JP2025516719A - Nlrp3を阻害するためのオキソインドリニルアミド誘導体およびその使用 - Google Patents

Nlrp3を阻害するためのオキソインドリニルアミド誘導体およびその使用 Download PDF

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JP2025516719A
JP2025516719A JP2024567587A JP2024567587A JP2025516719A JP 2025516719 A JP2025516719 A JP 2025516719A JP 2024567587 A JP2024567587 A JP 2024567587A JP 2024567587 A JP2024567587 A JP 2024567587A JP 2025516719 A JP2025516719 A JP 2025516719A
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cycloalkyl
compound
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haloalkyl
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JP2025516719A5 (enExample
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パトリック・シル
ステファン・シブラ
ジェイソン・バーチ
ステファン・ドリッチ
ミゲル・サン-オンジュ
ラムゼイ・ベヴリッジ
アレクサンドル・コート
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ヴェンタス・セラピューティクス・ユー・エス・インコーポレイテッド
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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JP2024567587A 2022-05-13 2023-05-12 Nlrp3を阻害するためのオキソインドリニルアミド誘導体およびその使用 Pending JP2025516719A (ja)

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US202263341614P 2022-05-13 2022-05-13
US63/341,614 2022-05-13
PCT/US2023/066934 WO2023220715A1 (en) 2022-05-13 2023-05-12 Oxoindolinyl amide derivatives for inhibiting nlrp3 and uses thereof

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JP2025516719A true JP2025516719A (ja) 2025-05-30
JP2025516719A5 JP2025516719A5 (enExample) 2026-05-21

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US (1) US20240368131A1 (enExample)
EP (1) EP4522591A1 (enExample)
JP (1) JP2025516719A (enExample)
KR (1) KR20240172228A (enExample)
CN (1) CN119212978A (enExample)
AU (1) AU2023268557A1 (enExample)
CA (1) CA3251062A1 (enExample)
CL (1) CL2024003460A1 (enExample)
CO (1) CO2024015371A2 (enExample)
IL (1) IL316674A (enExample)
JO (2) JOP20240257A1 (enExample)
MX (1) MX2024013978A (enExample)
PE (1) PE20251252A1 (enExample)
TW (1) TW202409013A (enExample)
WO (1) WO2023220715A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP2026510921A (ja) * 2023-03-17 2026-04-10 ヴェンタス・セラピューティクス・ユー・エス・インコーポレイテッド Nlrp3を阻害するためのアミド誘導体及びその使用
WO2025106863A1 (en) * 2023-11-15 2025-05-22 Ventus Therapeutics U.S., Inc. Lactam derivatives for inhibiting nlrp3 and uses thereof
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies

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US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
UY38687A (es) * 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso

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JOP20240257A1 (ar) 2024-11-12
CL2024003460A1 (es) 2025-04-11
MX2024013978A (es) 2024-12-06
JOP20240258A1 (ar) 2024-11-12
KR20240172228A (ko) 2024-12-09
CA3251062A1 (en) 2023-11-16
CO2024015371A2 (es) 2024-12-30
IL316674A (en) 2024-12-01
US20240368131A1 (en) 2024-11-07
PE20251252A1 (es) 2025-05-06
EP4522591A1 (en) 2025-03-19
CN119212978A (zh) 2024-12-27
WO2023220715A1 (en) 2023-11-16
AU2023268557A1 (en) 2024-11-14
TW202409013A (zh) 2024-03-01

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