KR20230093323A - 셀리악 스프루 질환 치료용 조성물 및 방법 - Google Patents

셀리악 스프루 질환 치료용 조성물 및 방법 Download PDF

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Publication number
KR20230093323A
KR20230093323A KR1020237017895A KR20237017895A KR20230093323A KR 20230093323 A KR20230093323 A KR 20230093323A KR 1020237017895 A KR1020237017895 A KR 1020237017895A KR 20237017895 A KR20237017895 A KR 20237017895A KR 20230093323 A KR20230093323 A KR 20230093323A
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KR
South Korea
Prior art keywords
ala
amino acid
polypeptide
gly
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020237017895A
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English (en)
Korean (ko)
Inventor
잉그리드 스완슨 펄츠
클랜시 울프
저스틴 블룸필드 시걸
크리스틴 엘라인 틴버그
랜스 스튜어트
데이비드 베이커
Original Assignee
유니버시티 오브 워싱톤
더 리전츠 오브 더 유니버시티 오브 캘리포니아
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Application filed by 유니버시티 오브 워싱톤, 더 리전츠 오브 더 유니버시티 오브 캘리포니아 filed Critical 유니버시티 오브 워싱톤
Publication of KR20230093323A publication Critical patent/KR20230093323A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020237017895A 2020-10-30 2021-10-29 셀리악 스프루 질환 치료용 조성물 및 방법 Withdrawn KR20230093323A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063108163P 2020-10-30 2020-10-30
US63/108,163 2020-10-30
PCT/US2021/057197 WO2022094177A1 (en) 2020-10-30 2021-10-29 Compositions and methods for treating celiac sprue disease

Publications (1)

Publication Number Publication Date
KR20230093323A true KR20230093323A (ko) 2023-06-27

Family

ID=78819631

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237017895A Withdrawn KR20230093323A (ko) 2020-10-30 2021-10-29 셀리악 스프루 질환 치료용 조성물 및 방법

Country Status (12)

Country Link
US (1) US20250064903A1 (https=)
EP (1) EP4237554A1 (https=)
JP (1) JP2023548083A (https=)
KR (1) KR20230093323A (https=)
CN (1) CN116829166A (https=)
AR (1) AR123961A1 (https=)
AU (1) AU2021368118A1 (https=)
CA (1) CA3195929A1 (https=)
CO (1) CO2023006731A2 (https=)
MX (1) MX2023004807A (https=)
TW (1) TW202233834A (https=)
WO (1) WO2022094177A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025068987A1 (en) 2023-09-28 2025-04-03 Takeda Pharmaceutical Company Limited A method of producing a kumamolisin-as polypeptide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4475707B2 (ja) * 1998-10-05 2010-06-09 武田薬品工業株式会社 Ｎ末端メチオニンの除去方法
CA2882502A1 (en) 2011-08-10 2013-02-14 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
US10266815B2 (en) * 2013-08-14 2019-04-23 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
NZ737500A (en) * 2015-06-08 2025-02-28 Univ Washington Compositions and methods for treating celiac sprue disease
AU2017380106B2 (en) * 2016-12-22 2024-05-09 Ew Nutrition Gmbh Stable protease variants

Also Published As

Publication number Publication date
EP4237554A1 (en) 2023-09-06
AU2021368118A9 (en) 2023-07-06
CA3195929A1 (en) 2022-05-05
TW202233834A (zh) 2022-09-01
AR123961A1 (es) 2023-01-25
MX2023004807A (es) 2023-05-10
US20250064903A1 (en) 2025-02-27
AU2021368118A1 (en) 2023-05-11
JP2023548083A (ja) 2023-11-15
WO2022094177A1 (en) 2022-05-05
CN116829166A (zh) 2023-09-29
CO2023006731A2 (es) 2023-06-09

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US20240207376A1 (en) Compositions and Methods for Treating Celiac Sprue Disease
US20240158774A1 (en) Compositions and Methods for Treating Celiac Sprue Disease
KR20230093323A (ko) 셀리악 스프루 질환 치료용 조성물 및 방법

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Patent event date: 20230525

Patent event code: PA01051R01D

Comment text: International Patent Application

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PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20241025

Comment text: Request for Examination of Application

PC1202 Submission of document of withdrawal before decision of registration

Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment)

Patent event code: PC12021R01D

Patent event date: 20250514

WITB Written withdrawal of application