TW202246315A - 對冠狀病毒s蛋白具特異性之化合物及其用途 - Google Patents

對冠狀病毒s蛋白具特異性之化合物及其用途 Download PDF

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Publication number
TW202246315A
TW202246315A TW111104400A TW111104400A TW202246315A TW 202246315 A TW202246315 A TW 202246315A TW 111104400 A TW111104400 A TW 111104400A TW 111104400 A TW111104400 A TW 111104400A TW 202246315 A TW202246315 A TW 202246315A
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Taiwan
Prior art keywords
cov
antibody
antigen
binding fragment
sars
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TW111104400A
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English (en)
Chinese (zh)
Inventor
蘿拉 華可
C 格禮特 瑞帕佐
牧魯諾 薩哈卡
蘿拉 德瓦
承冀 郭
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美商亞得捷歐治療公司
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Publication of TW202246315A publication Critical patent/TW202246315A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002Coronaviridae
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002Coronaviridae
    • C07K16/1003Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW111104400A 2021-02-05 2022-02-07 對冠狀病毒s蛋白具特異性之化合物及其用途 TW202246315A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202163146090P 2021-02-05 2021-02-05
US63/146,090 2021-02-05
US202163151278P 2021-02-19 2021-02-19
US63/151,278 2021-02-19
US202163181467P 2021-04-29 2021-04-29
US63/181,467 2021-04-29
US202163187982P 2021-05-13 2021-05-13
US63/187,982 2021-05-13

Publications (1)

Publication Number Publication Date
TW202246315A true TW202246315A (zh) 2022-12-01

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TW111104400A TW202246315A (zh) 2021-02-05 2022-02-07 對冠狀病毒s蛋白具特異性之化合物及其用途

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TW (1) TW202246315A (fr)
WO (1) WO2022170126A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114230674A (zh) * 2020-12-01 2022-03-25 中国医学科学院基础医学研究所 一种含Fc结构域的新型冠状病毒S蛋白受体结合域融合蛋白及其用途

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023154824A1 (fr) * 2022-02-10 2023-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux humains ciblant largement les coronavirus
WO2024036313A2 (fr) * 2022-08-12 2024-02-15 The Rockefeller University Anticorps anti-sars-cov-2 et procédés d'utilisation associés
WO2024076982A2 (fr) * 2022-10-05 2024-04-11 University Of Washington Vaccins à nanoparticules de pan-sarbecovirus
WO2024089277A2 (fr) * 2022-10-27 2024-05-02 Oxford University Innovation Limited Anticorps

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005035732A2 (fr) * 2003-02-19 2005-04-21 Dyax Corporation Ligands de papp-a
US8008445B2 (en) * 2008-03-03 2011-08-30 Dyax Corp. Metalloproteinase 9 binding proteins
JO3701B1 (ar) * 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
ES2753551T3 (es) * 2014-07-22 2020-04-13 Sutro Biopharma Inc Anticuerpos anti-cd74, composiciones que comprenden anticuerpos anti-CD74 y procedimientos de uso de los anticuerpos anti-CD74
IL304950A (en) * 2015-04-10 2023-10-01 Amgen Inc Interleukin for the expansion of myotonic control T-2 cells
BR112019008063A2 (pt) * 2016-10-21 2019-07-02 Adimab Llc anticorpos contra o vírus sincicial anti-respiratório e métodos de sua geração e uso
KR20210057705A (ko) * 2018-06-01 2021-05-21 유니버시티 오브 써던 캘리포니아 세포 요법을 위한 다양한 항원 결합 도메인, 신규한 플랫폼 및 다른 향상

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114230674A (zh) * 2020-12-01 2022-03-25 中国医学科学院基础医学研究所 一种含Fc结构域的新型冠状病毒S蛋白受体结合域融合蛋白及其用途
CN114230674B (zh) * 2020-12-01 2023-09-26 中国医学科学院基础医学研究所 一种含Fc结构域的新型冠状病毒S蛋白受体结合域融合蛋白及其用途

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WO2022170126A2 (fr) 2022-08-11
WO2022170126A3 (fr) 2022-09-15

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