TW202233613A - 去氧胞苷激酶抑制劑之結晶型及其用途 - Google Patents

去氧胞苷激酶抑制劑之結晶型及其用途 Download PDF

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Publication number
TW202233613A
TW202233613A TW110140820A TW110140820A TW202233613A TW 202233613 A TW202233613 A TW 202233613A TW 110140820 A TW110140820 A TW 110140820A TW 110140820 A TW110140820 A TW 110140820A TW 202233613 A TW202233613 A TW 202233613A
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Taiwan
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compound
formula
theta
composition
polymorph
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TW110140820A
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English (en)
Chinese (zh)
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大衛 利辛格
肯尼斯 舒爾茲
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美商崔瑟拉公司
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Publication of TW202233613A publication Critical patent/TW202233613A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW110140820A 2020-11-02 2021-11-02 去氧胞苷激酶抑制劑之結晶型及其用途 TW202233613A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063108803P 2020-11-02 2020-11-02
US63/108,803 2020-11-02
US202163190107P 2021-05-18 2021-05-18
US63/190,107 2021-05-18

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Publication Number Publication Date
TW202233613A true TW202233613A (zh) 2022-09-01

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TW110140820A TW202233613A (zh) 2020-11-02 2021-11-02 去氧胞苷激酶抑制劑之結晶型及其用途

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US (3) US20220133735A1 (https=)
EP (1) EP4237421A4 (https=)
JP (1) JP2023548605A (https=)
KR (1) KR20230129384A (https=)
AU (1) AU2021368138A1 (https=)
CA (1) CA3196694A1 (https=)
CL (1) CL2023001230A1 (https=)
MX (1) MX2023005056A (https=)
PE (1) PE20231656A1 (https=)
TW (1) TW202233613A (https=)
WO (1) WO2022094409A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022094409A1 (en) 2020-11-02 2022-05-05 Trethera Corporation Crystalline forms of a deoxycytidine kinase inhibitor and uses thereof

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Also Published As

Publication number Publication date
PE20231656A1 (es) 2023-10-17
US11446307B2 (en) 2022-09-20
JP2023548605A (ja) 2023-11-17
EP4237421A1 (en) 2023-09-06
US20220135555A1 (en) 2022-05-05
US20250049808A1 (en) 2025-02-13
CL2023001230A1 (es) 2023-11-17
WO2022094409A1 (en) 2022-05-05
AU2021368138A1 (en) 2023-06-22
CA3196694A1 (en) 2022-05-05
KR20230129384A (ko) 2023-09-08
EP4237421A4 (en) 2024-11-06
MX2023005056A (es) 2023-07-24
US20220133735A1 (en) 2022-05-05

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