TW202321436A - 同種異體人類t細胞之替代生產 - Google Patents

同種異體人類t細胞之替代生產 Download PDF

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TW202321436A
TW202321436A TW111134138A TW111134138A TW202321436A TW 202321436 A TW202321436 A TW 202321436A TW 111134138 A TW111134138 A TW 111134138A TW 111134138 A TW111134138 A TW 111134138A TW 202321436 A TW202321436 A TW 202321436A
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cells
cd3ε
cd3γ
cd3δ
hla
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TW111134138A
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Chinese (zh)
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飛利浦 比朵雅
大衛 貝瑞特
維傑 葛博 瑞迪 佩達雷迪加里
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美商蒂慕尼堤治療公司
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
    • A61K40/4276—Prostate specific membrane antigen [PSMA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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TW111134138A 2021-09-10 2022-09-08 同種異體人類t細胞之替代生產 TW202321436A (zh)

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US202163242909P 2021-09-10 2021-09-10
US63/242,909 2021-09-10

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TW202321436A true TW202321436A (zh) 2023-06-01

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US (1) US20230190809A1 (https=)
EP (1) EP4399280A4 (https=)
JP (1) JP2024533375A (https=)
KR (1) KR20240058915A (https=)
CN (1) CN118355111A (https=)
AU (1) AU2022343108A1 (https=)
CA (1) CA3231670A1 (https=)
CO (1) CO2024004474A2 (https=)
IL (1) IL311307A (https=)
MX (1) MX2024002903A (https=)
TW (1) TW202321436A (https=)
WO (1) WO2023039041A1 (https=)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
EP4377334A4 (en) * 2021-07-26 2025-06-18 Kite Pharma, Inc. DNVSIG3 AND DNVSIG8 RECEIVERS AND METHODS OF USE THEREOF
AU2023276763A1 (en) 2022-05-25 2024-12-12 Metagenomi Therapeutics, Inc. Supplementation of liver enzyme expression
WO2024023802A2 (en) * 2022-07-29 2024-02-01 Crispr Therapeutics Ag Genetically engineered immune cells having disrupted transporter associated with antigen processing-2 (tap-2) gene
CN118109416B (zh) * 2023-03-30 2024-11-22 广州百吉生物制药有限公司 功能增强型工程化免疫细胞及其制备和应用
WO2025031347A1 (zh) * 2023-08-07 2025-02-13 上海交通大学 肿瘤疫苗及其用途
CN117025541B (zh) * 2023-08-15 2025-10-17 福建医科大学附属协和医院 一种靶向b7-h3并共表达细胞因子和趋化因子的car-t细胞及其用途
CN116987699B (zh) * 2023-09-05 2024-08-27 深圳市艾迪贝克生物医药有限公司 用于制备通用型car-t细胞的基因片段、其工具系统及应用
WO2025097031A1 (en) * 2023-11-02 2025-05-08 Metagenomi, Inc. Compositions and methods for cell therapy
WO2025231191A1 (en) * 2024-05-01 2025-11-06 Cargo Therapeutics, Inc. Compositions and methods for allogeneic immune cells

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JP6681837B2 (ja) * 2014-03-11 2020-04-15 セレクティスＣｅｌｌｅｃｔｉｓ 同種移植に適合するｔ細胞を作製するための方法
CN107921148A (zh) * 2015-05-08 2018-04-17 哈佛学院校长同事会 通用供体干细胞和相关方法
WO2017093969A1 (en) * 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology
MX2019013514A (es) * 2017-05-12 2020-01-20 Crispr Therapeutics Ag Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia.
CA3082204A1 (en) * 2017-12-13 2019-06-20 Janssen Biotech, Inc. Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression
CN110616186A (zh) * 2018-06-20 2019-12-27 西安桑尼赛尔生物医药有限公司 增加同种异体t细胞移植相容性的方法及其应用
WO2020103013A1 (en) * 2018-11-21 2020-05-28 Nanjing Bioheng Biotech Co., Ltd Modified t cells and uses thereof
US11739136B2 (en) * 2019-03-18 2023-08-29 Innovative Cellular Therapeutics Holdings, Ltd. Inducible dominant negative PD-1 and uses in adoptive cell therapy
EP4419672A2 (en) * 2021-06-01 2024-08-28 Artisan Development Labs, Inc. Compositions and methods for targeting, editing, or modifying genes

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EP4399280A1 (en) 2024-07-17
CO2024004474A2 (es) 2024-07-18
JP2024533375A (ja) 2024-09-12
US20230190809A1 (en) 2023-06-22
MX2024002903A (es) 2024-06-19
AU2022343108A1 (en) 2024-03-21
EP4399280A4 (en) 2025-10-29
IL311307A (en) 2024-05-01
KR20240058915A (ko) 2024-05-07
CA3231670A1 (en) 2023-03-16
CN118355111A (zh) 2024-07-16
WO2023039041A1 (en) 2023-03-16

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