TW202333736A - 稠合吡咯啶精神成形素(psychoplastogen)及其用途 - Google Patents
稠合吡咯啶精神成形素(psychoplastogen)及其用途 Download PDFInfo
- Publication number
- TW202333736A TW202333736A TW111148111A TW111148111A TW202333736A TW 202333736 A TW202333736 A TW 202333736A TW 111148111 A TW111148111 A TW 111148111A TW 111148111 A TW111148111 A TW 111148111A TW 202333736 A TW202333736 A TW 202333736A
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- optionally substituted
- alkyl
- formula
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163290037P | 2021-12-15 | 2021-12-15 | |
| US63/290,037 | 2021-12-15 | ||
| US202263387225P | 2022-12-13 | 2022-12-13 | |
| US63/387,225 | 2022-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202333736A true TW202333736A (zh) | 2023-09-01 |
Family
ID=86773439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111148111A TW202333736A (zh) | 2021-12-15 | 2022-12-14 | 稠合吡咯啶精神成形素(psychoplastogen)及其用途 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP4448532A4 (https=) |
| JP (1) | JP2025502614A (https=) |
| KR (1) | KR20240150418A (https=) |
| AU (1) | AU2022415426A1 (https=) |
| CA (1) | CA3239571A1 (https=) |
| IL (1) | IL313457A (https=) |
| MX (1) | MX2024007220A (https=) |
| TW (1) | TW202333736A (https=) |
| WO (1) | WO2023114320A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2023014630A (es) | 2021-06-08 | 2024-01-30 | Atai Therapeutics Inc | Activadores de dimetoxifenilalquilamina de receptores de serotonina. |
| IL313455A (en) | 2021-12-15 | 2024-08-01 | Delix Therapeutics Inc | Phenoxy and benzyloxy modified psychroplastogens and their uses |
| EP4457203A4 (en) | 2021-12-27 | 2025-12-17 | Atai Therapeutics Inc | AMINOTETRALINE ACTIVATORS OF SEROTONIN RECEPTORS |
| US12343319B2 (en) | 2023-05-01 | 2025-07-01 | Atai Therapeutics, Inc. | Compositions and methods for treatment of diseases and disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0808312T3 (da) * | 1995-02-02 | 2001-02-12 | Smithkline Beecham Plc | Indolderivater som 5-HT-receptorantagonist |
| AR023574A1 (es) * | 1999-04-23 | 2002-09-04 | Pharmacia & Upjohn Co Llc | Compuestos de azepinindol tetraciclico,composiciones farmaceuticas y el uso de dichos compuestos para preparar un medicamento, e intermediarios |
| WO2002024700A2 (en) * | 2000-09-20 | 2002-03-28 | Pharmacia & Upjohn Company | SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES |
| EP1632491A1 (en) * | 2004-08-30 | 2006-03-08 | Laboratorios Del Dr. Esteve, S.A. | Substituted indole compounds and their use as 5-HT6 receptor modulators |
| WO2021076572A1 (en) * | 2019-10-14 | 2021-04-22 | The Regents Of The University Of California | Ergoline-like compounds for promoting neural plasticity |
-
2022
- 2022-12-14 CA CA3239571A patent/CA3239571A1/en active Pending
- 2022-12-14 WO PCT/US2022/052879 patent/WO2023114320A1/en not_active Ceased
- 2022-12-14 JP JP2024533214A patent/JP2025502614A/ja active Pending
- 2022-12-14 MX MX2024007220A patent/MX2024007220A/es unknown
- 2022-12-14 KR KR1020247023489A patent/KR20240150418A/ko active Pending
- 2022-12-14 IL IL313457A patent/IL313457A/en unknown
- 2022-12-14 EP EP22908391.0A patent/EP4448532A4/en active Pending
- 2022-12-14 AU AU2022415426A patent/AU2022415426A1/en active Pending
- 2022-12-14 TW TW111148111A patent/TW202333736A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3239571A1 (en) | 2023-06-22 |
| WO2023114320A1 (en) | 2023-06-22 |
| EP4448532A1 (en) | 2024-10-23 |
| KR20240150418A (ko) | 2024-10-15 |
| EP4448532A4 (en) | 2025-12-24 |
| AU2022415426A1 (en) | 2024-07-25 |
| JP2025502614A (ja) | 2025-01-28 |
| MX2024007220A (es) | 2024-08-27 |
| IL313457A (en) | 2024-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230295106A1 (en) | Ergoline-like compounds for promoting neural plasticity | |
| TW202333736A (zh) | 稠合吡咯啶精神成形素(psychoplastogen)及其用途 | |
| US20230219969A1 (en) | Isotryptamine psychoplastogens and uses thereof | |
| KR20230066311A (ko) | 삼환형 사이코플라스토겐 및 이의 용도 | |
| EP4323359A2 (en) | Tetracyclic compounds for treating brain disorders | |
| US12295959B2 (en) | Phenoxy and benzyloxy substituted psychoplastogens and uses thereof | |
| WO2023114858A1 (en) | Benzofuran and benzothiophene psychoplastogens and uses thereof | |
| US20250051276A1 (en) | Aryloxy psychoplastogens and uses thereof | |
| CN118742551A (zh) | 苯氧基和苄氧基取代的精神重塑剂及其用途 | |
| CN118696047A (zh) | 稠合吡咯烷精神重塑剂及其用途 | |
| WO2024258995A2 (en) | Fused tetrahydroazepine psychoplastogens and uses thereof | |
| US20250101001A1 (en) | Constrained amine psychoplastogens and uses thereof | |
| WO2023114844A1 (en) | Imidazopyridine psychoplastogens and uses thereof | |
| WO2025137596A1 (en) | Mixed serotonin receptor binders for treatment of psychotic disorders | |
| WO2024258988A2 (en) | Serotonin releasing compounds and uses thereof | |
| WO2025137639A1 (en) | Mixed serotonin receptor binders for treatment of psychotic disorders | |
| CN116507625A (zh) | 异色胺神经可塑剂及其用途 |