWI253346B TW92136774A TW92136774A TWI253346B TW I253346 B TWI253346 B TW I253346B TW 92136774 A TW92136774 A TW 92136774A TW 92136774 A TW92136774 A TW 92136774A TW I253346 B TWI253346 B TW I253346B
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collagen
skin
nano
vitamin
value
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TW92136774A
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Chinese (zh)
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TW200520773A (en
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Abel Sun
Ya-Yi Lin
Yu-Lou Suen
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Abel Sun
Jiang Jau Wang
Greatforce Biochem Tech Co Ltd
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Abstract

This invention relates to a manufacturing method of nano compound collagen, which hydrolyzes and extracts small molecular collagen with molecular weight less than 10K Dalton and concentration between 0.05 to 25% from collagen obtained from animals, mixes the small molecular collagen with 1 to 200 ppm nano photocatalytic compound silver particles and 1 to 500 ppm photocatalytic compound nano iron and levorotary vitamin C and further adjust the pH value to approach the value of skin which is around 6 ± 3, so as to form a liquid lotion with affinity to human skin. Cyclical disinfection and bacteriostatic mechanism of the nano photocatalytic compound silver particles is used to replace the regular preservatives available on the market which cause an allergic reaction on sensitive skin. Besides, the nano iron is able to stimulate the start factor effect of collagen to repair skin, which accelerates the repair mechanism of skin cells and reduces the allergic reaction of skin induced by collagen. The levorotary vitamin C is able to assist cells to more effectively absorb collagen and stabilize the composition in skin, which makes it be able to maintain young and skin elasticity and further achieve the benefit of promoting the usage of collagen.

Description

1253346 五、發明說明(1) 【發明所屬之技術領域】1253346 V. Description of invention (1) [Technical field to which the invention pertains]

本發明為有關一種奈米複合膠原蛋白之製造方法,乃 係將由動物體上取得的膠原蛋白,經過水解萃取分子量為 10K dalton以下,濃度在0 05-25%之小分子膠原蛋白,於 其中混入:l-200ppra奈米光觸媒複合銀粒子、i-5〇〇ppm光觸 媒複合奈米鐵及左旋維他命C,再調整其PH值使接近皮膚 值6 ± 3左右,促使成對人體皮膚具親合性之液態乳液,而 可藉由奈米光觸媒複合銀粒子之循環殺菌抑菌機制,取代 市面上一般防腐劑對於敏感肌膚所造成之過敏反應,另奈 米鐵則有刺激膠原蛋白修復皮膚之啟動因子作用,可加速 皮膚細胞的修復機制,並減低皮膚對於膠原蛋白所引發的 過敏反應,左旋維他命C則可協助細胞更有效吸收膠原蛋 白,並穩定膠原蛋白在皮膚中的組成,使更能維持年經及 肌膚的彈性,致可達增進膠原蛋白使用之效益者。 【先前技術】 自古埃及時代開起,人們即不斷在尋求皮膚美麗的方 法,時至今日,最熱門的保養品首推膠原蛋白,而膠原蛋 白普遍存在人體中,包括皮膚、骨骼、軟骨、肌腱、眼球The invention relates to a method for producing a nano-composite collagen, which is characterized in that a collagen obtained from an animal body is subjected to hydrolysis to extract a small-molecule collagen having a molecular weight of 10K dalton or less and a concentration of 0 05-25%, and is mixed therein. :l-200ppra nano photocatalyst composite silver particles, i-5〇〇ppm photocatalyst composite nano-iron and levo-vitamin C, and then adjust its PH value to make it close to the skin value of 6 ± 3, which promotes affinity for paired human skin. The liquid emulsion can replace the allergic reaction caused by the general preservatives on the market for sensitive skin by the cyclic bactericidal and antibacterial mechanism of the nano photocatalyst composite silver particles. The other nano-iron has the function of stimulating collagen to repair the skin. It can accelerate the repair mechanism of skin cells and reduce the allergic reaction caused by collagen on the skin. L-Vitamin C can help cells absorb collagen more effectively and stabilize the composition of collagen in the skin, so that it can maintain the longevity. And the elasticity of the skin, which can improve the use of collagen. [Prior Art] Since the ancient Egyptian era, people have been searching for ways to make skin beautiful. Today, the most popular skin care products are the first to push collagen, which is ubiquitous in the human body, including skin, bones, cartilage, and tendon. ,eyeball

中其中,皮膚的70 %即是由膠原蛋白所構成。致膠原蛋 ^對於防止皮膚老化、防止皺紋產生,甚至於去除皺紋具 口極大的功效,因此,近幾年來膠原蛋白的化粧品、保養 口口逐漸變得炙手可熱。 然市面上製成的膠原蛋白產品,多為分子量較大的膠Among them, 70% of the skin is made up of collagen. The collagen-producing egg ^ has a great effect on preventing skin aging, preventing wrinkles, and even removing wrinkles. Therefore, in recent years, collagen cosmetics and maintenance mouths have become hot. However, the collagen products made on the market are mostly rubbers with larger molecular weight.

【發明内 有鑑 究、設计 尋求改良 一奈米複 本發 造方法, 取分子量 原蛋白, 調整其PH 親合性之 菌抑菌機 實用發明 本發 造方法, .1253346 五、發明説明(2) 原蛋白’藉由塗抹於皮膚表面, 含量有限’多停滯於皮膚表面, ;而且’為了在室溫下保存膠原 有人工抗菌劑,對於皮膚細胞而 當大眾花了金錢取得一樣產品時 的效益,但在以往的膠原蛋白產 蛋白,事實上尚須其他輔助成分 膠原蛋白,是以針對於此,而有 容】 於此,本發明人乃積十 之經驗,悉心研究,竭 之方法,並經過多次之 合膠原蛋白之製造方法 明之主要目的在提供一 乃係將由動物體上取得 為10K dalton以下,濃 於其中混人1-200ppm奈 值使接近皮膚位6± 3左 液態乳液,使可籍由光 制,使避免人工抗菌劑 明之次要目的在提供一 為將由動物體上取得的 夕原蛋白能渗入真皮層之 故而僅能達到保濕之作用 ^白’大部分產品皆添加 ° 更添加了一層負擔。 三當然希望能夠獲得最大 口,口中,只一昧的強調膠原 ,才可加速促進細胞接受 再加研究改進之必要。 ;年從事膠原*白產品研 ς心智,針對上述問題, 實驗試做,終於發明出此 Ο 種奈米複合膠原蛋白之製 的膠原蛋白,姆^ 經過水解墓 度在0· 05〜25❶/ » , 之小分子膠 米光觸媒複合銀粒子,再 右,促使4人體皮膚且 觸媒複合報私2 ’、 ’對皮膚細皰造成負擔之 種奈米複纟冑u ㈣蛋自’_水解萃i[Invented, invented, designed to improve the nano-replica production method, take the molecular weight of the original protein, adjust its PH affinity, the bacteria antibacterial machine practical invention, the hair-making method, .1253346 5, invention description (2 The original protein 'by smearing on the surface of the skin, the content is limited to more than stagnant on the surface of the skin; and 'in order to preserve collagen at room temperature, there are artificial antibacterial agents, for the skin cells, when the public spends money to get the same product. However, in the past, collagen production protein, in fact, requires other auxiliary components of collagen, which is aimed at this, and the present inventors have accumulated 10 experiences, carefully studied, exhausted methods, and After a number of times, the main purpose of the method for producing collagen is to provide a liquid emulsion of 10K dalton or less, which is rich in the concentration of 1-200 ppm, which is close to the skin level of 6 ± 3 left liquid emulsion. It can be made by light, so that the secondary purpose of avoiding artificial antibacterial agents is to provide only one that can penetrate the dermis layer from the animal body. To the role of moisturizing ^White's most products are added ° adds a layer of burden. Thirdly, I hope that I can get the most out of it. In the mouth, only one glimpse of collagen can accelerate the promotion of cell acceptance and the need for research and improvement. Years engaged in collagen* white products research and development mind, in response to the above problems, experimental trials, finally invented the collagen produced by this kind of nano-composite collagen, m ^ after hydrolysis of the tomb in 0 · 05 ~ 25 ❶ / » , the small molecule glue rice photocatalyst composite silver particles, and then right, promote 4 human skin and the catalyst compound private 2 ', 'the kind of burden on the skin blisters nano-recovery u (four) egg from '_ hydrolysis extract i

第6頁 1253346 五、發明說明(3) 分子量為10K dalton以下,濃度在0.05-25%之小分子膠原 蛋白,於其中混入卜20Oppm奈米光觸媒複合銀粒子及1 -500ppm光觸媒複合奈米鐵,再調整共ph值使接近皮膚值6 ± 3左右,促使成對人體皮膚具親合性之液態乳液,使可 產生抑菌作用外,尚可以奈米鐵刺激膠原蛋白啟動修復皮 膚之作用,使加速皮廣細胞的修復機制,並減低皮膚對於 膠原蛋白所引發的過敏反應之實用發明者。 本發明之再一目的在提供一種奈米複合膠原蛋白之製 造方法,為將由動物體上取得的膠原蛋白,經過水解萃取 分子量為10K dalton以下,濃度在0·0 5-25%之小分子膠原 蛋白’於其中混入1-2 00 ppm奈米光觸媒複合銀粒子及左旋 維他命C,再調整其PH值使接近皮膚值6 ± 3左右,促使成 對人體皮膚具親合性之液態乳液,使可產生抑菌作用外, 尚可以左旋維他命C協助細胞更有效吸收膠原蛋白,並穩 定膠原蛋白在皮膚中組成之實用發明者。 【實施方式】 茲就本創作之作用及其它目的,配合流程圖式詳細說 明如後,俾便更加了解: 本發明係將由動物體上取得的膠原蛋白,經過處理後 水解萃取分子量為10K dalton以下,濃度在0 0 5 — 2 5%之小 分子膠原蛋白,再於其中混入光觸媒搭載奈米級銀粒子組 成之卜200ppm奈米光觸媒複合銀粒子,另亦可加入卜5〇〇 ppm光觸媒複合奈米鐵及在旋維他命C,再調整其pH值使接Page 61253346 V. Description of invention (3) Small-molecule collagen with molecular weight of 10K dalton or less and concentration of 0.05-25%, in which 20Oppm nano photocatalyst composite silver particles and 1-500ppm photocatalyst composite nano-iron are mixed. Then adjust the total ph value so that the skin value is close to 6 ± 3, which promotes the liquid emulsion with affinity to the human skin, so that it can produce bacteriostatic effect, and it can still stimulate the effect of collagen on the skin to repair the skin. A practical inventor that accelerates the repair mechanism of the skin-wide cells and reduces the skin's allergic reaction to collagen. Still another object of the present invention is to provide a method for producing a nanocomposite collagen, which is characterized in that a collagen obtained from an animal body is subjected to hydrolysis to extract a small molecular collagen having a molecular weight of 10 K dalton or less and a concentration of 0·0 5 to 25 %. The protein 'mixes 1-2 00 ppm nano photocatalyst composite silver particles and L-vitamin C, and adjusts its pH to a skin value of about 6 ± 3, which promotes the affinity of the liquid skin to the human skin. In addition to the antibacterial effect, L-Vitamin C can help the cells absorb collagen more effectively and stabilize the collagen in the skin. [Embodiment] For the purpose of this creation and other purposes, as well as a detailed description of the flow chart, it will be better understood. The present invention is a collagen obtained from an animal body, and after hydrolysis, the molecular weight of the collagen is 10K dalton or less. , a small molecule of collagen with a concentration of 0 0 5 - 2 5%, and then mixed with a photocatalyst containing 200 ppm nano photocatalyst composite silver particles composed of nano-sized silver particles, and may also be added to a photocatalyst composite nanocap. Rice iron and in the vitamin C, then adjust its pH to make the connection

1253346 五、發明說明(4) 近皮膚值6± 3左右,促使成璧 液,亦可將其加添於美容保養# 同具親合性之液態乳 狀或膏狀之美容保養品。養樂劑中,使調合製做成乳液 膠原蛋白修復皮膚的啟動因子,加速皮膚細胞的修復機制 ’並減低皮膚對於膠原蛋白所引發的過敏反應,奈米鐵更 由於本發明之膠原蛋白分 較易於滲入真皮層及為肌膚所 過多造成浪費,及阻礙其餘膠 ;利用光觸媒搭載奈米級銀粒 銀粒子’光觸媒之強氧化特性 氧化分解成水及二氧化礙,而 殘留披覆、發臭、病菌滋長等 特性,致可啟動抑菌機制,因 擔的抗菌劑,另光觸媒複合銀 ’不僅可保持製成品的無菌狀 ’亦可在皮膚表面產生抑菌作 膚之作用;另膠原蛋白並不是 反應’尚須有刺激它發生作用 子莖為在10K dalton以下, 吸收的狀態,而不致因使用 原蛋白為肌膚所吸收之情事 子,形成之奈米光觸媒複合 ’可將細菌、病毒等,加以 自然去除消滅,使不致產生 問題,並促進銀粒子之殺菌 而不需額外添加增加肌膚負 粒子的抑菌機制只針對細菌 態,當塗抹於皮膚、臉上時 用,使產生更深一層清潔肌 塗抹上之後’即可產生快速 的物質,而奈米鐵即可作為1253346 V. INSTRUCTIONS (4) The skin value is about 6±3, which promotes the formation of sputum. It can also be added to the beauty care product. It is a liquid milky or creamy beauty care product with affinity. In the music agent, the blending system is made into a start-up factor for repairing the skin of the collagen collagen, accelerating the repair mechanism of the skin cells' and reducing the allergic reaction caused by the skin to the collagen, and the nano-iron is further classified by the collagen of the present invention. It is easy to penetrate into the dermis layer and cause excessive waste to the skin, and hinder the rest of the glue. The photocatalyst is loaded with nano-sized silver silver particles. The strong oxidizing properties of the photocatalyst are oxidatively decomposed into water and oxidizing, and the residual coating and odor are left. The characteristics of the growth of the bacteria can lead to the inhibition mechanism. The antibacterial agent and the photocatalyst composite silver can not only keep the aseptic content of the finished product, but also produce antibacterial effect on the skin surface; another collagen is not The reaction 'has to be stimulated to cause the stalk to be below 10K dalton, the state of absorption, without the use of the original protein for the skin to absorb the affair, the formation of the nano photocatalyst compound 'can be used to bacteria, viruses, etc. Naturally removes and eliminates, so as not to cause problems, and promotes the sterilization of silver particles without additional addition to increase skin negative particles Antibacterial mechanism against bacteria only condition, when applied to the skin, face when using the generated deeper muscle after cleaning the applicator 'can produce rapid substances, and iron can be used as nano

能引領膠原蛋白進入真皮層,提高膠原蛋白的功效;又經 實驗研究註明,增加左旋維他命C可以使皮膚細胞增生膠 原蛋白,左旋維他命c也是膠原蛋白合成時的必須要件, 而左旋維他命c是人體每天必備的營養素,因此,本發明 中添加之左旋維他命c,可協助細胞更有效吸收膠原蛋白 ’並且穩定膠原蛋白在皮膚中的組成,使更能維持年輕及It can lead collagen into the dermis and improve the efficacy of collagen. It has been experimentally noted that increasing L-vitamin C can make skin cells proliferate collagen, and L-vitamin c is also an essential component in collagen synthesis, while L-vitamin c is a human body. Essential nutrients every day, therefore, the L-vitamin c added in the present invention can help cells absorb collagen more efficiently and stabilize the composition of collagen in the skin, so that it can maintain younger and more

第8頁 'l253346Page 8 'l253346

五、 (5)Five, (5)

發明說明 机膚的彈性,致 < 達增進皮 更進一步啟動膠原蛋白的修 按專利法第十九條有明 自然法則之技術思想、之高 未見於市場及刊物上’除可 感肌膚所造成之過敏反感外 抑菌之效用,是以功效及產 分符合發明專利之要件。 綜上所述,以上所舉者 並非用以限制本發明,致依 加變化修飾而成者,亦應包 膚對膠原蛋白的吸收能力,及 復功效。 文規定:『稱發明者,謂利用 度創作。』而本發明之方法從 取代市面上一般防腐劑對於敏 ,亦可發揮清潔、修復肌膚及 業上有明顯之利用價值,而充 儘乃本發明之部份實施例,但 本發明之創意精神及特徵,稍 括在本專利範圍之内。The invention explains the elasticity of the skin, and the patent law of the skin is further improved. The nineteenth article has the technical idea of the natural law, and the high is not seen in the market and the publication. The effect of allergic and anti-inhibition of external bacteria is that the efficacy and production scores meet the requirements of the invention patent. In summary, the above is not intended to limit the present invention, and it is also suitable for the absorption of collagen by the skin, and the complex effect. The article stipulates: "We call the inventor, that is, the use of creation. The method of the present invention can replace the common preservatives on the market, and can also exert a clear use value for cleaning, repairing the skin and the industry, and is a part of the embodiment of the present invention, but the inventive spirit of the present invention And features are included in the scope of this patent.

•1253346•1253346

第ίο頁Page ίο

Claims (1)

1255346 六、申請專利範圍 1· 一種奈米複合膠原蛋白之箩、生 得的膠原蛋白,經過水解s k方法,為將由動物體上取 ’濃度在0·251八7 77子里為10Κ dalton以下 200Ppm奈米光觸媒複:原蛋白,而於其中混入卜 膚值6土 3左右,使成對人、辦:南再調整其PH值使接近皮 其特徵者。 ’體皮膚具親合性之液態乳液為1255346 Sixth, the scope of application for patents 1 · A collagen complex of collagen, produced by the hydrolysis of sk method, will be taken from the body of the body 'concentration in 0. 251 八 77 77 is 10 Κ dalton below 200Ppm Nai Rice photocatalyst complex: the original protein, and mixed into the skin value of 6 soil 3, so that the pair of people, do: South and then adjust its PH value to make it close to the characteristics of the skin. 'The skin liquid with affinity for the skin is 3·=申請專利範圍幻項所述之奈米複合膠原蛋白之製造 方法’其中該液態乳液中亦混有左旋維他命^者。 4·如申請專利範圍第1項、第2項或第3項所述之奈米複合 膠原蛋白之製造方法,其中該液態乳液加添於美容保養 藥劑中,調合製做成乳液狀或膏狀之美容保養品。3·=Manufacturing method of nano-composite collagen described in the patent application scope illusion wherein the liquid emulsion is also mixed with L-vitamin. 4. The method for producing a nanocomposite collagen according to the first, second or third aspect of the patent application, wherein the liquid emulsion is added to a cosmetic care preparation, and is blended into an emulsion or a paste. Beauty care products. 第11頁Page 11
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