TW202317197A - 一種核酸配體及其綴合物、其製備方法和用途 - Google Patents
一種核酸配體及其綴合物、其製備方法和用途 Download PDFInfo
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Classifications
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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| JP2024542929A (ja) * | 2021-10-05 | 2024-11-19 | セーンジーン バイオ ユーエスエー インコーポレイティド | ポリヒドロキシル化されたシクロペンタン誘導体及び使用方法 |
| EP4467645A4 (en) | 2022-01-20 | 2026-01-21 | Tuojie Biotech Shanghai Co Ltd | DOUBLE-STRANDED RNA, ITS USES AND PREPARATION PROCESS |
| JP2026507146A (ja) | 2023-03-02 | 2026-02-27 | 上海拓界生物医薬科技有限公司 | インヒビンβＥを標的とするｓｉＲＮＡ、ｓｉＲＮＡ複合体及びその医薬的使用 |
| CN119019475B (zh) * | 2023-05-24 | 2026-02-06 | 北京炫景瑞医药科技有限公司 | GalNAc化合物、缀合物、组合物以及它们的用途 |
| CN119019354B (zh) * | 2023-05-24 | 2025-07-22 | 北京炫景瑞医药科技有限公司 | 化合物及其制备方法和用途 |
| WO2024240101A1 (zh) * | 2023-05-24 | 2024-11-28 | 北京炫景瑞医药科技有限公司 | GalNAc化合物、缀合物、组合物以及它们的用途 |
| AU2024280186A1 (en) | 2023-05-31 | 2025-12-04 | Tuojie Biotech (Shanghai) Co., Ltd. | Dsrna targeting lpa and use thereof |
| KR20260026026A (ko) | 2023-06-13 | 2026-02-25 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | MMP7을 표적으로 하는 siRNA, siRNA 접합체 및 이의 의학적 용도 |
| KR20260046111A (ko) | 2023-08-01 | 2026-04-06 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | MAPT를 표적으로 하는 dsRNA 및 이의 의약적 용도 |
| AU2024329194A1 (en) | 2023-08-24 | 2026-02-19 | Tuojie Biotech (Shanghai) Co., Ltd. | Rage-targeted rnai agent and pharmaceutical use thereof |
| CN117563009B (zh) * | 2023-09-01 | 2025-07-01 | 杭州天龙药业有限公司 | 一种含有核糖环或其衍生结构的GalNAc化合物及其寡核苷酸缀合物 |
| WO2025140434A1 (zh) * | 2023-12-26 | 2025-07-03 | 成都倍特药业股份有限公司 | 一种肝靶向化合物及其在药物缀合物中的用途 |
| WO2025232840A1 (zh) * | 2024-05-09 | 2025-11-13 | 石药集团中奇制药技术（石家庄）有限公司 | GalNAc衍生物及其寡聚核苷酸缀合物 |
| CN119143818B (zh) * | 2024-06-13 | 2025-10-31 | 广州必贝特医药股份有限公司 | 用于靶向递送寡核苷酸药物的化合物、缀合物及其应用 |
| CN119241613A (zh) * | 2024-09-26 | 2025-01-03 | 北京悦康科创医药科技股份有限公司 | 含有核糖环或其衍生结构的GalNAc单体及其在小核酸药物肝靶向递送中的应用 |
| CN120192442B (zh) * | 2025-05-22 | 2025-09-12 | 北京悦康科创医药科技股份有限公司 | 一种含核糖环的GalNAc化合物的制备方法 |
| CN120737137B (zh) * | 2025-09-08 | 2025-12-09 | 北京悦康科创医药科技股份有限公司 | 一种含芳环骨架的GalNAc化合物及其应用 |
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| AU2013299717B2 (en) | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| CA2921162A1 (en) * | 2013-05-01 | 2014-11-06 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| US10570169B2 (en) * | 2014-05-22 | 2020-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| CA2968114A1 (en) * | 2014-11-17 | 2016-05-26 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof |
| US10246709B2 (en) * | 2016-03-07 | 2019-04-02 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands for therapeutic compounds |
| CN110997919B (zh) * | 2017-12-01 | 2024-04-02 | 苏州瑞博生物技术股份有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
| CN110959011B (zh) * | 2017-12-29 | 2023-03-28 | 苏州瑞博生物技术股份有限公司 | 缀合物及其制备方法和用途 |
| CN112390835A (zh) * | 2019-08-14 | 2021-02-23 | 苏州瑞博生物技术股份有限公司 | 肝靶向化合物及缀合物 |
| WO2021254360A1 (zh) | 2020-06-16 | 2021-12-23 | 上海拓界生物医药科技有限公司 | 一种碳水化合物分子簇及其制备方法和医药用途 |
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