TW202336221A - Detergent for indoor water-using venues - Google Patents

Abstract

An object of the present disclosure is to provide a detergent for indoor water-using venues capable of suppressing sliminess. The present disclosure includes the following aspects. A detergent for indoor water-using venues, containing at least one selected from the group consisting of hydrolyzable tannins formed by ester-bonding a glucose with various gallic acids, and salts thereof. A method for suppressing sliminess, including bringing the detergent into contact with a water-using surface in an indoor water-using venue. A deodorizing method, including bringing the detergent into contact with an odorous substance. A method for dissolving fatty acid calcium, including bringing the detergent into contact with a fatty acid calcium.

Description

Detergent for indoor water use areas

This disclosure is about detergents used in indoor water use areas.

In indoor water use places (indoor water use places) such as kitchens, bathrooms, toilets, kitchens, and washrooms, dirt caused by microorganisms that multiply due to the presence of water will occur. In such places, slime produced by microorganisms forming biofilms is a typical problem. From the viewpoints of hygiene, appearance, etc., it is desirable to suppress this problem.

As a cleaning agent for indoor water use areas, sodium hypochlorite, which is a chlorine-based cleaning agent, is known (Non-Patent Document 1). However, sodium hypochlorite is highly corrosive/oxidizing, and reacts with acidic detergents to produce toxic chlorine gas. Therefore, a detergent that is more friendly to the body and the environment is needed.

[Prior technical literature]

[Non-patent literature]

[Non-patent document 1]

Tomoji Fukusaki, "Theory and practice of cleaning/sterilizing operations using sodium hypochlorite", Cooking Food and Technology, Japan Cooking Food Research Association, 2010, Volume 16, No. 1, p1-14

The object of this disclosure is to provide a cleaning agent for indoor water use areas that can suppress mucus.

As a result of detailed research conducted by the inventor of the present case in view of the above-mentioned subject, at least one selected from the group consisting of hydrolyzable tannins and their salts formed by ester bonding between glucose and various gallic acids has mucus-inhibiting properties. effect. The inventor of the present case conducted further research based on this insight, and as a result completed the invention disclosed herein. That is, this disclosure includes the following aspects.

Item 1 A detergent for indoor water use areas, containing at least one selected from the group consisting of hydrolyzable tannins and their salts formed by ester bonding between glucose and various gallic acids.

Item 2 is a detergent for indoor water use places as described in Item 1, where the aforementioned indoor water use places are selected from residences, factories, offices, accommodation facilities, hospitals, stores, schools, restaurants, airport facilities, At least one type of indoor water use place in the group consisting of stations, bus terminals, service areas, sports facilities and assembly halls.

Item 3: Detergent for indoor water use places as described in Item 1 or 2, where the aforementioned indoor water use places are indoor commonly used water places.

Item 4: Detergent for indoor water use places as described in any one of Items 1 to 3, wherein the aforementioned indoor water use places are selected from household kitchens, professional kitchens, bathrooms, toilets, kitchens, washrooms and water circulation At least one of the groups the device belongs to.

Item 5: The detergent for indoor water use places as described in any one of Items 1 to 4, wherein the hydrolyzable tannin is tannic acid.

Item 6: A cleaning agent for indoor water use areas as described in any one of Items 1 to 5, which contains a solvent.

Item 7: The detergent for indoor water use areas as described in Item 6, wherein the content of the aforementioned hydrolyzable tannin and its salt is 5000 μg or less based on 1 mL of the aforementioned solvent.

Item 8: A cleaning agent for use in indoor water use areas as described in Item 6 or 7, wherein the pH of the aforementioned solvent is 2.0 to 12.0.

Item 9. The cleaning agent for indoor water use places as described in Item 6 or 7, wherein the aforementioned solvent is alcohol and water, a pH adjuster containing a weak acid, and the pH of the solvent is 2.0 to 4.0.

Item 10: The detergent for indoor water use areas as described in Item 9, which contains antiseptic and antifungal agents and surfactants.

Item 11 The cleaning agent for indoor water use places as described in Item 10, wherein the aforementioned surfactant is a nonionic surfactant.

Item 12. The detergent for indoor water use areas as described in Item 11, wherein the aforementioned surfactant is polyoxyethylene alkyl ether.

Item 13. The cleaning agent for indoor water use areas as described in any one of Items 1 to 12, wherein the aforesaid is used at a concentration that does not substantially exert a growth-inhibitory effect on bacteria of the genus Methylobacterium. Hydrolyzable tannins.

Item 14: The detergent for indoor water use places as described in any one of Items 1 to 13 is used to contact mucus originating from microorganisms in indoor water use places.

Item 15: The detergent for indoor water use places as described in any one of Items 1 to 14 is used to inhibit slime originating from microorganisms.

Item 16: A cleaning agent for indoor water use places as described in Item 14 or 15, wherein the aforementioned microorganisms are selected from the group consisting of bacteria of the genus Methylobacterium, bacteria of the genus Brevundimonas, and Pseudomonas At least one species from the group consisting of bacteria of the genus Xanthomonas, bacteria of the genus Sphingomonas, and bacteria of the genus Rhodococcus.

Item 17 The cleaning agent for indoor water use places as described in any one of Items 14 to 16, wherein the aforementioned microorganism is a bacterium of the genus Methylobacterium.

Item 18 A method for suppressing mucus, which includes bringing the cleaning agent for indoor water use places described in any one of Items 1 to 17 into contact with a water surface of an indoor water use place.

Item 19: The method for suppressing mucus as described in Item 18, which includes contacting a cleaning agent for indoor water use places as described in any one of Items 1 to 18 with slime originating from microorganisms in indoor water use places. .

Item 20: A deodorizing method, which includes bringing the cleaning agent for indoor water use areas described in any one of Items 1 to 13 into contact with an odorous substance.

Item 21 A method for dissolving fatty acid calcium, which includes bringing the indoor water use detergent described in any one of Items 1 to 13 into contact with fatty acid calcium.

According to the present disclosure, it is possible to provide a cleaning agent for indoor water use areas that can suppress mucus.

Figure 1 shows that in Experiment 1, tannic acid inhibited the formation of biofilm by Methylobacterium, which is a representative bacteria of mucus commonly found in indoor water.

In this specification, the terms "contains" and "include" include concepts such as "contains", "includes", "consists essentially of" and "consists only of".

One aspect of the present disclosure relates to a detergent for indoor water use (sometimes also referred to as "the detergent of the present disclosure" in this specification), which contains a mixture selected from glucose and a variety of gallic acids. At least one kind from the group consisting of hydrolyzable tannins bonded with esters and their salts. This is explained below.

1. Ingredients

The detergent of the present disclosure contains at least one selected from the group consisting of hydrolyzable tannins and their salts formed by ester bonding between glucose and various gallic acids (sometimes referred to as " Active ingredients").

The hydrolyzable tannin is not particularly limited as long as it is formed by ester bonding between glucose and various gallic acids.

Glucose is not particularly limited. Glucose may be any of a peranose type (glucopyranose), a furanose type (glucofuranose), and a chain type, and is preferably a glucose type. Moreover, glucose may be either D type or L type, and D type is preferable. In addition, glucose may be either α-type or β-type, and β-type is preferred. Preferable examples of glucose include glucose, preferably D-glucopyranose, more preferably β-D-glucopyranose, and the like.

The ester bond is not particularly limited as long as it is an ester bond between a hydroxyl group derived from glucose and a carboxyl group derived from gallic acid. Furthermore, the gallic acid linked to glucose can be further linked to other gallic acids. Hydrolyzable tannin, more specifically, is a hydroxyl group that glucose has at least 1 (preferably 2 or more, more preferably 3 or more, more preferably 4 or more, most preferably 5 or more) hydroxyl group and Hydrolyzable tannin is a hydrolyzable tannin formed by ester bonding the carboxyl groups of gallic acid or gallic acid linkers.

Here, the so-called linkers of gallic acid are 2 or more (preferably 2 to 6, more preferably 2 to 5, more preferably 2 to 4, still more preferably 2 to 3 (preferably 2) gallic acids are linked by ester bonds (that is, ester bonds derived from a hydroxyl group derived from one gallic acid and a carboxyl group derived from other gallic acids). The hydroxyl group forming the ester bond may be either a meta-position hydroxyl group or a para-position hydroxyl group, but is preferably a meta-position hydroxyl group. In addition, the linker composed of three or more gallic acids may be one in which the gallic acids are connected in a straight chain (that is, only one hydroxyl group among the three hydroxyl groups of gallic acid is used to form ester bond), or gallic acid linked into a branched chain (that is, for at least one gallic acid, more than two of the three hydroxyl groups of gallic acid are For those that form ester bonds), linear linkers are preferred.

Examples of linkages of gallic acid include those represented by the following formula.

The hydrolyzable tannin is preferably tannic acid. Examples of tannic acid include hydrolyzable tannin represented by general formula (1):

[In the formula: R ¹ , R ² , R ⁴ and R ⁵ are the same or different, and represent a group obtained by removing the hydroxyl group in the carboxyl group from a linker of gallic acid or gallic acid. R ³ represents a hydrogen atom or a group obtained by removing the hydroxyl group of the carboxyl group from a linker of gallic acid or gallic acid].

In the general formula (1), R ¹ , R ² , R ³ , R ⁴ and R ⁵ are the same or different, and are preferably obtained by removing the hydroxyl group in the carboxyl group from a linker of gallic acid or gallic acid. group; R ¹ , R ² , R ³ , R ⁴ and R ⁵ are the same or different, more preferably a group obtained by removing the hydroxyl group from the carboxyl group from the linker of gallic acid.

Preferable specific examples of tannic acid include two compounds represented by the following formulas.

Another preferred specific example of tannic acid includes plant-derived tannins such as gall tannin and gallotannin.

The molecular weight of the hydrolyzable tannin is, for example, 300 to 2500, preferably 800 to 2200, more preferably 1200 to 2000, still more preferably 1500 to 1900.

The source and type of hydrolyzable tannins are not particularly limited. For example, partially purified hydrolyzable tannins such as plant extracts, hydrolyzable tannins isolated from plants, and artificially synthesized hydrolyzable tannins can be used. Ning, etc., these can be used alone or in combination.

The salt of hydrolyzable tannin is not particularly limited as long as it is a pharmaceutically acceptable salt and can be used as a detergent for indoor water use areas. Examples of alkali addition salts include those with alkali metals such as sodium and potassium. Salts, salts with alkaline earth metals such as calcium and magnesium, and salts with amines such as ammonium and triethylamine.

The active ingredient may be used individually by 1 type, or in combination of 2 or more types.

The detergent disclosed in the present disclosure may contain only active ingredients, or may contain active ingredients and other ingredients. The content of the active ingredient in the detergent of the present disclosure is, for example, 0.00001 to 100% by mass, and its upper limit and lower limit may be, for example, a range formed by any combination of two of the following values: 100% by mass, 90 mass%, 70 mass%, 50 mass%, 30 mass%, 20 mass%, 10 mass%, 5 mass%, 2 mass%, 1 mass%, 0.5 mass%, 0.1 mass%, 0.01 mass%, 0.001 mass %, 0.0001 mass%.

There are no particular limitations on other components that can be included in the detergent of the present disclosure as long as the hydrolyzable tannin is stable. For example, whether hydrolyzable tannins are stable in liquid preparations can be determined by measuring the residual rate of hydrolyzable tannins or quantifying gallic acid, which is a hydrolyzate of hydrolyzable tannins. For example, when the hydrolyzable tannin content in a liquid preparation is 0.25%, it can be evaluated as stable as long as the initial gallic acid production rate does not reach 500 ( μ g/mL/day), and preferably it does not reach 100 ( μ g/mL/day), more preferably less than 10 ( μ g/mL/day), more preferably less than 1.0 ( μ g/mL/day), most preferably less than 0.1 ( μ g/ mL/day). Alternatively, the quantitative value of gallic acid when hydrolyzable tannin is completely hydrolyzed by tannase is set to 100%, and the ratio (%) of gallic acid hydrolyzed in the liquid can be calculated.

Other components include solvents. Examples of the solvent include non-polar solvents, polar solvents, etc., and polar solvents are preferred.

Examples of polar solvents include: polar aprotic solvents such as methylene chloride, tetrahydrofuran, acetone, acetonitrile, N,N-dimethylformamide, and dimethylstyrene; acetic acid, 1-butanol, and 1,3-butanol. Polar protic solvents such as glycol, glycerol, 2-propanol, 1-propanol, ethanol, methanol, formic acid, and water.

Preferable polar protic solvents include alcohol and water. The alcohol is preferably a lower alcohol with a carbon number of less than 5, such as 1,3-butanediol, glycerin, 2-propanol, 1-propanol, ethanol, etc., and more preferably a carbon number such as 2-propanol, 1-propanol, ethanol, etc. Lower alcohols with a number of 3 or less. By using this alcohol, the hydrolyzable tannins in this detergent can be maintained more stably. Moreover, this alcohol can also be used mixed with water. When mixed with water, the content ratio of alcohol relative to the entire solvent is, for example, 0.00001 to 100% by mass, and the upper and lower limits thereof may be, for example, a range of any combination of two of the following values: 90% by mass , 80 mass%, 70 mass%, 60 mass%, 50 mass%, 30 Mass%, 20 mass%, 10 mass%, 5 mass%, 2 mass%, 1 mass%, 0.5 mass%, 0.1 mass%, 0.01 mass%, 0.001 mass%, 0.0001 mass%.

The pH of the solvent can be appropriately set according to its effects by those with ordinary knowledge in the art. The pH of the solvent is, for example, 2.0 to 12.0. As for the pH of the solvent, for example, the pH can be acidic from 2.0 to 3.0, weakly acidic from 3.0 to 6.0, neutral from 6.0 to 8.0, weakly alkaline from 8.0 to 10.0, or weakly alkaline from 8.0 to 10.0. The pH of the solvent is preferably 2.0 to 6.0, more preferably 2.0 to 4.0, from the viewpoint of the stability of the hydrolyzable tannin contained in the detergent. The detergent disclosed in the present disclosure, for example, does not produce chlorine gas even under acidic conditions, is friendly to the body and the environment, and can inhibit mucus. In order to adjust to the above-mentioned pH, it is preferable to contain a pH adjuster. The pH adjuster is not particularly limited, but is preferably a weakly acidic pH adjuster. Examples of weakly acidic pH adjusters include: citric acid, gluconic acid, tartaric acid, lactic acid, acetic acid, malic acid, etc. The content of the pH adjuster can be appropriately adjusted in the range of 0.0001 mass % to 2 mass % in accordance with the target pH.

When the detergent of the present disclosure contains a solvent, the content of the active ingredient per 1 mL of solvent may be, for example, 2 μg or more, 5 μg or more, 20 μg or more, 100 μg or more, 500 μg or more, or 1000 μg or more. Above μ g, below 50000 μ g, below 40000 μ g, below 5000 μ g.

Examples of other components other than solvents include antibacterial/antifungal agents, antiseptic and antifungal agents, aromatic sulfonic acid compounds, antioxidants, rust inhibitors, ultraviolet absorbers, light stabilizers, bioadhesion inhibitors, and removal agents. Additives such as odorants, organic acids, fatty acid metals, metal compounds, polyvalent metal ion scavengers, cyclodextrins, porous body components, pigments, surfactants, thickeners, etc.

Examples of antibacterial/antifungal agents include: methyl 2,4-dihydroxy-6-methylbenzoate, ethyl 2,4-dihydroxy-6-methylbenzoate, and 2,4-dihydroxy-3, Methyl 6-dimethylbenzoate, isopropyl 2,4-dihydroxy-6-methylbenzoate, 3-methoxy-5-methylphenyl-2,4-dihydroxy-6-methyl hydroxybenzoate, 2,4-dihydroxy-3,6- Ethyl dimethylbenzoate, 3-formyl-2,4-dihydroxy-6-methylbenzoate, 3-formyl-2,4-dihydroxy-6-methylbenzoic acid ethyl ester Propyl ester, 3-hydroxy-5-methylphenyl-2,4-dihydroxy-6-methylbenzoate, 3-hydroxy-5-methylphenyl-2-dihydroxy-4-methoxy Hydroxy-6-methylbenzoate, 3-methoxy-5-methylphenyl-2-hydroxy-4-methoxy-6-methylbenzoate, 3-chloro-2,6 - Phenol/alcohol-based antibacterial/antifungal agents such as dihydroxy-4-methylbenzoate;

Pyridine/quinoline antibacterial/antifungal agents such as sodium (2-pyridylthio-1-oxide), nalidixic acid, gatifloxacin, copper pyrithione, zinc pyrithione, etc. agent;

等三

系抗菌/防黴劑； Hexahydro-1,3,5-shen(2-hydroxyethyl)-S-tri

Wait three

It is an antibacterial/antifungal agent;

1,2-Benzisothiazolin-3-one, 2-methyl-5-chloro-4-isothiazolone complex, octylisothiazolinone, methylisothiazolinone, chloromethylisothiazolinone Isothiazolone-based antibacterial/antifungal agents such as thiazolinone, dichlorooctylisothiazolinone, and benzisothiazolinone;

4’-Hydroxyacetamidebenzene, N-(3-hydroxyphenyl)benzenecarboxamide, N-(3-hydroxyphenyl)benzamide and other amidebenzene antibacterial/antifungal agents;

Nitrile antibacterial/antifungal agents such as monobromocyanoacetamide, dibromocyanoacetamide, 1,2-dibromo-2,4-dicyanobutane, tetrachlorophthalonitrile, etc.;

2-(4-thiazolyl) benzimidazole, 2-benzimidazolylamine carboxylic acid methyl ester, 1-(butylaminemethyl)-2-benzimidazolylamine carboxylic acid methyl ester and other imidazole/thiazole antibacterial/antibacterial agents mildew agent;

Aldehydes such as dehydroacetic acid are antibacterial/antifungal agents;

Carboxylic acid-based antibacterial/antifungal agents such as acetic acid, formic acid, and sorbic acid;

Ester-based antibacterial/antifungal agents such as parabens;

Disulfide compounds such as disulfide-2,2-bis(benzomethylamide), tetramethylthiuram disulfide, dimethylphenylsulfonamide;

Thiourethane compounds such as Mancozeb, maneb, Zineb, and polyurethane;

Nitro compounds such as 1,1-dibromo-1-nitropropanol, 1,1-dibromo-1-nitro-2-acetyloxypropane;

benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetylpyridinium chloride, cetrimonium, polychloride Level 4 ammonium salts such as dofanium chloride, tetraethylammonium bromide, didecyldimethylammonium chloride, and domiphen bromide;

Metformin, buformin, phenformin, proguanil, chlorproguanil, chlorhexidine, alexidine, polyamines Biguanides such as propylbiguanide and polyhexanide;

Sodium alkyl benzene sulfonate, polyoxyethylidene nonylphenyl ether, polyoxyethylidene oleyl ether, polyoxyethylidene stearamide, lauryl dimethyl benzyl ammonium chloride and other surfactants ;

Inorganic antibacterial agents such as silver-supported zeolite, copper-supported zeolite, zinc-supported zeolite, silver-supported calcium phosphate, copper-supported calcium phosphate, zinc-supported calcium phosphate, titanium oxide, etc.

In addition, as for antibacterial/antifungal agents, as other ingredients in the above classification, or as ingredients not included in the above classification, examples include: thiabendazole, triclosan, lohexidine, Zinc pyrithione, chloroxylenol, etc., or natural antibacterial ingredients such as chitosan, catechin, thymol, hinokitol, Mengzong bamboo extract, mustard seed essential oil, wasabi essential oil, etc.

Examples of antiseptic and antifungal agents include parabens, 2-phenoxyethanol, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, dehydrogenation Acetic acid and its salts, p-toluenesulfonic acid and its salts, alcohols such as ethanol or isopropanol, benzalkonium chloride chloride) and other quaternary ammonium salts, as well as polyols, medium-chain fatty acids and their esters, glycerin derivatives and chelating agents such as EDTA, which are raw materials with antiseptic effects.

Examples of aromatic sulfonic acid compounds include methoxybenzenesulfonic acid, methoxybenzenesulfonic acid, dimethoxybenzenesulfonic acid, dimethoxybenzenesulfonic acid, ethoxybenzenesulfonic acid, and ethoxybenzenesulfonic acid. Benzene disulfonic acid, diethoxybenzenesulfonic acid, diethoxybenzenesulfonic acid, propoxybenzenesulfonic acid, propoxybenzenesulfonic acid, butoxybenzenesulfonic acid, butoxybenzene di Sulfonic acid, methyl methoxy benzene sulfonic acid, methyl methoxy benzene disulfonic acid, methoxy naphthalene sulfonic acid, methoxy naphthalene disulfonic acid, dimethoxy naphthalene sulfonic acid, dimethoxy naphthalene Disulfonic acid, ethoxynaphthalene disulfonic acid, ethoxynaphthalene disulfonic acid, diethoxynaphthalene disulfonic acid, diethoxynaphthalene disulfonic acid and their sodium, potassium, lithium, calcium salts, etc.

Examples of antioxidants include phenol-based antioxidants, sulfur-based antioxidants, phosphorus-based antioxidants, hindered amine-based antioxidants, and the like.

-2,4,6-(1H,3H,5H)-三酮、2,2’-亞甲基雙(6-第三丁基-4-甲基酚)、4,4’-亞丁基雙(6-第三丁基-3-甲基酚)、4,4’-硫基雙(6-第三丁基-3-甲基酚)等。 Examples of phenolic antioxidants include: N-octadecyl-3-(4-hydroxy-3,5-di-tert-butylphenyl)propionate, 2,6-di-tert-butyl-4 -Methylphenol; 2,2-Thio-diethylene-bis-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate], tri-ethylene glycol -Bis-[3-(3-tert-butyl-5-methyl-4-hydroxyphenyl)propionate], 3,9-bis[2-{3-(3-tert-butyl-4) -Hydroxy-5-methylphenyl)propyloxy}-1,1-dimethylethyl]-2,4,8,10-tetraoxaspiral[5‧5]undecane, 4{ 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-propionate}neopenterythritol, 2-tert-butyl-6-(3-tert-butyl-2-hydroxy -5-Methylbenzyl)-4-methylphenylacrylate, 2-[1-(2-hydroxy-3,5-di-tertiary pentylphenyl)ethyl]-4,6-di -Tertiary amylphenyl acrylate, 1,3,5-trimethyl-2,4,6-gin(3,5-di-tert-butyl-4-hydroxybenzyl)benzene, gin(3) ,5-di-tert-butyl-4-hydroxybenzyl)tripolyisocyanate, 1,3,5-shen(4-tert-butyl-3-hydroxy-2,6-dimethylbenzyl)- 1,3,5-Three

-2,4,6-(1H,3H,5H)-trione, 2,2'-methylenebis(6-tert-butyl-4-methylphenol), 4,4'-butylenebis (6-tert-butyl-3-methylphenol), 4,4'-thiobis(6-tert-butyl-3-methylphenol), etc.

Examples of sulfur-based antioxidants include: 3,3'-di-N-dodecyl thiodipropionate, 3,3'-di-N-tetradecyl thiodipropionate, 3,3- Di-N-octadecyl thiodipropionate, tetra(3-dodecylthiopropionate) neopentylerythritol, etc.

Examples of phosphorus-based antioxidants include bis(2,4-di-tert-butylphenyl)phosphite and bis(2,4-di-tert-butylphenyl)nepentylerythritol diphosphite. , bis (2,6-di-tert-butyl-4-methylphenyl) neopentyl erythritol diphosphite, bis (2,4-di-cumylphenyl) neopentyl erythritol diphosphite Ester, 4(2,4-di-tert-butylphenyl)-4,4'-biphenyl diphosphonite, bis-[2,4-di-tert-butyl, (6-methyl base) phenyl] ethyl phosphite, etc.

-2,4-二基}{(2,2,6,6-四甲基-4-哌啶基)亞胺基}-1,6-六亞甲基{(2,2,6,6-四甲基-4-哌啶基)亞胺基}]等。 Examples of hindered amine antioxidants include bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate and 2,2,6,6-tetramethyl-4-piperidine. methyl methacrylate, poly[{6-(1,1,3,3-tetramethylbutyl)amino-1,3,5-tri

-2,4-diyl}{(2,2,6,6-tetramethyl-4-piperidinyl)imino}-1,6-hexamethylene{(2,2,6,6 -tetramethyl-4-piperidinyl)imino}], etc.

Examples of rust inhibitors include alkanolamines, quaternary ammonium salts, alkanethiols, imidazolines, sodium metavanadate, bismuth citrate, phenol derivatives, polyenamines, alkyl imidazoline derivatives, and cyanoalkanes. Amines, carboxamides, alkylenediamines, pyrimidines and their carboxylic acids, naphthenic acids, sulfonic acid complexes, calcium nitrite, alkylamines and esters, polyols, polyphenols, alkanolamines, molybdic acid Sodium, sodium tungstate, sodium nitrite, sodium phosphonate, sodium chromate, sodium silicate, gelatin, polymers of carboxylic acids, aliphatic amines, aliphatic diamines, aromatic amines, aromatic diamines, ethoxy Cylated amines, imidazole, benzimidazole, nitro compounds, formaldehyde, acetylenic alcohol, aliphatic mercaptans, aliphatic thioethers, aromatic mercaptans, aromatic thioethers, trisine, thiourea, acetylenic alcohol, 2- Mercaptobenzimidazole, mixtures of amines or quaternary ammonium salts and halide ions, acetylene mercaptans and thioethers, dibenzyl styrene, mixtures of alkylamines and potassium iodide, dicyclohexylamine nitrite, cyclohexylamine benzoate, Benzotriazole, mixture of tannins and sodium phosphate, triethanolamine With the mixture of lauryl sarcosine and benzotriazole, the mixture of alkylamine and benzotriazole, sodium nitrite and sodium phosphate, etc.

-2-基)-5[(己基)氧基]-酚、2-乙氧基-2’-乙基-乙二酸雙醯胺苯等。 Examples of ultraviolet absorbers and light stabilizers include: 2-(5-methyl-2-hydroxyphenyl)benzotriazole, 2-[2-hydroxy-3,5-bis(A,A-dimethyl) Benzyl)phenyl]-2H-benzotriazole, 2-(3-tert-butyl-5-methyl-2-hydroxyphenyl)-5-chlorobenzotriazole, 2-(2'- Hydroxy-5'-tert-octylphenyl)benzotriazole, methyl-3-[3-tert-butyl-5-(2H-benzotriazol-2-yl)-4-hydroxyphenyl ] Propionate-polyethylene glycol, hydroxyphenylbenzotriazole derivatives, 2-(4,6-diphenyl-1,3,5-tri

-2-yl)-5[(hexyl)oxy]-phenol, 2-ethoxy-2'-ethyl-oxalic acid bisamide benzene, etc.

、烷基吡啶化合物、禾草鹼(gramine)系化合物、isotonyl化合物等。 Examples of bioadhesion inhibitors include tetramethylthiuram disulfide, zinc bis(N,N-dimethyldithiocarbamate), and 3-(3,4-dichlorophenyl)- 1,1-Dimethylurea, dichloro-N-((dimethylamino)sulfonyl)fluoro-N-(P-tolyl)aminothiomethane, pyridine-triphenylborane, N, N-dimethyl-N'-phenyl-N'-(fluorodichloromethylthio)sulfonamide, cuprous thiocyanate, cuprous oxide, tetrabutylthiuram disulfide, 2,4 ,5,6-tetrachloroisophthalonitrile, zinc bisdithiocarbamate, 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine, N-(2,4,6 -Trichlorophenyl)maleimide, bis(2-pyridinethiol-1-oxide) zinc salt, bis(2-pyridinethiol-1-oxide) copper salt, 2-methylthio -4-tertiary butylamino-6-cyclopropylamino-S-tertiary

, alkylpyridine compounds, gramine compounds, isotonyl compounds, etc.

Examples of deodorants include organic acids, fatty acid metals, metal compounds, cyclodextrins, porous materials, and the like.

Examples of organic acids include lactic acid, succinic acid, malic acid, citric acid, maleic acid, malonic acid, ethylenediamine polyacetic acid, alkane-1,2-dicarboxylic acid, and olefin-1,2-dicarboxylic acid. , cycloalkane-1,2-dicarboxylic acid, cycloalkene-1,2-dicarboxylic acid, naphthalenesulfonic acid, etc.

Examples of fatty acid metals include zinc undecenoate, zinc 2-ethylhexanoate, and zinc ricinoleate.

Examples of metal compounds include: iron oxide, iron sulfate, zinc oxide, zinc sulfate, zinc chloride, silver oxide, steel oxide, metal (iron, copper, etc.) sodium chlorophyllate, metal (iron, copper, cobalt, etc.) phthalide Cyanine, metal (iron, copper, cobalt, etc.) tetrasulfonate phthalocyanine, titanium dioxide, visible light-responsive titanium dioxide (nitrogen-doped type, etc.), etc.

Examples of multivalent metal ion scavengers include: nitrilotriacetate acid (NTA), ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentacetic acid (DPTA), hydroxyethylethylenediaminetriacetic acid (HEDTA) ), hydroxyethylene diphosphonic acid (HEDP), aminotrimethylenephosphonic acid (ATMP) or their salts, etc.

Examples of cyclodextrins include α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, their methyl derivatives, hydroxypropyl derivatives, glucosyl derivatives, maltosyl derivatives, and the like.

Examples of porous body constituent components include polyunsaturated carboxylic acid, aromatic polymer, chitin, chitosan, activated carbon, silica gel, activated alumina, zeolite, ceramics, and the like.

系顏料、雙偶氮縮合系顏料、苯并咪唑酮系顏料等。 Examples of the pigment include carbon black, titanium oxide, phthalocyanine pigments, quinacridone pigments, isoindolinone pigments, perylene pigments, perinone pigments, and quinophthalone pigments. Pigments, diketo-pyrrolo-pyrrole pigments, diketo-pyrrolo-pyrrole pigments,

pigments, disazo condensation pigments, benzimidazolone pigments, etc.

Examples of the surfactant include cationic surfactants, amphoteric surfactants, anionic surfactants, nonionic surfactants, and the like.

Examples of the cationic surfactant include quaternary ammonium salts, primary amine salts, secondary amine salts, tertiary amine salts, quaternary amine salts, and pyridine derivatives.

Examples of amphoteric surfactants include betaine-type surfactants, carboxylic acid derivatives, imidazoline derivatives, and the like.

Examples of anionic surfactants include alkyl phosphate surfactants, sulfated oils, soaps, sulfated ester oils, sulfated amide oils, olefin sulfated ester salts, fatty alcohol sulfated ester salts, alkyl Sulfate ester salt, fatty acid ethyl ester sulfonate, alkyl naphthalene sulfonate, alkyl benzene sulfonate, succinate ester sulfonate, phosphate ester salt, etc.

Examples of the nonionic surfactant include partial fatty acid esters of polyhydric alcohols, ethylene oxide adducts of fatty alcohols, ethylene oxide adducts of fatty acids, and ethylene oxides of fatty amine groups or fatty amide groups. Adducts, ethylene oxide adducts of alkylphenols, ethylene oxide adducts of partial fatty acid esters of polyols, polyethylene glycol, polyoxyethylene alkyl ether, alkyl glucosides , fatty acid alkanolamides, etc. From the viewpoint of the stability of the hydrolyzable tannins contained in this detergent, polyoxyethylene alkyl ethers, alkyl glucosides, and fatty acid alkanolamides are preferred, and polyoxyethylene is more preferred. alkyl ethers and alkyl glucosides, particularly preferably polyoxyethylene alkyl ethers. This surfactant is preferable from the viewpoint of being easy to handle in an acidic solvent and suppressing the hydrolysis of the hydrolyzable tannin or keeping it within an acceptable range by mixing with the hydrolyzable tannin.

Examples of polyoxyethylene alkyl ethers include: polyethylene glycol monododecyl ether, polyethylene glycol monocetyl ether, coconut oil alkyl ethoxylate, polyethylene glycol (polymerization degree 10) tridecyl ether , polyethylene glycol (polymerization degree 12) tridecyl ether, polyethylene glycol (polymerization degree 18) tridecyl ether, etc. Examples of alkyl glucosides include n-octyl-β-D-glucopyranoside, n-heptyl-β-D-glucosinolate, n-octyl-β-D-glucosinolate, and the like.

The content of the surfactant in the detergent of the present disclosure is, for example, 0.00001 to 60 mass%, and its upper limit and lower limit, for example, can be a range of any combination of two of the following values: 60 mass%, 50 Mass%, 30 mass%, 20 mass%, 10 mass%, 5 mass%, 2 mass%, 1 mass%, 0.5 mass%, 0.1 mass%, 0.01 mass%, 0.001 mass%, 0.0001 mass%.

Examples of the thickening agent include oxides or hydroxides such as magnesium and calcium.

As additives belonging to other components, other components that overlap with the above classification or components that are not included in the above classification include, for example: fixing agents, dispersants, wetting agents, stabilizers, propellants, penetration accelerators, and fragrances. , fragrances, solubility adjusters, dyes, gelling agents, kneading resins, non-volatile oils, pH adjusters, biological repellents, antibiotics, antiviral agents, flame retardants, foaming agents, emulsifiers, gloss agents , binders, inorganic salts, oily ingredients, polymer substances, medicinal ingredients, enzymes, fragrances/essential oils, pigments, whitening ingredients, pigments, sulfur, sebum secretion promoting ingredients, vitamins categories, seaweed extracts, cooling substances, moisturizing ingredients, etc.

When the detergent of the present disclosure contains additives, the content of the active ingredient in the detergent of the present disclosure is, for example, 0.000001 to 50% by mass, and the upper limit and the lower limit thereof may be, for example, any combination of two of the following values. Range of results: 50 mass%, 40 mass%, 30 mass%, 20 mass%, 10 mass%, 5 mass%, 2 mass%, 1 mass%, 0.5 mass%, 0.1 mass%, 0.01 mass%, 0.001 mass %, 0.0001 mass%, 0.00001 mass%, 0.000001 mass%.

2. Type and purpose

The type of the detergent disclosed in the present disclosure is not particularly limited. It is a type that can clean indoor water-using places. Specifically, as long as the active ingredients in the detergent disclosed herein can be brought into contact with water in indoor water-using places. Surface, there are no special restrictions. As the form of the cleaning agent disclosed in the present disclosure, it can be prepared, for example, into liquids (oils, emulsions, aqueous solutions, etc.), powders, granules, granules, microgranules, tablets, agglomerates, baits, Pastes, glues, wettable powders, foaming preparations, foams, aerosols, sprays, fumigants, coating agents and other preparations, or can be carried on a carrier for use. These product types can be in a form that matches the concentration of action, or they can be in a high-concentration form in advance and be diluted during use.

Indoor water use places include places where water (preferably tap water) is used in various buildings, that is, places where there are surfaces that come into contact with water (also referred to as "water use surfaces" in this manual). No special restrictions. Because mucus will be produced in such places, it is suitable to use the cleaning agent of the present disclosure. Examples of buildings include: residences, factories, offices, accommodation facilities, hospitals, stores, schools, restaurants, airport facilities, stations, bus terminals, service areas, sports facilities, etc. The factory can be a printing factory, paper/pulp factory, chemical factory, petrochemical factory, machinery factory, metal factory, iron and steel factory, construction factory, residential factory, food factory, beverage factory, automobile factory, auto parts factory, motorcycle factory, Pharmaceutical factories, cosmetics factories, semiconductor factories, electronics factories, home appliance factories, computer factories, logistics factories, etc. are not particularly limited, but paper/pulp factories are preferred.

Specific examples of indoor water use places include household kitchens, professional kitchens, bathrooms, toilets, kitchens, washrooms, water circulation equipment, etc. Examples of water circulation equipment that easily generate slime include white water circulation equipment in the papermaking step of a papermaking/pulp factory. The detergent disclosed in the present disclosure is particularly suitable for cleaning "indoor commonly used water places" represented by the above specific examples.

The so-called cleaning can remove all or part of the foreign matter from the water surface, and can also inhibit the attachment or increase of foreign matter on the water surface. There is no particular limitation on the water surface as long as it is an object to which foreign matter adheres. Examples include drain outlets, drainage ditches, drainage pipes, pipelines, walls, floors, appliances, etc. installed in household kitchens, bathrooms, toilets, washstands, etc. The surface of machines, etc. can specifically include: plastic, ceramics, metal, glass, etc. Examples of plastics include: fiber reinforced plastic (FRP), polyvinyl chloride, polypropylene, polyethylene, ABS, polyamide, acrylic, polystyrene, etc. Ceramics can include: various nitrides, carbonitrides, oxides, etc. Metals can be listed: iron, stainless steel, aluminum, zinc, silver, copper, etc.

Foreign objects refer to things that should not exist in the first place. The so-called foreign objects in indoor water use places refer to things that should not appear in indoor water use places. Examples of foreign matter in indoor water use areas include: Foreign matter from microorganisms, foreign matter from animals, foreign matter from minerals, etc. Examples of foreign matter derived from microorganisms include slime derived from microorganisms (hereinafter also referred to as biofilm). The so-called "mucus derived from microorganisms" refers to the production of living substances such as polysaccharides, proteins or nucleic acids from the microbial cells to form structures during the process of microorganisms adhering to solid surfaces and multiplying, that is, including microorganisms and microorganisms. The structure of living matter. As the cleaning agent of the present disclosure, the foreign matter that is intended to remove or inhibit the adhesion of foreign matter is preferably a foreign matter derived from microorganisms, and more preferably is a mucus derived from microorganisms. The detergent disclosed herein has a particularly excellent effect in inhibiting mucus derived from microorganisms and can be used to inhibit mucus or be used in contact with mucus.

The microorganisms may be bacteria, fungi (molds/yeasts), etc., and are not particularly limited. From the viewpoint of efficiently inhibiting mucus, bacteria are preferred, and bacteria having an outer membrane type membrane on the outside of the cell wall are more preferred. Preferably it is a Gram-negative bacterium, and more preferably it is a Methylobacterium genus. Examples of outer membrane type membranes include outer membranes possessed by Gram-negative bacteria and mycotic acid membranes possessed by bacteria belonging to the genus Rhodococcus.

Examples of bacteria include: Methylobacterium adhaesivum, Methylobacterium aerolatum, Methylobacterium aminovorans, Methylobacterium aquaticum, Methylobacterium brachiatum, Methylobacterium brachythecii, Methylobacterium bullatum, Methylobacterium cerastii, Methylobacterium chloromethanicum, Methylobacterium crusticola, Methylobacterium currus , Methylobacterium dankookense, Methylobacterium dichloromethanicum, Methylobacterium durans, Methylobacterium extorquens, Methylobacterium frigidaeris, Methylobacterium fujisawaense, Methylobacterium funariae, Methylobacterium gnaphalii, Methylobacterium goesingense, Methylobacterium gossipiicola, Methylobacterium gregans, Methylobacterium haplocladii, Methylobacterium hispanicum, Methylobacterium indicum, Methylobacterium iners, Methylobacter ium isbiliense, Methylobacterium jeotgali, Methylobacterium komagatae, Methylobacterium longum, Methylobacterium lusitanum, Methylobacterium marchantiae, Methylobacterium mesophilicum, Methylobacterium nodulans, Methylobacterium nonmethylotrophicum, Methylobacterium organophilum, Methylobacterium oryzae, Methylobacterium oryziha bitans, Methylobacterium oxalidis, Methylobacterium persicinum, Methylobacterium phyllosphaerae, Methylobacterium phyllostachyos, Methylobacterium planium, Methylobacterium platani Methylobacterium podarium lobacterium soli, Methylobacterium suomiense, Methylobacterium symbioticum, Methylobacterium tardum, Methylobacterium tarhaniae, Methylobacterium terrae, Methylobacterium terricola, Methylobacterium thiocyanatum, Methylobacterium thuringiense, Methylobacterium trifolii, Methylobacterium variabile, Methylobacterium zatmanii and other Methylobacterium (Methylobacterium) genera; Pseudomonas aeruginosa (Pseudomonas aeruginosa), Pseudomonas putida and other pseudogenes Pseudomonas genus; Escherichia genus such as Escherichia coli; Serratia genus such as Serratia marcescens, Brevundimonas dimuta and other short-wave monocytogenes Gram-negative bacteria such as Brevundimonas; Xanthomonas such as Xanthomonas campestris, Sphingomonas such as Sphingomonas paucimobilis Bacteria; Bacillus subtilis, Bacillus cactus Bacillus genus such as Bacillus cereus and Bacillus lentus; Staphylococcus genus such as Staphylococcus aureus and Staphylococcus epidermidis, Rhodococcus rhodochrous ) and other Gram-positive bacteria of the genus Rhodococcus, etc.

Examples of fungi include Cladosporium genus such as Cladosporium cladosporioides, Penicillium genus such as Penicillium citrinum, and Aspergillus such as Aspergillus brasiliensis. ) genus, Alternaria genus such as Alternaria alternata, Fusarium genus such as Fusarium solani, Eurotium genus such as Eurotium herbariorum, Rhodotorula genus ( Rhodotorula mucilaginosa and other red yeasts, Aureobasidium genus, Exophiala genus and other black yeasts, Phoma genus, Candida genus, Saccharomyces Genus etc.

The detergent disclosed in the present disclosure is preferably used to inhibit Methylobacterium bacteria, Brevundomonas bacteria, Pseudomonas bacteria, Xanthomonas bacteria, Sphingomonas bacteria, Rhodococcus bacteria Slime derived from microorganisms such as bacteria, or mucus that can be used to contact such microorganisms. The detergent disclosed in the present disclosure is suitable for use in Methylobacterium bacteria, which have a particularly high frequency of producing mucus among the pathogenic bacteria, and is more suitable for Methylobacterium fujisawaense, which is also prone to mucus formation among Methylobacterium bacteria.

Among bacteria, Methylobacterium genus is known to be pathogenic bacteria with pink or red mucus. Therefore, the detergent disclosed herein is suitable for inhibiting pink or red mucus in mucus.

The so-called "living substances of microorganisms" are a general term for chemical substances that exist in living organisms. Examples include: nucleic acids, proteins, polysaccharides and other living polymers, nucleotides, nucleosides, amino acids, sugars, Constituents of living polymers such as lipids, alcohols, amino acids, nucleic acids, antioxidants, organic acids, polyols, vitamins, hormones and other metabolites.

The detergent of the present disclosure is preferably used at a concentration that does not substantially inhibit the growth of bacteria of the genus Methylobacterium. The concentration that does not substantially inhibit growth, for example, refers to the substantial number of bacteria of the genus Methylobacterium when the detergent of the present disclosure is not used and the number of bacteria of the genus Methylobacterium when the detergent of the present disclosure is used. Above is an equal range of concentrations. Whether the concentrations are within a substantially equal range can be determined by comparing the number of bacteria of the genus Methylobacterium when no detergent is used and the number of bacteria of the genus Methylobacterium when the detergent is used. This comparison method can adopt the method of Experiment 2 of the Examples described later. The ratio of Methylobacterium bacteria when the detergent is used to the Methylobacterium bacteria when the detergent is not used is required to be 50% or more, 60% or more, 70% or more, 80% or more, or 90% or more. The concentration can be said to be a concentration that does not substantially inhibit proliferation. The concentration when using the detergent of the present disclosure (that is, when the detergent of the present disclosure is used directly without diluting it) is the concentration of the active ingredients in the detergent of the present disclosure. When used by dilution or dilution with running water, it is the active ingredient concentration in the obtained dilution), for example, as long as it is 300 μg /mL or less, 200 μg /mL or less, 100 μg /mL or less, or 50 μg /mL. Concentrations below, 20 μg /mL or below, or 10 μg /mL below can be said to be concentrations that do not substantially inhibit growth.

The types of detergents disclosed in this disclosure are not particularly limited, and can be of various types depending on the target indoor water use location, purpose, type, and usage method. Examples of the detergents disclosed in this disclosure include household detergents, kitchen/professional kitchen detergents, industrial detergents, slime removers, slime preventers, household kitchen drain cleaners, and bathroom cleaners. Detergents, toilet detergents, in-tank agents, on-tank agents, automatic toilet flushing detergents, drain pipe detergents, dishwasher detergents , bathtub detergent, bathtub detergent, etc.

The manufacturing method of the detergent disclosed in the present disclosure is not particularly limited, and may include, for example, a method of mixing active ingredients and other ingredients blended as required. Appropriate methods can be adopted according to the type and type of detergent.

When cleaning indoor water use areas, the method of using the cleaning agent disclosed in this disclosure is not particularly limited. For example, the cleaning agent of the present disclosure can be directly applied to the water surface, or can be applied by dropping the cleaning agent of the present disclosure on the water surface, or by spraying the cleaning agent of the present disclosure on the wet surface. Once on a paper towel or sponge, spread it over a surface with water to spread. Alternatively, the cleaning agent of the present disclosure may be filled into a pump container or a spray container and then sprayed on the water surface. Furthermore, the cleaning agent of the present disclosure is placed at or around a water outlet (faucet, etc.) in an indoor water place, and the detergent of the present disclosure is diluted with water flowing out from the water outlet, and the resulting The diluent (which is also an aspect of the cleaning agent disclosed in the present disclosure) contacts the water surface, whereby cleaning can also be performed.

The detergent according to the present disclosure can inhibit mucus in indoor water use places. Therefore, one aspect of the present disclosure relates to a method of suppressing mucus (hereinafter referred to as "the method of suppressing mucus of the present disclosure") including bringing the detergent of the present disclosure into contact with water surfaces in indoor water use places.

The target water surface can be a surface on which mucus already exists, or a surface on which mucus has not yet formed. In the former case, by contacting the cleaning agent of the present disclosure with mucus derived from microorganisms, the increase in mucus can be inhibited or the mucus itself can be reduced. In the latter case, the formation of slime can be inhibited by contacting the cleaning agent of the present disclosure with the water surface.

When there is mucus on the water surface, the mucus suppression method of the present disclosure may include removing the mucus before the step of contacting the water surface with the cleaning agent of one aspect of the present invention. The steps for removing mucus are not particularly limited. Mucus can be removed physically or chemically. After removing mucus in advance, the formation of mucus can be more effectively inhibited by using the detergent disclosed herein.

According to the mucus suppression method of the present disclosure, mucus can be suppressed in a safe and environmentally friendly manner.

The conditions of the above contact step are not particularly limited. This step can be performed at a temperature of, for example, 20 to 35°C, or at a temperature of 25 to 30°C. The pH during use can be acidic from 2.0 to 3.0, weakly acidic from 3.0 to 6.0, neutral from 6.0 to 8.0, weakly alkaline from 8.0 to 10.0, or alkaline from 10.0 to 12.0. For example, it does not produce chlorine gas even under acidic conditions, is friendly to the body and the environment, and suppresses mucus.

The amount of detergent used in the mucus suppression method of the present disclosure can be appropriately set taking into account the type and concentration of mucus, the volume of the reaction system, the reaction temperature, etc. Specifically, in the case of slime derived from Methylobacterium produced in drains, etc., the concentration of the active ingredient when in contact with the slime may be 2 μg /mL or more and 300 μg /mL or less, and may be 5 μg /mL. It may be more than mL and less than 250 μg /mL, it may be more than 10 μg /mL and less than 200 μg /mL, or it may be more than 20 μg /mL and less than 100 μg . When the detergent exerts a bactericidal effect, the killed bacteria will become the matrix to form the next batch of mucus. Therefore, within this concentration range, the bactericidal effect will not be exerted but the formation of mucus will be suppressed, and mucus can be effectively suppressed.

Whether the mucus suppression method of the present disclosure suppresses mucus can be determined, for example, according to the following method. First, bacteria are cultured for a period of time in the presence or absence of detergents of the present disclosure. After the culture is completed, remove the culture medium and stain the formed mucus with a dye such as crystal violet. SDS was added to the stained mucus, and the absorbance of the solution after the mucus was dissolved was measured. Compare the absorbance in the presence of detergent with that in the absence of detergent. If the absorbance in the presence of detergent is lower than the absorbance in the absence of detergent, it can be judged that the mucus is inhibited. As the bacteria to be used, Methylobacterium which is considered to be the main pathogenic bacteria of mucus in water commonly used indoors is preferred.

The mucus formation rate is preferably small, and the biofilm formation rates calculated in the examples described below include: 80% or less, 70% or less, 60% or less, 50% or less, 40% or less, 30% or less, or 20% or less.

3. Additional effect: deodorizing effect

According to the cleaning agent of the present disclosure, it is possible to deodorize odorous substances that are a problem in indoor water use places. Therefore, one aspect of the present disclosure relates to a deodorizing method (hereinafter referred to as "the deodorizing method of the present disclosure") involving contacting the cleaning agent of the present disclosure with an odorous substance.

Examples of odor substances that are problematic in indoor water use areas include N-based substances such as ammonia, trimethylamine, and pyridine, hydrogen sulfide, methyl mercaptan, methyl sulfide (methyl sulfilde), and dimethyl disulfide (methyl disulfilde). S-based substances such as propanethiol, and lower fatty acid-based substances such as acetic acid, propionic acid, n-butyric acid, isocitric acid, and caproic acid. By bringing the cleaning agent of the present disclosure into contact with odorous substances, odorous substances can be reduced and removed.

The conditions of the contact step are not particularly limited, and may include the conditions described in the contact step with the mucus. From the viewpoint of the stability of hydrolyzable tannins, the pH during use is preferably 2.0 to 6.0, more preferably 2.0 to 4.0.

Whether the deodorizing method of the present disclosure removes odorous substances can be judged, for example, according to the following method. First, after contacting the odorous substances in the aqueous solution for a period of time in the presence or absence of the cleaning agent of the present disclosure, the odorous substances in the aqueous solution are quantified. Compare the quantitative value of the odor substances in the presence of the detergent and the absence of the detergent. If the quantitative value in the presence of the detergent is lower than the quantitative value in the absence of the detergent, it can be judged that the odor substance has been removed.

4. Additional effect: fatty acid calcium dissolution

In places where water is used indoors, fatty acids that are components of soap may react with calcium in tap water and precipitate as unnecessary calcium fatty acids in the water. The fatty acid calcium can also be dissolved by the detergent disclosed in this disclosure. untie. Therefore, one aspect of the present disclosure relates to a method of dissolving fatty acid calcium (hereinafter referred to as “the method of dissolving fatty acid calcium of the present disclosure”) including contacting the detergent of the present disclosure with fatty acid calcium.

Examples of fatty acid calcium that poses a problem in indoor water use areas include calcium salts of fatty acids in soap components. Such fatty acid calcium is not particularly limited as long as it is a calcium salt of the fatty acid contained in the soap component, and may be saturated fatty acid calcium or unsaturated fatty acid calcium. The fatty acid calcium is preferably a linear fatty acid calcium having 10 to 20 carbon atoms, more preferably a linear fatty acid calcium having 12 to 18 carbon atoms. Examples of such fatty acid calcium include calcium laurate, calcium myristate, calcium palmitate, calcium stearate, and calcium oleate. By bringing the detergent of the present disclosure into contact with fatty acid calcium, the fatty acid calcium can be dissolved.

The conditions of the contact step are not particularly limited, and may include the conditions described in the contact step with the mucus. From the viewpoint of the stability of hydrolyzable tannins, the pH during use is preferably 2.0 to 6.0, more preferably 2.0 to 4.0.

Whether the fatty acid calcium is dissolved according to the dissolution method of the present disclosure can be confirmed by visual observation after contacting the fatty acid calcium in an aqueous solution for a period of time in the presence or absence of the detergent of the present disclosure. Quantitative method, quantitative method using image analysis to judge. Compare the amount of fatty acid calcium in the presence of the detergent and the absence of the detergent. If the amount of fatty acid calcium in the presence of the detergent is lower than the amount of fatty acid calcium in the absence of the detergent, it is determined to be dissolved.

In addition, whether the fatty acid calcium is dissolved according to the dissolution method of the present disclosure can also be determined by, for example, quantifying the fatty acid or calcium derived from the dissolved fatty acid calcium. Examples of such methods include methods using LC analysis, GC analysis, elemental analysis, and calcium quantification kits. For example, using a calcium quantification kit to compare the free calcium concentration in the presence of a detergent and in the absence of the detergent, if the free calcium concentration in the presence of the detergent is compared to the amount of free calcium in the absence of the detergent is If it increases, it can be judged as dissolved.

[Example]

An aspect of the present invention will be described in detail below based on examples, but the present invention is not limited to these examples.

Experiment 1. The effect of using tannic acid to inhibit the formation of biofilm (BF) by Methylobacterium bacteria

(Material)

‧Methylobacterium fujisawaense NBRC15843; (hereinafter referred to as NBRC15843 strain)

‧R2A medium

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

In addition, the "tannic acid" used in the examples is a product manufactured by FUJIFILM Wako Pure Chemical Co., Ltd. and has the following structural formula.

(method)

The glycerol stock solution of the NBRC15843 strain was added at a ratio of 100 μL /50 mL-R2A medium, and cultured at 30° C. and 150 rpm for 3 days to serve as a preculture medium. The turbidity (OD600) of the preculture solution was measured with a turbidity meter (CO80000 cell density meter; WPA biowave).

Prepare a cell dilution solution (OD600=0.2) obtained by diluting the pre-culture medium with R2A medium and a sample phase dilution solution obtained by diluting the sample phase to a predetermined concentration. To a 96well PS plate (manufactured by Thermo Fisher Scientific), the bacterial cell dilution and the specimen stage dilution were added one by one at 100 μL /well (a total of 200 μL /well), and the plates were cultured statically at 30°C for 10 days. The culture medium was replaced after 72 hours and 144 hours. After the culture, remove the culture medium, add 0.2% crystal violet solution at 200 μL /well, and stain at room temperature for about 60 minutes. After staining, wash twice with 200 μL /well dH ₂ O, add 200 μL /well 2% SDS solution, and let stand for about 30 minutes to dissolve the bacteria. The bacterial cell lysate was transferred to another measurement plate at 150 μL /well, and the absorbance at 575 nm was measured with a plate reader (SpectraMax 340PC; Molecular Devices). From the obtained absorbance, the following formula 1 was used The BF formation rate was calculated, and based on the calculated BF formation rate, it was judged as A to C based on the following criteria.

Formula 1: BF formation rate (%) = (sample-BG)/(negative control-BG) × 100

Specimen: The measurement value when the specimen is added.

Negative control: measured value without added specimen.

BG: Measurement of culture medium only.

A: More than 0% and less than 30%.

B: More than 30% but less than 70%.

C: More than 70%.

(Results) The results are shown in Table 1. By adding tannic acid, the formation of biofilm derived from the NBRC15843 strain was inhibited in a concentration-dependent manner. The 50% inhibitory concentration (hereinafter referred to as IC50) is 2.8 μg /mL.

[Table 1]

Experiment 2. The effect of using tannic acid to inhibit the proliferation of Methylobacterium bacteria

(Material)

‧NBRC15843 strain

‧R2A medium

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

(method)

The cultured preculture medium was used in the same manner as in Experiment 1. Prepare a cell dilution solution in which the pre-culture solution is diluted to OD600=0.2 using R2A medium, and a specimen phase dilution solution in which the specimen phase is diluted to a predetermined concentration. Add the bacterial cell diluent and specimen stage diluent one by one to the 48well deep well (manufactured by Thermo Fisher Scientific) (2 mL/well in total) at 1 mL/well, and measure the turbidity (OD600) after 24 hours of culture. For the turbidity, the growth rate was calculated using the following equation 2, and judged as A to C based on the following criteria.

Formula 2: Proliferation rate (%) = (sample-BG)/(negative control-BG) × 100

Specimen: Turbidity when adding specimen.

Negative control: measured value without added specimen.

BG: turbidity with culture medium only.

A: More than 90%.

B: More than 50% but less than 90%.

C: More than 0% and less than 50%.

(result)

The results are shown in Table 2. Even at a concentration of 200 μg /mL, tannic acid did not inhibit the growth of the NBRC15843 strain. Taken together with the results of Experiment 1, it is considered that tannic acid does not show an inhibitory effect on the proliferation of Methylobacterium bacteria but inhibits BF formation in the range of 2.5 to 200 μg /mL.

[Table 2]

Experiment 3. Effect of sodium hypochlorite on inhibiting biofilm formation by Methylobacterium bacteria

(Material)

‧NBRC15843 strain

‧R2A medium

‧Sodium hypochlorite (manufactured by Nacalai Tesque Co., Ltd.).

(method)

The BF formation rate was calculated in the same manner as in Experiment 1 except that sodium hypochlorite was used as the evaluation sample.

(result)

The results are shown in Table 3. Although the formation of biofilm derived from the NBRC15843 strain was slightly inhibited by the addition of sodium hypochlorite, the BF formation inhibitory activity was lower than that of tannic acid because the IC50 was higher than tannic acid (IC50>20 μg /mL).

[table 3]

Experiment 4. Inhibition of biofilm-forming activity of Methylobacterium bacteria using various specimens

(Material)

‧NBRC15843 strain

‧R2A medium

‧Compounds listed in Table 4.

(method)

The compounds listed in Table 4 were used as evaluation samples, except that the IC50 was calculated from the BF formation rate in the same manner as in Experiment 1, and the compounds were classified into A to C based on the following criteria.

A: Less than 5 μg /mL.

B: 5 μg /mL or more and less than 10 μg /mL.

C: 10 μg /mL or more.

(result)

The results are shown in Table 4. Among these samples, tannic acid and 1,2,3,4,6-pentagalloylglucose were particularly effective in inhibiting biofilm formation by Methylobacterium bacteria. The structural formula of 1,2,3,4,6-pentagalloylglucose is as follows.

[Table 4]

Experiment 5. The effect of using tannic acid to inhibit the formation of corresponding biofilms by various bacteria

(Material)

‧Bacteria listed in Table 5

‧R2A medium

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

(method)

Except using the conditions described in Table 5 as BF-forming bacterial cells and BF formation time, the IC50 was calculated from the BF formation rate in the same manner as in Experiment 1, and classified into A to D based on the following criteria.

A: Less than 3 μg /mL.

B: 3 μg /mL or more and less than 10 μg /mL.

C: 10 μg /mL or more and less than 20 μg /mL.

D: 20 μg /mL or more.

(result)

The results are shown in Table 5. Tannic acid inhibited the formation of biofilm by all bacteria listed in Table 5. It is particularly effective in inhibiting the formation of biofilms by bacteria with outer membrane-type membranes (outer membranes or mycolic acid membranes), and further effectively inhibits the formation of biofilms by NBRC15843.

[table 5]

Experiment 6. Effect of inhibiting biofilm formation with tannic acid solution (pH 2 to 12)

(Material)

‧NBRC15843 strain

‧R2A medium

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

(method)

A tannic acid solution is prepared by dissolving tannic acid in a solution (tannic acid solution) prepared with a pH of 2 to 12 using 1M sodium hydroxide or 1M hydrochloric acid. After shaking the prepared tannic acid solution at room temperature for 24 hours, the IC50 was calculated from the BF formation rate in the same manner as in Experiment 1, and classified into A to D based on the following criteria.

A: Less than 3 μg /mL.

B: 3 μg /mL or more and less than 10 μg /mL.

C: 10 μg /mL or more and less than 20 μg /mL.

D: 20 μg /mL or more.

(result)

The results are shown in Table 6. Regardless of the pH solution used to dissolve tannic acid, the tannic acid solution inhibited the formation of biofilm.

[Table 6]

Experiment 7. Stability of tannic acid in tannic acid solution (pH 2 to 12)

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

(method)

Tannic acid is dissolved in a solution prepared with pH 2 to 12 using 1M sodium hydroxide or 1M hydrochloric acid to prepare a tannic acid solution. After the prepared tannic acid solution was stored at room temperature and shielded from light for 3 months, it was sent to HPLC for analysis.

HPLC analysis conditions:

×25cm,5μm)(Sumika Chemical Analysis Service公司製) Column: SUMIPAX ODS A-211 (4.6mm

×25cm, 5μm) (manufactured by Sumika Chemical Analysis Service Co., Ltd.)

Mobile phase: Liquid A 0.1w/v% phosphoric acid aqueous solution; Liquid B containing 0.1w/v% phosphoric acid in methanol

Dissolution method: Gradient

[Table 7]

Flow rate: 1.0ml/minute

Tube string temperature: 40℃

Detection: 280nm

The tannic acid residual rate was calculated according to Equation 3, and judged as A to D based on the following criteria.

Formula 3: Tannic acid residual rate (%) = area value of tannic acid in the specimen after 3 months/area value of tannic acid in the specimen when the solution was just prepared × 100

Tannin retention time: 10 minutes to 25 minutes

A: More than 80%

B: More than 60% but less than 80%

C: More than 40% but less than 60%

D: Less than 40%

The gallic acid production rate was calculated according to the following formula 4, and judged as A to D based on the following criteria.

Equation 4: Gallic acid production rate (%) = area value of gallic acid in the specimen/calculated when tannase is completely hydrolyzed Area value of generated gallic acid × 100

Gallic acid retention time: 4.3 minutes

A: Less than 20%

B: More than 20% but less than 40%

C: More than 40% but less than 60%

D: Less than 60%

(result)

The results are shown in Table 8. Tannic acid remains in aqueous solutions at any pH. Especially in the pH range of 2 to 6, the tannic acid residual rate is over 80%, and the gallic acid production rate is less than 20%. In the pH range of 2 to 4, the tannic acid residual rate is over 90%. Furthermore, the gallic acid production rate is less than 5%, so it is considered that tannic acid exists extremely stably.

[Table 8]

Experiment 9. Stability of tannic acid when pH adjuster is mixed

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.)

‧Compounds listed in Table 9

(method)

Mix tannic acid as described in Table 9 to prepare a tannic acid solution. After the prepared tannic acid solution was stored at room temperature for 24 hours, it was sent to HPLC for analysis. The initial rate of gallic acid production is calculated by the following formula 5, and is judged as A to E based on the following criteria.

Formula 5: Initial rate of gallic acid production ( μ g/mL/day) = ([Gallic acid (Day 1)]-[Gallic acid (Day 0)])/(1-0)

[Gallic acid (day 1)]: Gallic acid concentration on day 1 ( μ g/mL)

[Gallic acid (day 0)]: Gallic acid concentration on day 0 ( μ g/mL)

A: Less than 1.0 ( μ g/mL/day)

B: 1.0 ( μ g/mL/day) or more but less than 10 ( μ g/mL/day)

C: 10 ( μ g/mL/day) or more but less than 100 ( μ g/mL/day)

D: More than 100 ( μ g/mL/day) and less than 500 ( μ g/mL/day)

E: 500 ( μ g/mL/day) or more

(result)

The results are shown in Table 9. The initial rate of gallic acid formation in the specimens mixed with any pH adjuster was reduced. Therefore, it is thought that the stability of tannic acid can be improved by mixing the pH adjuster.

[Table 9]

Experiment 10. Stability of tannic acid when mixed with alcohol

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

‧Alcohols listed in Table 10

(method)

Mix tannic acid as described in Table 10 to prepare a tannic acid solution. After the prepared tannic acid solution was stored at room temperature for 24 hours, the amount of gallic acid was quantified in the same manner as in Experiment 9, and classified into S to E based on the following criteria.

S: less than 0.1 ( μ g/mL/day)

A: 0.1 ( μ g/mL/day) or more but less than 1.0 ( μ g/mL/day)

B: 1.0 ( μ g/mL/day) or more but less than 10 ( μ g/mL/day)

D: More than 100 ( μ g/mL/day) and less than 500 ( μ g/mL/day)

E: 500 ( μ g/mL/day) or more

(result)

The results are shown in Table 10. The initial rate of gallic acid formation in the sample mixed with any kind of alcohol became smaller, so it is thought that the stability of tannic acid can be improved by mixing alcohol.

[Table 10]

Experiment 11. Stability of tannic acid when mixing antibacterial, antifungal, antiseptic and antifungal agents

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.)

‧Compounds listed in Table 11

(method)

Mix tannic acid as described in Table 11 to prepare a tannic acid solution. After the prepared tannic acid solution was stored at room temperature for 24 hours, the amount of gallic acid was quantified in the same manner as in Experiment 9, and classified into A to E based on the following criteria.

A: Less than 1.0 ( μ g/mL/day)

B: 1.0 ( μ g/mL/day) or more but less than 10 ( μ g/mL/day)

C: 10 ( μ g/mL/day) or more but less than 100 ( μ g/mL/day)

D: More than 100 ( μ g/mL/day) and less than 500 ( μ g/mL/day)

E: 500 ( μ g/mL/day) or more

(Results) The results are shown in Table 11. In the sample mixed with acetic acid or phenoxyethanol, the initial rate of gallic acid production was both reduced, so it is thought that the stability of tannic acid is improved. In addition, in the sample obtained by mixing sodium dehydroacetate, sodium benzoate, or sodium formate, although the initial rate of gallic acid production increased, it was still within the allowable range, so it is considered that the mixture can be mixed with tannic acid.

[Table 11] Stability of tannic acid aqueous solution: antifungal agent

Experiment 12. Stability of tannic acid when surfactant (polyoxyethylene alkyl ether) is mixed

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

‧Compounds listed in Table 12

(method)

Mix tannic acid as described in Table 12 to prepare a tannic acid solution. After the prepared tannic acid solution was stored at room temperature for 24 hours, the amount of gallic acid was quantified in the same manner as in Experiment 9, and classified into A to E based on the following criteria.

A: Less than 1.0 ( μ g/mL/day)

B: 1.0 ( μ g/mL/day) or more but less than 10 ( μ g/mL/day)

C: 10 ( μ g/mL/day) or more but less than 100 ( μ g/mL/day)

D: More than 100 ( μ g/mL/day) and less than 500 ( μ g/mL/day)

E: 500 ( μ g/mL/day) or more

(result)

The results are shown in Table 12. In the sample mixed with a polyoxyethylene alkyl ether-based surfactant, the initial rate of gallic acid production was reduced, so it is considered that the stability of tannic acid was improved.

[Table 12]

Experiment 13. Stability of tannic acid when surfactant (alkyl glucoside) is mixed

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

‧Compounds listed in Table 13

(method)

Mix tannic acid as described in Table 13 to prepare a tannic acid solution. After the prepared tannic acid solution was stored at room temperature for 24 hours, the amount of gallic acid was quantified in the same manner as in Experiment 9, and classified into A to E based on the following criteria.

A: Less than 1.0 ( μ g/mL/day)

B: 1.0 ( μ g/mL/day) or more but less than 10 ( μ g/mL/day)

C: 10 ( μ g/mL/day) or more but less than 100 ( μ g/mL/day)

D: More than 100 ( μ g/mL/day) and less than 500 ( μ g/mL/day)

E: 500 ( μ g/mL/day) or more

(result)

The results are shown in Table 13. In the sample mixed with an alkyl glucoside-based surfactant, the initial rate of gallic acid production is reduced, so it is considered that the stability of tannic acid is improved. In samples mixed with n-heptyl-β-D-thioglucoside or n-octyl-β-D-thioglucoside, the initial rate of gallic acid production is reduced, so the stability of tannic acid is considered promote. In addition, in the sample mixed with n-octyl-β-D-glucopyranoside, although the initial rate of gallic acid production increased, it was still within the allowable range, so it is considered that it can be mixed with tannic acid.

[Table 13]

Experiment 14. Preparation and use of tannic acid-containing detergents

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.)

‧NBRC15843 strain

‧R2A medium

(method)

Mix 0.25% tannic acid, 0.5% phenoxyethanol, 0.5% acetic acid, 50% ethanol and the remainder pure water to make a tannic acid-containing detergent. Using the prepared detergent, the same method as in Experiment 1 was used to evaluate whether the formation of BF was inhibited.

(result)

The detergent containing tannic acid inhibits the formation of biofilm at a low concentration. The 50% inhibition concentration (IC50) in tannic acid conversion is 0.78 μg /mL.

Experiment 15. Additional effect of tannic acid aqueous solution (1): deodorizing effect

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.).

‧Sodium methyl mercaptide (manufactured by Tokyo Chemical Industry Co., Ltd.)

‧5,5'-Disulfobis(2-nitrobenzoic acid) (DTNB; Tokyo Chemical Industry)

(method)

Add 0.1M phosphate buffer (pH 6.3), tannic acid and sodium methyl mercaptide (final concentration 0.01%) to the screw-top test tube, and shake at 200 rpm and 25°C for 6 hours. After 6 hours, mix 50 μL of shaking solution, 200 μL of 100mM phosphate buffer (pH8.0), 750 μL of pure water, and 20 μL of 10mM DTNB, and let stand for 1 hour. After standing for 1 hour, the solution was transferred to a 1 mL optical centrifuge tube, and the absorbance at 412 nm was measured with a spectrophotometer. The methyl mercaptan residual rate was calculated according to Equation 6, and classified into A to E based on the following criteria.

Formula 6: Methyl mercaptan residual rate (%) = (Absorbance of specimen - Absorbance of BG) / (Absorbance of negative control - Absorbance of BG) × 100

Specimen: Add tannic acid

Negative control: no tannic acid added.

A: Less than 20%

B: More than 20% but less than 40%

C: More than 40% but less than 60%

D: More than 60% but less than 80%

E: More than 80%

(result)

The results are shown in Table 14. By adding the tannic acid aqueous solution, the concentration of methylmercaptan which is an odor substance is reduced. Therefore, it is considered that the deodorizing effect of the tannic acid aqueous solution is different from the mucus-inhibiting effect.

[Table 14]

Experiment 16. Additional effect of tannic acid aqueous solution (2): dissolution of fatty acid calcium (1)

(Material)

‧Tannic acid (manufactured by FUJIFILM Wako Pure Chemical Co., Ltd.)

‧Calcium Assay Kit (QuantiChrom; manufactured by Funakoshi Corporation)

‧Fat acid calcium listed in Table 15

(method)

After the fatty acid calcium was dispensed into the 6-well plate, a tannic acid aqueous solution was added (final concentration: fatty acid calcium: 0.2%, tannic acid: 2%). The plate shaker (BioShaker M-BR-024, manufactured by TAITEC Co., Ltd.) was used to shake the plate at room temperature overnight for culturing, and the degree of dissolution of fatty acid calcium was visually observed and classified from A to D based on the following criteria.

A: All dissolved

B: Mostly dissolved

C: Partially dissolved

D: Insoluble

(result)

The results are shown in Table 15. By adding tannic acid aqueous solution, the dissolution of fatty acid calcium is promoted. Therefore, it is considered that the fatty acid calcium dissolving effect of the tannic acid aqueous solution is different from the mucus-inhibiting effect.

[Table 15]

Experiment 17. Additional effect of tannic acid aqueous solution (2): dissolution of fatty acid calcium (2)

(Material)

‧The mixture of fatty acid calcium and tannic acid described in Experiment 16

‧Calcium Assay Kit (QuantiChrom; manufactured by Funakoshi Corporation)

(method)

Take 1.0 mL of the mixture of fatty acid calcium and tannic acid described in Experiment 16, remove the insoluble components by centrifugation (2,0000g × 10 minutes), and quantify the free calcium in the supernatant using a calcium quantification kit. The ratio of free calcium is calculated according to the following formula 7, and classified into A to E based on the following criteria.

Formula 7: Free calcium (%) = (quantitative value of free calcium)/(theoretical value of calcium calculated from the amount of added fatty acid calcium) × 100

A: More than 40%

B: More than 30% but less than 40%

C: More than 20% but less than 30%

D: More than 10% but less than 20%

E: Less than 10%

(result)

The results are shown in Table 16. By adding the tannic acid aqueous solution, the free calcium concentration in the supernatant increases. Therefore, it is considered that the fatty acid calcium dissolving effect of the tannic acid aqueous solution is different from the mucus-inhibiting effect.

[Table 16]

Claims (21)

A detergent for indoor water use areas, which contains at least one selected from the group consisting of hydrolyzable tannins and their salts formed by ester bonding between glucose and various gallic acids. The detergent for indoor water use places as described in claim 1, wherein the indoor water use places are selected from residences, factories, offices, accommodation facilities, hospitals, stores, schools, restaurants, airport facilities, stations, buses At least one type of indoor water use place in the group consisting of the main station, service area, sports facilities and assembly halls. The detergent for indoor water use places as described in claim 1, wherein the aforementioned indoor water use places are indoor commonly used water places. The detergent for indoor water use places as described in claim 1, wherein the aforementioned indoor water use places are at least one selected from the group consisting of household kitchens, professional kitchens, bathrooms, toilets, kitchens, washrooms and water circulation equipment. species. The detergent for indoor water use areas as described in claim 1, wherein the hydrolyzable tannin is tannic acid. The cleaning agent for indoor water use places as described in claim 1 contains a solvent. The detergent for indoor water use as claimed in claim 6, wherein the content of the hydrolyzable tannin and its salt is 5000 μg or less based on 1 mL of the solvent. The cleaning agent for indoor water use places as described in claim 6, wherein the pH of the aforementioned solvent is 2.0 to 12.0. The cleaning agent for indoor water use places as described in claim 6, wherein the solvent is alcohol and water, which contains a weakly acidic pH adjuster, and the pH of the solvent is 2.0 to 4.0. The detergent for use in indoor water use areas as described in claim 9 contains an antiseptic and antifungal agent and a surfactant. The cleaning agent for indoor water use places according to claim 10, wherein the aforementioned surfactant is a nonionic surfactant. The cleaning agent for indoor water use as claimed in claim 11, wherein the surfactant is polyoxyethylene alkyl ether. The detergent for indoor water use areas according to any one of claims 1 to 12, wherein the hydrolyzable tannin is used at a concentration that does not substantially exert a growth-inhibitory effect on bacteria of the genus Methylobacterium. The detergent for indoor water use places as described in any one of claims 1 to 12 is used to contact mucus originating from microorganisms in indoor water use places. The detergent for indoor water use as described in any one of claims 1 to 12 is used to inhibit slime originating from microorganisms. The cleaning agent for indoor water use as claimed in claim 14, wherein the microorganisms are selected from the group consisting of bacteria of the genus Methylobacterium, bacteria of the genus Breundomonas, bacteria of the genus Pseudomonas, bacteria of the genus Xanthomonas, At least one species from the group consisting of bacteria of the genus Lipomonas and bacteria of the genus Rhodococcus. The cleaning agent for indoor water use as claimed in claim 14, wherein the microorganism is a bacterium of the genus Methylobacterium. A method for suppressing mucus, which includes bringing the cleaning agent for indoor water use places according to any one of claims 1 to 12 into contact with the water surface of the indoor water use places. The method of suppressing mucus according to claim 18, which includes contacting the cleaning agent for indoor water use places according to any one of claims 1 to 12 with mucus originating from microorganisms in indoor water use places. A deodorizing method, which includes bringing the cleaning agent for indoor water places according to any one of claims 1 to 12 into contact with an odorous substance. A method for dissolving fatty acid calcium, which includes bringing the indoor water use detergent according to any one of claims 1 to 12 into contact with fatty acid calcium.