TW202540181A - 抗體-光敏感性物質複合體 - Google Patents
抗體-光敏感性物質複合體Info
- Publication number
- TW202540181A TW202540181A TW113144051A TW113144051A TW202540181A TW 202540181 A TW202540181 A TW 202540181A TW 113144051 A TW113144051 A TW 113144051A TW 113144051 A TW113144051 A TW 113144051A TW 202540181 A TW202540181 A TW 202540181A
- Authority
- TW
- Taiwan
- Prior art keywords
- antibody
- group
- ch2ch2o
- groups
- alkyl group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023-196281 | 2023-11-17 | ||
| JP2023196281 | 2023-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202540181A true TW202540181A (zh) | 2025-10-16 |
Family
ID=95742828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW113144051A TW202540181A (zh) | 2023-11-17 | 2024-11-15 | 抗體-光敏感性物質複合體 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPWO2025105486A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW202540181A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2025105486A1 (cg-RX-API-DMAC7.html) |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| JP3540315B2 (ja) | 1991-09-23 | 2004-07-07 | メディカル リサーチ カウンシル | キメラ抗体の製造−組合せアプローチ |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| EP0656941B1 (en) | 1992-03-24 | 2005-06-01 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| CA2177367A1 (en) | 1993-12-03 | 1995-06-08 | Andrew David Griffiths | Recombinant binding proteins and peptides |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| JP4334141B2 (ja) | 1998-04-20 | 2009-09-30 | グリカート バイオテクノロジー アクチェンゲゼルシャフト | 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作 |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| CN103333860B (zh) | 2000-10-06 | 2015-07-08 | 协和发酵麒麟株式会社 | 产生抗体组合物的细胞 |
| DK1392359T4 (da) | 2001-05-11 | 2013-06-10 | Ludwig Inst For Cancer Res Ltd | Specifikke bindingsproteiner og deres anvendelser. |
| HUP0600340A3 (en) | 2002-07-15 | 2011-06-28 | Genentech Inc | Methods for identifying tumors that are responsive to treatment with anti-erbb2 antibodies |
| US7662387B2 (en) | 2003-02-20 | 2010-02-16 | Seattle Genetics | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| US7943586B2 (en) * | 2003-06-09 | 2011-05-17 | The Trustees Of The University Of Pennsylvania | Antineoplastic agents targeted via glut transporters |
| RU2450018C2 (ru) * | 2006-08-23 | 2012-05-10 | Йеда Рисерч Энд Диверлопмент Ко. Лтд | Конъюгаты rgd-пептидов и фотосенсибилизаторов порфирина или (бактерио)хлорофилла и их применение |
| WO2009028639A1 (ja) | 2007-08-30 | 2009-03-05 | Daiichi Sankyo Company, Limited | 抗epha2抗体 |
| CN100567301C (zh) * | 2007-10-23 | 2009-12-09 | 东华大学 | 一种叶绿素衍生物、其制备方法及在医农药领域的应用 |
| EP2100621A1 (en) * | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether polyol dendron conjugates with effector molecules for biological targeting |
| US10195288B2 (en) | 2012-10-11 | 2019-02-05 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
| WO2016052971A1 (ko) | 2014-09-30 | 2016-04-07 | 가톨릭대학교 산학협력단 | 유방암 진단용 허셉틴-광감각제 접합체 및 이의 제조 방법 |
| KR101656238B1 (ko) * | 2014-12-03 | 2016-09-09 | 인제대학교 산학협력단 | 광역학 치료용 광민감제로 유용한 양이온성 클로린계 및 퍼퓨린이마이드계 화합물과 이들의 클로린계- 및 퍼퓨린이마이드계-다중금속산화물의 착화합물 |
| US11559581B2 (en) | 2015-01-09 | 2023-01-24 | Oxford University Innovation Limited | Antibody conjugates and methods of making the antibody conjugates |
| ES2992591T3 (en) | 2015-08-18 | 2024-12-16 | Rakuten Medical Inc | Compositions, combinations and related methods for photoimmunotherapy |
| CN109462989A (zh) | 2016-07-01 | 2019-03-12 | 第三共株式会社 | Hanp-含fc分子缀合物 |
| TWI926682B (zh) | 2017-05-15 | 2026-05-21 | 日商第一三共股份有限公司 | 抗體-藥物結合物之製造方法 |
| US12678512B2 (en) | 2020-03-06 | 2026-07-14 | Daiichi Sankyo Company, Limited | Anti-EGFR antibody-drug conjugate with a cyclic dinucleotide derivative |
-
2024
- 2024-11-15 JP JP2025557935A patent/JPWO2025105486A1/ja active Pending
- 2024-11-15 TW TW113144051A patent/TW202540181A/zh unknown
- 2024-11-15 WO PCT/JP2024/040709 patent/WO2025105486A1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025105486A1 (ja) | 2025-05-22 |
| JPWO2025105486A1 (cg-RX-API-DMAC7.html) | 2025-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7556073B2 (ja) | 抗体-ピロロベンゾジアゼピン誘導体コンジュゲート | |
| JP7627655B2 (ja) | 抗体-ピロロベンゾジアゼピン誘導体コンジュゲート | |
| AU2024336691A1 (en) | Macrocyclic compound and antibody-drug conjugate thereof | |
| TWI757740B (zh) | 甘胺酸醯胺化合物及其製造方法 | |
| TW202102226A (zh) | 抗體-吡咯并苯二氮呯衍生物結合物及parp抑制劑之組合 | |
| CN113166764B (zh) | 抗cdh6抗体-吡咯并苯并二氮杂环庚三烯衍生物缀合物 | |
| JP2020512270A (ja) | ピロロベンゾジアゼピン二量体前駆体及びそのリガンド−リンカーコンジュゲート化合物 | |
| KR20250150111A (ko) | 캄프토테신 유도체 및 이의 접합체, 이의 제조 방법 및 의학적 용도 | |
| JP2024509099A (ja) | 抗her2抗体‐薬物コンジュゲートおよびその使用 | |
| CA3232764A1 (en) | Pyrrolo benzodiazepine derivative, and conjugate, preparation method and use thereof | |
| JP2018123122A (ja) | カリケアマイシン誘導体およびその抗体薬物コンジュゲート | |
| CN119095625A (zh) | 抗体-药物偶联物 | |
| TW202444425A (zh) | 抗ror1抗體與pbd類化合物的偶聯物、其製備方法及其應用 | |
| CN119156232A (zh) | 抗体-药物偶联物前体及其合成中间体 | |
| WO2025105486A1 (ja) | 抗体-光感受性物質コンジュゲート | |
| HK40081719B (en) | Preparation method for antibody medicament conjugate | |
| HK40054688A (en) | (anti-cdh6 antibody)-(pyrrolobenzodiazepine derivative) conjugate |