TW202300530A - 一種抗egfr/vegf雙功能融合蛋白及其用途 - Google Patents
一種抗egfr/vegf雙功能融合蛋白及其用途 Download PDFInfo
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110458717.0 | 2021-04-27 | ||
| CN202110458717.0A CN115246886A (zh) | 2021-04-27 | 2021-04-27 | 一种抗egfr/vegf双功能融合蛋白及其用途 |
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| TW202300530A true TW202300530A (zh) | 2023-01-01 |
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| TW111115786A TW202300530A (zh) | 2021-04-27 | 2022-04-26 | 一種抗egfr/vegf雙功能融合蛋白及其用途 |
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| Country | Link |
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| CN (2) | CN115246886A (fr) |
| TW (1) | TW202300530A (fr) |
| WO (1) | WO2022228424A1 (fr) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102633883B (zh) * | 2012-02-24 | 2014-06-25 | 上海白泽生物科技有限公司 | 一种能与egfr、her2、vegf高效结合的融合蛋白、其编码序列及用途 |
| WO2017186950A1 (fr) * | 2016-04-28 | 2017-11-02 | Biomunex Pharmaceuticals | Anticorps bispécifiques ciblant l'egfr et her2 |
| EP3668893A4 (fr) * | 2017-08-16 | 2021-08-04 | Dragonfly Therapeutics, Inc. | Protéines se liant à nkg2d, cd16 et à l'egfr, hla-e, ccr4, ou pd-l1 |
| CN110835375B (zh) * | 2018-08-16 | 2021-04-06 | 上海洛启生物医药技术有限公司 | 一种抗pd-1/egfr双特异性抗体及其用途 |
| CN112552410A (zh) * | 2019-09-26 | 2021-03-26 | 三生国健药业（上海）股份有限公司 | 一种抗体融合蛋白及其制法和在抗肿瘤中的应用 |
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2021
- 2021-04-27 CN CN202110458717.0A patent/CN115246886A/zh active Pending
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- 2022-04-26 WO PCT/CN2022/089244 patent/WO2022228424A1/fr active Application Filing
- 2022-04-26 TW TW111115786A patent/TW202300530A/zh unknown
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| Publication number | Publication date |
|---|---|
| WO2022228424A1 (fr) | 2022-11-03 |
| CN115246886A (zh) | 2022-10-28 |
| CN117242097A (zh) | 2023-12-15 |
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