TW275632B - - Google Patents
Info
- Publication number
- TW275632B TW275632B TW081103168A TW81103168A TW275632B TW 275632 B TW275632 B TW 275632B TW 081103168 A TW081103168 A TW 081103168A TW 81103168 A TW81103168 A TW 81103168A TW 275632 B TW275632 B TW 275632B
- Authority
- TW
- Taiwan
- Prior art keywords
- mutant rsv
- rsv
- pharmaceutical compositions
- mutant
- vaccinating
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C12N2760/18564—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87142092A | 1992-04-21 | 1992-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW275632B true TW275632B (https=) | 1996-05-11 |
Family
ID=25357402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW081103168A TW275632B (https=) | 1992-04-21 | 1992-04-22 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5932222A (https=) |
| EP (1) | EP0567100B1 (https=) |
| JP (1) | JPH0622756A (https=) |
| AT (1) | ATE177785T1 (https=) |
| AU (1) | AU671983B2 (https=) |
| CA (1) | CA2094464C (https=) |
| DE (1) | DE69323921T2 (https=) |
| DK (1) | DK0567100T3 (https=) |
| ES (1) | ES2130189T3 (https=) |
| GR (1) | GR3029716T3 (https=) |
| NZ (1) | NZ247444A (https=) |
| TW (1) | TW275632B (https=) |
| ZA (1) | ZA932763B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2142817C1 (ru) * | 1993-08-06 | 1999-12-20 | Коннот Лабораториз Лимитед | Инактивированные вакцины респираторно-синцитиального вируса |
| PT784486E (pt) * | 1994-10-05 | 2006-07-31 | Univ Vanderbilt | Inerleucina-12 como um adjuvante para vacinas contra paramyxoviridae |
| US7846455B2 (en) * | 1996-07-15 | 2010-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated chimeric respiratory syncytial virus |
| US6689367B1 (en) * | 1995-09-27 | 2004-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
| US6015664A (en) * | 1995-11-03 | 2000-01-18 | Mcw Research Foundation | Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B |
| US6077514A (en) * | 1996-04-04 | 2000-06-20 | The Regents Of The University Of Michigan | Attenuated respiratory syncytial virus |
| EP0917592A4 (en) * | 1996-04-04 | 2002-04-24 | Univ Michigan | REDUCED RSV |
| KR20000048628A (ko) * | 1996-09-27 | 2000-07-25 | 윌리암 에이취 캘넌, 에곤 이 버그 | 모노네가비랄레스 목의 바이러스에서 감쇠를 책임지는 3' 게놈프로모터 영역 및 폴리머라제 유전자 돌연변이 |
| DE19729161A1 (de) | 1997-07-08 | 1999-01-14 | Basf Ag | Thermisch härtbare, wässrige Zusammensetzungen |
| CN1273603A (zh) * | 1997-09-19 | 2000-11-15 | 美国氰胺公司 | 减毒的呼吸道合胞病毒 |
| JP2002507408A (ja) * | 1998-03-26 | 2002-03-12 | アメリカン・サイアナミド・カンパニー | 麻疹ウイルスもしくはヒト呼吸合胞体ウイルスサブグループｂの弱毒化の原因である突然変異 |
| CA2418939A1 (en) * | 2000-08-07 | 2002-02-14 | Aventis Pasteur Limited | Stabilization of immunogens derived from paramyxoviruses |
| EP1701738B1 (en) * | 2003-12-17 | 2015-03-11 | Wyeth LLC | Method for producing storage stable RSV compositions |
| GB201202091D0 (en) | 2012-02-07 | 2012-03-21 | Renishaw Ireland Ltd | Drug delivery apparatus |
| GB201202093D0 (en) * | 2012-02-07 | 2012-03-21 | Renishaw Ireland Ltd | Drug storage apparatus |
| CA3178538A1 (en) * | 2020-05-13 | 2021-11-18 | Peter L. Collins | Rsv vaccine bearing one or more p gene mutations |
| CN112501134B (zh) * | 2020-12-09 | 2023-01-20 | 贵州医科大学附属医院 | 一种人呼吸道合胞病毒毒株及其应用 |
| CN113462656B (zh) * | 2021-03-24 | 2022-09-30 | 兰州生物制品研究所有限责任公司 | 一种人三型副流感病毒冷适应温度敏感株及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149650A (en) * | 1986-01-14 | 1992-09-22 | University Of North Carolina At Chapel Hill | Vaccines for human respiratory virus |
| WO1987004185A1 (en) * | 1986-01-14 | 1987-07-16 | University Of North Carolina | Vaccines for human respiratory virus |
| US5223254A (en) * | 1987-09-29 | 1993-06-29 | Praxis Biologics, Inc. | Respiratory syncytial virus: vaccines |
| WO1989004835A1 (en) * | 1987-11-20 | 1989-06-01 | The Upjohn Company | HUMAN RESPIRATORY SYNCYTIALVIRUS VACCINE DERIVED FROM THE 1A (9.5 kD) PROTEIN |
| KR0137963B1 (ko) * | 1987-12-23 | 1998-04-30 | 로버트 에이. 아미테이지 | 인간의 호흡기 합포체성 바이러스에 대한 당단백질 면역 단편을 함유하는 키메라(chimeric) 당단백질 |
| IL105456A (en) * | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
-
1992
- 1992-04-22 TW TW081103168A patent/TW275632B/zh active
-
1993
- 1993-04-20 NZ NZ247444A patent/NZ247444A/en unknown
- 1993-04-20 CA CA002094464A patent/CA2094464C/en not_active Expired - Fee Related
- 1993-04-20 ZA ZA932763A patent/ZA932763B/xx unknown
- 1993-04-21 EP EP93106496A patent/EP0567100B1/en not_active Expired - Lifetime
- 1993-04-21 DE DE69323921T patent/DE69323921T2/de not_active Expired - Fee Related
- 1993-04-21 JP JP5117812A patent/JPH0622756A/ja active Pending
- 1993-04-21 DK DK93106496T patent/DK0567100T3/da active
- 1993-04-21 AT AT93106496T patent/ATE177785T1/de not_active IP Right Cessation
- 1993-04-21 AU AU37057/93A patent/AU671983B2/en not_active Ceased
- 1993-04-21 ES ES93106496T patent/ES2130189T3/es not_active Expired - Lifetime
- 1993-05-07 US US08/059,444 patent/US5932222A/en not_active Expired - Fee Related
-
1999
- 1999-03-18 GR GR990400565T patent/GR3029716T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5932222A (en) | 1999-08-03 |
| ES2130189T3 (es) | 1999-07-01 |
| DK0567100T3 (da) | 1999-09-27 |
| GR3029716T3 (en) | 1999-06-30 |
| DE69323921T2 (de) | 1999-08-26 |
| EP0567100B1 (en) | 1999-03-17 |
| AU3705793A (en) | 1993-10-28 |
| CA2094464C (en) | 2005-08-23 |
| NZ247444A (en) | 1994-12-22 |
| JPH0622756A (ja) | 1994-02-01 |
| CA2094464A1 (en) | 1993-10-22 |
| DE69323921D1 (de) | 1999-04-22 |
| EP0567100A1 (en) | 1993-10-27 |
| ZA932763B (en) | 1994-02-08 |
| ATE177785T1 (de) | 1999-04-15 |
| AU671983B2 (en) | 1996-09-19 |
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