CN116829166A - 用于治疗乳糜泻的组合物和方法 - Google Patents

用于治疗乳糜泻的组合物和方法 Download PDF

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Publication number
CN116829166A
CN116829166A CN202180068658.4A CN202180068658A CN116829166A CN 116829166 A CN116829166 A CN 116829166A CN 202180068658 A CN202180068658 A CN 202180068658A CN 116829166 A CN116829166 A CN 116829166A
Authority
CN
China
Prior art keywords
amino acid
ala
polypeptide
gly
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180068658.4A
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English (en)
Chinese (zh)
Inventor
I·S·普利茨
C·沃夫
J·B·西格尔
C·E·廷伯格
L·斯特沃特
D·贝克尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
University of California San Diego UCSD
Original Assignee
University of Washington
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, University of California San Diego UCSD filed Critical University of Washington
Publication of CN116829166A publication Critical patent/CN116829166A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202180068658.4A 2020-10-30 2021-10-29 用于治疗乳糜泻的组合物和方法 Pending CN116829166A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063108163P 2020-10-30 2020-10-30
US63/108,163 2020-10-30
PCT/US2021/057197 WO2022094177A1 (en) 2020-10-30 2021-10-29 Compositions and methods for treating celiac sprue disease

Publications (1)

Publication Number Publication Date
CN116829166A true CN116829166A (zh) 2023-09-29

Family

ID=78819631

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180068658.4A Pending CN116829166A (zh) 2020-10-30 2021-10-29 用于治疗乳糜泻的组合物和方法

Country Status (12)

Country Link
US (1) US20250064903A1 (https=)
EP (1) EP4237554A1 (https=)
JP (1) JP2023548083A (https=)
KR (1) KR20230093323A (https=)
CN (1) CN116829166A (https=)
AR (1) AR123961A1 (https=)
AU (1) AU2021368118A1 (https=)
CA (1) CA3195929A1 (https=)
CO (1) CO2023006731A2 (https=)
MX (1) MX2023004807A (https=)
TW (1) TW202233834A (https=)
WO (1) WO2022094177A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025068987A1 (en) 2023-09-28 2025-04-03 Takeda Pharmaceutical Company Limited A method of producing a kumamolisin-as polypeptide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4475707B2 (ja) * 1998-10-05 2010-06-09 武田薬品工業株式会社 Ｎ末端メチオニンの除去方法
CA2882502A1 (en) 2011-08-10 2013-02-14 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
US10266815B2 (en) * 2013-08-14 2019-04-23 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
NZ737500A (en) * 2015-06-08 2025-02-28 Univ Washington Compositions and methods for treating celiac sprue disease
AU2017380106B2 (en) * 2016-12-22 2024-05-09 Ew Nutrition Gmbh Stable protease variants

Also Published As

Publication number Publication date
EP4237554A1 (en) 2023-09-06
AU2021368118A9 (en) 2023-07-06
CA3195929A1 (en) 2022-05-05
TW202233834A (zh) 2022-09-01
AR123961A1 (es) 2023-01-25
MX2023004807A (es) 2023-05-10
US20250064903A1 (en) 2025-02-27
AU2021368118A1 (en) 2023-05-11
JP2023548083A (ja) 2023-11-15
WO2022094177A1 (en) 2022-05-05
KR20230093323A (ko) 2023-06-27
CO2023006731A2 (es) 2023-06-09

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