TW202409013A - 用於抑制nlrp3之側氧基吲哚啉基醯胺衍生物及其用途 - Google Patents

用於抑制nlrp3之側氧基吲哚啉基醯胺衍生物及其用途 Download PDF

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TW202409013A
TW202409013A TW112117756A TW112117756A TW202409013A TW 202409013 A TW202409013 A TW 202409013A TW 112117756 A TW112117756 A TW 112117756A TW 112117756 A TW112117756 A TW 112117756A TW 202409013 A TW202409013 A TW 202409013A
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TW112117756A
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史蒂芬妮 杜瑞奇
米格爾 聖安格
傑森 布奇
拉姆賽 貝弗瑞
史蒂芬 賽伯特
亞歷山大 科特
派翠克 賽
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美商凡特斯治療美國公司
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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TW112117756A 2022-05-13 2023-05-12 用於抑制nlrp3之側氧基吲哚啉基醯胺衍生物及其用途 TW202409013A (zh)

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US202263341614P 2022-05-13 2022-05-13
US63/341,614 2022-05-13

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US (1) US20240368131A1 (enExample)
EP (1) EP4522591A1 (enExample)
JP (1) JP2025516719A (enExample)
KR (1) KR20240172228A (enExample)
CN (1) CN119212978A (enExample)
AU (1) AU2023268557A1 (enExample)
CA (1) CA3251062A1 (enExample)
CL (1) CL2024003460A1 (enExample)
CO (1) CO2024015371A2 (enExample)
IL (1) IL316674A (enExample)
JO (2) JOP20240258A1 (enExample)
MX (1) MX2024013978A (enExample)
PE (1) PE20251252A1 (enExample)
TW (1) TW202409013A (enExample)
WO (1) WO2023220715A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20252770A1 (es) * 2023-03-17 2025-12-22 Ventus Therapeutics U S Inc Derivados de amida para inhibir nlrp3 y usos de estos
CN122206665A (zh) * 2023-11-15 2026-06-12 万特斯治疗美国公司 用于抑制nlrp3的内酰胺衍生物及其用途
TW202545527A (zh) 2024-01-16 2025-12-01 英商諾得瑟拉公司 Nlrp3及glp-1a組合療法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
AR119731A1 (es) * 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3

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WO2023220715A1 (en) 2023-11-16
US20240368131A1 (en) 2024-11-07
CO2024015371A2 (es) 2024-12-30
PE20251252A1 (es) 2025-05-06
EP4522591A1 (en) 2025-03-19
CA3251062A1 (en) 2023-11-16
KR20240172228A (ko) 2024-12-09
JOP20240257A1 (ar) 2024-11-12
JP2025516719A (ja) 2025-05-30
IL316674A (en) 2024-12-01
MX2024013978A (es) 2024-12-06
CN119212978A (zh) 2024-12-27
CL2024003460A1 (es) 2025-04-11
AU2023268557A1 (en) 2024-11-14
JOP20240258A1 (ar) 2024-11-12

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