TW202421780A - T細胞的製造方法 - Google Patents
T細胞的製造方法 Download PDFInfo
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- TW202421780A TW202421780A TW112136655A TW112136655A TW202421780A TW 202421780 A TW202421780 A TW 202421780A TW 112136655 A TW112136655 A TW 112136655A TW 112136655 A TW112136655 A TW 112136655A TW 202421780 A TW202421780 A TW 202421780A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12N2500/00—Specific components of cell culture medium
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2303—Interleukin-3 (IL-3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2333—Interleukin-33 (IL-33)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/505—CD4; CD8
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022152606 | 2022-09-26 | ||
| JP2022-152606 | 2022-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202421780A true TW202421780A (zh) | 2024-06-01 |
Family
ID=90477815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW112136655A TW202421780A (zh) | 2022-09-26 | 2023-09-25 | T細胞的製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20260109949A1 (https=) |
| EP (1) | EP4600352A1 (https=) |
| JP (1) | JPWO2024071010A1 (https=) |
| KR (1) | KR20250077533A (https=) |
| CN (1) | CN120112629A (https=) |
| AU (1) | AU2023353929A1 (https=) |
| CO (1) | CO2025004449A2 (https=) |
| MX (1) | MX2025003519A (https=) |
| TW (1) | TW202421780A (https=) |
| WO (1) | WO2024071010A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025205612A1 (ja) * | 2024-03-25 | 2025-10-02 | 国立大学法人京都大学 | 制御性細胞の増殖方法 |
| TW202603163A (zh) * | 2024-03-25 | 2026-01-16 | 國立大學法人京都大學 | 免疫細胞 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US7661738B2 (en) | 2006-11-28 | 2010-02-16 | Veritainer Corporation | Radiation detection unit for mounting a radiation sensor to a container crane |
| CN105861443A (zh) | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
| EP2164951A2 (en) | 2007-05-30 | 2010-03-24 | The General Hospital Corporation | Methods of generating pluripotent cells from somatic cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US8598344B2 (en) | 2009-11-30 | 2013-12-03 | Senex Biotechnology | CDKI pathway inhibitors and uses thereof |
| JPWO2011096482A1 (ja) | 2010-02-03 | 2013-06-13 | 国立大学法人 東京大学 | 多能性幹細胞を用いた免疫機能再建法 |
| WO2013001310A1 (en) | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| EA027531B1 (ru) | 2011-09-13 | 2017-08-31 | Игорь Ронинсон | ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ И НАРУШЕНИЙ, ВЫЗВАННЫХ АКТИВНОСТЬЮ ТРАНСКРИПЦИОННОГО ФАКТОРА NF-κB |
| KR20150023223A (ko) | 2012-02-02 | 2015-03-05 | 세넥스 바이오테크놀러지 인코포레이티드 | Cdk8/cdk19 선택성 억제제 및 암에 대한 항-전이 및 화학예방 방법에서 이들의 용도 |
| JP6164746B2 (ja) | 2012-05-22 | 2017-07-19 | 国立大学法人 東京大学 | 抗原特異的t細胞の製造方法 |
| RU2015107550A (ru) | 2012-08-23 | 2016-10-10 | Ф. Хоффманн-Ля Рош Аг | Новые фенилпиридин/пиразинамиды для лечения рака |
| WO2014063778A1 (en) | 2012-10-08 | 2014-05-01 | Merck Patent Gmbh | 2-aminopyridine compounds |
| GB201220157D0 (en) | 2012-11-08 | 2012-12-26 | Selvita Sa | Substitute tricyclic benzimidazoles as kinase inhibitors |
| HK1213544A1 (zh) | 2012-12-10 | 2016-07-08 | 霍夫曼-拉罗奇有限公司 | 新型二环苯基-吡啶/吡嗪用於治疗癌症 |
| WO2014106606A1 (en) | 2013-01-05 | 2014-07-10 | F. Hoffmann-La Roche Ag | Nove phenyl/pyridine series substitued by hydroxyethylamino for the treatment of cancer |
| WO2014123900A1 (en) | 2013-02-05 | 2014-08-14 | Sirenas Marine Discovery | Anti-cancer and anti-hiv compounds |
| WO2014154723A1 (en) | 2013-03-29 | 2014-10-02 | F. Hoffmann-La Roche Ag | Novel pyrrole derivatives for the treatment of cancer |
| WO2014194245A2 (en) | 2013-05-31 | 2014-12-04 | Nimbus Iris, Inc. | Cdk8 inhibitors and uses thereof |
| TW201605857A (zh) | 2013-10-03 | 2016-02-16 | 赫孚孟拉羅股份公司 | Cdk8之醫療性抑制劑及其用途 |
| AU2014369834B2 (en) | 2013-12-24 | 2018-12-20 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| WO2015144290A1 (en) | 2014-03-27 | 2015-10-01 | Merck Patent Gmbh | Pyridyl piperidines |
| JP6521387B2 (ja) | 2014-04-18 | 2019-05-29 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| JP6529085B2 (ja) | 2014-04-18 | 2019-06-12 | 武田薬品工業株式会社 | 複素環化合物 |
| JP2017522324A (ja) | 2014-07-17 | 2017-08-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 新規ナフチリジン及びイソキノリンならびにcdk8/19阻害剤としてのその使用 |
| EA038554B1 (ru) * | 2015-03-04 | 2021-09-14 | Зе Рокфеллер Юниверсити | Противовоспалительные полипептиды |
| SG11201803419PA (en) | 2015-10-30 | 2018-05-30 | The Regents Of The Universtiy Of California | Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells |
| US11578310B2 (en) | 2016-06-23 | 2023-02-14 | Kyoto University | Method for producing CD4/CD8 double-positive T cells |
| CN110199017A (zh) | 2017-01-20 | 2019-09-03 | 国立大学法人京都大学 | CD8α+β+细胞毒性T细胞的制备方法 |
| EP3591040A4 (en) | 2017-03-03 | 2020-11-11 | Kyoto University | METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS |
| CA3061289A1 (en) | 2017-04-26 | 2019-10-23 | Kyoto University | Hematopoietic progenitor cell marker |
| CA3068286A1 (en) * | 2017-06-22 | 2018-12-27 | Board Of Regents, The University Of Texas System | Methods for producing regulatory immune cells and uses thereof |
| WO2019040655A1 (en) * | 2017-08-22 | 2019-02-28 | The Regents Of The University Of California | LENTIVIRAL VECTORS EXPRESSING FOXP3 IN HEMATOPOIETIC STEM CELLS TO TREAT IMMUNITY DEFICIENCIES AND AUTOIMMUNE DISEASES |
| AU2019379604B2 (en) * | 2018-11-16 | 2026-04-23 | Rapa Therapeutics, Llc | Als treatment using induced regulatory T (iTREG) cells |
| EP4053267A4 (en) | 2019-11-01 | 2024-03-20 | Kyoto University | Method for producing t cell |
| JP2023501388A (ja) | 2019-11-08 | 2023-01-18 | サンガモ セラピューティクス, インコーポレイテッド | 操作された制御性t細胞の生成 |
| CN116323921A (zh) * | 2020-10-28 | 2023-06-23 | 桑格摩生物治疗股份有限公司 | 从人多能干细胞生成cd4+效应t细胞和调节性t细胞 |
| JP7805009B2 (ja) | 2020-11-20 | 2026-01-23 | オリヅルセラピューティクス株式会社 | 成熟化剤 |
| JP2022152606A (ja) | 2021-03-29 | 2022-10-12 | 凸版印刷株式会社 | 自立性包装袋 |
| AU2022349176A1 (en) * | 2021-09-27 | 2024-04-11 | Kyoto University | Method for producing t cell |
| CN119256076A (zh) * | 2022-03-23 | 2025-01-03 | 国立大学法人京都大学 | 用于产生调节性t细胞的方法 |
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2023
- 2023-09-25 EP EP23872234.2A patent/EP4600352A1/en active Pending
- 2023-09-25 KR KR1020257012930A patent/KR20250077533A/ko active Pending
- 2023-09-25 WO PCT/JP2023/034652 patent/WO2024071010A1/ja not_active Ceased
- 2023-09-25 US US19/114,947 patent/US20260109949A1/en active Pending
- 2023-09-25 CN CN202380075403.XA patent/CN120112629A/zh active Pending
- 2023-09-25 TW TW112136655A patent/TW202421780A/zh unknown
- 2023-09-25 JP JP2024549353A patent/JPWO2024071010A1/ja active Pending
- 2023-09-25 AU AU2023353929A patent/AU2023353929A1/en active Pending
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2025
- 2025-03-25 MX MX2025003519A patent/MX2025003519A/es unknown
- 2025-04-07 CO CONC2025/0004449A patent/CO2025004449A2/es unknown
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| Publication number | Publication date |
|---|---|
| MX2025003519A (es) | 2025-05-02 |
| EP4600352A1 (en) | 2025-08-13 |
| US20260109949A1 (en) | 2026-04-23 |
| CN120112629A (zh) | 2025-06-06 |
| WO2024071010A1 (ja) | 2024-04-04 |
| CO2025004449A2 (es) | 2025-04-16 |
| AU2023353929A1 (en) | 2025-05-01 |
| KR20250077533A (ko) | 2025-05-30 |
| JPWO2024071010A1 (https=) | 2024-04-04 |
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