TW544315B - A composition for external use containing xyloglucan - Google Patents

Abstract

A composition for external use which contains xyloglucan. This composition preferably furthermore contains an ultraviolet shielding agent, a thickening polysaccharide, a thickening polysaccharide and sericin, a carboxyvinylpolymer, or, an alkyl-denatured carboxyvinylpolymer.

Description

544315 V. Description of the invention (2) The key points that can be found in the invention of the best combination for external use. Disclosure of the invention The present invention is to solve the above-mentioned key sugars. The Indian tamarind (T species having xylose, structure 1 and molecular weight substances associated with the related substance π) of the present invention, 'the inventor has made various attempts. The problem of solution =' is to overcome the above-mentioned problems widely. "Cultivated Knife" thus provides the use of this product in external compositions. This staff member repeatedly focused on the review, and found that the xyloglucan can be made and the cutter is a kind of external composition from plants (the following) It is called "the external combination xyloglucan κ sugar of the present invention, which is mainly the main component of the leguminous plant (amarundus indica) produced in tropical places. It is a galactose side chain bonded to the main chain of -1,4-glucan. It is about 650,000 polysaccharides [Formula (丨)]. (Gal) (I) xy 1 xy1 xyi g 1 υ S 1 ug 1 u In the formula, glu represents a glucose unit, and xyl represents a xylose unit.

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^ 4315 V. Description of the invention 最佳 The best form for implementing the present invention △ · The first shape bear of the present invention: Too much to take ^, L ^ ~, non-glucosamine and ultraviolet defense agent # composition for external use (also below) Called ", and and made up"). Do n’t invent a brother-in-law sad combination for external use. Public ΐ = ’The harmful effects of ultraviolet rays in sunlight on the human body have a tendency. For skin care, more and more attention has been directed to this point. In order to shield the human body, external compositions such as cosmetics with too much UV-defense agents are various: be = = Matching:: Effective; Of course: the rational scattering of UV-defense agents 2 ' It is made with ultraviolet scattering agent (mainly made by the king “Wang Qi shot to make ultraviolet scattering). The agent will salivate in the mouth over time, due to the ultraviolet scattering; and ι will agglomerate, and there is a strong tendency to greatly reduce the effect. Secondly, it is necessary to seek a more stable dispersion system. The apple agent is now 'combined with the above-mentioned xyloglucan and UV-protection compound, even if a large amount of this UV anti-proliferation is formulated, it will not produce a change point. The feeling of use, even if it is large, I, etc., I did not find ultraviolet light scattering agent to agglutinate, the effect of the defensive line defense agent may continue to increase, and then page 10 C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (5): Don't = Zhengguo 4 The composition for external use with a sugar-based ultraviolet absorbent is added to promote the completion of the first form of the external use group of the present invention. IΪ = t5 purple Line of defense agent "who is the Lord = Ϊ :: Γ absorb ultraviolet radiation" ultraviolet absorbers ", and into the main concept. The line-scattering "ultraviolet scattering agent" is combined and the external composition of the first aspect of the present invention φ μ .1,,. It's more ugly. Weight ° / ° ′ and the total composition of the first form of the external form of Benzyl 4.0% by weight

If the total weight of the external composition is 0 0 i K ^ dextran formula L UV recording & weight%, then the desired " cover with the feel of the composition with external use "and" ultraviolet light " The scattering agent is stably dispersed in the composition, and the effect of L + T which is "lii π kai · men" is hard to be exhibited. Therefore, if it exceeds 10.0 ℃, the platinum itself will form a polymer. The unique coating, and the wooden man ^ In this way, the external use composition has a strong tendency to use the external composition. Therefore, it is not the same as the external defense agent in the first form of the external composition of the present invention. There is no special ^; A ^ τ ^ side defense agent.% Restrictions, for example, can be combined with the following, that is, as the ultraviolet absorber (for example, referred to as PABA for short), PABA monoglyceride, Mvf amino group ^ Xinxiang ester, N, N-diethoxy PABA ethyl ester, N, dipropylene glycol PABA ethyl N, N-dimethyl PAB butyl vinegar, N, ΝΛΝψ, ethyloxy? Partial ethyl acetate, —Phenyl group, PABA ester, etc.

544315 V. Description of the invention (7) Octylphenyl) Dipyridylhydroxy-5-tolylbenzotriazole, 2- (2, -hydroxy-5, -dibenzotriazole, 2- (2,- Hydroxy-5, _tolyl) benzotriazole, dinitrogen, carbamidine, 4-methoxy-4'-tert-butylmonomethyl, 5- (3, 3--methyl-2-norbornyl) -3-pentan-2-residue and other ultraviolet rays are used as cesium, etc. The above water-soluble ten-year composition, if selected, is sugar, and the above absorption sword is ultraviolet ultraviolet rays In the ultraviolet selective sugar system of ultraviolet rays, in this way, the combined ultraviolet rays are increased, and the portion of the purple line is absorbed in the outer line, so the range of the purple form of the outer black i ' The weight ratio of the external line absorber and absorber, when the wood gluconate is aggregated, if the purple and other linear diffusing agents are, for example, titanium dioxide, zinc oxide, and oxygen diffusing agents. A linear absorber (for example, a sugar-based ultraviolet absorber) is preferred. The ultraviolet absorber is blended with the ultraviolet absorber molecule for external use in the first aspect of the present invention. The synergistic effect of the combination of the sugar portion and the above-mentioned xylophyllum t makes the viscosity of the composition gelatinous. Therefore, when the ultraviolet absorber is combined with the scattering agent, the external scattering agent is added due to the point of the composition. The dispersion is more stable, and as a result, the ultraviolet ray shielding effect of the composition for hair is continuously improved. In the external composition of the first aspect of the present invention, the sugar-based purple is selected to have a particularly good effect. The mixing ratio of the above-mentioned xyloglucan and the agent is specifically selected according to the dosage form of the selected ultraviolet type and external composition, and the general rule is that 1 part of xyloglucan is used for the ultraviolet absorber. Between 2 parts of 2000 sugar and 1 part of ultraviolet absorbent. When the amount of outside absorbent deviating from this ratio is relatively large, it is desirable "

544315 V. Description of the invention (8) The effect of improving the first sensation of the present invention with a UV absorber is substantially difficult to exert. If the amount of xyloglucan is relatively large, the coating unique to the polymer makes the present invention The tendency of the first-use feeling to deteriorate is also strong, so it is also a good blending ratio of the external combination in the first form of the present invention, calculated by weight, ranging from 200 parts of wood extractant to 1 part of xyloglucan to ultraviolet In addition, in the first aspect of the present invention, the mixing ratio of the external use group with the above-mentioned ultraviolet scattering agent, the type of the ultraviolet scattering agent and the external composition, and the approximate weight ratio are between 800 parts by weight of wood and wood, and When the ratio of 2 parts of dextran to the ultraviolet scattering seed is, if the amount of the ultraviolet scattering agent is in phase, the propellants are apt to agglutinate, but the ultraviolet scattering agent in the composition for external use is difficult to play, so it is not suitable; on the contrary, If: then, the used gadolin glucan itself is high in the use of the external composition of the first form of the present invention, and therefore it is not suitable. Secondly, in the first aspect of the present invention, the preferred ratio of the external use group is calculated by weight, ranging from 2QQ parts of the scatterer to 1 part of xyloglucan. This is the same. The use of a composition for external use is therefore unsuitable; on the contrary, the xyloglucan itself is not suitable for use as a shape / form external use compound '=. Among the above two components, 1 part of dextran is more than 1 part of ultraviolet absorber. In the composition, the xyloglucan body is appropriately selected according to the selected dosage form, and between 1 part of sugar and 1 part of ultraviolet scattering agent. When there are many deviations from this pair, the ultraviolet light makes the effect of firstly dispersing the present invention substantially substantial. The amount of xyloglucan is relatively large, and the coating is peculiar to the molecule, so that the tendency to deteriorate is also strong. , 1 part of the above two components of xyloglucan to 1 part of ultraviolet external light scattering agent. UV protection agent (UV

C: \ 1234 \ 54664. Ptd page 14 544315 V. Description of the invention (9) Absorbent and UV ray |…, the sticky feeling will be caused by the external force = and it will be added to the composition for external use. Absorbent =: Removed by the presence of the absorbing agent, and if you choose to thicken and gel, especially in the case of external absorbents, the composition can be dispersed. As a result, UV = This can ensure ultraviolet scattering agent The stability points are determined in the present invention: = ,: = :: Fruit can be long-term ". In addition, other components of the above two essential components can be used according to needs, but are not limited to ^^ 1 mouth usually mix with external composition中 之 其 _ ^ '不 # 贝 害 present invention expects # 494I r # # 口 i alone, can also combine the effect of 2 Langi (not only /, dry, for example, can be magnetic outsiders 4 other Ingredients to match). Agents, silicon, substances, oils, soils, surface actives, anti-oxidant anti-oxidants, anti-dicarboxylic acids, moisturizers, low-grade: etc., suitably blended in: ;; 1st: = Pigment, citron, refined X Yuedi form external composition. Smoke! T Amino acids, organic acids, vitamins, ' Phenylamine, nicotinic acid ester, r-vitamin, p I main ^ Although allantoin, glycyrrhizic acid (§4>, sun tomb acid and its derivatives, all kinds of animals and plants come from: clamp: Medicinal alcohol, Zanthoxylum, thyme, inositol, divinyl biben; di 6 di di etc.:::=, tranexamic acid, arbutin, bellowsin, placenta extract, night hunting various suitable agents Formulated in the external composition of the first aspect of the present invention: 'These ingredients are blended in the external composition of the first aspect of the present invention.' Of course, the ingredients that impair the above-mentioned effect of improving the feeling of use must not be incorporated in the first In the form of a composition for external use, the property of increasing the viscosity of the composition due to the presence of tritium must be very careful

C: \ 1234 \ 5 4664.ptd Page 15 544315 V. Description of the invention (ίο) Dextran and thickening polysaccharides are the first form of the present invention for external use combination B. The second form of the present invention: Compositions for external use in wood (hereinafter also referred to as "materials"). The above-mentioned external-use composition compounded with xyloglucan has almost no sticky feel, which is often found in the case of other types of blends, and has been found to have a refreshing and unique feel. x However, this type of xyloglucan is formulated into a composition for external use, and it has a long-term stability when placed on the stomach. Specifically, this type of xyloglucan: It has been found that the viscosity of the combination has been reduced after a period of time at high temperatures. Therefore, only xyloglucan alone and two external compositions are undeniable. The present inventors have discovered that the composition of the combination of xyloglucan and thickening polysaccharides 'maintains the salty feel when xyloglucan is compounded alone, and even the composition is left for a long time at high temperature' the viscosity of the composition It has hardly changed and has excellent stability over a long period of time. Furthermore, it was found that these stabilizers change in the gradation of surfactants (especially non-ionic surfactants, of which sugar-based surfactants are the best) with xyloglucan and tackifier polysaccharides. Is even more significant. _ In the external composition of the second aspect of the present invention, the viscosifying polysaccharide sound means that xyloglucan is usually added to the external composition as a total polysaccharide for selective drilling agents. The mucopolysaccharides defined in the second form external composition exclude xyloglucan. That is, in the external composition of the second aspect of the present invention, the compounding amount of the xyloglucan is 〇. 0 1 to 1 〇. ％ by weight based on the total weight of the external composition, and

C: \ 1234 \ 54664.ptd Page 16 544315 V. Description of the invention (11) 0.1 ~ 4.0% by weight is better. In the second aspect of the external composition of the present invention, the compounding amount of the xyloglucan is less than 0.01% by weight based on the total weight of the composition for the second aspect of the present invention, so-called π The long-term stability improvement when the composition for external use is exposed to high temperatures is substantially difficult to exert, so it is not suitable; similarly more than 10.0% by weight, because the xyloglucan used itself forms a polymer-specific feature in the composition It is unsuitable because the coating composition of the external use is poor. In the external composition of the second aspect of the present invention, the homo-viscous polysaccharides combined with the above-mentioned xyloglucan means all the polysaccharides that can be used as a thickener in the external composition, for example, fiber Cellulose, hydroxyethyl cellulose, hydroxypropylcellulose, methylhydroxypropyl cellulose, methyl cellulose, carboxymethyl cellulose, sea fan seed gum, carrageenan, pectin, mannan, Cardolan, chondroitin, starch, galactan, chondroitin sulfate B, glycogen, gum arabic, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate , Chondroitin, Xanthan Gum, Mucopolysaccharide Sulfate, Hydroxyethyl Guar Gum, Carboxymethyl Guar Gum, Guar Gum, Dextrin, Cutin Sulfate, Locust Bean Gum, Amber Glucan, Caronine , Chitin, chitosan, hydroxymethyl chitin, mucopolysaccharide, agar, etc., but it is not limited to these thickening polysaccharides. Among these viscosity-increasing polysaccharides, hydroxyethyl cellulose, xanthan gum, agar, locust bean extract, and tragacanth gum have the characteristics of high stability at high temperatures, and are particularly suitable for blending in the first aspect of the present invention. Viscosity-promoting polysaccharides in two-form external composition.

C: \ 1234 \ 54664. ptd P.17 544315 Five descriptions of the invention (12): The 'thickening polysaccharides can be blended separately in the external topical compounds of this hair, or two or more of them can be appropriately combined. Form A second aspect is an external composition. _ ° In the second aspect of the present invention, the external composition of the composition: polysaccharides, in terms of weight, is wood escape: poly: and sugar increase: 1], and ": 1 ~ 2〇⑴ Is ^ .. When the relative amount of dextran is excessive, the compound of the second form and the external form of the present invention is high, and w ^. Than the problem of wood ... not suitable "phase two = sex: when the external use composition tends to have a strong tendency to deteriorate, two; the second way so-come, by using the wood Portuguese polymer, although can provide a feeling of use The iridium compound is used, however, if the external topical composition is used again, the effect will be up to one step. The active agent of the present invention is not particularly limited. For example, the agent 0 sugar and the thickening polysaccharide are excellent in the external use group. Moreover, the high temperature stability is also excellent, and the active agent is more significant in the second form of the present invention. ¥ The interface T in the external form of the two forms uses the materials for the interfacial activity listed below, sodium laurate, anionic interfacial activity Examples of the agent are fatty acid fats such as fatty palm, sodium; higher alkyl sulfates such as sodium lauryl sulfate, potassium lauryl sulfate; polyoxyethylene (hereinafter referred to as ρ〇Ε) lauryl sulfate diethanolamine, POE lauryl Alkyl ether sulfates such as sodium sulfate; N-methyltetraamino acids such as sodium lauryl sarcosinate; N_myristyl —N — sodium methyltaurate, coconut oil fatty acids 曱Sodium Taurate, Laurel Armor

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18th tribute 544315 V. Description of the invention (13) Higher fatty acid ammonium sulfonate such as sodium taurine, etc .; Sodium hexyl base of pOE oil sodium ether phosphate, POE stearic acid ether tank sodium Succinate, monolaurate, monomethyl ethoxylate, scorched acid =, lauric acid ^ polypropylene glycol hindering acid steel and other continyl succinates; τ, ^ gill succinic acid triethanolamine, Alkyl benzyl sulfonates of linear dodecyl benzyl acid; etc .; lauryl glutamate monosodium, N-stearyl glutamate di-steel, nitro-myristate-L-amylate Monosodium glutamate; hardened coconut oil fatty acid; glycerol sodium sulfate; higher fatty acid ester sulfate salts; mineralized sesame oil; sulfated oil; ρ〇Ε alkyl mysterate carbonate; POE Burned propyl ether carbonate, alkene sulfonate, sulphuric acid salt of higher fatty acid S, sulphuric acid salt of second alcohol, sulfuric acid of higher fatty acid amine citrulline Sa 'laurel 月 monoethanol amine succinate sodium , N-bromomethyl aspartic acid di (triethanolamine), casein, etc. Cationic surfactants, such as alkyltrimethylammonium salts of stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; distearyldifluorenyl ammonium dialkyldichloride Methyl ammonium salts, poly (N, N, -diamidino-3,5-methylenehexahydropyridine phosphonium salts), cetyl pyridinium chloride, and other alkyl pyridinium salts: alkyl Quaternary ammonium salt, alkyl difluorenyl ammonium ammonium salt, alkyl quinoline ammonium salt, monoalkylmorpholine salt compound, PQE alkylamine, polyamine fatty acid salt, polyamine fatty acid derivative, pentanol fatty acid Derivatives, gasified alkylammonium, ethoxylated ammonium chloride, etc. Amphoteric surfactants, such as 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl): 2-imidazoline sodium, 2-cocofluorenyl-2-imidazolium salt hydroxide _ Imidazoline amphoteric surfactants such as sodium ethoxylate; 2_seven

C: \ 1234 \ 54664. Ptd page 19 544315 V. Description of the invention (14) Alkyl-N-chimethyl-N-hydroxyethylimidazolium salt sweet vinegar, beet test, fluorenyl beet test, amido Beet test, F-glycine amino beet test system surfactants, etc. & Jun beet test etc. Lipophilic non-isolated? Interfacial activity # 1, such as _ ::, sorbitan monoisostearate vinegar 'sorbitol monoolein sesquiol olein, sorbitol three oil c, sorbitol to one glycerin sorbus Sugar alcohol anhydride, tetra-2-ethylhexyl diglycerol = hexyl acid =: sugar alcohol anhydrides, fatty acids and vinegars; mono-cotton oil fats-glycerol, etc. Glyceryl stearic acid§ Instruction, mono-glycerol :: glyceryl pyroglyceride, glyceryl monostearate malate: ': ~ type; hardened quince oil derivative, glycerin burning vinegar, etc. Those with a fatty acid content of hydrophilic nonionic surfactants, such as p0E sorbose: ester P :: glycolic anhydride monostearic acid 3 purpose, POE sorbitan monooleic acid Said P 〇E sorbitol four oils and stalks ρ η 17 ϊ Μ · ΡηΡ I Μ i Temple 0E sorbitan fatty acid esters, POE sorbitol monolaurate, ρ〇Εsorbose Alcohol monooleate, POE. Sorbitol pentaoleate, ρ〇Εsorbitan monostearate, etc. ρsorbate fatty acid esters; POE glycerol monostearate, ρ 〇Ε glycerol monoisostearate is cool. , POE glycerol triisostearate, etc. POE glycerol fatty acid esters; POE monooleate, POE distearate, POE monodioleate 'ρ〇Ε

POE fatty acid esters such as ethylene glycol stearate; Poe lauryl ether, POE oleyl ether, POE stearyl ether, p0E behenyl ether, pOE_2 octyldodecyl ether , POE alkyl ethers such as dihydrocholesterol; p〇E

C: \ 1234 \ 54664.ptd Page 20 544315 V. Description of the invention (15) pqe phenyl ethers of octyl ether, POE nonyl ether, POE dinonylphenyl, etc. Pluronic type; P0E-polyfluorinated propylene (hereinafter referred to as pop) cetyl ether, ροΕ · p〇p_2 —decyl tetradecyl bond, POE. POP monobutyl ether, Poe · pop POE · POP alkyl ethers of lanolin, POE · POG glyceryl ether, etc .; ιζ ^ POE · izg of acetonitrile condensates of oxobutyrolactone (Tetronic); p oE ramie oil , P0E hardened ramie oil, P0E hardened ramie oil monoisostearic acid S, P 0 E hardened ramie oil triisostearic acid | Purpose, p 〇 £ Hardened ramie oil monopyroshell acid monoisostearate Fatty acid diesters, POE hardened ramie oil maleic acid derivatives such as POE hemp oil derivatives or hardened ramie oil derivatives; POE beeswax and lanolin derivatives such as sorbitol t; coconut Oil fatty acid diethanolamine, lauric acid monoethanolamine, fatty acid isopropanolamine, and other alcohol amines; POE propylene glycol fatty acid ester, POE alkylamine, p. E fatty acid ammonium amine, sucrose fatty acid motif, POE nonphenylammonium aldehyde condensate, alkyl ethoxy diammonium amine oxide, trioleyl phosphate and the like. ^ ^ Among the surfactants, non-ionic surfactants are selected as the base pH. Di-I: ⑮ The composition of the external composition is better, especially the choice of fatty acid P, POE sorbitol fatty acid _, sugar sugar month Said non-ionic surfactants such as fatty acid and vinegar are more preferred. Use of the substance Ϊ sugar: ί The long-term stability of the composition of the sugar unit of the surfactant and the xyloglucan phase interaction with the interaction of the active agent outside the second form of the present invention; also possible Gelation), and further, these withered polysaccharides can be individually formulated in the m_two form

C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (16) In the external composition, two or more kinds may be appropriately combined in the external composition of the second aspect of the present invention. In the second aspect of the present invention, the proportion of the active agent is equal to 4 = 1.200 to 100: 1 by weight, and [the relative amount of xyloglucan for external use in the second form of the present invention is excessive. It is not suitable for the problem of timeliness. When it is excessive, the use feeling becomes worse. By combining the xylophyl polymer with the interfacial active sugars, the effect is even more second in the present invention. Forms, external use, and external ingredients can be added as required, but are not limited to the present invention. These other ingredients can be alone. For example, hydrocarbon-based alcohols, higher fatty acids, fermentatives, oxidation inhibitors, UV rays, perfumes, purified water, and the like are suitably used in the composition. In the composition, the above-mentioned xyloglucan and interface are preferably [xyloglucan: interfacial activity 1: 2 0 to 4 0: 1]. In the composition, exceeding this mixing ratio, viscosity stability occurs when left at high temperature. Conversely, the blending amount of the surfactant is strong, so it is not suitable. The combination of sugars and thickening polysaccharides in topical agents will make xyloglucan and thickening more prominent. In the composition, the above two essential ingredients are often combined with other desired effects in the external composition (not only alone or in a combination of two or more). , Oils, waxes, silicon breams, high-humidity agents (except withered polysaccharides), low-level defense agents, antibacterial agents, formulations, and color combinations in the second form of the present invention for external use, or 'amine groups Acid, nicotinic acid esters, r-oryzanol and its derivatives, various extracts from plants and organic acids, vitamins, nicotinic acid, allantoin, glycyrrhizic acid (salt), glycyrrhetic acid plants, Japanese cypress Sweet and sweet

544315

Myrrh alcohol, eucalyptus ketone ketone ether, ethinyl estradiol, and other pharmaceutical preparations. , Thyme, inositol, tranexamic acid, and arbutin are locally combined in the second form of the present invention, saponin, ubiquinone B, bellowsin, placenta extract c.im3 form: xyloglucan A polysomal composition (hereinafter also referred to as "the nth external composition of the present invention") formulated with a polysaccharide and silk membrane protein. + Second month of the second month of sadness Most cosmetic and other external combinations have the normal function of energy. Therefore, 'in order to achieve this purpose, one of the main purposes of the product is to maintain the skin's originality and maintain the constancy of skin moisturization. It is very important to address this, and the above-mentioned objectives can be achieved again' The relevant aerosol was developed to absorb fish Excellent performance and composition. Therefore, water moisturizer-oil balance is provided to provide many external-use compositions. Research on the protection of fisheries materials is prevalent, and so far there have been various protections. Among them, the water-soluble polyvalent alcohols are widely used as moisturizing agents for external compositions and pharmaceuticals due to their moisturizing properties ^, but these water-soluble polyvalent alcohols can maintain skin health and make rough skin Excellent effect, but on the other hand, it is often considered that the composition for external use with strong stickiness feels the composition for external use is often changed to the external use composition which attaches great importance to good use feeling. The greasy feeling caused by the combination of water-soluble polyvalent alcohols is considered a very big problem.

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苐 Page 23, 544315 5. Explanation of the invention (18) The inventor has found that the above-mentioned xyloglucan is combined with a thickening polysaccharide and sericin, and the composition for external use is the same as the case of using a water-soluble polyvalent alcohol. · It shows a high skin moisturizing effect. On the other hand, it has a good affinity with the skin and there is no feeling of weariness, and it is confirmed that it has a refreshing feeling. In the external application composition of the third aspect of the present invention, the compounded xyloglucan® is 0. 01 to 5 by 0% by weight of the total weight of the external composition, and q. 1 to 300% by weight is less than good. In the external composition of the third aspect of the present invention, if the compounding amount of the xyloglucan is less than 0. 0.001% by weight based on the total weight of the external composition, the moisturizing effect and refreshment provided by the external composition The feeling of use is actually difficult to play, which is not suitable; similarly, if it exceeds 5.0% by weight, the xyloglucan used will form a polymer-specific coating in the composition, so that it is applied externally. The use of characters feels bad and inappropriate. Compounds are used in groups. Polysaccharide _ is the same as that shown in the item of thickening polysaccharides in the myosinates. Among the third form of the present invention, hydroxyethyl is particularly good; skin with these ingredients In terms of ductility and irregularities, the viscosity-increasing bran is 6% by weight, and the percentage is 0 !. The group of saccharides for external use in the third aspect of the present invention means that it can be generally used in the composition for all the thickening polysaccharides except for the external xyloglucan of the second aspect of the present invention. The xanthan gum and the xanthan gum are used as the Zengsu polysaccharide. The third aspect of the present invention is an external composition. In the third aspect of the present invention, the combined amount for external use is preferably 0.01% by weight or less of the total weight of the external composition.

544315 V. Description of the invention (19) In the external application composition of the third form of the present invention, the total weight of the external application composition is 0.01% by weight. If the composition in the affinity sample exceeds 5.0% by weight, it is not suitable to increase the amount of dryness, so it is not suitable; the same film produces a sticky feeling, so the sugar itself is not formed on the skin. The mucopolysaccharides can be used in a single external composition, or can be appropriately combined and mixed in the third aspect and third aspect external composition of the present invention. The above is combined with the third aspect of the present invention, the third aspect of the present invention, the external combination of polysaccharides, the weight ratio, 'the above xyloglucan and sugar-enhancing = 1: 10 ~ 40: 1], and' [Xyloglucan: Tackifier is more commonly used in the third aspect of the present invention as an external combination 20: 1]. When the relative amount of dextran is excessive, it is high ^: medium, exceeding this mixing ratio and the tendency of wood problems, so it is not suitable; on the contrary: when there is a residual viscosity stability when placed, the external use composition will not feel more thick The amount of sugar is too high. It has a strong tendency, so it cannot be combined with the sericin 'acid, aspartic acid, and amino acid in the compound contained in the silk that is discharged from the silk gland when the cocoon is made from silkworm outside the third form of the present invention, and Ingredients that are rich in serine proteins. Hydrophilic products such as glycine, alanine, etc. are, for example, sericin produced by Thetafam (Switzerland). In the third form of the present invention, the external composition φ θ is equal to the total weight of the external composition 0 · 0 0 1 ~ 5. 〇weight |. 〇 π ^-inside!蕙%, and the weight is from 0 · 0 1 ~ 3 · 0

C: \ 1234 \ 54664.ptd page 25 544315

5. Description of the invention (20)% is Xingjiaojia. In the external composition of the third aspect of the present invention, if the above-mentioned blending amount is less than 0.001% by weight of the external composition, the edge-protection effect, excellent affinity and no It is not suitable to have a sticky feeling, so it is not suitable. Similarly, if it exceeds 5.0% by weight, the sericin used will form a coating on the skin and produce a sticky feeling, so it is also not suitable. Therefore, it provides a good moisturizing effect and good skin affinity: = the external application group of the third aspect of the present invention that produces stickiness and has a refreshing use feeling; in the external application composition of the third aspect of the present invention, in addition to the above Basic coordination i: need for Xizhongbu: When the addition is usually added to the external use group (this is not a knife without compromising the desired effect of the present invention (the other ingredients can be combined alone or in two kinds) The combination of the above is the combination) 〇 And: t can 石 Shinong hydrogen compounds, oils, waxes, silicones, circles Sun, alcohols, higher fatty acids, humectants (add points The polysaccharide is suitably blended in the second form of the external composition of the present invention with purified water, etc. Oral # + 义 月 Further, amino acids, organic acids such as nicotinic acid, vinegar, and r-glutamicin 'Allantoic sounds, vitamins,' nicotinamide, allantoin, glycyrrhizic acid (salt), glycyrrhetic acid, and, ah bio, all kinds of plants and animals), hinokitiol, bisabolol, eucalyptus Cinnamomum oleifera extract = silk knee protein in addition to alcohol, weight, ubiquitinyl ethyl 0, thyme age, muscle g Estradiol, tranexamic acid, arbutin

C: \ 1234 \ 54664.ptd Page 26 544315 V. Description of the invention ii) The third form of the glycosides and bellowsin D. The composition other than the first composition of the present invention "). Goodness of topical composition. As The right one is that the extracting agent is mixed in a large amount in the composition. Therefore, by using a cylinder composition, the composition is drilled. However, the composition is good in use and the salt can be used as an object. In addition to the external use group, and the completion of the present invention to make the polymer compound, the external use group generates a carboxyethyl group that can increase the dimensions of the carboxyethyl group, but due to the combination, the compound is used. Feeling the composition of the composition for external use and polymerizing it with the sensory nature. Holding the external use to polymerize its alkenyl group. In addition to the general carboxyethyl group, the wood starch used for a long time is not only salt-resistant, but also compared to the composition. Various agents, such as Yuekoufeng extract, are appropriately blended in the external composition of the present invention. Form 4 complaints: the combination of xyloglucan and carboxyvinyl polymer (hereinafter also referred to as "the fourth form of the present invention for external use. ^ Important factors, including stability and the use of mouthfeel, of course It is necessary to satisfy these two stability as much as possible, although this problem can be roughly solved, but this kind of problem. The use feeling of water-soluble polymer compositions such as polymers is qualitatively improved. Although the composition for external use is a salt-tolerant combination of dilute polymer The problem of qualitative properties of the compound in combination with Chitosan. Excellent glycan and carboxyvinyl polymerizability, long-term use of xyloglucan and only significant improvement, due to the interfacial activity of the external combination, it can also promptly make sure Poor properties make the alkenyl polymer group well formulated. This promotes the combination of the xyloglucan in the external composition of the fourth aspect of the present invention.

544315 V. Description of the invention (22) The amount is 0. 0-5 to 10. 0% by weight based on the total weight of the external composition, and 0.1 to 4.0% by weight is preferred. In the fourth external composition of the present invention, if the compounding amount of the xyloglucan is less than 0.5% by weight of the total weight of the external composition, the external composition of the carboxyvinyl polymer is compounded. The desired effect of improving salt resistance and remarkably improving the feeling of use is hard to exert, so it is not suitable; similarly, if it exceeds 10 · 0% by weight, a polymer-specific coating is formed in the composition, which makes the feeling of use Deterioration 'is therefore inappropriate. In the composition for external use according to the fourth aspect of the present invention, the carboxyvinyl polymer 'co-blended with the xyloglucan is an acid polymer mainly composed of an acrylic polymer, and is also commercially available. Specifically, for example, Hebiswaco-1 03, 104, 105 (manufactured by Heguang Pure Pharmaceutical Industry Co., Ltd.), Carbopol® (manufactured by BF Guliqi), Aqupec Series (manufactured by Sumitomo Chemical Co., Ltd.), Chunron PW series (manufactured by Japan Pure Pharmaceutical Co., Ltd.), etc. Furthermore, in the external composition of the fourth aspect of the present invention, a salt of a carboxyethylene polymer may also be blended (in the external composition of the fourth aspect of the present invention, such a salt of an ethylene polymer Category is also included in the concept of "complete vinyl polymer"), for example, you can use commercially available ONE-XIX ECT-203 (Ethylene-based polymer Ma Shushu; manufactured by Yueben Oil Company) In the external composition of the fourth aspect of the invention, the mixing ratio of the xyloglucan and the carboxyvinyl polymer is specifically selected according to the dosage form of the selected external composition, and the approximate weight ratio is, Between wood

C: \ 1234 \ 54664. Ptd page 28 544315 V. Description of the invention (24) The salt tolerance of the composition tends to be worse. The external composition in the fourth aspect of the present invention, of course, does not incorporate such a large number of vinyl polymers, and is a combination of xyloglucan and carboxyvinyl polymers that do not form that complex in the composition. The composition is a combination of a composition for external use having both excellent use feeling and salt resistance. In the external application composition of the fourth aspect of the present invention, in addition to the above-mentioned basic compounding into a knife, other components usually added to the external composition can be appropriately added as required, but it is not limited to the desired effect of the present invention. (These other ingredients can be mixed alone or in a combination of two or more). Mouth ° For example, hydrocarbons, oils, waxes, silicones, surfactants, higher alcohols, higher fatty acids, humectants, lower grades, oxidation inhibitors, UV protection agents, antibacterial agents , Neutralizing agent, f perfume, purified water, etc. in combination with the fourth aspect of the present invention ^ The composition can further amino acids, organic acids, vitamins, nicotinic acid seven purposes, r-oryzanol, allantoin, Glycyrrhizic acid (salt), Lin ^,: its derivatives, various extracts derived from animals and plants (Siyiyiwai), Japanese paclitaxel, bisabolol, press off the brain net, white except alcohol, soap grass Glycosides, ubiquinyl ethyl hydrazone, 7CD, glucosinolate, inosine, bellowsin, placenta extract, and other alcohols, tranexamic acid, and ursula four-form external composition are used in the composition of the present invention. The second one is to "give the surfactant g to people * ..." in order not to detract from the shape = the effect of the combination of external use on the moon, you need to carefully adjust

C: \ 1234 \ 54664. Ptd page 30 544315 S 'invention description. The fifth aspect of the invention: xyloglucan properties: J topical composition 'made to impart appropriate moisturization to the skin [/ t part by weight, means of chemical chemistry to promote emulsification and dissolution. The composition for external use has always been active. In recent years, due to concerns about safety and environmental pollution, the amount of such agents / sex agents in external compositions has been reduced. From this point of view, instead of using ordinary surfactants, the alkyl modified carboxyvinyl polymer can be blended into the outer compound by milk method and dissolution method. Technology for obtaining stable compound for external use. However, this kind of compound has the disadvantages of poor affinity in the use of the group-modified modified vinyl polymer, and it is not good for salinity. Furthermore, the emulsification method and dissolution method are not suitable for compounding. Since there are compositions for external use of salts, it has been criticized in this regard. The present inventors have found that a composition for external use in which the above-mentioned xyloglucan and an alkyl-modified carboxyvinyl polymer are combined has excellent use feeling and high salinity. In addition, the use of the "finely blended stilbene derivative" improves the use feeling. In the fifth aspect of the external composition of the present invention, the xyloglucan is blended in an amount of 0.05 to 10% of the total weight of the external composition, and is preferably 0.1 to 4.0% by weight.

C: \ 1234 \ 54664. Ptd page 31 544315 V. Description of the invention (26) Man, in the fifth form of the external composition of the present invention, if the amount of the xyloglucan is less than the total weight of the external composition 〇. 5% by weight, the effect of improving the feeling of use and salt resistance expected of the composition for external use is hardly exhibited. Therefore, if it exceeds 1% by weight, the composition It is not suitable to form a polymer-specific coating in the middle, which makes the use feeling worse. In the external composition of the fifth aspect of the present invention, the alkyl modified carboxyvinyl polymer cooperating with the above-mentioned xyloglucan is a polymer mainly composed of acrylic acid and methacrylic acid dialkyl copolymers. There are also on sale. Specific examples include CARBOPOL j 342, pEMULEN TR_J, PEMULEN TR-2 (manufactured by BF Coli and others). In the fifth aspect of the external composition of the present invention, the compounding amount of the alkyl-modified carboxyvinyl polymer is 0.05% by weight of the total weight of the external composition, and 0.05% by weight 5.0 weight ° / ◦ is preferred. In the external composition of the fifth aspect of the present invention, if the compounding amount of the alkyl-modified carboxyvinyl polymer is less than 0. 〇 丨 weight / ^ of the total weight of the external composition, emulsification will be difficult; similarly If it exceeds i 〇. ％ by weight, the effect of improving the emulsifying effect and emulsifying stability cannot be expected due to an increase in the blending amount. In the fifth aspect external composition of the present invention, the mixing ratio of the xyloglucan and the alkyl-modified carboxyvinyl polymer is specifically selected according to the dosage form of the composition for external use The approximate weight ratio is between 1 part of xyloglucan and 20 parts of alkyl modified carboxyvinyl polymer to 40 parts of xyloglucan and modified alkyl carboxyvinyl polymer. In this

Page 32 C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (27) In the fifth form of the external composition on day t, if the ratio deviates from this ratio, the amount of alkyl benzyl vinyl polymer is relatively large. For a long time, it is expected that the effect of the external use combination 2 to improve the use feeling and the salt tolerance will be difficult to produce. It is not appropriate. If the amount of xyloglucan is relatively large, it will be 1. Do not form a polymer-specific coating, which makes the use feeling worse, so it is not suitable. In the fifth aspect of the external composition of the present invention, these compounding ingredients are preferred. Calculating the reset ratio, it is between 1 part of xyloglucan and 5 parts of modified m-based substance to xyloglucan. Between 20 parts of polysaccharide and 1 part of p-alkyl modified carboxyethylene polymer. Human: Therefore 6 The above-mentioned xyloglucan and alkyl-modified carboxyvinyl group are polymerized in an external composition, and the existence of a few vinyl compounds modified by a calcined group can be transmitted for external use. 4 1 ^ ^ Β ^ ^ ,,, And σ have poor affinity for use, which improves payment feeling and improves salt tolerance. In addition, in JP-A-9-70264, the hybrid sister-student tester-glucan complex is combined and i: external and special ... In the case of use with a combination of membranes, it is necessary to improve the feeling of the film. And with the present ^, if combined with alkyl modified carboxyvinyl polycharacter, ^ ,, and. The same xyloglucan complex mentioned above, due to the existence of a very high viscosity "residual polymer", however, in the case of such a large blend; in the case of a vinyl polymer based on hydrazine, the modified carboxyl group is strong. And the tendency of the mouth salt to deteriorate

544315 V. Description of the invention (2 8) The external composition of the fifth aspect of the present invention 'of course does not use a large amount of stilbene-modified carboxyvinyl polymer to compound it like that, and does not form that kind of compound in the composition The combination of xyloglucan and alkyl modified carboxyvinyl polymer is a composition for external use that has both excellent use feeling and salt resistance. In the external composition according to the fifth aspect of the present invention, in addition to the above-mentioned essential components, since the silicone derivative is added in combination, the hair feel can be improved. The silicone derivative that can be incorporated in the external composition of the fifth aspect of the present invention is not particularly limited, and it can be widely selected from silicone derivatives that are usually incorporated in external compositions. Specifically, for example, dimethyl polysiloxane, fluorene phenyl polysiloxane, high-polymer dimethyl polysiloxane, dimethyl siloxane, and methyl (polyethylene oxide) can be used. Polyether-modified silicones such as siloxane copolymers; cyclic stone sulphur oxides such as decyl ring five-stone oxalate, octadecyl ring four-stone oxidized benzene; highly polymerized difluorenyl oxalate · An amine-modified silicone such as a fluorenyl (aminopropyl) siloxane copolymer and the like can be used in combination with the external composition of the fifth aspect of the present invention. These silicone derivatives may be blended into the external composition of the fifth aspect of the present invention alone, or two or more of them may be appropriately combined and blended into the external composition of the fifth aspect of the present invention as necessary. In a fifth aspect of the external composition of the present invention, the compounding amount of the Shi Xi _ derivative is 0.01% to 10% by weight of the total weight of the external composition, and 0.05% to 5% by weight below Is better. In the external composition of the fifth aspect of the present invention,

C: \ 1234 \ 54664. Ptd page 34 544315 Five 'invention description (29) When the total weight of the external composition is 0.001% by weight, the usability of the external composition will be further improved if it is compounded. Difficult, it is not suitable; similarly, if it exceeds 10 · 0% by weight, the stability of the composition tends to cause a problem, so it is also not suitable. In the fifth aspect of the external composition of the present invention, the mixing ratio of the above-mentioned xyloglucan and lithone derivative is appropriately selected according to the dosage form of the external composition, and the approximate weight ratio is between that of xyloglucan 1 part of polysaccharide to 10 parts of silicone derivative 'to 20 parts of xyloglucan to 1 part of silicone derivative. When deviating from this ratio, if the amount of the silamidine derivative is relatively large, the stability of the topical composition Λ will cause problems; on the contrary, if the amount of xyloglucan is relatively large, it will form in the composition. The coating film peculiar to the polymer tends to strongly deteriorate the feeling of use of the composition for external use, and is therefore not suitable. Moreover, in the fifth aspect of the external composition of the present invention, the preferred mixing ratio of these compounding ingredients is calculated by weight ratio, ranging from 1 part of xyloglucan to 5 parts of silicone derivative to xyloglucan. Between 10 parts of i-silicone derivatives. In this way, the composition for external use containing the alkyl-modified carboxyvinyl polymer and xylulose polysaccharide can be significantly improved in use feeling due to the combined use of silicone derivatives. In the external composition of the fifth aspect of the present invention, in addition to the above-mentioned basic compounding ingredients, other ingredients usually compounded in the external composition can be appropriately blended as needed, but it is not limited to those that do not impair the desired effect of the present invention ( These other ingredients can be mixed alone or in a combination of two or more). For example, hydrocarbons, greases, waxes, surfactants, higher alcohols, higher fatty acids, humectants, lower alcohols, oxidation

544315 V. Description of the invention (30) Preventive agent, UV-green anti-stolen ^ Preparation of anti-inhibition, anti-shaking agent, neutralizing agent, pigment, perfume combination 7 'can be suitable in the external composition of the fifth form of the present invention It is composed of amino acids, organic acids, vitamins, nicotinamide, nicotinic acid, 7-oryzanol, allantoin, glycyrrhizic acid (salt), glycyrrhetic acid and its derivatives, and various kinds of plants and animals. The extracts (except sericin), hinokitiol, bisabolol, eucalyptol, thymol, inositol, saponin, pantothenate ethyl, ethinyl estradiol, tranexamic acid, ursin Various agents, such as bellowsin, placenta extract and the like are blended in the external composition of the fifth aspect of the present invention. In addition, when a surfactant is blended in the external composition of the fifth aspect of the present invention, in order not to reduce the desired effect of the present aspect, it is necessary to carefully adjust the composition of the external composition of the present invention in all the forms described above. There are no particular restrictions on the use, for example, aqueous solution, soluble system, emulsified system, powder dispersion system, water-oil two-layer system, water-oil to powder three-layer system, and the like. All the present invention can be applied. In addition, its uses also cover most types of cosmetics, such as basic cosmetics such as lotions, lotions, creams, powders, powders, foundations and other external makeup compositions, shampoos, conditioners, and hair dyes. Products, special cosmetics, such as sunscreen cosmetics, ^ ointments and other related pharmaceutical products, and foreign medicine products. & ‘i soft example but the present invention is limited. In addition, the following examples are given to explain the present invention in more detail. The technical scope is not based on the scope that these examples can explain.

544315

Unless otherwise specified, the amount of the compounding amount shown in Example K means the weight percentage of the total weight of the composition. A. Related Example of the First Aspect of the Present Invention First, before presenting various examples, the evaluation method used for the external-use composition of the present invention will be described. 1 · Sensitivity test For each test article, 30 male and female (60 in total) reviewers are invited to judge the sense of use, and the number of reviewers who feel sticky use feeling is calculated. Usability of each test article. Evaluation Criteria ◎ · The number of people who feel greasy feels less than 5 people. • The number of people who feel greasy feel is less than 5 people and less than 10 people. Number of people 30 or more 2 · Stability test

′ The stability of its viscosity over time is determined based on the viscosity measured by a test product using a beta-type penetrometer (each test product is placed at 50 ° C at 50 ° C, and immediately after being left for 30 days after preparation). 3. Continuous test of UV protection effect = For each test product, place it immediately after preparation and then measure the SPF in the test tube. (To save under / dish), in particular, 'will be 2 pieces of Sheng cloth and then pasted with cloth (2.0 亳 Coupon / Feng Gu 88, evenly coated this sample see / thousand square centimeters), after 15 minutes at a distance (10 sets of semi-mysterious battles from a, illuminate the WHOM outside the tape. At this time,

544315 V. Description of the invention (3 2) In the range of 290 ~ 400 nm, every 2 times the measured value is multiplied by the coefficient of effect. In addition, the following test products include the "Ancient [Example A 1] Milk" manufactured by Pharmaceutical Co., Ltd. Paste (aqueous phase) (1) purified water (2) 1,3-butanediol (3) xyloglucan (oil 4 mesh) (4) octyl p-oxycinnamate (5) acetophenone ( 6) Thirty carbon burning (7) Vaseline (8) Rock stearyl alcohol (9) I fatty acid (1 0) glyceryl monostearate (11) polyethyl acrylate (1 2) oxidation inhibitor (1 3 ) Preservative (14) Spices were measured at 4 points on the tape. Calculate the SPF value in the test tube. For Seki-dextran, Roy Bean 6 C made by Daiichimoto was used. Mixing amount (% by weight) Residual amount 5. 0 2.0 5. 0 2. 0 10. 0 5. 0 3. 0 3. 0 3. 0 1. 0 Right amount Right amount Right amount

Page 38 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (33) [Example A2] Cream blending amount (% by weight) (water phase) (1) Refined water residue (2) 1,3-D Diol 5.0 (3) Xyloglucan 2.0 (4) 2-Hydroxy-4-methoxybenzophenone-keto-5-sulfonate 5.0 (oil phase.) (5) Menthyl benzophenone 2.0 (6 ) Tricosane 10.0 (7) Vaseline 5.0 (8) Stearyl alcohol 3.0 (9) Stearyl acid 3.0 (1 0) Glyceryl monostearate 3.0 (11) Polyethyl acrylate 1.0 (1 2 ) Proportion of oxidation inhibitor (1 3) Proportion of preservative (1 4) Proportion of perfume [Example A3] Cream (aqueous phase) (1) Refined water blending amount (% by weight) Residual amount

C: \ 1234 \ 54664. Ptd page 39 544315 V. Description of the invention (34) (2) 1,3-butanediol 5. (3) Xyloglucan 2. (4) 2 —hydroxy-4- ( 2- / 5-pyranose-glucosylsilyloxy) propoxybenzophenone 5. (Oceanyl) (5) Acetyl ketone 2 (6) Eicosane 10 (7) Vaseline 5 (8 ) Stearyl alcohol 3 (9) Stearic acid 3 (1 0) Glyceryl monostearate 3 (11) Polyethyl acrylate 1 (1 2) Antioxidant amount (1 3) Preservative amount (14) Flavor Appropriate amount [Example A4] Cream blending amount (% by weight) Residual amount 5.0 0 2. 0 (aqueous phase) (1) purified water (2) 1,3-butanediol (3) xyloglucan (4) 2-Hydroxy-4- (2-cold-pyranoglucosilyloxy) propoxybenzophenone 5.

Page 40C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (3 5) (5) Dioxide — 5.0 (g / g) (6) Acetyl ketone 2.0 (7) tridecane 10.0 (8 ) Vaseline 5.0 (9) stearyl alcohol 3.0 (1 0) stearic acid 3.0 (11) glyceryl monostearate 3.0 (12) polyethyl acrylate 1.0 (1 3) antioxidant amount (1 4 ) Amount of preservative (1 5) Amount of perfume [Comparative Example A1] Cream (aqueous phase) (1) Purified water (2) 1,3-butanediol (3) Diethylene glycol polymer (4) Triethanolamine (5) octyl p-methoxycinnamate (oil-eye mesh) (6) blending amount (wt%) of triphenylalkanoyl (7) tridecane residue 5.0 0 0. 1 1. 0 5. 0 2.0 10 . 0

C: \ 1234 \ 54664. Ptd Page 41 544315 V. Description of the invention (36) (8) Vaseline 5.0 (9) Stearyl alcohol 3.0 (1 0) Stearic acid 3.0 (11) Glyceryl monostearate 3.0 ( 12) Polyethyl acrylate 1.0 (1 3) Antioxidant amount (1 4) Preservative amount (1 5) Perfume amount [Comparison example A 2] Cream hydration (weight%) (water phase) (1) Residual water content (2) 1,3-butanediol 5.0 (3) 2-hydroxy-4-methoxybenzophenone-5-sulfonate 5.0 (4) Slow vinyl polymer 0.1 (5) Triethanolamine 1.0 (oil-eye) (6) Hydroxybenzone 2.0 (7) Heicosane 10.0 (8) Vaseline 5.0 (9) Stearyl alcohol 3.0 (1 0) Stearic acid 3.0

C: \ 1234 \ 54664.ptd Page 42 544315 V. Description of the invention (37) (1 1) Glyceryl monostearate 3.0 (1 2) Polyethyl acrylate 1.0 (1 3) Antioxidant amount (1 4 ) Appropriate amount of preservative (1 5) Appropriate amount of fragrance [Comparative Example A3] Cream blending amount (% by weight) (aqueous phase) (1) Residual water content (2) 1,3-butanediol 5.0 (3) 2 — Hydroxy-4- (2-/ 3-pyranoglucosilyloxy) propoxybenzophenone 5.0

(4) retarded vinyl polymer (5) triethanolamine (oleic acid) (6) hydroxybenzophenone (7) tricosane (8) petrolatum (9) petrolatum alcohol (1 0) stearic acid ( 11) glyceryl monostearate (1 2) polyethylene acrylate (1 3) oxidation inhibitor

C: \ 1234 \ 54664. Ptd Page 43 544315 V. Description of the invention (38) (1 4) Preservative amount (1 5) Perfume amount [Comparative Example A4] Cream / Amount (aqueous phase) (1) Refined water residue (2) 1,3-butanediol 5. 0 (3) 2 —Hydroxy-4- (2 -zhao-pyranoglucosilyloxy) propoxybenzophenone 5.0 0 ( 4) Titanium dioxide (5) Slow vinyl polymer (6) Triethanolamine (oil), (7) Passive benzophenone (8) Thirty carbon burn (9) Shihlin (1 0) Stearyl alcohol (11) Stearic acid (1 2) glyceryl monostearate (13) polyethylene acrylate (1 4) oxidation inhibitor (1 5) preservative 5. 0 · 1. 10 3. 0 1. 0

C: \ 1234 \ 54664. Ptd Page 44 544315 V. Description of the invention (39) (1 6) Proper amount of spices < Preparation method> The cream of the above examples A 1 to A 4 and comparative examples A 1 to A 4, any one The components of the water phase part and the oil phase part are each heated and dissolved at 70 ° C, the oil phase part is added to the water phase part and emulsified with a homogenizer, and then the emulsified product is cooled by a heat exchanger to complete the manufacture. The creams of these examples and comparative examples manufactured in this way were subjected to the above-mentioned use sensitivity test, viscosity stability test, and continuous test of ultraviolet shielding effect, and the results were judged individually. The results are shown in the following table A1 (use sensitivity test), table A2 (decay stability test), and table A3 (continuous test of ultraviolet shielding effect). Table A1

In this case, it is obvious that in the case where xyloglucan is combined with the xyloglucan = example, the second item of the present invention, examples and comparisons "Π: ϊ" has a better feeling of use. For the line absorber, the combination of Xiao and other types = ultraviolet absorption is used as the ultraviolet. It is obvious that the test phase of the external phase absorbent is used.

C: \ 1234 \ 54664.ptd Page 45 544315 V. Description of the invention (40) Table A2 item breeding case A1 night case A2 fence case A3 breeding case A4 immediately 2300cps 2200cps 3510cps 3450cps 30 Example A1 Comparative example A2 a: Comparative example as Comparative example A4 Immediately 2000cps 1900cps 2100cps 2200cps 30days later 1500cps 1600cps 1800cps 2000cps 甴 This result, it can be clearly determined that in each example with xyloglucan and ultraviolet absorber The composition for external use according to the first aspect of the present invention has better stability over time in viscosity than the test product in the comparative example without the addition of xyloglucan. In addition, when the sugar-based ultraviolet absorber and xyloglucan (Example A3 and Example A4) were blended, the viscosity was obviously increased compared with other test products. Table A3

Item A1 Case A1 Case A2 Case A3 Case A4 Immediate 12.1 11.3 11.5 14.3 After 30 days 10.2 9.9 10.1 13.9 Item Large Comparative Example A1 Comparative Example A2 Comparative Example A3 Comparative Example A4 Richter 11.5 1LO 10.9 13.8 After 30 days 9.8 8.9 8.5 10.9 Page 46 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention <41> From this result, the report clearly shows that in each of the examples of the absorbent, J is determined to be mixed with xyloglucan and ultraviolet without the wood. The comparison of dextran shows that the external composition of the first form is more durable than the external defense effect. Among the test products, there are relatively good purple shots! Species in the group are equipped with sugar-based ultraviolet absorbers, spot UV radiation, and Λ θ θ ', which confirms that the existence of these sugar-based ultraviolet absorption ^ increases consumption, As a result, the dispersion stability of the ultraviolet scattering agent is improved upward (refer to the above table 42). Hereinafter, examples of various dosage forms of the external composition of the first aspect of the present invention will be described. Moreover, regarding these examples of the external composition of the first aspect of the present invention, all of the first aspect of the present invention are in terms of Φ usability, ® stability over time, and ③ UV protection effect during the above test. The compositions for external use were significantly better than the comparative examples in which xyloglucan was removed. [Example A 5] Compounding amount of washing solution (% by weight) Residual amount 5.0 0 0.1 10. 0 10. 0 16. 0 3.0 (1) purified water (2) dipropylene glycol (3) xyloglucan (4) 1 , 3-Butanediol (5) Polyethylene glycol 40 0 (6) Ethanol (7) POE (60) Hardened E sesame oil (8) 2-Hydroxy-4-methoxydiphenylhydrazone

C: \ 1234 \ 54664.ptd

544315

&lt; Manufacturing method> Appropriate amount The other two (6 °) hardened E pocktails ... the material is dissolved (alcohol phase). On the other hand, other alcohols, wood and glucose are mixed in the purified water, and the% phase). j-methoxybenzophenone-5-sulfonate is added fully, hexa and 2 ~ hydroxy groups are added to this aqueous phase, fully stirred, and cooled (aqueous phase). Will be liquid. Can get the desired washing [Example A 6] Lipstick (1) Titanium dioxide (2) Red 2 No. 01 (3) Red 2G2 (4) Red 2 2 3 (5) Earth wax (6) Candelilla wax ( 7) Carnauba wax (8) ramie oil (9) diglyceryl isostearate (10) POE (25) POP (20) 2-tetradecyl ether (11) purified water (1 2) glycerol (13 ) The amount of xyloglucan (weight 05 30 37 95 0 residual amount 2. 0 〇 · 5

C: \ 1234 \ 54664.ptd Page 48 544315 V. Description of the invention (43) ι · ο 2 · Ο Appropriate amount (1 4) Propylene glycol (15) 2 -Hydroxy-4-benzophenone (1 6) Antioxidant (1ΌSpices <manufacturing method> Add titanium monoxide, red No. 21 and red No. 202 to Kun Mazi, and then use a roller (pigment part) to process it. Then, Dissolve Red No. 22 ^ in the remaining ramie seed oil (dye part). Furthermore, dissolve the purified water, sugar, propylene glycol, and xyloglucan at 80 (water phase). Mix and heat the other ingredients After dissolving, the pigment part and dye part are added, and they are uniformly dispersed in the homogenizer. After dispersing, the aqueous phase is added and emulsified and dispersed in the homogenizer. The shape of the lipstick is as expected. [Example A 7] The amount of powder foundation (% by weight) 20. 3 33. 0 5. 0 10. 0 1. 0 1. 0 2 · 0 3. 0 (1) Talc powder (2) Mica (3) Surface ridge clay (4) Titanium dioxide (5) Mica titanium (6) Zinc stearate (7) Xyloglucan (8) Yellow iron oxide

C: \ 1234 \ 54664.ptd Page 49 544315 V. Description of the invention (44) (9) Black iron oxide 0.2 (10) Nylon powder 10. 0 (11) Heicosane 6. 0 (12) Acetic acid Wool month purpose 1. 0 (13) Nutmegyl octyl dodecyl ester 2.0 (14) neopentyl glycol diisocaprylate 2. 0 (15) sorbitan monooleate 0.5 (16) ) Isopropyl cinnamate acetic acid 2.0 0 (17) Antioxidant agent suitable for sterilization (18) Perfume &Preparation; talc powder, yellow acid iron and black acid iron are mixed in a blender. Add the remaining powder to this mixture. After mixing, add the binding agent and preservative. After toning, add the fragrance by spraying and mix well. This homogeneous mixture is pulverized by a pulverizer, sieved, and compressed into a mold to obtain a desired powdery foundation. [Example A 8] Emulsified foundation blending amount (% by weight) (powder)

(1) Talc powder (2) Titanium dioxide (3), red iron oxide (4) yellow iron oxide

Page 50 C: \ 1234 \ 54664. Ptd 544315

V. Description of the invention (45) (5) Black iron oxide (water phase) 0.1 (6) Polystearic acid sorbitan monostearate 0.9 (7) Triethanolamine 1.0 (8) Propylene glycol 5. 0 (9) refined water 46.4 (1 0) xyloglucan (11) 2 -hydroxy-4- (2- / 3-[I pyran type grape 1.0 sugar sugar silyloxy) propoxy diphenyl Methyl ketone 10. 0 (oil g) (1 2) stearic acid 2.2 (13) isohexadecanol 7. 0 (1 4) glyceryl monostearate 2.0 (1 5) liquid Lanolin 2.0 (1 6) Flow paraffin 8.0 (17) Preservative amount (18) Proportion amount <Preparation method> Propylene glycol in which xyloglucan is dispersed is added to purified water, and the remaining amount is processed by a homomixer at 70t. Add the water phase ingredients and stir well (water phase part). The pulverized powder portion was thoroughly mixed, added to the aqueous phase while stirring, and treated at 70 ° C by a homomixer. After heating and dissolving at 70 ~ 80 ° C, the oil phase is added to the material of this homomixer, and then the homomixer is processed at 70 ° C. Stir this equivalence Page 51 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (46) While cooling, when it reaches 4 5. (At a temperature of 3, add the fragrance, continue to cool to the level of "Lihou" sleeve gas and fill it in the container to obtain the desired emulsified foundation. B. Related examples of the second aspect of the present invention First, everywhere Before the examples are shown, the evaluation method used for the external composition of the present invention will be described. I. Sensitivity test For each test product, 30 male and female reviewers (60 in total) are invited to judge the feeling of use and calculate the feeling of occurrence. The number of sticky feelers was judged based on the following criteria. The evaluation criteria ◎: The number of people who felt sticky was less than 5 people 0: The number of people who felt sticky was 5 or more and less than 10 people Δ •• Number of people who feel sticky 10 or more and less than 30 people X: Number of people who feel greasy or more than 30 people Stability test Each test article is placed at 50 ° C, and its viscosity is stable over time. The product was left to stand for 30 days, and it was judged by the viscosity (25 ° C) measured by a b-type dryness meter. Furthermore, in the following test products, Dainippon was used for xyloglucan. "Guluro Izu 6C" manufactured by Pharmaceutical Co., Ltd. The lotions shown in the following examples B 1 to B 5 and comparative example β 1 are prepared according to the conventional method, and these test products are used as described above. Sensitivity test and viscosity stability test.

544315 V. Description of the invention (47) The results are shown in Table B 1 below. [Example B 1] Compounding amount of washing liquid (% by weight) (oil oil s) (1) cetyl alcohol (2) beeswax (3) petroleum jelly (4) tricarbonate (5) difluorenyl polysiloxane (Aqueous phase) (6) Glycerin (7) 1,3-Butanediol (8) POE (20) Oleol ether (9) Xyloglucan (1 0) Locust bean gum (1 1) Preservative (1 2) Colorant (1 3) Fragrance (14) Refined water [Example B2] Washing liquid 0.5 2. 0 6. 0 2. 0 4. 0 4. 0 0. 5 2. 0 0. 1 Right amount Right amount Mixing amount (% by weight) (youcai a)

C: \ 1234 \ 54664. Ptd Page 53 544315 V. Description of the invention (48) (1) Cetyl alcohol 1.0 (2) Beeswax 0.5 (3) Vaseline 2.0 (4) Triacontane 6.0 (5) Dioxin Polysiloxane 2.0 (water phase) (6) glycerol 4.0 (7) 1,3-butanediol 4.0 (8) POE (20) oleyl ether 0.5 (9) xyloglucan 2.0 (1 0) Robinia pseudoacacia Bean gum 0.5 (11) Preservative amount (12) Colorant amount (1 3) Perfume amount (14) Refined water residue [Example B3] Washing compounding amount (% by weight)

(1) Cetyl alcohol (2) Beeswax (3) Vaseline (4) Thirty carbon burner (5) Difluorinated polysiloxane

Page 54 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (49) (aqueous phase) (6) glycerol 4.0 (7) 1,3-butanediol 4.0 (8) sucrose fatty acid ester 0.5 (9) Xyloglucan 2.0 (1 0) Locust bean gum 0.5 (11) Preservative amount (1 2) Colorant amount (1 3) Flavor amount (1 4) Refined water residue [Example B 4] Washing liquid blending amount ( % By weight) (oil phase)

(1) Resin alcohol (2) Beeswax (3) Vaseline (4) Thirty carbon burn (5) Difluorinated polysiloxane (aqueous phase) (6) Glycerin (7) 1,3-butanediol 4.0 · (8) Acrylic acid / alkyl acrylate copolymer 1.0 (9) Xyloglucan 2.0

Page 55 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (50) (1 0) Locust bean gum (11) Preservative (1 2) Colorant (13) Perfume (1 4) Refined water [Example B 5] lotion (oil phase) (1) residual wax alcohol (2) beeswax (3) Shihlin (4) sesquidecane (5) difluorenyl polysiloxane (water phase) (6) glycerol ( 7) 1,3-butanediol (8) acrylic acid methacrylic acid (9) xyloglucan (1 0) locust bean gum (11) preservative (1 2) colorant (13) perfume (14) refined Water 0.1, appropriate amount, appropriate amount, residual amount (% by weight)

Burned ester copolymer 1. ◦ 2.0 0. 5 Right amount Right amount Right amount Residual amount

C: \ 1234 \ 54664. Ptd Page 56 544315 V. Explanation of the invention (51) [Comparative Example B1] Washing compounding amount (% by weight) (oil phase) (1) Resin alcohol 1. · (2) beeswax 0 · 5 (3) Vaseline 2.0 (4) Heicosane 6.0 0 (5) Dimethicone 2.0 (water phase) (6) Glycerin 4.0 (7) 1,3-butanediol 4.0 ( 8) Acrylic acid alkyl methacrylate copolymer 1.0 (9) Xyloglucan 2.0 (1 0) Preservative amount (11) Colorant amount (1 2) Perfume amount (1 3) Refined water residue

Table B1 makes the ffl waste viscosity (cps) immediately after 30 days. Case B1 ◎ 25000 23600 Case B2 ◎ 92300 91200 Page 57 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (52) Example B3 ◎ 113000 109000 Example B4 〇20800 17900 Example B5 ◎ 84600 68000 Comparison plan B1 Δ 2100 510 Based on this result, it can be judged that the composition for external use combined with xyloglucan and tackifier polysaccharides has stability in use and viscosity stability over time. They are all excellent. Furthermore, examples B1 and B2 (the surfactant contains POE (20) oleyl ether) were copolymerized with examples B4 and B5 (containing acrylic acid / methacrylic acid sulfanyl group instead of POE (20) oleyl ether) Compared with the combination, it can be seen that due to the combination of surfactants, the stability over time at high temperature is more improved. In addition, it can be seen that by blending a sugar-based surfactant such as Example B3, the viscosity stability is further increased. Hereinafter, examples of various dosage forms of the external composition of the second aspect of the present invention will be described. In addition, the external use composition of the second aspect of the present invention according to any one of the examples has a "◎" in the above reference, and the stability of the viscosity over time at high temperature is also significantly higher than that of removing the thickening polysaccharide and replacing it with water. Comparative example is excellent 0 [Example B6] Cream blending amount (% by weight)

Page 58 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (53) (1) Cetyl alcohol 5.0 (2) Stearic acid 3.0 (3) Vaseline 5, 0 (4) Thirty carbon 1 0 (5) tris- (2-ethylhexanoic acid) glycerol siege 7.0 (6) dipropylene glycol 5.0 (7) glycerin 5.0 (8) propylene glycol monostearate 1.5 ( 9) POE (20) cetyl ether 1.5 (10) triethanolamine 1.0 (11) xyloglucan 1.0 (1 2) hydroxyethylcellulose 0.5 (1 3) preservative amount ( 1 4) An appropriate amount of oxidation inhibitor (15) An appropriate amount of fragrance (1 6) Residual water content &lt; Preparation method &gt; The humectant and test ingredients are added to the purified water and adjusted at 70 ° C (aqueous phase). After heating and dissolving the oily ingredients, add a surfactant, anti-corrosive agent, oxidation inhibitor, and fragrance, and adjust at 70 ° C. It was added to the previous aqueous phase for preliminary emulsification. The emulsified particles of this preliminary emulsion are uniformly mixed in a homomixer, and then degassed, filtered, and cooled to obtain the desired cream.

C: \ 1234 \ 54664. Ptd page 59 544315 V. Description of the invention (54) [Example B7] Emulsion blending amount (% by weight)

Appropriate amount Appropriate amount (1) Yukonol (2) Beeswax (3) Vaseline (4) Hexadecane (5) Difluorenyl polyisostiloxane (6) Ethanol (7) Glycerin (8) 1 , 3-butanediol (9) POE (10) monooleate (1 0) glyceryl monostearate (11) xyloglucan (1 2) xanthan gum (1 3) preservative (1 4 ) Colorant (15) Fragrance (1 6) Purified water <manufacturing method> Add a humectant and a coloring agent to the purified water, and adjust at 70 ° C (aqueous phase). Then add the surfactant and preservative to the oily ingredients and adjust by heating at 70 ° C. It is added to the previous aqueous phase for preliminary emulsification. Xyloglucan and ethanol are added to this pre-emulsion, and the emulsified particles are uniformly mixed in a homomixer, and then degassed, filtered, and cooled to obtain the desired milk.

Page 60 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (55) Liquid 0 [Example B8] Foundation Mixing amount (% by weight)

(1) Talc powder (2) Titanium dioxide (3) Red iron oxide (4) Yellow iron oxide (5) Black iron oxide (6) Polyethylene oxide sorbitan monostearate (7) Triethanolamine (8) Propylene glycol (9) Glycol (10) Xyloglucan (11) Stearic acid (12) Isohexadecyl alcohol (1 3) Glyceryl monostearate (1 4) Liquid wool month purpose (1 5) Flowable Shikan (1 6) Preservative amount (17) Flavor amount (1 8) Refined water 60.9 <Method> Add propylene glycol in which xyloglucan is dispersed to purified water and perform at 70 ° C

Page 61 C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (56) Propylene glycol in which xyloglucan is dispersed is added to purified water, and the remaining water phase is processed by a homomixer at 70 ° C. Add ingredients and stir well. The pulverized powder portion was thoroughly mixed, added to this portion while stirring, and processed at 70 ° C by a homomixer. Cool this while stirring. When the temperature reaches 45 ° C, add the spices. Finally, aspirate and fill the container to obtain the desired foundation. [Example B9] Amount of acidic hair dye (% by weight) (1) Acid dye 1.0 (2) Alcohol 6.0 (3) Isopropanol 20.0 (4) Citric acid 0.3 (5) Xyloglucan 2.0 (6) Robinia pseudoacacia Bean gum 2.0 (7) Refined water 68.7 &lt; Method of preparation> The ingredients are uniformly stirred and mixed to obtain the desired acidic hair dye. Furthermore, xyloglucan and locust bean gum were dispersed in alcohol and added. [Example B 10] Lipstick (1) Titanium dioxide (2) Red_Color 201 Compounding amount (% by weight) 4. 5 0.5

Page 62 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (57) 〇 05. 0 4. 0 8.0 2 · 0 30. 〇37. 95 1. 0 Residual amount 2. 0 〇 · 5 1. 0 2 . 0 Right amount (4) Red No. 223 (5) Earth wax (6) Candel tree soil (7) Brazilian standard landfill (8) Hedge * seed oil (9) diglyceryl isostearate (1) POE (25) POP (20) 2 ~ tetradecyl ether (11) purified water (1 2) glycerol (13) xyloglucan (1 4) propylene glycol (15) tragacanth (1 6) oxidation Preventing agent (1 7) Fragrance <manufacturing method> f-Emulsification Chin, Red 2 (H and Red No. 202, plus parts, the portion is treated with a roller (pigment part). Furthermore, the oil is-the remaining quince Dissolve in the oil (dye part). Then, place 3 at: from '. Xyloglucan, Xihuang ¥ 璆, and propylene glycol at δ0. Dissolve: J Shui Gan, then mix the other ingredients, heat to dissolve, Add the pigment 4 points and the dye part, and disperse it in the homogenizer. Add the aforementioned water phase to this mash, emulsify and disperse it in the homogenizer, inject it into the model, quench it, and make it columnar. Expected lipstick.

544315 V. Description of the invention (58) [Example B11] Shampoo blending amount (% by weight) (1) Lauryl POE (3) Sodium sulfate (30% aqueous solution) 30.0 (2) Sodium lauryl sulfate ( 30% aqueous solution) 10.0 (3) coconut oil anti-acid diethanolamine 4.0 (4) glycerol 1 · 0 (5) xyloglucan 2.0 (6) light ethyl cellulose 0.5 (7) flavor amount ( 8) Appropriate amount of colorant (9) Appropriate amount of preservative (1 0) Appropriate amount of metal ion blocking agent, appropriate amount of pH adjuster (11) Residual water content <manufacturing method> Heat the purified water to 70 ° C, add other ingredients to it, uniform After dissolving and cooling, you can get the desired shampoo. [Example B12] The blending amount (% by weight) of moisturizer 3. 0 (1) Lithone oil (2) Flowing stone soil (3) Waxol (4) Stearyl alcohol 1.0 (5) Stearyl trimethyl Ammonium chloride 0.7

Page 64C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (59) (6) Glycerin 3.0 (7) Xyloglucan 1.0 (8) West tragacanth gum 0.1 (9) Spices Right amount (10) Right amount of colorant (11) Right amount of preservative (12) Residual water content &lt; Preparation method &gt; Xyloglucan, tragacanth gum, stearyltrimethylammonium chloride, glycerin and the like 'After adding the toner, add the other ingredients and add the * oil phase to the aforementioned, then cool the water while stirring, heat and keep it together, heat and dissolve, and dissolve it in the water phase to get the desired 7 (TC (water phase). Continue to be maintained at 70 ° C (oil phase). Emulsified in silky mixer & conditioner. [Example B13]-Body conditioner shampoo (1) panzozone salt beet Basic amphoteric interfacial activity 卞 (2) Nose oil fatty acid diethanolamine ^ Blending amount (weight 0 / 〇) 16.0 (3) Stearyltrimethylammonium chloride 4.0 (4) N -Lauryl-N-N -Amino group-stone w 1 Φ p alanine fine (5) stone ketone derivative &lt; sodium 2.0 1.0 (6) polyoxyethylene alkyl polyamine 1.0 1.0 (7) xyloglucan 1. 0 (8) Cassia gum 1. 5 0. 1

C: \ 1234 \ 54664. Ptd 苐 page 65 544315 V. Description of the invention (60) (9) Appropriate amount of fragrance (10) Appropriate amount of colorant (11) Appropriate amount of preservative (1 2) p Appropriate amount of adjuster (1 3) Refined water residue &lt; Preparation method &gt; Add xyloglucan, tragacanth gum, stearyltrimethylammonium chloride and amphoteric surfactant to purified water, heat to dissolve and keep at 70 ° C, and other Add the remaining ingredients, cool after dissolving, and you will get one of the desired body shampoos. C. A related example of the third aspect of the present invention First, before showing various examples, the evaluation method used for the external-use composition of the present invention will be described. 1 · Sensitivity test For each test product, 30 (60 in total) reviewers of both sexes were asked to perform a sensory test using sensory judgment. In other words, for each test product, the number of reviewers who felt skin affinity, sticky feel, and refreshing feel was counted, and judged based on the following criteria. μ Evaluation criteria for skin affinity ◎: Number of people who feel skin affinity 30 or more. Number of people who feel skin affinity 1 Q or more and less than 3 Q people Δ: Number of people who feel skin affinity 5 or more x: The number of people who feel skin affinity is less than 5

544315 V. Description of the invention (61) &quot;-Evaluation criteria for the use of thieves ◎: Number of people who feel non-sticky is more than 30 people 0: Number of people who feel non-sticky is more than 10 people and less than 30 people △ ·· Number of people who do not feel greasy 5 or more and less than 10 people x: Number of people who feel no greasy and less than 5 people have evaluation criteria for refreshing use ◎: Number of people with refreshing use are 3 or more 〇: There are refreshing use feelings Number of people 10 or more and less than 30 people △: Number of people with refreshing feelings 5 or more and less than 10 people x: Number of people with refreshing feelings less than 5 people 2 · Test of moisture evaporation based on moisture evaporation rate Measurement of moisture evaporation It can be used as a test to determine the moisturizing effect. — That is, after dropping 10 microliters of sample on a filter paper of 2.0 × 2.0 cm, the weight loss of the sample liquid per minute is calculated for ten minutes, and the average weight loss per minute is calculated. . Evaluation criteria of moisturizing effect ◎: Moisture evaporation rate is less than 0.5 micrograms per minute 〇: Moisture evaporation rate is 0.5 micrograms or more and less than 55 micrograms △: Moisture evaporation rate is 0.555 micrograms or more and less than 0.6 micrograms x : Moisture evaporation rate of 0.6 micrograms per minute or more First, the lotions formulated in the following Comparative Examples C1 to C6 (Table C1) and Examples C1 to C6 (Table C2) were prepared according to a conventional method.

C: \ 1234 \ 54664. Ptd P.67 544315 V. Description of the invention (62) Table C1 fit (% reset) Comparative example C1 C2 C3 C4 C5 C6 (1) Glycerin 10.0-----(2) 1,3-: Γ diol 4.0 4.0 4.0 4.0 4.0 4.0 (3) POE (2G) oleyl ether 0.5 0.5 0.5 0.5 0.5 0.5 ⑷7t \ dextran--2.0---(5) HydroxyZ-based cellulose- --2.0--(6) Xanthan Gum----2.0-Filament protein-----2.0 (8) Preservatives are suitable and suitable (9) Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appropriate Appreciation Coordination (reset%) Breeding example C1 C2 C3 C4 C5 C6 (1) 1, 3-: Γ glycol 4.0 4.0 4.0 4.0 4.0 4.0 (2) POE (2〇) oil alcohol boat 0.5 0.5 0.5 0.5 0.5 0.5 ( 3) Dextran 2.0 2.0 2.0 0.1 2.0 0.1 (4) Hydroxyethyl cellulose 1.0 1.0 0.1 2.0-0.1 (5) Xanthan knee 1.0 1.0--0.1 0.1 (6) Sericin 1.0 0.1 1.0 1.0 1.0 1.0 (7) Preservatives are suitable and appropriate. (8) Preservatives are suitable and appropriate. Suitable counter suitable counter means (9) purified water balance opposing counter residues residues lizard residues remaining amount counter is set for these residual test article using the above sensory analysis of sensation and moisturizing effect test. The results are shown in Table C3 (comparative example) and Table C4 (example). Page 69 C: \ 1234 \ 54664. Ptd 544315 V. Explanation of the invention (64) Table C3 Comparative Examples C1 C2 C3 C4 C5 C6 Make ffi feel muscles and grind affinity Δ Δ ◎ Δ Δ 〇 Sticky make leisure X Δ 〇〇Δ Δ Refreshing makes the sense of relaxation Δ △ ◎ 〇Δ 〇Moisturizing effect ◎ X 〇Δ Δ Δ Table C4 C1, C1, C2, C3, C4, C5, C6 Makes the leisure muscles close to each other ◎ ◎ ◎ ◎ ◎ ◎ Tired to make sense of leisure ◎ ◎ ◎ ◎ ◎ ◎ Wei Shuang makes S feel 黉 ◎ ◎ ◎ ◎ ◎ Moisturizing effect 捃 ◎ ◎ ◎ ◎ Page 70 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention ( 65) As shown in Tables C3 and C4, it is clear that due to the combination of xyloglucan, thickening polysaccharides and sericin, the synergistic effect of these ingredients is promoted, so long: for excellent moisturizing A composition for external use with excellent effect and excellent usability. Various dosage forms of the external composition according to the third aspect of the present invention are described in κ Example. In addition, the third and the same "use sensory test" of the present invention invite 7 objects' to perform and in any kind of test, the above-mentioned "Ping Erbao", "effect test" "Khan Khan" also Both are "◎" or "^ 4, [Example C7] Cream d ^ (I) Waxol (2) &gt; 5 More fatty acid (3) Vaseline (4) Eicosane (5) Di- ( 2-Ethylhexanoic acid) glyceride (6) Dipropylene glycol (7) Glycerin (8) Propylene glycol monostearate Purpose (9) POE (20) Cetyl alcohol_ (10) Triethanolamine (II) Wood glucose polymer Sugar (1 2) hydroxyethylcellulose (1 3) sericin compounding amount (weight 5.0 〇 量 0 / 〇10

C: \ 1234 \ 54664.ptd p. 71 544315

V. Description of the invention (66) (1 4) Appropriate amount of preservatives (1 5) Appropriate amount of oxidation inhibitors (1 6) Appropriate amount of fragrances (17) Refined water residue <Preparation method> Add humectant and alkaline ingredients to purified water, Adjust at 70 ° C (water phase). After heating and dissolving the oily ingredients, add a surfactant, preservative, oxidation inhibitor, and fragrance, and adjust at 70 ° C. It was added to the previous aqueous phase for preliminary emulsification. After uniformly mixing the emulsified particles of the preliminary emulsion in a homomixer, degassing, filtering, and cooling are performed to obtain the desired cream. [Example C8] Emulsion blending amount (% by weight) (1) Cetyl alcohol 1.0 (2) Beeswax 0.5 (3) Vaseline 2.0 0 (4) Thirty carbon burn 6. 0 (5) two 曱Polysiloxane 2.0 (6) Ethanol 5.0 (7) Glycerol 4.0 (8) 1,3-Butanediol 4.0 (9) POE (10) Monooleate 1.0 (1 0) Mono Glyceryl stearate 1.0 Page 72 C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (67) (11) Xyloglucan 2.0 (12) Xanthan gum 0.1 (1 3) Sericin 1.0 (1 4) Appropriate amount of preservative (1 5), appropriate amount of colorant (16) appropriate amount of fragrance (1 7) Residual water content &lt; Preparation method &gt; Add humectant and colorant to purified water and adjust (water phase) at 70 ° C. Next, add the surfactant and preservative to the oily ingredients and adjust by heating at 70 ° C. It is added to the previous aqueous phase for preliminary emulsification. Xyloglucan and ethanol are added to this preliminary emulsion, and the emulsified particles are uniformly mixed in a homomixer, and then degassed, filtered, and cooled to obtain the desired emulsion. [Example C9] Foundation blending amount (% by weight) (1) Talc powder 3.0 (2) Titanium dioxide 5.0 (3) Red iron oxide 0.5 (4) Yellow iron oxide 1.4 (5) Black iron oxide 0.1 (6) Single hard Fatty acid polyoxyethylene sorbitan ester 0.9 (7) Triethanolamine 1.0

C: \ 1234 \ 54664. Ptd P.73 5.544315 V. Description of the invention (68) (8) Propylene glycol (9) via ethyl cellulose (10) xyloglucan (11) sericin (1 2) stearic acid (13) isoodecyl alcohol (1 4) glyceryl monostearate (15) liquid wool month purpose (1 6) mobile stone soil (1 Ό preservative (18) fragrance amount (19 ) Proper amount of purified water &lt; Preparation method &gt; Residual propylene glycol in which xyloglucan is dispersed is added to the report] u 丄 After homogenization of the mixer, the remaining C is added to 仃 tj, starting with + a 4 cores in water Add the phase ingredients, and stir in the powder. Mix the powder / knife and crush the powder part ^ ^. Stir the Yin and mix the locust in 70t: s line homogeneously. Add this part while giving it, when it reaches 45 X: At the temperature, it will be equal to the temperature. Cold-filled in the container while stirring, and the desired "last" pumping and filling D is obtained. · A related example of the fourth form of the present invention "a poor first" everywhere Examples show the evaluation method used for compound a. J &quot; Ermin related to the external use group 1 of the present invention. · Using sensory test for each test article, invite 30 (, 60) male and female reviewers to compare Page 74 C: \ 1234 \ 54664.ptd 544315 V. Explanation of the invention (69) Use of reference product 磙 The feeling of use of each test product shall be determined according to the following criteria. Evaluation Criteria ◎ · When more than 40 people evaluate the situation better than the reference product 〇 · 20 or more and less than 40 people rated better than the control △ _ · 10 or more and less than 20 people evaluated better than the control x x Only less than 10 people rated better than the control 2 2 points Post-stabilization test (salt resistance test) —The following shows examples D1 and D3 and comparative example D1. The viscosity of each test product was measured with a B-type viscometer immediately after preparation, and it was determined based on the presence or absence of sodium chloride. The difference in the degree of investigation was measured. The viscosity was measured at 25. Furthermore, after the addition of carboxyvinyl polymer xyloglucan, sodium gasification was added to the total amount of the composition 丨. 〇 (1) In addition, in the following test samples, the wood ^ was used "Guli Roy" manufactured by Daiichi Pharmaceutical Co., Ltd. [Example D1] Emulsion blending amount (% by weight) Residual amount 5. 0 (1 ) Refined water (2) 1,3-butanediol (3) Compounds (4) Xyloglucan (5) Glyceryl monostearate (6) ΡΟΕ (10) Monooleate

544315 V. Description of the invention (70) (7) Flow paraffin 5.0 (8) Potassium hydroxide 0.1 (9) Preservative 0.1 (1 0) Chelating agent amount (11) Oxidation prevention 丨 proper amount (1 2) Perfume amount [Example D2] Emulsion content (wt%) (1) Residual water content (2) 1,3-butanediol 5.0 (3) Carboxyvinyl polymer 0.1 (4) Xyloglucan 5.0 (5) single Glyceryl stearate 0.5 (6) POE (10) Monooleate 0.5 (7) Flow paraffin 5.0 (8) Potassium hydroxide 0.1 (9) Preservatives 0 · 1 (10) Chelator amount (11) Proper amount of oxidation inhibitor (1 2) Proper amount of perfume [Example D3] Emulsion blending amount (% by weight)

C: \ 1234 \ 54664. Ptd Page 76 544315 V. Description of the invention (71) (1) Residual water content (2) 1,3-butanediol 5.0 (3) Several vinyl polymers 0.1 (4) Wood Dextran 0.01 (5) glyceryl monostearate 0.5 (6) POE (10) monooleate 0.5 (7) mobile paraffin 5.0 (8) potassium hydroxide 0.1 (9) preservative 0.1 (1 0) chelate Mixing amount (11) Antioxidant amount (1 2) Flavoring amount [Comparative Example D1] Emulsion blending amount (% by weight) (1) Residual water content (2) 1,3-butanediol 5.0 (3) Carboxyvinyl polymer 0.1 (4) glyceryl monostearate 0.5 (5) POE (10) monooleate 0.5 (6) flowing paraffin 5.0 (7) potassium hydroxide 0.1 (8) preservative 0.1 (9) chelate Mix amount

C: \ 1234 \ 54664. Ptd page 77 544315, description of the invention (72) proper amount proper amount (1 0) oxidation inhibitor (1 1) perfume <manufacturing method>

The test samples of Examples D1 to D3 and Comparative Example 01 were added with a humectant and a chelating agent to purified water according to the following common method, and heated at 70 ° C to adjust the water phase. In addition, add flowing paraffin, surfactant, preservative, and fragrance, and heat and mix at 70 ° C. It is added to the previous aqueous phase for preliminary emulsification. Furthermore, carboxyvinyl polymer and xyloglucan were added to this preliminary emulsion, and the emulsified particles were uniformly mixed in a homomixer, followed by deaeration, filtration, and cooling to obtain each test product. The emulsions of the examples and comparative examples thus prepared were subjected to the above-mentioned functional tests and viscosity stability tests. The results are shown in the following Table D 1 (using the sensory palace energy test) and Table D 2 (viscosity stability test). Table D1: Example D1, Example D2, Example D3, Comparative Example D1, Make the sense of leisure ◎ Δ X ^ Control. From this result, it is shown that the xyloglucan and carboxyvinyl polymer are mixed in an appropriate amount. The composition for external use in form (Example D1) 'obviously improved the use feeling compared to Comparative Example D1, which was not compounded with xylose but only with a carboxyvinyl polymer.

Page 78 C: \ 1234 \ 54664. Ptd 544315

V. Description of the invention (73) Table D2 Item Example D1 Example D2 Example D3 Comparative Example D1 NaCl 3560cps 25000cps 2700cps 2500cps East NaCl 3600cps 26000cps 450cps 30Ocps Based on this result, it can be determined that xyloglucan and carboxylic The external composition of the fourth aspect of the present invention of the vinyl polymer, when the compounding amount of xyloglucan is 0. 5% by weight or more of the total composition (examples D1 and D2), the salt resistance is excellent. Hereinafter, various dosage forms of the external composition of the fourth aspect of the present invention are described in the examples. Furthermore, when the fourth-form external composition of the present invention is subjected to the above-mentioned two tests, all the fourth-form external composition of the present invention are substantially more effective than xyloglucan in terms of usability and salt resistance. The comparative example is more excellent. [Example D4] Cream blending amount (% by weight) Residual amount 8. 0 0. 1 1. 0 (1) Refined water (2) 1, 3-butanediol (3) Triethylene polymer (4) Xyloglucan (5) POE (10) Monooleate (6) Glycerol stearate (7) Eterol

C: \ 1234 \ 54664. Ptd page 79 544315 V. Description of the invention (74) (8) Beeswax 0.5 (9) Vaseline 2.0 0 (10) Thirty carbon burning 6.0 0 (11) Dimethyl Polysiloxane 2.0 (12) Bell hydroxide 0.1 (13) Preservative amount (14) Colorant amount (15) Chelating agent amount (16) Perfume amount &lt; Manufacturing method &gt; Add humectant, colorant Add purified water and heat at 70 ° C to adjust the water phase. Then add the surfactant and preservative to the oil part and adjust by heating at 70 ° C. It is added to the previous aqueous phase for preliminary emulsification. Carboxyvinyl polymer and xyloglucan are added to this pre-emulsified material and stirred, and the emulsified particles are uniformly mixed in a homomixer, and then degassed, filtered, and cooled to obtain the desired cream. [Example D5] Formulation amount (% by weight) of residual water 10.0 5.0 0. 1 0. 05 (1) purified water (2) dipropylene glycol (3) PEG1500 (4) vinyl polymer (5) sugar

C: \ 1234 \ 54664. Ptd page 80 544315 V. Description of the invention (75) (6) POE (20) oleic acid alcohol ether 0.5 (7) ethanol 5.0 (8) potassium hydroxide 0.1 ( 9) Amount of fragrance (1 0) Amount of coloring agent (11) Amount of preservative (12) Amount of chelating agent (1 3) Preventing fading &lt; Preparation method &gt; Amount of agent Take a part of purified water to dissolve the chelating agent, and then dissolve Carboxyvinyl polymer and xyloglucan were added thereto and mixed and stirred. Then, a moisturizing agent, a discoloration preventing agent, etc. are added to the remaining purified water, and they are dissolved at room temperature, and the aforementioned solution is added thereto to obtain a uniform aqueous solution. Furthermore, preservatives, surfactants, and fragrances are added to ethanol to make an alcohol solution, and these are added to the previous aqueous solution and mixed to dissolve them. Then, after toning with the colorant, a desired lotion is obtained. [Example D 6] Cosmetic bag blending amount (% by weight) Residual amount 5.0 5. 0 5.0 1. 0 (1) Purified water (2) PEG1500 (3) Dipropylene glycol (4) Sorbitol (5) Polyvinyl Thing

Page 81 C: \ 1234 \ 54664. Ptd 544315 V. Description of the invention (76) (6) Xyloglucan 4.0 (7) POE lauryl ether 1.0 (8) Ethanol 5.0 (9) Potassium hydroxide 0.5 (1 0 ) Appropriate amount of fragrance (11) Preservative amount (preparation method) In a part of purified water, carboxyvinyl polymer and xyloglucan are added and dissolved (aqueous phase). Furthermore, the perfume, preservative, and surfactant are dissolved in ethanol, and these are added to the previous aqueous solution and mixed to dissolve them. Finally, potassium hydroxide was dissolved in the remaining purified water, and the soluble matter was added. After neutralizing and degassing, filtering was performed to obtain the desired cosmetic bag.

[Example D7] The blending amount of hair dye (% by weight) (1) purified water 67.7 (2) benzyl alcohol 6.0 (3) isopropyl alcohol 20.0 (4) carboxyvinyl polymer 0.5 (5) wood glucose polymer Sugar 4.0 (6) Citric acid 0.3 (7) Potassium hydroxide 0.5 (8) Acid dye 1.0 0 Page 82 C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (77) (8) Acid dye 1.0 &lt; Production method &gt; A desired hair dye can be obtained by uniformly stirring and mixing each component. Further, a carboxyethoxy polymer and xyloglucan were dispersed in an alcohol and added. [Example D8] The blending amount of sunscreen agent (% by weight) Residual amount 6. 0 0. 1 0. 5 0. 1 (aqueous phase part) (1) purified water (2) dipropylene glycol (3) slow vinyl polymer ( 4) Xyloglucan (5) Potassium Hydroxide (Olympic part) (6) Octyl p-methoxycinnamate (7) Glyceryl octyl p-methoxycinnamate (8) 4-Third-butyl Methyl-4, -methoxyhexyl methane (9) g phenyl ketone (1 ◦) oleyl oleate (1 1) difluorenyl polysiloxane (12) petrolatum (13) cetyl alcohol (14) Sorbitan sesquioleate (15) POE (20) oleyl ester

C: \ 1234 \ 54664.ptd Page 83 544315 V. Description of the Invention (78)

(1 7) Preservative (1 8) Fragrance <Manufacturing method> The water phase part and the oil phase part are added to the water phase part and emulsified. The oil phase is discarded to obtain the desired sunscreen. Ritual compounds are heat exchangers, and the related examples of the fifth aspect of the present invention are first described in various places. The evaluation of the external composition used in the seventh state a method will first explain the fifth aspect of the present invention. Test, teach the judgement of the sense of use for each test article, and manage ^ 〇 (60 in total) the number of reviewers, and then follow; ^ quasi 1 = sexual use of the reviewer evaluation criteria The standard judges the feeling of using each test product.

◎ △ ΔX The number of people who feel bad affinity is less than 5 people, and the number of people who have bad affinity is 5 people or less and less than 10 people. The number of people who feel bad sex is more than 10 people. The number of people who feel bad affinity is 30 people. · Said degree stability test (salt resistance test) &gt; The following shows examples E1 to E6 and comparative examples ^ and E2. The viscosity of each test product at the time of preparation is measured with a B-type viscometer. Investigate the difference in viscosity with or without sodium sulfide. The viscosity was measured at 25 ° C. In addition, after the addition of the alkyl-modified carboxyvinyl polymer and xyloglucan, sodium gasification was added in a compounding amount of 1 to 0% by weight of the total composition. ° Page 84C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (79) In addition, the xyloglucan in each of the following test products uses "Guliroi bean" manufactured by Daiyoshimoto Pharmaceutical Co., Ltd. 6C ". [Example E1] Emulsion blending amount (% by weight) Residual amount 5.0 2. 0 0. 2 3. 0 2.0 3. 0 0. 5 0. 1 Right amount Right amount Right amount blending amount (% by weight) Residual amount 5. 0 2. 0 0.2 (1) refined water (2) 1,3-butanediol (3) xyloglucan (4) modified vinyl polymer (5) octamethylcyclotetrasiloxane ( 6) Flowing stone butterfly (7) Macadamia nut oil (8) anhydrous silicic acid (9) potassium hydroxide (1 0) oxidation inhibitor (11) preservative (1 2) perfume [Example E2] emulsion (1 ) Refined water (2) 1,3-butane (3) xyloglucan (4) alkyl modified carboxyvinyl polymer

I

Page 85 C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (80) (5) Highly polymerized dimethylsiloxanyl (aminopropyl) petroloxane copolymer 3.0 (6) Flow paraffin 2.0 (Ό Macadamia Nut Oil 3.0 (8) Anhydrous Silicic Acid &lt; 0.5 (9) Potassium Hydroxide 0.1 (1 0) Amount of Antioxidant (1 1) Amount of Preservative '(12) Amount of Flavor [Example E3] Emulsion blending amount (% by weight) (1) Residual water content (2) 1,3-butanediol 5.0 (3) Xyloglucan 2.0 (4) Carbyl modified carboxyvinyl polymer 0.2 ( 5) High polymer difluorenyl polysiloxane 3.0 (6) Flow paraffin 2.0 (7) Macadamia nut oil 3.0 (8) Anhydrous silicic acid 0.5 (9) Potassium hydroxide 0.1 (1 0) Antioxidant amount (11) The right amount of preservatives (12) The right amount of spices

C: \ 1234 \ 54664. Ptd Page 86 544315 V. Description of the invention (81) [Example E4] Emulsion (1) Refined water (2) 1,3-butane (3) Xyloglucan (4) Burned Modified carboxyvinyl polymer (5) fluorenyl polysiloxane (6) flow paraffin (7) macadamia nut oil (8) anhydrous silicic acid (9) potassium hydroxide (1 0) oxidation prevention Agent (11) preservative (12) perfume [Example E5] emulsion (1) purified water (2) 1,3-butanediol (3) xyloglucan (4) alkyl modified carboxyvinyl polymer (5) Pyrophenyl polysiloxane (6) Flowing rocky soil compounding amount (% by weight) Residual amount 5.0 2.0 0. 2 3. 0 2. 0 3. 0 0. 5 0. 1 Amount (% by weight) Residual amount 5. 0 2.0 0 · 2 3.0 2.0

Page 87C: \ 1234 \ 54664.ptd 544315 V. Description of the invention (82) (Ό Macadamia nut oil 3.0 (8) Anhydrous silicic acid 0.5 (9) Potassium hydroxide 0.1 (1 0) Antioxidant amount (11) Amount of preservative (1 2) Amount of perfume [Example E6] Emulsion (1) Refined water (2) 1,3-butanediol (3) Xyloglucan (4) Burning-based modified carboxyethyl Base polymer (5) flowing stone loam (6) macadamia nut oil (7) anhydrous silicic acid (8) potassium hydroxide (9) oxidation inhibitor (1 0) preservative (11) fragrance content (weight ％) Residual amount 5.0 Appropriate amount Appropriate amount [Comparative Example E1] Emulsion (1) Refined water blending amount (% by weight) Residual amount

C: \ 1234 \ 54664. Ptd P.88 544315 V. Description of the invention (83) (2) 1,3-butanediol 5.0 (3) Carbyl modified carboxyvinyl polymer 0.2 (4) Phenyl Polysiloxane 3.0 (5) Flow paraffin 2.0 (6) Macadamia nut oil 3.0 (7) Anhydrous silicic acid 0.5 (8) Potassium hydroxide 0.1 (9) Antioxidant amount (1 0) Preservative amount ( 11) Proper amount of perfume [Comparative Example E2] Emulsion blending amount (% by weight) (1) Residual water content (2) 1,3-butanediol 5, 0 (3) Carbo-based modified carboxyvinyl polymer 0.2 (4) Flow paraffin 2.0 (5) Macadamia nut oil 3.0 (6) Anhydrous silicic acid 0.5 (7) Potassium hydroxide 0.1 (8) Amount of oxidation inhibitor (9) Amount of preservative (1 0) perfume Moderate &lt; Manufacturing Method>

C: \ 1234 \ 54664.ptd Page 89 544315 V. Description of the invention (84) The test samples of Examples E1 to E6 and Comparative Examples El and E2 are each the oil phase part added to the water phase part. Obtained by emulsification. The emulsions of the examples and comparative examples thus prepared were subjected to the above-mentioned use sensitivity test and viscosity stability test. The results are shown in the following Table E 1 (use sensitivity test) and Table E2 (viscosity stability test). Table E1

Xiang Juyu Comparative Example E1 E2 E3 E4 E5 E6 E1 E2 Sensation ◎ ◎ ◎ 〇〇Δ Δ X From this result, it was shown that the carboxyvinyl polymer compounded with xyloglucan and an alkyl group was modified for external use of the present invention Compared with the test article of the comparative example, the composition was obviously superior in use feeling. Furthermore, it can be judged that the addition of the silicone derivative at the same time further improves the feeling of use. Table E2. Giant breeding case El. Breeding case E2. Breeding case E3. Case E4. East NaCl 2850cps 2750cps SOOOcps 2800cps NaCl 2900cps 2700cps 3lOOcps 2840cps Item E5 Case E6 Comparative example El ^ Comparative example E2 NaCl 2800cps 2700cps 2650cps 2560cps with NaCl 2850cps 2750cps 250cps 200cps

C: \ 1234 \ 54664.ptd Page 90 544315 5. Description of the invention (85) The result is good.

Excellent salt resistance The external composition of the fifth aspect of the present invention can be judged. In the following, various dosage forms of the external composition of the fifth aspect of the present invention are described in the examples. Furthermore, when the above-mentioned external composition according to the fifth aspect of the present invention was subjected to the above-mentioned tests, all the external compositions according to the fifth aspect of the present invention were substantially superior to the comparative examples in which xyloglucan was removed. [Example E 7] Cream blending amount (% by weight) (aqueous phase) (1) Residual water content (2) 1,3-butanediol 6.0 (3) PEG 1 50 0 4. 0 (4) Wood glucose Glycan 1.0 (5) Difluorenylsilyl · methyl (polyethylene oxide) siloxane copolymer 1.0 (6) Carbovinyl modified carboxyvinyl polymer (oil only) 0. 1 (7 ) Stearyl alcohol 3.0 (8) Water-containing lanolin 3.0 (9) Thirty saucer burn 5.0 (10) Octyl twelve burn 8. 0 (11) Preservative amount (1 2) Antioxidant amount

544315 V. Description of the invention (86) (1 3) Fragrance Proper amount &lt; Preparation method &gt; Add moisturizer and colorant to purified water, and heat at 70 ° C to prepare water phase. Secondly, after the oil is heated and melted, add preservatives, oxidation inhibitors, and spices, and adjust at 70 ° C. Add it to the previous water phase, homogenize and then degas, filter and cool. The blending amount (% by weight) Residual amount 6.0 5. 0 3.0 0. 1 0. 05 Substance 0.05 5.0 0.5 Appropriate amount Appropriate amount The emulsified particles are homogenized to obtain the desired cream. [Example E 8] toner (1) purified water (2) 1,3-butanediol (3) glycerol (4) PEG400 0 (5) xyloglucan (6) octamethylcyclotetrasiloxane ( 7) Burned-based modified carboxyvinyl poly ¥ (8) Ethanol (9) Olive oil (1 0) Spice (11) Colorant (1 2) Preservative (1 3) Anti-fading inhibitor <Preparation method>

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'Explanation of the invention (87) It is dissolved in refined water at room temperature and added to ethanol, which is combined with the previous water to prepare a purple composition from the above-mentioned composition used in the micro industry, and in the case of, ③ In order to maintain good quality and excellent time-lapse fruit, the composition for external use, Φ unused interfacial activity will be accompanied by affinity; and, in addition, the present invention uses Moisturizing agent, discoloration and preparation of water phase. Dissolve at room temperature and modify the chitosan emulsion to obtain the possibility of household catties. Right According to the external absorbent of the present invention, it is easy to agglomerate, which can make this ultraviolet xyloglucan uniquely stable. It has excellent skin-friendly properties, and has a feeling of poor use when combined with a composition containing external modifiers. The use feeling is more suitable for various consumer inventions. A preventive agent, xyloglucan and the like are added, and on the other hand, a preservative and a fragrance are prepared into an alcohol phase. This alcoholic phase is a base polymer and a second ketone derivative is mixed with a desired lotion. , It can provide: φ will remove the greasy feeling from external use, remove the external ultraviolet scattering agent, the composition for external use, stabilizing and dispersing the composition for external use, and make it feel good for use. The tacky feel, refreshing, etc. are used to improve the ethylene-based polymer other than the excellent salt resistance (having the advantage of maintaining stability), so that the combination of the external use and the external use composition is not only excellent in salt resistance. All in all demand while providing better

C: \ 1234 \ 54664.ptd Page 93 544315 Attachment [(ga 1). 1, (I) xy 1 xy 1 xy 1-· i ——g 1 ug 1 υ — g 1 u — ε lu — n Table A1: Case A1, Case A2, Case A3, Case A4: Sleepiness 〇 ◎ ◎ Item Comparative Example A1 Comparative Example A2 Comparative Example A3 0: Comparative Example A4 Make the sense of leisure X Δ 〇 Table A2 item back Case A1, Case A2, Case A3, Case A4, Case A4 Immediately 2300cps 2200cps 3510cps 3450cps 30 days later 2300cps 2150cps 3450cps 3450cps Item Comparative Example A1 (± Comparative Example A2 Comparative Example A3 Comparative Example A4 Riser 2000cps 1900cps 2100cpcp 2200cps 1500s 1500s 2000 C: \ 1234 \ 54664.ptd Page 544315 Attachment A3 Table item Big night example A1 Night example A2 Child example A3 Child example A4 Immediate 12.1 11.3 11.5 14.3 30 days later 10.2 9.9 10.1 13.9 Project comparative example A1 Comparative example A2 Comparative Example A3 Comparative Example A4 Immediately 11.5 11.0 10.9 13.8 30 days later 9.8 8.9 8.5 10.9 Table B1 Make idle waste viscosity (cps) Immediately after 30 days Incubation case BI © 25000 23600 Incubation case B2 ◎ 92300 91200 Incubation case B3 113000 109000 Late example B4 〇20800 17900 Breeding example B5 ◎ 84600 68000 Comparative example B1 Δ 2100 510 C: \ 1234 \ 54664.pld 544315 Coordination (reset%) Comparative example C1 C2 C3 C4 C5 C6 1Glycerin 10.0-one one-edit (2) 1, 3 -Glycol 4.0 4.0 4.0 4.0 4.0 4.0 4.0 (3) POE (20) Oleoresin 0.5 0.5 0.5 0.5 0.5 0.5 (4) Dextran--2.0-Fine-(5) Ethyl cellulose--- 2.0 one (6) xanthan gum---one 2.0 one (7) sericin--•--2.0 (8) preservatives suitable amount appropriate amount appropriate amount appropriate amount (9) suitable material suitable Set appropriate amount (10) Refined water residual amount Residual amount Residual amount Residual amount Residual amount Residual amount Table C2 (Reset%) Breeding example C1 C2 C3 C4 C5 C6 (1) 1,3-7 diol 4.0 4.0 4.0 4.0 4.0 4.0 (2) POE (20) oleyl alcohol_ 0.5 0.5 0.5 0.5 0.5 0.5 0.5 (3) Dextran 2.0 2.0 2.0 0.1 2.0 0.1 (4) Hydroxyethyl fiber Qin 1.0 1.0 0.1 2.0-0.1 ( 5) Xanthan gum 1.0 1.0--0.1 0.1 (6) Sericin 1.0 0.1 1.0 1.0 1.0 1.0 1.0 ⑺ Preservatives are suitable and appropriate. (8) Materials are suitable and appropriate. 鼍 Are appropriate and suitable. Appropriate (9) Residual water Residual Residual Residual C: \ 1234 \ 54664.ptd 544315 Attachment Table C3 Comparative Example C1 C2 C3 C4 C5, C6 Make the leisure muscles grind to the SD animal Δ Δ ◎ Δ Δ 〇 Sticking makes the leisure cost X Δ 〇〇Δ Δ Freshness makes the sense of relaxation Δ △ ◎ 〇Δ 〇 Moisturizing effect ◎ X 〇Δ Δ Δ Table C4 C1, C2, C3, C4, C5, C6 C6 makes the sensory muscles abuse the animal ◎ ◎ ◎ ◎ ◎ Sticky dirt makes you feel free ◎ ◎ ◎ ◎ ◎ ◎ Refreshing makes you feel free ◎ ◎ ◎ ◎ ◎ 〇 Moisturizing effect ◎ ◎ ◎ ○ ◎ Table D1 Night example D1 Incubation example D2 Night example D3 Comparative example D1 Leisure Abandoned ◎ Δ X Covered product Page f: C: \ 1234 \ 54664. Ptd 544315 Attachment Table D2 Item Example D1 Night example D2 Example D3 Comparative example D1 NaCl 3560cps 25000cps 2700cps 2500cps 繊 QNaCl 3600cps 26000cps 450cps 300cps 300cps Table E1

The item of the big night example tt Comparative example El E2 E3 E4 E5 E6 El E2 makes sense of leisure ◎ ◎ ◎ 〇〇Δ Δ X Table E2 item giant breeding case El breeding case E2 breeding case E3 palace case E4 without adding NaCl 2850cps 2750cps 3000cps 2800cps Add NaCl 2900cps 2700cps 3100cps 2840cps Item Breeding Example E5 Breeding Example E6 Comparative Example El Comparative Example E2 Without NaCl 2800cps 2700cps 2650cps 2560cps Add NaCl 2850cps 2750cps 250cps 200cps C: \ 1234 \ 54664.ptd Page &gt; Λ, i .ί : '!!-1 ”I 4 Ί 年 丨 υυ. Ι ί -Γ 〇η π · year ^ month 隹 10 right application amendment L date: mv ί / ϊ, case number: 81 1S197' 'Ai &gt; i f &lt; ^ / συ (The above is filled by the main body of this Council)

544315

Technical Range_ &gt; This rabbit month is an invention of a technical range of an external composition. More specifically, it is formulated with xyloglucan, a polysaccharide derived from tamarind bean, as a basic compounding ingredient, and has a variety of excellent characteristics.

Technical Background Conventionally, as a compounding component of a composition for external use for cosmetic materials, various suitable materials are used in accordance with the functions that can be realized in the composition for external use. For example, in order to protect the skin exposed to the sun's ultraviolet rays, and prevent the occurrence of skin diseases such as age spots, freckles, skin aging, and even skin cancer, an ultraviolet shielding agent is added to the composition for external use. When the external composition is made into an emulsion such as an emulsion or cream, or when the external composition is stabilized, a surfactant is used as a means for emulsifying and stabilizing the composition. When ingredients suitable for these purposes are added to a composition for external use, although one side may provide products that meet the needs of diverse consumers, the other side

On the i-side, due to the combination of these components, there are actually many cases that are considered to have some adverse effects.

In the above-mentioned case, for example, the use of a composition for external use with an ultraviolet shielding agent has an undeniable tendency to deteriorate the feeling of use. Furthermore, compounding a composition for external use with a large amount of a surfactant has been known to cause problems in terms of safety and usability. To overcome these shortcomings, we now offer

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2000.08.02.007 87115197% Modification Fanfan ----—— ^ V. Description of the invention (3) Not = f position of lactose, and η represents the number of bonds. 7 Contact is ::::] Newtonian fluid with amyloid fluidity, which is related to sugar, and then: two! Chemical, excellent stability to acid, heat, and salt = sugar J !: Youliang water retention ability And other excellent characteristics.本本 二 二 ;;: sold on the surface (brand name "G! _D", mainly used for seasoning sauce, ice ^ ^), widely used as a thickener for food, and will be sold on the market It is better to mix the product for external use in the present invention. In the case of blends, it is manufactured by the method described in the phylogenetic catalogue of this xyloglucan. The above-mentioned "Gly loid" product, that is, 'from tamarind tree seeds, is crushed, foreign matter is removed from the pulverized material, and it is dipped and crushed to obtain xyloglucan.彳 / yin, drying, and finally micronization ^ glucan in the external composition of the present invention varies according to the specific type, and can be formulated with a $, there is no particular limitation depending on the composition. Guanji ^ 1 type or commercial form is suitable for selection, and the amount is as follows :; The specific combination of each specific type of the composition of the present invention is hunted, and the method of compounding xyloglucan to the hair style is as follows: It can be used in δ and δ and in various compositions. 'It has the superiority that has never been achieved. Moreover, the term "plant for external use on the epidermis (including scalp, hair)" in the present invention is not the same as the concept of a widely used form (such as makeup σ g ; .. The thing does not go to the law, such as make-up ... medical products, foreign products of the Ministry of Medicine, etc.) Bureau O: \ 54 \ 54664.ptc Page 9 2000.08.02.009 ^ 315

Description of the Invention (6) ::: Department: Ultraviolet Absorbent; High-Carbon Menthyl-N_Ethylamidobacic Acid :: tt L 回 / &quot;, Ultraviolet Absorbent; Peppermint i 笮 i ll, charcoal, menthol, salicylic acid, phenyl salicylic acid, salicylic acid, etc. Salicylic acid-based UV-absorbing UV-absorbing monoethyl octyl ester, ethyl cinnamate ~ Isopropyl ester, methyl cinnamate- ^ isopropyl hydrazone, ethyl cinnamate 1,2 ~ diisopropyl ester, methyl cinnamate s / di ^ propyl ester, propyl p-methoxycinnamate, Iso-p-methoxycinnamic acid ^ iso-amyl p-methoxycinnamate, octyl p-methoxycinnamate (p-methoxycinyl t-hexyl), 2-ethoxyethyl p-methoxycinnamate, p-methyl Dioxin, α-cyano-cold-phenyl-cinnamic acid ethyl ester, α-cyano-phenyl-cinnamic acid-2-ethylhexyl ester, di-p-oxocinnamic acid (glycerol monoethyl) Hexanoic acid) UV absorbers such as cinnamic acid esters; 2,4-dihydroxybenzylamine, 2,2-dihydroxy-methoxybenzophenone (ΒΕΖ〇ρΗΕΝ〇ΝΕ), dihydroxy-4 , 4-Dioxobenzophenone, 2, 2, 4, 4, 4'-tetramenthyl曱 _, 2 -hydroxy_4_methoxydibenzophenazine, 2-yl dioxenyl: benzophenazine, 2-Cyclo-4-methoxydibenzyl-5_ salt, benzyl-benzyl ketone 2-ethylhexyl-4, -phenyl-benzophenone-2-carboxylic acid-, 2-hydroxy-4-n-octyloxydiphenylhydrazone g, 4-light-yl-3, phenyl Dibenzyl, and other benzophenone-based ultraviolet absorbers; maltose ^ tripiconic acid, etc. The sugar cinnamic acid derivatives described in JP-A 4 -3 0 55 92, 2-meryl (2-dot-pyranyl type) Glucose silyloxy) propoxydibenzone and other sugar-based UV absorption of sugar benzophenone derivatives described in JP-A 6-87 8 79 = '3- (4 * • fluorenylidene) -d -Camphor, 3-aminoacyl _d, bu camphor, urocanic acid, ethyl urocanic acid, phenyl-5_methylbenzobenzoate, 2, 2, 2-ditto

Page 12 1999. 06.17.012 544315 Case No. 87115197 V. Description of the invention (23) 1 part of dextran, 10 parts of carboxyvinyl polymer, and 1 part of xyloglucan, 40% of vinyl polymer between. In the fourth aspect of the present invention, the external use = 1 carboxyl, when the ratio is deviated from this ratio, if the carboxy vinyl polymer is relative to 4 compounds, the desired combination of π and the external use of the carboxy vinyl polymer is expected. The effect of “lifting, and the use feeling is significantly improved” is not suitable for salt tolerance; on the contrary, if the amount of xyloglucan is difficult to play, it will form a polymer-specific coating, which makes the use feel ',: = In the external composition according to the fourth aspect of the present invention, 2 parts of the compound to 1 Q parts of xyloglucan and 1 part of ethylene polymer are finely divided; and the above-mentioned xyloglucan is mixed with the enemy Ethylene-based polymers are combined and in the composition

The poor salt resistance of Si ^ -2 is improved, and its long-term stability becomes significantly improved. Ding Leng-Portugal Production No. 70264 discloses a composition for external use in which xyloglucan and special body are combined with 彳 ^ 4 and a combination, but this kind of compound has a dry volume ^ liter when used. 'In addition to the complex, use this combination to improve the feeling of this coating and the disc = strong "coating feeling J. Moreover, if you want to mix the fourth form external composition of vinyl polymer / Numing, the same formulation The sugar complex Γ is polymerized by the above-mentioned xyloglucan due to the existence of a very high degree. However, a large amount of ethylene-based polymer is blended in this compound. In the case of human carboxyvinyl polymer, external use

2000. 08. 02. 029 O: \ 54 \ 54664.ptc Page 29

Claims (1)

[544315 ~ J. ::: I ί “j:, Case No. 87115197 Year of Operation & Month: Month and Day Amendment __VI. Application Circumstances 1. An external composition for ultraviolet and tritium defense, which comprises xyloglucan and ultraviolet light Absorbent, in which xyloglucan accounts for 0.01% to 1.0% by weight of the entire composition, and the weight ratio of xyloglucan to ultraviolet absorbent is 1: 2 0 0 0 to 2: 1 ^ 2 The external composition for ultraviolet defense according to item 1 of the scope of patent application, wherein the ultraviolet absorbent is a water-soluble ultraviolet absorbent. 3. The external composition for ultraviolet defense according to item 2 of the scope of patent application, wherein the water-soluble The ultraviolet absorbent is a sugar-based ultraviolet absorbent. 4. The external composition for ultraviolet defense according to item 3 of the patent application scope, which further adds an ultraviolet scattering agent, and the weight ratio of xyloglucan to the ultraviolet scattering agent is 1 : 800 ~ 2: 1. 5-A cosmetic composition comprising xyloglucan and a viscosity-increasing polysaccharide, wherein xyloglucan accounts for 0.01% to 1.0% by weight of the entire composition, And the weight ratio of xyloglucan to the withered polysaccharide is 1 : 1 0 ~ 4 0: 1. 6. The composition for chemical grains according to item 5 of the scope of patent application, which additionally adds a surfactant, and the weight ratio of dendritic dextran to the surfactant is 1: 2 0 0 ~ 10: 1. 7. The cosmetic composition according to item 6 of the patent application, wherein the interfacial active agent is a nonionic surfactant. 8. The cosmetic composition according to item 7 of the patent application Wherein the non-ionic surfactant is a sugar-based non-ionic surfactant. 9. The cosmetic composition according to any one of claims 5 to 8 of the patent application scope, wherein the thickening polysaccharide is made of hydroxyethyl Cellulose, xanthan gum, joan 0: \ 54 \ 54664 -920311 .ptc Page 95 544315 _Case No. 87115197_Year_Month__ VI. Patent application scope Month purpose, younger brother] selected from the group formed by locust bean gum and tragacanth One or more types of thickening polysaccharides. 0 1〜5. 0 重量 ％ ， 粘 加 多多 1 0. — A cosmetic composition comprising xyloglucan, a thickening polysaccharide and sericin, in which xyloglucan accounts for 0. 0 1 ~ 5. 0% by weight of the composition as a whole Carbohydrates account for 0.01 to 5.0% by weight of the entire composition, and sericin accounts for 0.001 to 5.0% by weight of the entire composition. 11. The cosmetic composition according to item 10 of the scope of the patent application, wherein the weight ratio of xyloglucan · to the thickening polysaccharide is 1: 1 to 4 to 1: 1. 12. A cosmetic composition according to claim 10 or 11, wherein the thickening polysaccharide is hydroxyethyl cellulose and / or xanthan gum. 1 3. A cosmetic composition comprising xyloglucan and a carboxyvinyl polymer, wherein xyloglucan accounts for 0.05 to 10% by weight of the entire composition, and xyloglucan The weight ratio to the slow vinyl polymer is 1: 1 to 0 to 4 0 to 1. 14. A cosmetic composition comprising xyloglucan and an alkyl-modified carboxyethylene polymer, wherein xyloglucan accounts for 0.05 to 10% by weight of the entire composition, And the alkyl-modified carboxyvinyl polymer accounts for 0.01 to 10.0% by weight of the composition as a whole. The weight ratio of xyloglucan to carboxyvinyl polymer is 1: 1 to 10 to 40: 1. 15. The cosmetic composition according to item 14 of the scope of the patent application, wherein the weight ratio of xyloglucan to carboxyvinyl polymer is 1:20 to 40: 1. 16. The cosmetic composition according to item 14 of the scope of application for a patent, wherein a lithoxone derivative is additionally added, and the silicone derivative accounts for 0.01 to 10.0% by weight of the entire composition. 17. The cosmetic composition according to item 16 of the scope of patent application, O: \ 54 \ 54664-920311.ptc Page 96 544315 Amendment No. 87115197 t. Patent Application Range The weight ratio of dextran to silicone derivative is 1: 1 to 0 to 2 0 to 1. 18. The cosmetic composition according to item 16 or 17 of the scope of the application for a patent, wherein the lithone derivative is composed of a high-polymer dimethyl polysiloxane, a high-polymer amine modified silicone and a ring. One or more silicone gluten organisms selected from the group of silicone-like groups. 1 9. A cosmetic composition comprising xyloglucan and an ultraviolet absorber, wherein xyloglucan accounts for 0.001% to 1.0% by weight of the entire composition, and xyloglucan and ultraviolet absorption The weight ratio of the agent is 1: 2 0 0 0 to 2: 1. O: \ 54 \ 54664-920311.ptc Page 97