TW491709B - Skin smoothing compositions containing hydroxyacids an - Google Patents

Description

Printed by the Consumers' Cooperative of the China Standards Bureau of the Ministry of Economic Affairs. 5. Description of the Invention (1) The scope of the present invention-generally relates to skin smoothing compositions, and more particularly to skin smoothing compositions containing citric acid. The present invention The other is about a method of using this composition to increase human skin smoothness. The goal of long-established makeup science is to develop products that increase the physical and / or smoothness of human skin. These skin smoothing compositions traditionally contain physical scavengers such as loofah and almond kernel cream, which are rubbed on the skin It will promote the detachment of residues and dead cells from the skin surface, and then remove the detached substances and products after use by wiping, moisturizing, and washing to make the skin smoother and cleaner. A phenomenon in cosmetic science is the development of products containing hydroxyamidine, see C.D. Weeler, Soap / Cosmetics / Chemical Specialities, 71 (2), 24 (1995). Hydroxy acids have been shown to be effective for the local treatment of a variety of skin lesions, such as itchy skin, dry skin and acne. Although the exact mechanism by which hydroxy acids work on the skin is not known, it is generally believed that these substances can accelerate cell regeneration by chemically removing dead cells from the surface of the skin over a period of days or weeks. The convenience of natural acid-based acids and their pleasing safety and effectiveness have made hydroxy acid-containing products widely accepted by consumers. These sources include sugarcane and yoghurt. Consumers also expect and require such products to be chemically and physically stable over a long period of time, easy to use on the skin, non-irritating and aesthetically pleasing to use, and safe and effective. Light-based acids often used in chemical products can be classified as warp-based acids, in which the paper size of -4 applies to the Chinese National Standard (CNTS) A4 specification (210X29? Mm) (Please read the precautions on the back before filling This page) Order Φ A7 -------- B7 _ V. Description of the invention (2) The group is located on the carbon adjacent to the carbonyl carbon, or a hydroxy acid, the hydroxyl position of which is two carbons away from the carbonyl radical On carbon. The most commonly used alpha-hydroxy acids in cosmetics are those with a relatively small backbone and low molecular weight, especially lactic acid (2-acrylic acid), glycolic acid (glycolic acid), and citric acid (2-hydroxy -1,2,3 -malonic acid) and tartaric acid (2,3-2 turtleyl succinic acid). The most commonly used hydroxy acid in cosmetics is salicylic acid (fluorenic benzoic acid). It is very useful to explore the chemical clearance properties of skin smoothing compositions containing physical scavengers', but unfortunately, hydroxy acids, especially the aforementioned low-molecular-weight α- # based acid, are extremely soluble in water and water-soluble The mixture, because the star check. The mixture has ^ 隹 a certain hydroxyl acid group 斑 Therefore, the use of hydroxy acid in skin smoothness, composition can achieve long-term benefits are limited to wiping, moisturizing or washing the skin Equipment for removing hydroxyl groups on the surface, when low molecular weight hydroxy acid is formulated into a skin smoothing composition together with a high amount of skin cleansing surfactant, 'This is a serious problem in particular, and the surfactant will further increase the light acid Water solubility. Summary of the invention Printed by the staff of the Ministry of Economic Affairs of the Central Bureau of Standards for consumer cooperation (please read the notes on the back before filling out this page). One of the objects of the present invention is to provide a magical skin smoothing composition containing hydroxy acid. Another item of the invention is to provide a method for using such a composition to increase the smoothness of human skin. These and related objects of the present invention are achieved by providing a skin smoothing composition containing the following ingredients: 0.5 to about 15.0% by weight of hydroxy acid; (b) from about 0.1 to about 5.0% by weight of a polymeric film-forming agent; (c) from about 5.0 to about 30.0% by weight of a physical scavenger; all scales are applicable to China Standard (CNS) A # specifications (21 × 297 mm) 491709 A7 B7 V. Description of the invention (3) (d) Pharmaceutical carrier from about 50.0 to about 94.4 weight percent. The present invention further relates to a method for improving the smoothness of human skin using a hydroxy acid-containing skin smoothing composition. The present invention has surprisingly and unexpectedly discovered that the addition of a polymeric film-forming agent to a skin smoothing composition containing a hyaluronic acid will improve the composition and increase the grip of human skin. The exact mechanism of this improvement is unknown, but it is generally believed that the film-forming agent will increase the ability of the composition to resist the removal from the skin via a base acid when wiped, moistened, or washed. In addition, the film-forming agent can also be used as an auxiliary skin smoothing agent in the composition of the present invention to generate a smooth and continuous Iκ film on the skin. It has the ability to resist removal from the skin during wiping, moisturizing or washing. . The skin smoothing composition of the present invention has chemical, physical and physical stability, and when used, the irritation meets aesthetic requirements. They can be immediately formulated into a variety of cosmetic product types, including, but not limited to, solutions, colloidal dispersions, emulsions, suspensions, creams, lotions, gels, aerosols, mousses, and more. Detailed description According to the present invention, the skin smoothing composition includes: printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (please read the precautions on the back before filling this page) (a) from about 0.5 to about 15.0 weight percent hydroxyl Acid; (b) from about 0.1 to about 5.0 weight percent of a polymeric film-forming agent; (c) from about 5.0 to about 30.0 weight percent of a physical scavenger; (d) from about 50.0 to about 94.4 weight Percent medicinal carrier. The composition of the present invention includes from about 0.5 to about 15.0 weight percent of a few bases, more preferably from about 1.0 to about 3.0 weight percent, and most preferably about 2.5 weight percent. The hydroxy acid of the present invention includes its free acid type of α-hydroxy acid and __6 · iS standard applicable CNS) A4 specification (210 × 297 mmΊ ^ '--- printed by the Consumer Cooperative of the Central Labeling Bureau of the Ministry of Economic Affairs 491709 A7 ----- ~ _______ B7 V. Description of the invention (4) Basic acids and their covalent derivatives. Suitable hydroxy acids include, but are not limited to, α · hydroxy acids, such as lactic acid, glycolic acid, citric acid, ... Caprylic acid, ... Scaly decanoic acid, α-Weiyldodecanoic acid, tartaric acid, glucose, add, galactouronic acid, hydroxybutyric acid, ... hydroxyisobutyric acid, maleic acid, phenylglycolic acid, ethylene glycol Acids, pyruvate and glyoxylic acid, in particular tarsalic acid, glycolic acid, citric acid, phenylglycolic acid, ... hydroxyoctanoic acid, ... hydroxydecanoic acid, α-hydroxydodecanoic acid, especially lactic acid, citric acid Β-hydroxy acids similar to fumaric acid; and mixtures thereof, especially lactic acid ... a mixture of hydroxydecanoic acid, α-hydroxydodecanoic acid. Suitable conjugated derivatives of hydroxy acids include esters, amidines and their lactones , And mixtures thereof. The composition of the present invention further comprises about 〇1 to about 50 weight percent, about 0.2 to about; L0 weight percent is better, about 0 3 weight percent is the best polymer film generator. In a preferred embodiment of the present invention, the polymer film generator is four Grade ammonium salt, a polymeric film-forming agent suitable for the purpose of the present invention includes, but is not limited to: Polymerized Quaternary-7, a polymerizable quaternary ammonium salt containing propylamine and dimethyldipropenyl gaseous monomer, Buy mostly products from Merquat (Calgon Corporation, Pittsburgh, PA); Polymerized quaternary -1 (), a polymerized quaternary salt produced by the reaction of hydroxyethyl fiber with trimethylammonium substituted epoxide, available for purchase It is a product of UCARE Polymer JR (Amerchol Corporation, Edison, NJ). The composition of the present invention also contains 5.0 to about 30.0 weight percent of a physical scavenger, and the term "physical scavenger" is used herein to refer to any medicinal particulate substance, These particles can rub the skin and promote the removal of dirt and / or dead cells from the surface of the skin. Suitable physical scavengers include, but are not limited to: Melting point (CNS) A4 size (210X 297 mm) (Please read the back first Notes on filling out this page)

491709 A 7 ___B7 V. Description of the invention (5) (Please read the precautions on the back before filling out this page) Natural radon above 70 ° C, especially Brazil palm soil, ozokerite, brown media and beeswax; high melting point Synthetic wax at 70 ° C, especially polyethylene and synthetic Brazil palm wax; vegetable and fruit derivatives such as almond flour, husk kernels, corn powder, corn flour, walnut shell powder, peach core powder, walnut shell powder and loofah ; And non-wax abrasives, such as diatomaceous earth, hydrated silica and apatite, especially polyethylene, Brazilian palm wax, synthetic Brazilian wax, montan wax, and mixtures thereof. A synthetic carnauba butterfly product can be obtained from Wax 124 Synthetic Carnaubas of Whittaker, Clark & Daniels. The invention also includes a pharmaceutical carrier from about 50.0 to 94.4 weight percent. The term "pharmaceutical carrier" is used herein to refer to a vehicle that transports hydroxy acids, polymeric film-forming agents and physical scavengers to the skin. This includes substances known to be harmless to humans. Pharmaceutical carriers include, but are not limited to, gas Glue, mousse, breast bone, lotion, gel, mask or latex. Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. In a preferred embodiment of the present invention, the medicinal carrier is an oil-soluble water-soluble latex. This latex contains one or more oil components and a water-soluble component. The oil in the water-soluble emulsifier component contains at least one oil-soluble water-soluble emulsifier component, that is, an emulsifier having a hydrophilic-lipophilic bucket equilibrium constant (HLB) of at least 6. The oil-soluble water-soluble emulsifier may also include a mixture of one or more oil-soluble water-soluble emulsifiers and one or more water-soluble oil-based emulsifiers (the HLB of the emulsifier is about 2 to 6). 'Each of the emulsifiers in the mixture The type and quantity should be selected so that the effective HLB of the final oil-soluble emulsifier component is at least about 6 °. We know the technology of combining and confirming the effective HLB of the emulsifier mixture. 'Refer to LM · DeNavarre's LM · Prince , " The Chemistry and Manufacture of -8-This paper size applies to the Chinese national standard CNS) A4 specification (210X 297 mm) 491709 A 7 _ ^ ___ B7_ V. Description of the invention (6)

Cosmetics, "Volume III, Second Edition (Continental Press, Orlando, 1975), pp. 25-37 0 Suitable water-soluble oil emulsifiers include, but are not limited to, glycerol, such as glyceryl stearate, glycerol caprylate Vinegar, glycerol oleate, and glycerol dioleate; ethylene glycol esters such as ethylene glycol octadecanoate; beeswax derivatives such as PEG-8 honey soil; lactates such as stearyl lactic acid steel, In a preferred embodiment, the oil-soluble water-emulsifier component comprises a mixture of oil-soluble water-emulsifier octadecylaminodiethylamine and water-soluble oil-emulsifier octadecanoic acid glycerol. This type of mixture can be obtained from Lexemul AR of Inolex Chemical Co. (Philadelphia, PA). Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs (please read the precautions on the back before filling this page). The emulsifier component also contains one or more emulsifiers with HLB 値 from about 15 to about 70. Such high-HLB emulsifiers, hereinafter referred to as "surfactants", are also used as oil soluble agents in the composition of the present invention. Water emulsion stabilizer and skin smoothing agentSuitable surfactants include, but are not limited to, a commercially available 39% aqueous solution of coconut amphoteric disodium diacetate, trade name Miranol C2M-NP (RTD Chemical Corp., Hackettstown, NJ); oleylamine MIPA-sulfonate Sodium acid succinate, commercially available in 38% aqueous solution, under the trade name Soleterge 8 (Strahl & Pitsch, West Babylon, NY); and mixtures thereof. Appropriate oil ingredients can be silicones, including, but not limited to, volatile silicones, such as cyclodimethyl silicone oil; non-volatile silicones, such as dimethyl petrolatum and methyl ethyl petrolatum; And its derivatives. The medicinal carrier may optionally include one or more ingredients well-known to those skilled in the art, such as preservatives, fragrances, softeners, preservatives, and anti -__________- 9 -_ The national standards apply to Chinese standards ( CNS) A4 specification (210X 297 mm) 491709 A7 B7 V. Description of the invention (7 Fuel, bactericide, sequestering agent, antioxidant, vitamin, pigment, dye, humectants and propellant, and other kinds of substances The composition of the invention has cosmetic, medicinal, or other desirable effects. Such materials can be found in the CTFA International Cosmetics Ingredients Dictionary (The Cosmetic, Toiletry and Fragrance Association, Washington, DC, 1991) and other similar sources. The present invention In addition, the present invention relates to a method for smoothing a skin composition containing hydroxy acid to increase the smoothness of human skin. This method comprises using the composition of the present invention on the skin and rubbing the composition on the skin for about one minute, which is sufficient time. Promote the removal of dirt and necrotic cells from the skin surface, and then remove the dirt from the skin together with the composition Removal with necrotic cells, and preferably by wiping, moisturizing or washing. 'The following non-limiting examples illustrate several different specific examples of the present invention: Example 1. Skin smoothing composition (please first Read the notes on the reverse side and fill in this page) Ordering ingredients weight percentage Φ ·. Printed phase of the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 1 Glyceryl octadecanoate / Octadecylaminodiethylamine 11.50 Dioctadecanoic acid Ethyl Ester 2.00 Phenoxyethanol / Methyl Paraben / Methyl Paraben 1.00 / Ethyl Paraben / Propyl Paraben / Butyl Paraben1 BHT 0.10 Academic Lactic Acid g purpose 1.50 Phase 2 -10- 6 Paper Music Standard Applicable to Chinese National Standard (CNS) A4 specification (210X297 mm) 491709 A 7 B7 V. Description of the invention (8) Magnesium aluminum silicate 0.52 Butylene glycol 1.00 Pure water 15.98 Phase 3 Polymerization quaternary -10 — 0.30 pure Water 14.70 Phase 4 Trisodium EDTA 005. Coconut amphoteric disodium diacetate (39% aqueous solution) 20.00 Phase 5 Oleoamido MIPA-sulfonic acid sodium succinate (38% aqueous solution) 12.0 Phase 6 Polyethylene 11.00 Phase 7 Titanium dioxide 0.26 Butanediol 0.39 8 Printed lactic acid by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 2.50 Phase 9 Fragrance 1.00 Phase 10 Carnauba wax / Dioxide / D & c Red No. 30 Lake2 4.0 ^ henonip (NIPA Hardwicke, Inc., Wilmington, DE) 2 Wax / Peach (International -11-This paper's standard is applicable to Chinese Standard (CNS) A4 specification (210X 297mm) (Please read the precautions on the back before filling out this page)

1T 491709 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs A7 B7 V. Description of Invention (9)

Flora Technologies, Ltd., Gilbert, AZ) Procedure 1-Phase 1 composition is disturbed in a first container at 80 ° C. 2 · Phase 2 components were decomposed in a second container at 78 ° C. 3. The composed phase 2 is added to the first container in 7 5 C stirring and mixed with phase 1, and the batch reaction can be continuously stirred to cool it slowly. 4. Phases 3 to 10 are added to the first vessel in sequence at the following temperatures: Phase 3 (70.0), Phase 4 (60 ° C), Phase 5 (55 ° C), Phase 6 (45X :), Phase 7 (45. (:), phase 8 (45 ° C), phase 9 (45 ° C), phase 10 (435C). 5. Stirring is continued until the composition temperature reaches 3 (TC. Exemption 2: increase skin smoothness) Methodology Procedures · Recruiting 19 women with dry, scaly skin on the calf area to conduct a blinding study to evaluate the skin smoothing composition of the present invention, half of the women continued to use the skin smoothing of Example 1 on both calves daily for four weeks Sex composition once, the other half of the control group also used a commercial skin smoothing composition on their calves, Estee Lauder Body Smoother Exfliating Creme, containing 15% by weight polyethylene as a physical scavenger. These women The product was rubbed on the skin for one minute and then washed with warm water. The benchmark skin smoothness was evaluated before the study, and subsequent skin smoothness measurements were made on the first use case 1 or in the control group. After the composition, and after four weeks, It is based on ^ Squames / Image Analysis method of Schatz et al., Drv Skin and Scaling Evaluated bv D-Squames and Image Analysis Handbook of ________-12- This paper is applicable to gsi family standard filial piety (CNS) A4 specifications (210 X297 mm) (Please read the notes on the back before filling this page)

491709 A7 B7 V. Description of the invention (10)

Non-invasive Methods and the Skin (CRC Press, Boca Raton, London and Tokyo, 1995), pp 153-157. According to this method, necrotic cells on the skin surface are peeled off with tape according to the analysis procedure and the number is measured. Results The skin smoothing composition of Example 1 improved the skin smoothness by 49% and 41%, respectively, after the first use and after four weeks. The control group improved skin smoothness by 36% and 28% after the first application and after four weeks, respectively. At each time point, there is a significant gap in the improvement in skin smoothness, which makes us prefer the composition of Example 1 to the composition of the control group. Although the present invention has been announced using its specific specific examples, those skilled in the art will know that there are many variations, so the present invention is only interpreted and limited by the scope of the attached patent application. ‘(Please read the notes on the back before filling out this page) Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X29? Mm)

Claims (1)

491709 No. 86101147 ^ Li Φ asked Qin Chinese to apply for a patent ^ Zheng; 9 years of release; A8 B8 C8 D8 Amendment printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 6. Scope of patent application-illtJy 1 · A kind of skin smoothness A composition comprising: (a) from 0.5 to 15.0 weight percent of wisnic acid; (b) from 0.1 to 5.0 weight percent of a polymeric film-forming agent; (c) from 5.0 to 30.0 weight percent of a physical scavenger; (d) a pharmaceutically acceptable carrier from 50.0 to 94.4 weight percent, wherein the polymeric film-forming agent is a polymeric quaternary ammonium salt. 2. The skin smoothing composition according to item 1 of the scope of patent application, wherein a human has 1.0 to 3.0 weight percent of a cationic acid. 3. The skin smoothing composition according to item 2 of the scope of patent application, which originally has 2.5% by weight of amenoric acid. 4. The skin smoothing composition according to item 1 of the scope of patent application, which originally has a polymer film-forming agent in an amount of 0.2 to 1.0% by weight. 5. The skin smoothing composition according to item 4 of the scope of patent application, which originally has a polymer film-forming agent in an amount of 0.3% by weight. 6. The skin smoothing composition according to item 1 of the scope of the patent application, wherein the hydroxy acid is selected from the group consisting of lactic acid, citric acid, α-hydroxyoctanoic acid, α-decanoic acid and α-light dodecanoic acid. 7. The skin smoothing composition according to item 6 of the patent application, wherein the lactic acid is lactic acid. 8. The skin smoothing composition according to item 1 of the scope of patent application, wherein the polymerized quaternary ammonium salt is polymerized quaternary-7. 9. The skin smoothing composition according to item 1 of the scope of patent application, wherein the polymerized quaternary ammonium salt is polymerized quaternary-10. 10. The skin smoothing composition according to item 1 of the scope of the patent application, in which the paper size applies the Chinese national standard (CNS> Α4 specification (210X29 * 7 mm) (Please read the precautions on the back before filling this page). Order Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 491709 A8 B8 C8 ___ — _D8 VI. Patent Application ^ ^-The substances included in the physical scavenger are selected from the group consisting of polyethylene, Brazilian palm wax, and synthetic carnauba wax A group consisting of montan wax. 11. The skin smoothing composition according to item 1 of the scope of the patent application, wherein the sensory carrier is an oil-in-water emulsion. 12. According to the scope of the patent application, item 11 Skin smoothing composition, wherein the oil-in-water emulsion contains a surfactant. &Quot; I3. The skin smoothing composition according to item u of the patent application scope, wherein the surfactant is selected from the group consisting of coconut ampholytic disodium diacetate And oleylamine-based MIPA-lithium succinate disodium. 14. A method for increasing the smoothness of human skin, comprising the following steps: (a) Human skin is applied with a skin smoothing composition containing 0.5 to 15.0 weight percent of hydroxy acid, 0.01 to 50 weight percent of a polymeric film-forming agent, and 50 to 300 weight percent of a physical scavenger. 50.0 to 94.4% by weight of a pharmaceutically acceptable carrier, wherein the polymeric film-forming agent is a polymeric quaternary ammonium salt; (b) the skin is smoothed with the skin smoothing composition for a sufficient time to promote skin surface dirt and death Cells fall off; (c) Remove the dirt and necrotic cells from the skin together with the skin smoothing composition by means of wiping, moisturizing or washing. This paper size is applicable to the national standard (CNS) of the towel. （210x297 公 楚） (Please read the notes on the back before filling in this page j