IL313457A - Compressed pyrrolidine psychoplastogens and their uses - Google Patents

Compressed pyrrolidine psychoplastogens and their uses

Info

Publication number
IL313457A
IL313457A IL313457A IL31345724A IL313457A IL 313457 A IL313457 A IL 313457A IL 313457 A IL313457 A IL 313457A IL 31345724 A IL31345724 A IL 31345724A IL 313457 A IL313457 A IL 313457A
Authority
IL
Israel
Prior art keywords
psychoplastogens
fused pyrrolidine
pyrrolidine
fused
pyrrolidine psychoplastogens
Prior art date
Application number
IL313457A
Other languages
English (en)
Hebrew (he)
Original Assignee
Delix Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delix Therapeutics Inc filed Critical Delix Therapeutics Inc
Publication of IL313457A publication Critical patent/IL313457A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems
    • C07D491/147Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL313457A 2021-12-15 2022-12-14 Compressed pyrrolidine psychoplastogens and their uses IL313457A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163290037P 2021-12-15 2021-12-15
US202263387225P 2022-12-13 2022-12-13
PCT/US2022/052879 WO2023114320A1 (en) 2021-12-15 2022-12-14 Fused pyrrolidine psychoplastogens and uses thereof

Publications (1)

Publication Number Publication Date
IL313457A true IL313457A (en) 2024-08-01

Family

ID=86773439

Family Applications (1)

Application Number Title Priority Date Filing Date
IL313457A IL313457A (en) 2021-12-15 2022-12-14 Compressed pyrrolidine psychoplastogens and their uses

Country Status (9)

Country Link
EP (1) EP4448532A4 (https=)
JP (1) JP2025502614A (https=)
KR (1) KR20240150418A (https=)
AU (1) AU2022415426A1 (https=)
CA (1) CA3239571A1 (https=)
IL (1) IL313457A (https=)
MX (1) MX2024007220A (https=)
TW (1) TW202333736A (https=)
WO (1) WO2023114320A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023014630A (es) 2021-06-08 2024-01-30 Atai Therapeutics Inc Activadores de dimetoxifenilalquilamina de receptores de serotonina.
IL313455A (en) 2021-12-15 2024-08-01 Delix Therapeutics Inc Phenoxy and benzyloxy modified psychroplastogens and their uses
EP4457203A4 (en) 2021-12-27 2025-12-17 Atai Therapeutics Inc AMINOTETRALINE ACTIVATORS OF SEROTONIN RECEPTORS
US12343319B2 (en) 2023-05-01 2025-07-01 Atai Therapeutics, Inc. Compositions and methods for treatment of diseases and disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0808312T3 (da) * 1995-02-02 2001-02-12 Smithkline Beecham Plc Indolderivater som 5-HT-receptorantagonist
AR023574A1 (es) * 1999-04-23 2002-09-04 Pharmacia & Upjohn Co Llc Compuestos de azepinindol tetraciclico,composiciones farmaceuticas y el uso de dichos compuestos para preparar un medicamento, e intermediarios
WO2002024700A2 (en) * 2000-09-20 2002-03-28 Pharmacia & Upjohn Company SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES
EP1632491A1 (en) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
WO2021076572A1 (en) * 2019-10-14 2021-04-22 The Regents Of The University Of California Ergoline-like compounds for promoting neural plasticity

Also Published As

Publication number Publication date
TW202333736A (zh) 2023-09-01
CA3239571A1 (en) 2023-06-22
WO2023114320A1 (en) 2023-06-22
EP4448532A1 (en) 2024-10-23
KR20240150418A (ko) 2024-10-15
EP4448532A4 (en) 2025-12-24
AU2022415426A1 (en) 2024-07-25
JP2025502614A (ja) 2025-01-28
MX2024007220A (es) 2024-08-27

Similar Documents

Publication Publication Date Title
IL313457A (en) Compressed pyrrolidine psychoplastogens and their uses
IL287391A (en) Antibody-drug amatoxin as an attached substance and its use
ZA202203580B (en) Il-17a modulators and uses thereof
HUE064032T2 (hu) Pozitív elektród-anyag és alkalmazása
SG11202101719PA (en) Antibody-drug conjugate and application thereof
IL284679A (en) Multifunctional chimeric proteins and their use
IL289138A (en) Antibody-drug antibody-tissue mediated conjugates, and related methods
GB202002010D0 (en) Microtopographies and uses thereof
GB202015226D0 (en) Pyrrol obenzodiazepine-antibody conugates and uses thereof
IL299254A (en) Tubulysins and protein-tubulysin conjugates
IL291312A (en) Anti-ptcra antibody-drug pairings and their use
IL325624A (en) Clasps and their uses
GB202019767D0 (en) Compostitions and methods
IL309562A (en) Regenerative polypeptides and their uses
GB201806022D0 (en) Pyrrolobenzodiazepines and conjugates thereof
IL309885A (en) Alpha-surface polypeptides and their use
IL286799A (en) Consolidated structures and their uses
GB202109082D0 (en) Polypeptides and uses thereof
GB202111039D0 (en) Materials and methods
GB201902182D0 (en) Pyrrolobenzodiazepines and conjugates thereof
EP4423260A4 (en) Truncated and fusion proteins
HK40117613A (en) Fused pyrrolidine psychoplastogens and uses thereof
IL311185A (en) MOG-binding proteins and uses thereof
GB202211784D0 (en) Methods and uses
GB202106040D0 (en) Methods and uses