TW202317148A - 用於靜默myoc表現之組合物及方法 - Google Patents

用於靜默myoc表現之組合物及方法 Download PDF

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TW202317148A
TW202317148A TW111124088A TW111124088A TW202317148A TW 202317148 A TW202317148 A TW 202317148A TW 111124088 A TW111124088 A TW 111124088A TW 111124088 A TW111124088 A TW 111124088A TW 202317148 A TW202317148 A TW 202317148A
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nucleotides
myoc
dsrna
strand
antisense strand
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TW111124088A
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Chinese (zh)
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亞當 克斯拓雷諾
布浩米卡 Ａ 潘迪雅
瑞查多司 伊蓮娜 卡司特拉儂
馬克 Ｋ 史齊歌
韋森 Ｒ 潔德哈維
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美商艾拉倫製藥公司
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Publication of TW202317148A publication Critical patent/TW202317148A/zh

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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TW111124088A 2021-06-28 2022-06-28 用於靜默myoc表現之組合物及方法 TW202317148A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202163215804P 2021-06-28 2021-06-28
US63/215,804 2021-06-28
US202163287404P 2021-12-08 2021-12-08
US63/287,404 2021-12-08
US202263351033P 2022-06-10 2022-06-10
US63/351,033 2022-06-10

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TW202317148A true TW202317148A (zh) 2023-05-01

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US (1) US20240318175A1 (https=)
EP (1) EP4363587A4 (https=)
JP (1) JP2024526234A (https=)
KR (1) KR20240026216A (https=)
AU (1) AU2022301058A1 (https=)
CA (1) CA3224868A1 (https=)
IL (1) IL309230A (https=)
MX (1) MX2023014976A (https=)
TW (1) TW202317148A (https=)
WO (1) WO2023278406A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240117571A (ko) * 2021-12-08 2024-08-01 리제너론 파마슈티칼스 인코포레이티드 돌연변이 마이오실린 질환 모델 및 이의 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117938A2 (en) * 2004-04-13 2005-12-15 Regents Of The University Of Minnesota Methods of treating ocular conditions
EP2313505A2 (en) * 2008-07-15 2011-04-27 F. Hoffmann-La Roche AG Compositions and methods for inhibiting expression of tgf-beta receptor genes
EP3540061A1 (en) * 2014-04-02 2019-09-18 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating primary open angle glaucoma
SG11201702055PA (en) * 2014-09-16 2017-04-27 Genzyme Corp Adeno-associated viral vectors for treating myocilin (myoc) glaucoma
PL4012035T3 (pl) * 2014-09-16 2025-03-24 Genzyme Corporation Wektory wirusowe związane z adenowirusami do leczenia jaskry miocylinowej (myoc)
KR20230008729A (ko) * 2020-04-06 2023-01-16 알닐람 파마슈티칼스 인코포레이티드 Myoc 발현을 사일런싱하기 위한 조성물 및 방법

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JP2024526234A (ja) 2024-07-17
CA3224868A1 (en) 2023-01-05
KR20240026216A (ko) 2024-02-27
WO2023278406A1 (en) 2023-01-05
MX2023014976A (es) 2024-02-09
US20240318175A1 (en) 2024-09-26
AU2022301058A1 (en) 2024-01-04
EP4363587A1 (en) 2024-05-08
EP4363587A4 (en) 2025-08-06
IL309230A (en) 2024-02-01

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