TW202233834A - 用於治療乳糜瀉的組合物及方法 - Google Patents

用於治療乳糜瀉的組合物及方法 Download PDF

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Publication number
TW202233834A
TW202233834A TW110140404A TW110140404A TW202233834A TW 202233834 A TW202233834 A TW 202233834A TW 110140404 A TW110140404 A TW 110140404A TW 110140404 A TW110140404 A TW 110140404A TW 202233834 A TW202233834 A TW 202233834A
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TW
Taiwan
Prior art keywords
ala
gly
amino acid
ser
asp
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TW110140404A
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English (en)
Chinese (zh)
Inventor
英格麗德 史旺森 普爾茲
克蘭西 沃爾芙
賈斯汀 布魯姆菲爾德 西格爾
克里斯汀 伊萊恩 汀伯格
蘭斯 斯圖爾特
大衛 貝克
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華盛頓大學
加利福尼亞大學董事會
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Application filed by 華盛頓大學, 加利福尼亞大學董事會 filed Critical 華盛頓大學
Publication of TW202233834A publication Critical patent/TW202233834A/zh

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW110140404A 2020-10-30 2021-10-29 用於治療乳糜瀉的組合物及方法 TW202233834A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063108163P 2020-10-30 2020-10-30
US63/108,163 2020-10-30

Publications (1)

Publication Number Publication Date
TW202233834A true TW202233834A (zh) 2022-09-01

Family

ID=78819631

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110140404A TW202233834A (zh) 2020-10-30 2021-10-29 用於治療乳糜瀉的組合物及方法

Country Status (12)

Country Link
US (1) US20250064903A1 (https=)
EP (1) EP4237554A1 (https=)
JP (1) JP2023548083A (https=)
KR (1) KR20230093323A (https=)
CN (1) CN116829166A (https=)
AR (1) AR123961A1 (https=)
AU (1) AU2021368118A1 (https=)
CA (1) CA3195929A1 (https=)
CO (1) CO2023006731A2 (https=)
MX (1) MX2023004807A (https=)
TW (1) TW202233834A (https=)
WO (1) WO2022094177A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025068987A1 (en) 2023-09-28 2025-04-03 Takeda Pharmaceutical Company Limited A method of producing a kumamolisin-as polypeptide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4475707B2 (ja) * 1998-10-05 2010-06-09 武田薬品工業株式会社 N末端メチオニンの除去方法
CA2882502A1 (en) 2011-08-10 2013-02-14 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
US10266815B2 (en) * 2013-08-14 2019-04-23 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
NZ737500A (en) * 2015-06-08 2025-02-28 Univ Washington Compositions and methods for treating celiac sprue disease
AU2017380106B2 (en) * 2016-12-22 2024-05-09 Ew Nutrition Gmbh Stable protease variants

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Publication number Publication date
EP4237554A1 (en) 2023-09-06
AU2021368118A9 (en) 2023-07-06
CA3195929A1 (en) 2022-05-05
AR123961A1 (es) 2023-01-25
MX2023004807A (es) 2023-05-10
US20250064903A1 (en) 2025-02-27
AU2021368118A1 (en) 2023-05-11
JP2023548083A (ja) 2023-11-15
WO2022094177A1 (en) 2022-05-05
CN116829166A (zh) 2023-09-29
KR20230093323A (ko) 2023-06-27
CO2023006731A2 (es) 2023-06-09

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