TW202227471A - 白介素15構建體和使用方法 - Google Patents

白介素15構建體和使用方法 Download PDF

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TW202227471A
TW202227471A TW110134537A TW110134537A TW202227471A TW 202227471 A TW202227471 A TW 202227471A TW 110134537 A TW110134537 A TW 110134537A TW 110134537 A TW110134537 A TW 110134537A TW 202227471 A TW202227471 A TW 202227471A
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欒旭東
雪松 劉
鳴 雷
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英屬開曼群島商百濟神州有限公司
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Abstract

本揭露提供了介白素15（白介素15，IL15）構建體、包含所述IL15構建體的藥物組成物、和該等IL15構建體或該組成物用於治療疾病如癌症、感染性疾病或免疫障礙之用途（使用方法）。

Description

白介素15構建體和使用方法
本文揭露了介白素15（IL15）構建體以及用於治療癌症的使用方法。
IL15係一種細胞介素，最初描述為T細胞生長因子。細胞介素屬於四種α-螺旋束家族，並且其受體由兩種負責訊息傳導的亞單位（IL-2R/IL-15R β和γ鏈）組成。該等受體在例如活化的T細胞（並且可用皮莫耳濃度的IL15活化）上表現。
作為治療劑，IL15表現出活化T細胞、特別是CD8+T細胞的潛力，但是由於分子半衰期短且清除速度快，在專利給藥方面存在問題。目前重組IL-15尚未核准使用，不過已有數項臨床試驗在進行中。
因此，本領域對提供IL15構建體存在未滿足的需求，該等構建體需可提供卓越的分子遞送方式直接將IL15遞送至腫瘤微環境。
本揭露關於IL15構建體。在一個實施方式中，IL15構建體為二價同源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IL15受體α（IL15Ra）結構域，連接至； b) 第一連接子（linker）（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 介白素2受體β（IL2Rb）結構域；和 f) IgG1 Fc區，其中該二價IL15構建體包含： (i) 示於SEQ ID NO:4（M123）的同源二聚體； (ii) 示於SEQ ID NO:5（M135）的同源二聚體； (iii) 示於SEQ ID NO:6（M140）的同源二聚體； (iv) 示於SEQ ID NO:7（M145）的同源二聚體； (v) 示於SEQ ID NO:8（M175）的同源二聚體； (vi) 示於SEQ ID NO:9（M176）的同源二聚體； (vii) 示於SEQ ID NO:10（M177）的同源二聚體； (viii) 示於SEQ ID NO:11（M178）的同源二聚體； (ix) 示於SEQ ID NO:12（M207）的同源二聚體； (x) 示於SEQ ID NO:13（M231）的同源二聚體； (xi) 示於SEQ ID NO:14（M233）的同源二聚體； (xii) 示於SEQ ID NO:15（M234）的同源二聚體； (xiii) 示於SEQ ID NO:16（M238）的同源二聚體； (xiv) 示於SEQ ID NO:17（M239）的同源二聚體； (xv) 示於SEQ ID NO:18（M240）的同源二聚體； (xvi) 示於SEQ ID NO:19（M241）的同源二聚體； (xvii) 示於SEQ ID NO:20（M243）的同源二聚體； (xviii) 示於SEQ ID NO:21（M244）的同源二聚體； (xix) 示於SEQ ID NO:22（M245）的同源二聚體； (xx) 示於SEQ ID NO:23（M246）的同源二聚體； (xxi) 示於SEQ ID NO:24（M247）的同源二聚體； (xxii) 示於SEQ ID NO:25（M248）的同源二聚體； (xxiii) 示於SEQ ID NO:26（M249）的同源二聚體； (xxiv) 示於SEQ ID NO:27（M327）的同源二聚體； (xxv) 示於SEQ ID NO:28（M328）的同源二聚體； (xxvi) 示於SEQ ID NO:29（M329）的同源二聚體； (xxvii) 示於SEQ ID NO:30（M330）的同源二聚體； (xxviii) 示於SEQ ID NO:31（M331）的同源二聚體；或 (xxix) 示於SEQ ID NO:32（M332）的同源二聚體。
一種二價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 介白素2受體β（IL2Rb）結構域，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域， 該結構域包含第一分子和第二分子，其從N-末端至C-末端包含： x) IL15受體α（IL15Ra）結構域；和 y) IgG1 Fc區，其中該異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:33（M43）的第一分子和示於SEQ ID NO:34（M24）的第二分子； (ii) 示於SEQ ID NO:35（M61）的第一分子和示於SEQ ID NO:36（M60）的第二分子；或 (iii) 示於SEQ ID NO:37（M62）的第一分子和示於SEQ ID NO:38（M60）的第二分子。
一種二價同源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 介白素2受體β（IL2Rb）結構域，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域，連接至； d) 第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域；和 f) IgG1 Fc區，其中該二價IL15構建體包含： (i) 示於SEQ ID NO:40（M148）和SEQ ID NO:41（M174）的同源二聚體。
一種二價同源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IgG1 Fc區，連接至； b) 第一連接子（L1），連接至； c) 介白素2受體β（IL2Rb）結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域，連接至； f) 第三連接子（L3），連接至； g) IL15結構域；和 其中該二價IL15構建體包含： (i) 示於SEQ ID NO:42（M232）的同源二聚體； (ii) 示於SEQ ID NO:43（M1001）的同源二聚體； (iii) 示於SEQ ID NO:44（M1002）的同源二聚體； (vi) 示於SEQ ID NO:45（M1003）的同源二聚體； (v) 示於SEQ ID NO:46（M1004）的同源二聚體； (vi) 示於SEQ ID NO:47（M1005）的同源二聚體；或 (vii) 示於SEQ ID NO:48（M1006）的同源二聚體。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IL15受體α（IL15Ra）結構域，連接至； b) 第一連接子（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 介白素2受體β（IL2Rb）結構域；和 f) 第一IgG1 Fc區， 作為第一分子和第二分子，包含第二IgG1 Fc區，其中該異源二聚體IL15構建體包含：示於SEQ ID NO:49（MK107）的第一分子和示於SEQ ID NO:50（MH2）的第二分子。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 第一連接子（L1），連接至； c) 介白素2受體β（IL2Rb）結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域，連接至； f) 第三連接子（L3），連接至； g) IL15結構域； 作為第一分子和第二分子，包含第二IgG1 Fc區，其中該一價異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:63（M111）的第一分子和示於SEQ ID NO:64（MH2）的第二分子； (ii) 示於SEQ ID NO:65（M2001）的第一分子和示於SEQ ID NO:52（MH7）的第二分子；或 (iii) 示於SEQ ID NO:66（M2002）的第一分子和示於SEQ ID NO:52（MH7）的第二分子。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IL15受體α（IL15Ra）結構域，連接至； b) 第一連接子（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 介白素2受體β（IL2Rb）結構域，連接至； f) 第三連接子（L3），連接至； g) 第一IgG1 Fc區， 作為第一分子和第二分子，包含第二IgG1 Fc區，其中該異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:51（MK114）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (ii) 示於SEQ ID NO:53（MK115）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (iii) 示於SEQ ID NO:54（MK117）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (iv) 示於SEQ ID NO:55（MK118）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (v) 示於SEQ ID NO:56（MK119）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (vi) 示於SEQ ID NO:57（MK120）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (vii) 示於SEQ ID NO:58（MK121）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (viii) 示於SEQ ID NO:59（MK123）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (ix) 示於SEQ ID NO:60（MK124）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (x) 示於SEQ ID NO:61（MK125）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xi) 示於SEQ ID NO:62（MK126）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xii) 示於SEQ ID NO:67（MK136）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xiii) 示於SEQ ID NO:68（MK137）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xiv) 示於SEQ ID NO:69（MK138）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xv) 示於SEQ ID NO:70（MK139）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xvi) 示於SEQ ID NO:71（MK140）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xvii) 示於SEQ ID NO:72（MK141）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xviii) 示於SEQ ID NO:73（MK146）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xix) 示於SEQ ID NO:74（MK145）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xx) 示於SEQ ID NO:76（MK149）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxi) 示於SEQ ID NO:77（MK150）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxii) 示於SEQ ID NO:78（MK151）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxiii) 示於SEQ ID NO:79（MK152）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxiv) 示於SEQ ID NO:80（MK153）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxv) 示於SEQ ID NO:81（MK154）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxvi) 示於SEQ ID NO:82（MK155）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xxvii) 示於SEQ ID NO:172（MK157）的第一分子和示於SEQ ID NO:75（MH8）的第二分子。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15受體α（IL15Ra）結構域，連接至； d) 第二連接子（L2），連接至； e) IL15結構域； 作為第一分子和第二分子，包含： x) 第二IgG1 Fc區； y) 連接子（L3），連接至； z) 介白素2受體β（IL2Rb）結構域； 其中該一價異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:83（M109）和示於SEQ ID NO:84（MH110）的異源二聚體； (ii) 示於SEQ ID NO:85（M2003）和示於SEQ ID NO:86（MH2004）的異源二聚體；或 (iii) 示於SEQ ID NO:87（M2003）和示於SEQ ID NO:88（MH2005）的異源二聚體。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域，連接至； d) 第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域； 作為第一分子和第二分子，包含： x) 第二IgG1 Fc區； y) 連接子（L3），連接至； z) 介白素2受體β（IL2Rb）結構域； 其中該一價異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:89（M005）和示於SEQ ID NO:90（MK5）的異源二聚體；或 (ii) 示於SEQ ID NO:91（M2006）和示於SEQ ID NO:90（MK5）的異源二聚體。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IL15受體α（IL15Ra）結構域，連接至； b) 第一連接子（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； 第一IgG1 Fc區； 作為第一分子和第二分子，包含： x) 介白素2受體β（IL2Rb）結構域，連接至； y) 連接子（L3），連接至； z) 第二IgG1 Fc區， 其中該一價異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:92（M006）和示於SEQ ID NO:93（MK6）的異源二聚體；或 (ii) 示於SEQ ID NO:94（M2007）和示於SEQ ID NO:93（MK6）的異源二聚體。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 介白素2受體β（IL2Rb）結構域，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域和； d) 第一IgG1 Fc區； 作為第一分子和第二分子，包含： x) IL15受體α（IL15Ra）結構域，連接至； y) 連接子（L3），連接至； z) 第二IgG1 Fc區， 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:95（M108）的第一分子和示於SEQ ID NO:96（MH4）的第二分子。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 第一連接子（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 介白素2受體β（IL2Rb）結構域； 作為第一分子和第二分子，包含： x) 第二IgG1 Fc區，連接至； y) 連接子（L3），連接至； z) IL15受體α（IL15Ra）結構域， 其中該一價異源二聚體IL15構建體包含： 示於SEQ ID NO:97（M112）的第一分子和示於SEQ ID NO:98（MK113）的第二分子。
一種二價同源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； b) 第一連接子（L1），連接至； c) 介白素2受體β（IL2Rb）結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域； f) IL15結構域； 其中該二價同源二聚體IL15構建體包含示於SEQ ID NO:99（M001）的序列和示於SEQ ID NO:100（MH333LC）的序列。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； b) 第一連接子（L1），連接至； c) 介白素2受體β（IL2Rb）結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 連接至第三連接子的IL15受體α（IL15Ra）結構域，連接至； f) IL15結構域； 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:101（M002）的序列、示於SEQ ID NO:102（MH2）的序列和示於SEQ ID NO:100（MH333LC）的序列。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15受體α（IL15Ra）結構域，連接至； d) 第二連接子（L2），連接至； e) IL15結構域； 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:103（MK3）的序列，和 x) 包含第二IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； y) 第一連接子（L3），連接至； z) 介白素2受體β（IL2Rb）結構域， 其中該序列示於SEQ ID NO:104（MH3）以及示於SEQ ID NO:100（MH333LC）。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的第一腫瘤相關抗原（TAA）結合抗體，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域，連接至； d) 第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域， 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:105（MK4）的序列，和 x) 具有第二IgG1 Fc區的第一腫瘤相關抗原（TAA）結合抗體，連接至； y) 第一連接子（L3），示於； z) 介白素2受體β（IL2Rb）結構域， 其中該序列示於SEQ ID NO:106（MH3）以及示於SEQ ID NO:100（MH333LC）。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 介白素2受體β（IL2Rb）結構域，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域； 作為第一分子；和 第二分子，包含 x) IL15受體α（IL15Ra）結構域；和 y) 第一IgG1 Fc區， 以及第三分子，包含第二IgG1 Fc區，其中該異源二聚體IL15構建體包含： 示於SEQ ID NO:107（MK143）的第一分子、示於SEQ ID NO:108（MK144）的第二分子和示於SEQ ID NO:52（H7）的第三分子。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 第一連接子（L1），連接至； c) IL15受體α（IL15Ra）結構域，連接至； d) 第二連接子（L2），連接至； e) IL15結構域； f) 含有蛋白酶可活化部分的第三連接子（L3），連接至； g) 介白素2受體β（IL2Rb）結構域； 作為第一分子和第二分子，包含第二IgG1 Fc區，其中該一價異源二聚體IL15構建體包含： (i)     示於SEQ ID NO:109（MK142）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (ii)    示於SEQ ID NO:173（MK156）的第一分子和示於SEQ ID NO:75（MH8）的第二分子；或 (iii)   示於SEQ ID NO:174（MK165）的第一分子和示於SEQ ID NO:75（MH8）的第二分子。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 作為第一分子的IL15受體α（IL15Ra）結構域，經由二硫鍵連接至； b) IL15結構域，連接至； c) 含有蛋白酶可活化部分的第一連接子（L1），連接至； d) 介白素2受體β（IL2Rb）結構域，連接至； e) 第二連接子（L2），連接至 f) 第一IgG1 Fc區， 以及第三分子，包含第二IgG1 Fc區，其中該異源二聚體IL15構建體包含：示於SEQ ID NO:110（MK147）的第一分子、和示於SEQ ID NO:111（MK148）的第二分子、和示於SEQ ID NO:52（MH7）的第三分子。
一種一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； b) 第一連接子（L1），連接至； c) IL15受體α（IL15Ra）結構域，連接至； d) 第二連接子（L2），連接至； e) IL15結構域，連接至； f) 含有蛋白酶可活化部分的第三連接子（L3），連接至； g) 介白素2受體β（IL2Rb）結構域；和 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:175（MK14）的序列、示於SEQ ID NO:102（MH2）的序列和示於SEQ ID NO:100（MH333LC）的序列。
一種藥物組成物，該藥物組成物包含與至少一種另外的IL15構建體組合的IL15構建體。
一種治療癌症之方法，該方法包括向有需要的患者施用有效量的IL15構建體
該方法，其中該癌症係胃癌、大腸癌、胰臟癌、乳癌、頭頸癌、腎癌、肝癌、小細胞肺癌、非小細胞肺癌、卵巢癌、皮膚癌、間皮瘤、淋巴瘤、白血病、骨髓瘤和肉瘤。
該方法，其中將該IL15構建體與另一種治療劑組合施用。
該方法，其中該治療劑為免疫檢查點劑。
該方法，其中該免疫檢查點劑為PD-1、PD-L1、PD-L2、TIM3、LAG-3、OX40或TIGIT抗體。
一種增加免疫細胞的存活之方法，該方法包括在向患者施用有效量的免疫細胞之前、期間或之後施用IL15構建體。
該方法，其中該免疫細胞表現嵌合抗原受體（CAR）。
該方法，其中該免疫細胞係NK細胞。
該方法，其中該免疫細胞係T細胞。
除非在本說明書的其他地方具體定義，否則本文所用的所有其他技術和科學術語具有熟悉該項技術者通常理解的含義。
如本文所用，包括所附請求項，除非上下文另外明確說明，否則如「一個」、「一種」和「該」的單數形式包括它們相應的複數指代。
除非上下文另外明確說明，否則術語「或」意指術語「和/或」並且可與術語「和/或」互換使用。
如本文所用的術語「抗癌劑」係指可用於治療細胞增殖性障礙（如癌症）的任何藥劑，包括但不限於細胞毒性劑、化學治療劑、放射療法和放射治療劑、靶向性抗癌劑、和免疫治療劑。
術語「介白素-15」或「IL15」為刺激T淋巴細胞增殖的細胞介素。人IL15的胺基酸序列（SEQ ID NO:1）也可在登錄號X94223中找到。 SEQ ID NO:1 MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILGCFSAGLPKTEANWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
術語「介白素-15受體α」或「IL15Ra」為IL15的高親和力受體。IL15Ra的胺基酸序列（SEQ ID NO:2）也可在登錄號CR542023中找到。 SEQ ID NO:2 MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL
術語「介白素-2受體β」或「IL2Rb」為參與受體介導的胞吞作用的β受體亞單位，並且轉導IL2的信號。它還與IL15Ra相關聯，參與刺激IL15的嗜中性細胞吞噬作用。人IL2Rb的胺基酸序列（SEQ ID NO:3）也可在登錄號CR456506中找到。 SEQ ID NO:3 MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV
如本文所用的術語「施用（administration/administering）」和「治療（treating/treatment）」，當應用於動物、人、實驗受試者、細胞、組織、器官或生物流體時，意指外源性藥物、治療劑、診斷劑或組成物與該動物、人、受試者、細胞、組織、器官或生物流體接觸。細胞的處理涵蓋試劑與細胞的接觸以及試劑與流體的接觸，其中該流體與細胞接觸。術語「施用」和「治療」還意指藉由試劑、診斷劑、結合化合物或另一種細胞進行的例如細胞的體外和離體處理。本文中的術語「受試者」包括任何生物，較佳的是動物，更較佳的是哺乳動物（例如，大鼠、小鼠、狗、貓、兔），最較佳的是人。在一方面，治療任何疾病或障礙係指改善該疾病或障礙（即，減緩或阻止或減少疾病或其至少一種臨床症狀的發展）。在另一方面，「治療（treat/treating/treatment）」係指緩解或改善至少一個身體參數，包括患者可能無法辨別的那些。在又另一方面，「治療（treat/treating/treatment）」係指在身體上（例如，可辨別症狀的穩定化）、在生理上（例如，身體參數的穩定化）或兩者上調節疾病或障礙。在又另一方面，「治療（treat/treating/treatment）」係指預防或延遲疾病或障礙的發作或發展或進展。
在本揭露的上下文中，術語「受試者」係哺乳動物，例如，靈長類動物，較佳的是高等靈長類動物，例如人（例如，患有本文所述的障礙或處於患有本文所述的障礙的風險的患者）。
本文中的術語「癌症」或「腫瘤」具有如本領域理解的最廣泛的含義，並且是指哺乳動物中典型地以不受調控的細胞生長為特徵的生理病症。在本揭露的上下文中，癌症不限於某個類型或位置。
術語「腫瘤相關抗原（TAA）」為在靶腫瘤中表現的抗原，其中抗體或抗體的抗原結合片段直接作用於TAA或與其特異性結合。例如，本文所述的TAA為PD-L1，而針對此抗原而產生的抗體揭露於WO 2016/000619。
在本揭露的上下文中，當提及胺基酸序列時，術語「保守取代」意指用新胺基酸取代原始胺基酸，該新胺基酸基本上不改變IL15構建體的化學、物理和/或功能特性，例如與IL15傳訊通路結合和將IL15傳訊通路活化的能力。特別地，胺基酸的常見保守取代係本領域熟知的並且示出如下。 [表1] 示例性胺基酸取代
原始胺基酸殘基 單字母和三字母代碼 保守取代
丙胺酸 A或Ala Gly；Ser
精胺酸 R或Arg Lys；His
天冬醯胺 N或Asn Gln；His；Asp；Lys；Arg；Gln
天冬胺酸 D或Asp Gln；Asn
半胱胺酸 C或Cys Ser；Ala；Thr
麩醯胺酸 Q或Gln Asn
麩胺酸 E或Glu Asp；Gln
甘胺酸 G或Gly Ala
組胺酸 H或His Asn；Gln
異白胺酸 I或Ile Leu；Val
白胺酸 L或Leu Ile；val；Ala；Cys
離胺酸 K或Lys Arg；His
甲硫胺酸 M或Met Leu；Ile；Tyr
苯丙胺酸 F或Phe Tyr；Met；Leu
脯胺酸 P或Pro Ala
絲胺酸 S或Ser Thr；Cys
蘇胺酸 T或Thr Ser；Trp
色胺酸 W或Trp Tyr；Phe
酪胺酸 Y或Tyr Trp；Phe；Val；Cys
纈胺酸 V或Val Ile；Leu；Gln
如本文所用的術語「杵臼（knob-into-hole）」技術係指胺基酸在體外或體內藉由在它們相互作用的介面上將空間突起（杵）引入一個多肽並將穴袋或空腔（臼）引入另一個多肽從而引導將兩條多肽配對在一起。例如，杵臼已經被引入了抗體的Fc:Fc結合介面、CL:CHI介面、或VH/VL介面（參見，例如，US 2011/0287009、US 2007/0178552、WO 96/027011、WO 98/050431、和Zhu等人, 1997, Protein Science [蛋白質科學] 6:781-788）。在一些實施方式中，杵臼確保了特異性IL15構建體表現期間兩個不同重鏈正確配對在一起。例如，在其Fc區具有杵臼胺基酸的IL15構建體可以進一步包含IL15構建體的第一分子和IL15構建體的第二分子，其中這兩種分子至少部分地藉由杵臼相互作用來組裝。
如本文在「杵臼」技術的上下文中所用的術語「杵」係指向多肽在該多肽與另一多肽相互作用的介面處引入突起（杵）的胺基酸改變。在一些實施方式中，另一多肽具有臼突變。
如本文在「杵臼」的上下文中所用的術語「臼」係指向多肽在該多肽與另一多肽相互作用的介面處引入穴袋或空腔（臼）的胺基酸改變。在一些實施方式中，另一多肽具有杵突變。
適用於確定序列同一性和序列相似性百分比的演算法的實例為BLAST演算法，其分別描述於Altschul等人, Nuc. Acids Res.[核酸研究] 25:3389-3402, 1977；和Altschul等人, J. Mol. Biol.[分子生物學雜誌] 215:403-410, 1990。用於進行BLAST分析的軟體可藉由國家生物技術資訊中心（National Center for Biotechnology Information）揭露獲得。該演算法包括首先藉由鑒定查詢序列中短字長W鑒定高得分序列對（HSP），當與資料庫序列中相同字長比對時，其匹配或滿足一些正值閾值得分T。T被稱為鄰域字得分閾值。該等初始鄰域字命中作為開始搜索以找到包含它們的較長HSP的值。字命中沿著每個序列在兩個方向上延伸，直到累積比對得分可以增加為止。對於核苷酸序列，使用參數M（一對匹配殘基的獎勵得分；始終＞0）和N（錯配殘基的罰分；始終＜0）來計算累積得分。對於胺基酸序列，使用得分矩陣來計算累積得分。在以下情況下，將停止字命中在每個方向上的延伸：累積比對得分從其最大實現值下降了數量X；由於一個或多個負得分殘基比對的累積，累積得分趨於零或更低；或者到達任一序列的末端。BLAST演算法參數W、T和X決定了比對的靈敏度和速度。BLASTN程式（對於核苷酸序列）默認使用字長（W）11，期望值（E）10，M=5，N=-4並比較兩條股。對於胺基酸序列，BLAST程式預設使用字長3，期望值（E）10和BLOSUM62得分矩陣（參見Henikoff和Henikoff, (1989) Proc. Natl. Acad. Sci. USA[美國國家科學院學報] 89: 10915）比對（B）50，期望值（E）10，M=5，N=-4並比較兩條股。
BLAST演算法還對兩個序列之間的相似性進行統計分析（參見例如Karlin和Altschul, Proc. Natl. Acad. Sci. USA[美國國家科學院學報] 90:5873-5787, 1993）。BLAST演算法提供的一種相似性度量係最小總和概率（P(N)），其提供了兩個核苷酸或胺基酸序列之間偶然發生匹配的概率的指示。例如，如果測試核酸與參考核酸的比較中最小總和概率小於約0.2，更較佳的是小於約0.01，最較佳的是小於約0.001，則認為該核酸與參考序列相似。
兩個胺基酸序列之間的同一性百分比還可使用以下的演算法來確定：E. Meyers和W. Miller, Comput. Appl. Biosci.[生物科學中的電腦應用] 4: 11-17, (1988)，其已併入ALIGN程式（2.0版本），使用PAM120權重殘基表，空位長度罰分為12，空位罰分為4。此外，可以使用以下確定兩個胺基酸序列之間的同一性百分比：Needleman和Wunsch, J.Mol.Biol. [分子生物學雜誌] 48:444-453 (1970) 的演算法，其已併入GCG套裝軟體中的GAP程式中，使用BLOSUM62矩陣或PAM250矩陣，空位權重為16、14、12、10、8、6或4，並且長度權重為1、2、3、4、5或6。
術語「核酸」在本文中可與術語「多核苷酸」互換使用，並且是指單股或雙股形式的去氧核糖核苷酸或核糖核苷酸及其聚合物。該術語涵蓋含有已知的核苷酸類似物或經修飾的主鏈殘基或連接的核酸，它們係合成的，天然存在的和非天然存在的，具有與參考核酸相似的結合特性，並且以與參考核苷酸相似的方式代謝。此類類似物的實例包括但不限於硫代磷酸酯、胺基磷酸酯、甲基膦酸酯、手性甲基膦酸酯、2-O-甲基核糖核苷酸、肽-核酸（PNA）。
在核酸的上下文中，術語「可操作地連接」係指兩個或更多個多核苷酸（例如，DNA）區段之間的功能關係。通常，它係指轉錄調節序列與轉錄序列的功能關係。例如，啟動子或增強子序列如果在合適的宿主細胞或其他表現系統中刺激或調節編碼序列的轉錄，則可操作地連接至編碼序列。通常，可操作地連接至轉錄序列的啟動子轉錄調節序列與轉錄序列在物理上鄰接，即它們係順式作用的。然而，一些轉錄調節序列（如增強子）不需要在物理上鄰接或緊鄰它們增強其轉錄的編碼序列。
術語「連接子」、「連接的」、「連接至」或「連接（linkered）」係指至少兩個胺基酸的多肽（蛋白質）插入兩個多肽之間從而使其連接在一起。連接子可以是不可裂解的，或具有蛋白酶可活化（可裂解）部分。連接子的實例示於以下表3和表4中。
在一些方面，本揭露提供了組成物，例如藥學上可接受的組成物，其包含與至少一種藥學上可接受的賦形劑一同配製的本文所述的IL15構建體。如本文所用，術語「藥學上可接受的賦形劑」包括生理學上相容的任何和所有溶劑、分散介質、等滲劑和吸收延遲劑等。賦形劑可適於靜脈內、肌內、皮下、腸胃外、直腸、脊柱或表皮施用（例如藉由注射或輸注）。
本文揭露之組成物可以是多種形式。該等包括例如液體、半固體和固體劑型，如液體溶液（例如可注射和輸注溶液）、分散液或懸浮液、脂質體和栓劑。合適的形式取決於預期的施用方式和治療應用。典型的合適組成物係可注射或輸注溶液的形式。一種合適的施用方式係腸胃外（例如靜脈內、皮下、腹膜內、肌內）。在一些實施方式中，IL15構建體藉由靜脈內輸注或注射來施用。在一些實施方式中，IL15構建體藉由肌內或皮下注射來施用。
如本文所用的術語「治療有效量」係指當施用於受試者以治療疾病、或疾病或障礙的至少一種臨床症狀時，足以影響該疾病、障礙或症狀的治療的IL15構建體的量。「治療有效量」可以隨IL15構建體，疾病，障礙，和/或疾病或障礙的症狀，疾病、障礙、和/或疾病或障礙的症狀的嚴重程度，待治療的受試者的年齡，和/或待治療的受試者的體重而變化。在任何給定情況下的合適量對於熟悉該項技術者而言係顯而易見的，或者可以藉由常規實驗確定。在組合療法的情況下，「治療有效量」係指用於有效治療疾病、障礙或病症的組成對象之總量。
術語「組合療法」係指施用兩種或更多種治療劑以治療本揭露中所述的治療病症或障礙。這種施用涵蓋以基本上同時的方式共同施用該等治療劑。這種施用也涵蓋在多個容器中或在每種活性成分的獨立容器（例如，膠囊、粉末和液體）中共同施用。可以將粉末和/或液體在施用之前重構或稀釋到所期望的劑量。此外，這種施用也涵蓋在大致相同的時間或在不同的時間以順序方式使用每種類型的治療劑。在任何一種情況下，治療方案將在治療本文描述的病症或障礙方面提供藥物組合的有益作用。
如本文所用，短語「與……組合」意指在施用另外的治療劑的同時、之前或之後將IL15構建體施用給受試者。在某些實施方式中，將IL15構建體作為與另外的治療劑的共同配製物來施用。
本揭露提供了與IL15傳訊通路結合並且將其活化的IL15構建體。此外，本揭露提供了具有期望的藥物動力學特徵和其他期望的屬性的IL15構建體，並且因此可用於降低癌症的可能性或治療癌症。本揭露進一步提供了包含IL15構建體的藥物組成物，和製備以及使用此類IL15構建體的藥物組成物預防和治療癌症及相關障礙之方法。
本揭露的其他IL15構建體包括胺基酸或編碼胺基酸的核酸已經改變，但仍與表2中所述的序列具有至少60%、70%、80%、90%、95%或99%的同一性百分比的那些。在一些方面，它包括胺基酸序列的改變，其中與表2中所述的序列相比，改變的胺基酸不超過1、2、3、4或5個，同時保持基本上相同的治療活性。 [表2]
構建體 SEQ ID NO ID 序列
構建體 A SEQ ID NO: 4 M123 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSISSGLLSGRSDNHGGGSSGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 5 M135 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 6 M140 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSSGGSGGSGGSGGGSGGGGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 7 M145 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO:8 M175 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSISSGLLSGRSDNHGGGSSGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 9 M176 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 10 M177 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGWRSGGSGGGGSGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 11 M178 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGRSASGGSGGGGSGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 12 M207 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 13 M231 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPEENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 14 M233 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 15 M234 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKD GGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 16 M238 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 17 M239 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGGSGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 18 M240 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPEENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 19 M241 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
[0001] SEQ ID NO: 20 M243 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 21 M244 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
[0001] SEQ ID NO: 22 M245 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
[0001] SEQ ID NO: 23 M246 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
[0001] SEQ ID NO: 24 M247 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
[0001] SEQ ID NO: 25 M248 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 26 M249 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 27 M327 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 28 M328 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTAPAPAPEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 29 M329 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTAPAPAPEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 30 M330 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGRSASGGSGGGGSGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 31 M331 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGRSASGGSGGGGSGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTEAAAKEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 32 M332 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGRSASGGSGGGGSGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTEAAAKEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
       
構建體 B SEQ ID NO: 33 M43與M24（SEQ ID NO:34）配對 AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSSGGSGGSGGGSGGGSLSGRSDNHGGSGNWVNVISDLKKIEDLIQSMHIDATLYSESDVHPSCKVTAMKCFLLEFQVISCESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 34 M24 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTCSLTECVLNKATNVAHWTTPSLKCIRDPALVHQREPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 35 M61與M60配對（SEQ ID NO: 36） GTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSIPVSLRSGGGGSSGGSGGSGGNWVNVISDLKKIEDLIQSMHIDATLYSESDVHPSCKVTAMKCFLLEFQVISCESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 36 M60 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTCSLTECVLNKATNVAHWTTPSLKCIRDPALVHQREPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 37 M62與M60（SEQ ID NO:38）配對 AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSISSGLLSGRSDNHGGGSSGGSNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISCESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 38 M60 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTCSLTECVLNKATNVAHWTTPSLKCIRDPALVHQREPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
       
構建體 C SEQ ID NO: 39 M101 AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSSGGSGGSGGSGGGSGGGSLSGRSDNHGGSGNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSSGGSGGGGSGGGSGGGGSLQITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIREPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
[0001] SEQ ID NO: 40 M148 AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSSGGSGGSGGIPVSLRSGGGGSNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSGGGGSGGGGSGGGGSGGGSLQITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIREPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 41 M174 AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGGSSGRIGFLRTAGGGGSNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSSGGGSGGGGSGGGGSGGGGSGGGSLQITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
       
構建體 D SEQ ID NO: 42 M232 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSIPVSLRSGGGGSSGGSGGSGGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 43 M1001 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 44 M1002 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 45 M1003 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 46 M1004 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 47 M1005 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 48 M1006 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVQGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTS
       
構建體 E1 SEQ ID NO: 49 MK107與MH2（SEQ ID NO:50）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
  SEQ ID NO: 50 MH2 EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
       
構建體 E3 SEQ ID NO: 51 MK114與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 52 MH7 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 53 MK115與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSIPVSLRSGGGGSSGGSGGSGGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 54 MK117與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 55 MK118與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVQGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 56 MK119與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSIPVSLRSGGGGSSGGSGGSGGAVQGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 57 MK120與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSIPVSLRSGGGGSSGGSGGSGGAVQGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 58 MK121與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGRSASGGSGGGGSGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 59 MK123與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 60 MK124與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGRSASGGSGGGGSGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGGSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 61 MK125與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTEAAAKEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 62 MK126與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGRSASGGSGGGGSGSGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTAPAPAPEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO:172 MK157與MH8（SEQ ID NO:75）配對： ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWKQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
       
構建體 E2 SEQ ID NO: 63 M111與MH2（SEQ ID NO:64）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSIPVSLRSGGGGSSGGSGGSGGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 64 MH2 EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 65 M2001與MH7（SEQ ID NO:52）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 66 M2002與MH7（SEQ ID NO:52）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVQGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTS
構建體 E3 SEQ ID NO: 67 MK136與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 68 MK137與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 69 MK138與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 70 MK139與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 71 MK140與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 72 MK141與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTQDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 73 MK146與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGGSGGGGSGGGGSGGGGSGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 74 MK145與MH8（SEQ ID NO:75）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 75 MH8 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 76 MK149與MH8（SEQ ID NO:75）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 77 MK150與MH8（SEQ ID NO:75）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 78 MK151與MH8（SEQ ID NO:75）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWKQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 79 MK152與MH8（SEQ ID NO:75）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWRQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 80 MK153與MH8（SEQ ID NO:75）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWQQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 81 MK154與MH8（SEQ ID NO:75）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 82 MK155與MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
       
構建體 F1 SEQ ID NO: 83 M109與MH110（SEQ ID NO:84）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGSIPVSLRSGGGGSSGGSGGSGGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 84 MH110 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKD
SEQ ID NO: 85 M2003與MH2004（SEQ ID NO:86）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGSIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 86 MH2004 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDT
SEQ ID NO: 87 M2003與M2005（SEQ ID NO:88）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGSIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 88 M2005 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVQGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDT
       
構建體 F2 SEQ ID NO: 89 M005與MK5（SEQ ID NO:90）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPEENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQ
SEQ ID NO: 90 MK5 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGSSGGSGGSGGIPVSLRSGGGGSNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSSGGSGGGGSGGGSGGGGSLQITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPP
SEQ ID NO: 91 M2006與MK5（SEQ ID NO:90）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKD
       
構建體 F3 SEQ ID NO: 92 M006與MK6（SEQ ID NO:93）配對 AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPEENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 93 MK6 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 94 M2007與MK6（SEQ ID NO:93）配對 AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
       
構建體 G1 SEQ ID NO: 95 M108與MH4（SEQ ID NO:96）配對 AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSIPVSLRSGGGGSSGGSGGSGGNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 96 MH4 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIREPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
       
構建體 G2 SEQ ID NO: 97 M112與MK113（SEQ ID NO:98）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSGGGSIPVSLRSGGGGSSGGSGGSGGAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKD
SEQ ID NO: 98 MK113 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIR
       
構建體 H1 SEQ ID NO: 99 M001與MH333LC配對（SEQ ID NO: 100） EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 100 MH333LC DIQMTQSPSSLSASVGDRVTITCKASQDVGIVVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYSNYPLYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
       
構建體 H2 SEQ ID NO: 101 M002與MH2 SEQ ID NO: 102和MH333 LC SEQ ID NO:100配對 EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSSGGSGGSGGIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 102 MH2 EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 100 MH333 LC DIQMTQSPSSLSASVGDRVTITCKASQDVGIVVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYSNYPLYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
       
構建體 K1 SEQ ID NO: 103 MK3與MH3（SEQ ID NO: 104）和MH333 LC（SEQ ID NO:100）配對 EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGSIPVSLRSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
SEQ ID NO: 104 MH3 EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDT
SEQ ID NO: 100 MH333LC DIQMTQSPSSLSASVGDRVTITCKASQDVGIVVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYSNYPLYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
       
構建體 K2 SEQ ID NO: 105 MK4與MH3（SEQ ID NO: 106）和MH333 LC（SEQ ID NO:100）配對 EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGSSGGSGGSGGIPVSLRSGGGGSNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSSGGSGGGGSGGGSGGGGSLQITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPP
SEQ ID NO: 106 MH3 EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRANISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWITLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDT
SEQ ID NO: 100 MH333 LC DIQMTQSPSSLSASVGDRVTITCKASQDVGIVVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYSNYPLYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
構建體 M SEQ ID NO: 107 MK143與MK144（SEQ ID NO:108）和MH7（SEQ ID NO:52）配對 GTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGSVPLSLYSGRSASGGSGGGGSGSGNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISCESGDASIHDTVENLIILAQDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTS
SEQ ID NO: 108 MK144 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTCSLTECVLNKATNVAHWTTPSLKCIRDPALVHQREPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
       
構建體 N SEQ ID NO: 109 MK142與MH7（SEQ ID NO:52）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPA
SEQ ID NO:173 MK156與MH8（SEQ ID NO:75）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPA
SEQ ID NO: 174 MK165與MH8（SEQ ID NO:75）配對 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPA
       
構建體 P SEQ ID NO: 110 MK147與MK148（SEQ ID NO:111）和MH7（SEQ ID NO:52）配對 ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTCSLTECVLNKATNVAHWTTPSLKCIRDPALVHQR
SEQ ID NO: 111 MK148 NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISCESGDASIHDTVENLIILAQDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGSGGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
構建體 Q SEQ ID NO: 175 MK14與MH2（SEQ ID NO:102）和MH333 LC（SEQ ID NO:100）配對 EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSGGSGGGGSGGGSGGGGSLQNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILAQNSLSSNGQVTESGCKECEELEEKNIKEFLQSFVHIVQMFIQTSGGGSVPLSLYSGRSASGGSGGGGSGTSQFTCFYNSRAQISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRAQISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWISLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPA
SEQ ID NO: 102 MH2 EVQLVESGGGLVQPGGSLRLSCAVSGFSLTSYGVHWVRQAPGKGLEWVAVIWAGGSTNYADSVKGRFTISKDTSKNTVYLQMNSLRAEDTAVYYCAKPYGTSAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPPAAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 100 MH333 LC DIQMTQSPSSLSASVGDRVTITCKASQDVGIVVAWYQQKPGKAPKLLIYWASIRHTGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYSNYPLYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
       
IgGGHG1-Fc SEQ ID NO: 112 IgHG1（99-330） EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 113 IgHG1（99-330，C103S） EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 114 IgHG1（104-330） DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 115 IgHG1（99-329，C103S） EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 116 IgHG1（104-329） DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 117 IgHG1（99-330，C103S、S354C、T366W）杵 EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 118 IgHG1（99-330，C103S、Y349C、T366S、L368A、Y407V）臼 EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 119 IgHG1（99-329，C103S、S354C、T366W）杵 EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 120 IgHG1（99-329，C103S、Y349C、T366S、L368A、Y407V）臼 EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 121 IgHG1（104-330，S354C、T366W）杵 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 122 IgHG1（104-330，Y349C、T366S、L368A、Y407V）臼 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 123 IgHG1（104-329，S354C、T366W）杵 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 124 IgHG1（104-329，Y349C、T366S、L368A、Y407V）臼 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SEQ ID NO: 125 IGHG1（104-330，T366W），杵 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
SEQ ID NO: 126 IGHG1（104-330，T366S、L368A、Y407V）臼 DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
連接子
還應理解，IL15構建體的多肽鏈的結構域和/或區域可含有各種長度的連接子區域。在一些實施方式中，IL15構建體結構域係藉由連接子區域彼此分開的。例如，IL15Ra-(連接子)-IL15。在一些方面，連接子可以含有蛋白酶可活化（可裂解）部分。
在一些實施方式中，胺基酸甘胺酸和絲胺酸包含連接子（「GS」連接子）的胺基酸。在另一個實施方式中，連接子可以但不限於是表3中的連接子或其任何組合。 [表3]
SEQ ID NO: 序列 AA 長度
SEQ ID NO: 127 SGGSGGGGSGGGSGGGGSLQ 20
SEQ ID NO: 128 GGS 3
SEQ ID NO: 129 GGGS 4
SEQ ID NO: 130 GGGGS 5
SEQ ID NO: 131 GGGSSGGS 8
SEQ ID NO: 132 GGGGSGGGGS 10
SEQ ID NO: 133 SGGSGGGGSGSG 12
SEQ ID NO: 134 GGGSSGGSGGSGG 13
SEQ ID NO: 135 GGGSSGGSGGSGGS 14
SEQ ID NO: 136 GGGSSGGSGGSGGSG 15
SEQ ID NO: 137 GGGSSGGSGGSGGSGGGSGGGGSG 24
SEQ ID NO: 138 GGGSSGGSGGSGGGSSGGSGGSGGS 25
SEQ ID NO: 139 GGGSGGGSSGGSGGSGGGGGSSGGS 25
SEQ ID NO: 140 GGGSSGGSGGG 11
SEQ ID NO: 141 GGGSSGGSGGSGGGSGGGS 19
SEQ ID NO: 142 GGSG 4
SEQ ID NO: 143 GGGSSGGSGGSGGSGGGSGGGS 22
SEQ ID NO: 144 SGGGSGGGGSGGGGSGGGGSGGGSLQ 25
SEQ ID NO: 145 GGGGSGGGGSGGGGS 15
SEQ ID NO: 146 GGGGSGGGGSGGGGSGGGGS 20
SEQ ID NO: 147 GGGGSSG 7
SEQ ID NO: 148 GGGGSGGGGSGGGGSSGGSGGSGG 24
SEQ ID NO: 149 SGGSGGGGS 9
SEQ ID NO: 150 SGGSGG 6
在其他實施方式中，連接子含有蛋白酶可活化（可裂解）部分。在某些實施方式中，蛋白酶可活化部分可以是但不限於表4中的連接子或其任何組合。表5示出了在代表性構建體中蛋白酶可活化部分的位置。 [表4]
SEQ ID NO: 序列 AA 長度
SEQ ID NO: 151 ISSGLLSGRSDNH 13
SEQ ID NO: 152 ISSGLLSGRSANP 13
SEQ ID NO: 153 LSGRSDNH 8
SEQ ID NO: 154 LSGRSANP 8
SEQ ID NO: 155 PLGLAG 6
SEQ ID NO: 156 IPVSLRSG 8
SEQ ID NO: 157 GPQGIAGQ 8
SEQ ID NO: 158 VPMSMRGG 8
SEQ ID NO: 159 RPMSMIMG 8
SEQ ID NO: 160 VPLSLTMG 8
SEQ ID NO: 161 VPLSLYSG 8
SEQ ID NO: 162 IPESLRAG 8
SEQ ID NO: 163 IPVSLRSGWR 10
SEQ ID NO: 164 IPVSLRSGRSA 11
SEQ ID NO: 165 VPLSLYSGWR 10
SEQ ID NO: 166 VPLSLYSGRSA 11
SEQ ID NO: 167 GAANLVRG 8
SEQ ID NO: 168 GYAELRMG 8
SEQ ID NO: 169 MPYDLYHP 8
SEQ ID NO: 170 RIGFLRTA 8
SEQ ID NO: 171 ARYRWLTA 8
[表5]
ID No. 構建體設計（可裂解的連接子標有底線）
M123             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- ISSGLLSGRSDNH （SEQ ID NO: 151）-8) -IL2R β (D1-D2)- Fc
M135             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- IPVSLRSG （SEQ ID NO: 156）-13) -IL2R β (D1-D2)- Fc
M141             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- GPQGIAGQ （SEQ ID NO: 157）-13) -IL2R β (D1-D2)- Fc
M142             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- VPMSMRGG （SEQ ID NO: 158）-13) -IL2R β (D1-D2)- Fc
M143             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- RPMSMIMG （SEQ ID NO: 159）-13) -IL2R β (D1-D2)- Fc
M144             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- VPLSLTMG （SEQ ID NO: 160）-13) -IL2R β (D1-D2)- Fc
M145             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- VPLSLYSG （SEQ ID NO: 151）-13) -IL2R β (D1-D2)- Fc
M146             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- IPESLRAG （SEQ ID NO: 161）-13) -IL2R β (D1-D2)- Fc
M162             (IL-15RaSu)-連接子1-IL15(N72D) -CM(5- IPVSLRSGWR （SEQ ID NO: 163）-5) -IL2R β (D1-D2)- Fc
M166             (IL-15RaSu)-連接子1-IL15(N72D) -CM(5- IPVSLRSGRSA （SEQ ID NO: 164）-5) -IL2R β (D1-D2)- Fc
M171             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- GAANLVRG （SEQ ID NO: 167）-13) -IL2R β (D1-D2)- Fc
M172             (IL-15RaSu)-連接子1-IL15(N72D) -CM(4- GYAELRMG （SEQ ID NO: 168）-13) -IL2R β (D1-D2)- Fc
M173             IL2RbECD-CM(7- ARYRWLTA （SEQ ID NO: 171）-5)-IL15-連接子2- IL15Ra sushi-G4S-IgG1 Fc
M174             IL2RbECD-CM(7- RIGFLRTA （SEQ ID NO: 170）-5)-IL15-連接子2- IL15Ra sushi-G4S-IgG1 Fc
M177             (IL-15RaSu)-連接子1-IL15 (N72D) - MMP9 (4- VPLSLYSGWR （SEQ ID NO: 165） -12) -IL2R β (D1-D2)- Fc
M178             (IL-15RaSu)-連接子1-IL15 (N72D) - MMP9 (4- VPLSLYSGRSA （SEQ ID NO: 166） -12) -IL2R β (D1-D2)- Fc
Fc 區
在又其他方面，藉由將至少一個胺基酸殘基用不同的胺基酸殘基替換來改變Fc區，以改變效應子功能。例如，可以將一個或多個胺基酸用不同的胺基酸殘基替換，使得Fc區對效應子配位基具有改變的親和力。親和力改變的效應子配位基可以是例如Fc受體或補體的C1組分。這種方法描述於例如Winter等人的美國專利案號5,624,821和5,648,260中。
在另一方面，可以將一個或多個胺基酸殘基用一個或多個不同的胺基酸殘基替換，使得Fc區具有改變的C1q結合和/或降低的或消除的補體依賴性細胞毒性（CDC）。該方法描述於例如Idusogie等人的美國專利案號6,194,551中。
在又另一方面，改變一個或多個胺基酸殘基從而改變Fc區固定補體的能力。該方法描述於例如Bodmer等人的公開WO 94/29351中。在特定方面，本揭露的IL15構建體的一個或多個胺基酸被（IgG1亞類和κ同種型的）一個或多個異型胺基酸殘基替換。同種異型胺基酸殘基還包括但不限於IgG1、IgG2和IgG3亞類的重鏈恒定區以及κ同種型的輕鏈恒定區，如Jefferis等人, MAbs [單株抗體]. 1:332-338 (2009)所述。
在另一方面，如果期望ADCC的降低，許多先前的報導顯示IgG4的Fc區僅具有適度的ADCC並且幾乎沒有CDC效應子功能（Moore G L等人, 2010 MAbs [單株抗體], 2:181-189）。然而，發現天然IgG4在應激條件下（如在酸性緩衝劑中或在升高的溫度下）較不穩定（Angal, S. 1993 Mol Immunol [分子免疫學], 30:105-108；Dall'Acqua, W.等人, 1998 Biochemistry [生物化學], 37:9266-9273；Aalberse等人, 2002 Immunol[免疫學], 105:9-19）。降低的ADCC可以藉由將IL5構建體可操作地連接至用降低FcγR結合或C1q結合活性的改變的組合工程化的IgG4 Fc，從而降低或消除ADCC和CDC效應子功能來實現。將IL15構建體的物理化學特性看作生物治療劑，IgG4的較不期望的固有特性之一係其兩條重鏈在溶液中動態分離（Van der Neut Kolfschoten M等人, 2007 Science [科學], 317:1554-157）。228位（EU編號系統）絲胺酸突變為脯胺酸表現出對IgG4重鏈分離的抑制作用（Angal, S. 1993 Mol Immunol [分子免疫學], 30:105-108；Aalberse等人, 2002 Immunol [免疫學], 105:9-19）。據報導，鉸鏈區和γFc區中的一些胺基酸殘基對Fc區與Fcγ受體的相互作用具有影響（Chappel S M等人, 1991 Proc. Natl. Acad. Sci. USA [美國國家科學院學報], 88:9036-9040；Mukherjee, J.等人, 1995 FASEB J [美國實驗生物學學會聯合會雜誌], 9:115-119；Armour, K. L.等人, 1999 Eur J Immunol [歐洲免疫學雜誌], 29:2613-2624；Clynes, R. A.等人, 2000 Nature Medicine [自然醫學], 6:443-446；Arnold J. N., 2007 Annu Rev immunol [免疫學年鑒], 25:21-50）。此外，在人群中一些罕見的IgG4同種型也可引起不同的物理化學特性（Brusco, A.等人, 1998 Eur J Immunogenet [歐洲免疫遺傳學雜誌], 25:349-55；Aalberse等人, 2002 Immunol [免疫學], 105:9-19）。為了產生具有低ADCC和CDC但具有良好穩定性的IL15構建體，可以修飾人IgG4的鉸鏈區和Fc區並引入許多改變。該等修飾的IgG4 Fc分子可在SEQ ID NO: 83-88，Li等人的美國專利案號8,735,553中找到。 Fc結構域可經由胺基酸改變來修飾，以提供「杵臼」技術並且引導兩個多肽在體外或體內配對在一起。例如，引入人IgG1 Fc中的「杵臼」突變以促進異源二聚體形成（Ridgway等人, Prot. Eng.[蛋白質工程] 1996 9:617-621）。此外，將杵臼引入抗體的Fc:Fc結合介面、CL:CHI介面、或VH/VL介面（參見，例如，US 2011/0287009、US 2007/0178552、WO 96/027011、WO 98/050431、和Zhu等人, 1997, Protein Science [蛋白質科學] 6:781-788）。在一些實施方式中，杵臼確保了兩個不同重鏈正確配對在一起，以產生特異性IL15構建體。 IL15 構建體的產生
IL15構建體可藉由本領域已知的任何方式來產生，包括但不限於重組表現或化學合成。重組表現可以來自本領域已知的任何合適的宿主細胞，例如哺乳動物宿主細胞、細菌宿主細胞、酵母宿主細胞、昆蟲宿主細胞等。
本揭露還提供了用於產生IL15構建體的表現載體和宿主細胞。表現載體的選擇取決於表現載體的預期宿主細胞。通常，表現載體含有可操作地連接至編碼IL15構建體的啟動子和其他調節序列（例如，增強子）。在一些方面，除了在誘導條件的控制下，使用誘導型啟動子來防止插入序列的表現。誘導型啟動子包括例如阿拉伯糖、lacZ、金屬硫蛋白啟動子或熱激啟動子。可以在非誘導條件下、而不在偏向宿主細胞更好耐受其表現產物的編碼序列的群體的情況下擴大經轉化的生物體的培養。除啟動子外，其他調節元件也可以是有效表現IL15構建體所需要或期望的。該等元件通常包括ATG起始密碼子和相鄰的核糖體結合位點或其他序列。此外，藉由包含適合於使用中的細胞系統的增強子，可以提高表現效率（參見例如，Scharf等人, Results Probl. Cell Differ. [細胞分化中的結果和問題] 20:125, 1994；和Bittner等人, Meth. Enzymol. [酶學方法], 153:516, 1987）。例如，SV40增強子或CMV增強子可以用來增加哺乳動物宿主細胞中的表現。
用於攜帶並表現IL15構建體的宿主細胞可以是原核或真核的。大腸桿菌係一種可用於選殖並表現本揭露多核苷酸的原核宿主。其他適用的微生物宿主包括桿菌，如枯草芽孢桿菌，和其他腸桿菌科，如沙門氏菌屬、沙雷氏菌屬和各種假單胞菌屬。在該等原核宿主中，還可以製備表現載體，其通常含有與宿主細胞相容的表現控制序列（例如複製起點）。此外，將存在任何數量的多種熟知的啟動子，如乳糖啟動子系統、色胺酸（trp）啟動子系統、β-內醯胺酶啟動子系統或來自噬菌體λ的啟動子系統。啟動子通常視需要用操縱子序列控制表現，並具有核糖體結合位點序列等，用於啟動和完成轉錄和翻譯。其他微生物如酵母也可用於表現IL15構建體。也可以使用昆蟲細胞與桿狀病毒載體的組合。
在其他方面，哺乳動物宿主細胞用於表現和產生本揭露的IL15構建體。例如，它們可以是攜帶外源表現載體的哺乳動物細胞株。該等包括任何正常死亡或正常或異常永生化動物或人細胞。例如，已經開發了幾種能夠分泌完整多肽的合適宿主細胞株，包括CHO細胞株、各種COS細胞株和HEK 293細胞。使用哺乳動物組織細胞培養物來表現多肽一般在例如Winnacker, From Genes to Clones[從基因到殖株], VCH出版社, NY, N.Y., 1987中討論。用於哺乳動物宿主細胞的表現載體可以包括表現控制序列，例如複製起點、啟動子和增強子（參見例如Queen等人, Immunol. Rev.[免疫學綜述] 89:49-68, 1986）和必要的加工資訊位點，例如核糖體結合位點、RNA剪接位點、聚腺苷酸化位點和轉錄終止子序列。該等表現載體通常含有衍生自哺乳動物基因或哺乳動物病毒的啟動子。合適的啟動子可以是組成型的、細胞類型特異性的、階段特異性的、和/或可調控的或可調節的。有用的啟動子包括但不限於金屬硫蛋白啟動子、組成型腺病毒主要晚期啟動子、地塞米松誘導型MMTV啟動子、SV40啟動子、MRP polIII啟動子、組成型MPSV啟動子、四環素誘導型CMV啟動子（例如人立即早期CMV啟動子）、組成型CMV啟動子和本領域已知的啟動子-增強子組合。 治療方法
本揭露的IL15構建體可用於多種應用，包括但不限於治療癌症、感染或免疫障礙之方法。
在一方面，本揭露提供了一種治療癌症之方法。在某些方面，該方法包括向有需要的患者施用有效量的IL15構建體。癌症可包括但不限於胃癌、大腸癌、胰臟癌、乳癌、頭頸癌、腎癌、肝癌、小細胞肺癌、非小細胞肺癌、卵巢癌、皮膚癌、間皮瘤、淋巴瘤、白血病、骨髓瘤和肉瘤。
如本文揭露之IL15構建體可以藉由任何合適的方式施用，包括腸胃外、肺內和鼻內，以及（如果期望用於局部治療）病灶內施用。腸胃外輸注包括肌內、靜脈內、動脈內、腹膜內或皮下施用。給藥可以藉由任何合適的途徑，例如藉由注射，例如靜脈內或皮下注射，這部分取決於施用係短暫的還是長期的。本文考慮了多種給藥方案，包括但不限於單次施用或在不同時間點的多次施用、推注施用、和脈衝輸注。
本揭露的IL15構建體可以以符合良好醫學實踐的方式配製、給藥和施用。關於這點要考慮的因素包括治療的特定障礙、治療的特定哺乳動物、個體患者的臨床病症、障礙的起因、藥劑的遞送位點、施用方法、施用方案、和醫療從業者已知的其他因素。IL15構建體不需要但視需要與目前用於預防或治療所研究的障礙的一種或多種藥劑一起配製。此類其他藥劑的有效量取決於配製物中存在的IL15構建體的量、障礙或治療的類型、以及上文討論的其他因素。該等通常以與如本文所述相同的劑量和施用途徑使用，或以本文所述劑量的約1%-99%使用，或以經驗/臨床確定為合適的任何劑量和任何途徑使用。
為預防或治療疾病，本揭露的IL15構建體的合適劑量將取決於待治療的疾病的類型、疾病的嚴重程度和病程、施用IL15構建體係用於預防目的還是治療目的、先前療法、患者的臨床病史和對IL15構建體的反應、以及主治醫生的判斷。IL15構建體適當地以一次或經一系列治療施用於患者。取決於疾病的類型和嚴重程度，約1 µg/kg至100 mg/kg的IL15構建體可以是用於向患者施用的初始候選劑量，無論是例如藉由一次或多次分開施用，還是藉由連續輸注。取決於上述因素，一個典型的日劑量可以為約1 μg/kg至100 mg/kg或更多。對於幾天或更長時間內的重複施用，取決於病症，治療通常會持續直到出現疾病症狀的期望抑制。這樣的劑量可以間歇地施用，例如每週或每三週（例如使得患者接受約兩個至約二十個，或例如約六個劑量的IL15構建體）。施用初始較高負載劑量，隨後施用一個或多個較低劑量。但是，其他給藥方案可以是有用的。藉由常規技術和測定可以容易地監測該療法的進展。 組合療法
在一方面，本揭露的IL15構建體可與其他治療劑組合使用。可以與本揭露的IL15構建體組合使用的其他治療劑包括但不限於：化學治療劑（例如，紫杉醇或紫杉醇劑（例如Abraxane®）；多西他賽；卡鉑；拓撲替康；順鉑；伊立替康、阿黴素、來那度胺、5-氮雜胞苷、異環磷醯胺、奧沙利鉑、培美曲塞二鈉、環磷醯胺、依託泊苷、地西他濱、氟達拉濱、長春新鹼、苯達莫司汀、苯丁酸氮芥、白消安、吉西他濱、美法侖、噴司他丁、米托蒽醌、培美曲塞二鈉）、酪胺酸激酶抑制劑（例如，埃羅替尼）、多激酶抑制劑（例如，司曲替尼（sitravatinib））、CD-20靶向劑（例如，利妥昔單抗、奧法木單抗）、CD52靶向劑（例如，阿侖單抗）、潑尼松龍、來那度胺、Bcl-2抑制劑（例如，奧利默森鈉（oblimersen sodium））、極光激酶抑制劑、蛋白酶體抑制劑（例如，硼替佐米）、MEK抑制劑（例如，ABT-348）、JAK-2抑制劑（例如，INCB018424）、mTOR抑制劑（例如，坦羅莫司、依維莫司）、BCR/ABL抑制劑（例如，伊馬替尼）。
在一方面，可以將本揭露的IL15構建體與免疫檢查點劑組合施用。不受限地，免疫檢查點劑可以是PD-1、PD-L1、PD-L2、TIM3、LAG-3、OX40或TIGIT抗體。在一方面，抗-PD1抗體可以是替雷利珠單抗。在一方面，抗-PD1抗體可以是奧賽培利單抗（Ociperlimab）、或替雷利珠單抗和奧賽培利單抗的組合。
在另一方面，已經在細胞療法中施用IL15，在向患者施用細胞療法之前、期間或之後施用時，對免疫細胞（如T細胞或NK細胞）提供了有益作用。對於含有抗CD19嵌合抗原受體（CAR）的NK細胞，引入了IL15融合轉基因以支持NK細胞功能和持久性（Kaufman等人, Blood [血液] 2018 第32卷, 增刊1, 4541）。將引入NK細胞中的EGFR CAR與IL15構建體組合施用以提高在膠質母細胞瘤模型中的功效（Ma等人, Cancer Res.[癌症研究], 2021 81(13) 3635-48）。將用CD123 CAR轉導的NK92細胞設計為靶向急性髓性白血病（AML）。將逆轉錄載體用於引入針對人IL-15的組成型表現的轉基因盒，這允許了NK細胞體內持久性的增加（Morgan等人, Viruses [病毒] 2021 13(7): 1365）。 藥物組成物和配製物
還提供了包含IL15構建體的組成物，包括藥物配製物。在某些實施方式中，組成物包含一個或多個IL15構建體，或包含編碼一個或多個IL15構建體的序列的一個或多個多核苷酸。該等組成物還可包含合適的載劑，例如本領域熟知的藥學上可接受的賦形劑，包括緩衝劑。
藉由將具有期望純度的這種IL15構建體與一種或多種視需要的藥學上可接受的載劑混合來製備如本文所述的IL15構建體的藥物配製物（Remington's Pharmaceutical Sciences [雷明頓藥物科學], 第16版 Osol, A.編輯 (1980)），呈凍乾配製物或水溶液的形式。藥學上可接受的載劑在所採用的劑量和濃度下對於接受者通常是無毒性的，並且包括但不限於：緩衝劑，如磷酸鹽、檸檬酸鹽、和其他有機酸；抗氧化劑，包括抗壞血酸和甲硫胺酸；防腐劑（如十八烷基二甲基苄基氯化銨、氯化六甲雙銨、苯紮氯銨、氯化苯索寧、苯酚、丁醇或苯甲醇、對羥基苯甲酸烷基酯（如對羥基苯甲酸甲酯或對羥基苯甲酸丙酯）、兒茶酚、間苯二酚、環己醇、3-戊醇以及間甲酚）；低分子量（少於約10個殘基）的多肽；蛋白質，如血清白蛋白、明膠或免疫球蛋白；親水性聚合物，如聚乙烯吡咯啶酮；胺基酸，如甘胺酸、麩醯胺酸、天冬醯胺、組胺酸、精胺酸或離胺酸；單糖、二糖和其他碳水化合物，包括葡萄糖、甘露糖或糊精；螯合劑，如EDTA；糖，如蔗糖、甘露醇、海藻糖或山梨醇；成鹽反離子，如鈉；金屬錯合物（例如Zn-蛋白錯合物）；和/或非離子型表面活性劑，如聚乙二醇（PEG）。本文的示例性藥學上可接受的載劑還包括間質藥物分散劑，例如可溶性中性活性透明質酸酶糖蛋白（sHASEGP），例如人可溶性PH-20透明質酸酶糖蛋白，例如rHuPH20（HYLENEX ®，百特國際有限公司（Baxter International, Inc.））。在美國專利案號US 7,871,607和2006/0104968中描述了某些示例性sHASEGP和使用方法，包括rHuPH20。在一方面，將sHASEGP與一種或多種另外的糖胺聚糖酶如軟骨素酶組合。
示例性凍乾配製物描述於美國專利案號6,267,958中。水性配製物包括美國專利案號6,171,586和WO2006/044908中描述的那些，後者中描述的配製物包括組胺酸-乙酸鹽緩衝劑。
可以製備緩釋製劑。緩釋製劑的合適實例包括含有IL15構建體的固體疏水性聚合物的半透性基質，該基質為成形製品的形式，例如膜或微膠囊。用於體內施用的配製物通常是無菌的。無菌可以例如通過無菌過濾膜過濾而容易地實現。 實例 實例 1 ： 以 不同 IL15 構建體處理的 HH 細胞株中的磷醯基 STAT5 評估
HH細胞係從ATCC取得的人類 T 淋巴細胞/白血病細胞株（CRL-2105）。藉由添加新鮮培養基或替換為新鮮培養基以維持培養。細胞培養自 2 x 10 5細胞/mL 開始並維持在 1 x 10 5至 1 x 10 6細胞/mL 之間，每2-3天更新培養基。所使用的 IL15 為未改變的 IL15。P22339 為已公開的 IL15 構建體，由 IL15 的兩個分子（連接至 IL15Ra 的 sushi 結構域和連接至 Fc）組成（Hu 等人，Sci. Rep. [科學報告] 2018 8:7675）。 IL-15刺激 1. 將細胞再懸浮於 PBS+0.5% BSA（密蘇里州聖路易斯的西格瑪公司（Sigma））緩衝劑中，並以 5×10 4細胞/25 μl/孔接種到 U 96 孔板（Corning TM#3799） 。2. 將測試板在 PBS（吉博科公司（GIBCO）#14190250，蓋瑟斯堡（Gaithersburg），馬里蘭州）+0.5% BSA 緩衝劑中製備為 6× 溶液，自 1000 nM 開始（最終濃度）4× 連續稀釋，共 11 個劑量。將溶劑製備為媒介物。 3. 每個測試孔接受 5 μl 製備的 6× 化合物溶液，並在 37 oC 5% CO 2下孵育15 分鐘。 使用來自 CisBio TM的 HTRF 磷酸-STAT5（Tyr694）細胞測定套組（CisBio #64AT5PEG）測試磷酸-STAT5（Tyr694）。 4. 細胞處理後，添加 10 μL 的補充溶解緩衝劑（4X）並在室溫震盪下孵育至少 60 分鐘。 5. 一旦在細胞溶解後，將16 µL細胞溶解產物轉移至 Cisbio 96 孔 HTRF 檢測板（Cisbio 66PL96025），並將 4 µL 預混合 HTRF 抗體添加至每個孔中。 6. 將板用板封膜（plate sealer）蓋住並在室溫隔夜孵育。 7. 讀取檢測板在兩個不同波長下（665 nm和620 nm）的螢光發射。
此測定可瞭解對專一性構建體的活性。在圖 15 中，M43 構建體（二價構建體 B）顯示存在溶解蛋白酶（蛋白溶解酶（matriptase））時， pSTAT5 活化程度及曲線與 IL15 和 P22339 相似。相對的，非蛋白溶解酶溶解的 M43，活性極小。M101 構建體（二價構建體 C）在溶解前顯示活性極低，且在溶解後也未達到 IL15 所證實的 pSTAT5 活化程度。此數據如圖16所示。當不存在基質金屬蛋白酶2（MMP2）蛋白酶時，M135（呈構建體 A 形式）的活性極小。若存在 MMP2 時，M135 在低濃度顯示的活性與 P22339 相似，但在較高濃度則否（圖17）。然而，M176（構建體 A）在 MMP2 存在時，活化曲線與 P22339 非常相似（圖18）。M178（構建體 A）在基質金屬蛋白酶 9（MMP9）存在時，顯示具有高活性，而在基質金屬蛋白酶 14（MMP14）存在時具有中等範圍的活性，可知 MMP14 在此專一性構建體中作為蛋白酶不如 MMP9 有效（圖 19）。M181（構建體 A）在 MMP2 存在時具有極高的 pSTAT5 活性，而不存在 MMP2 時活性極低（圖 20）。使用不同類型的構建體，MK107（構建體 E1）在 MMP2 存在時具有極高的 pSTAT5 活性，而不在在 MMP2 時活性極低（圖 21）。MK137/MH7 構建體（構建體 E3）也觀察到相似的結果，不存在金屬蛋白酶時活性極低；但存在 MMP2 時活性極高（圖 22）。在圖 23（MK142，構建體 N）和圖 24（MK6，構建體 F3）中，不存在金屬蛋白酶時，構建體以高濃度測試時僅顯示部分活性，但存在 MMP2 時，以低濃度測試即顯示高度活性。MK156（構建體 N）在 MMP2 存在時顯示具有良好活性，且在不存在蛋白酶時，以高濃度測試顯示具有活性。此數據如圖25所示。 實例 2 ： M07e 細胞增殖測定 M07e 細胞
M07e 細胞是人類巨核細胞株，自南京科佰生物科技有限公司（COBIOER #CBP60791）取得。在含有 10% FBS 和 GM-CSF（10 ng/ml）或 IL-2（10 ng/ml）的 RPMI 1640 中，添加新鮮培養基或替換新鮮培養基，以維持細胞培養。測定培養自 2 x 10 5細胞/mL 開始，並維持在 1 x 10 5至 1 x 10 6細胞/mL 之間。當存在 GM-CSF、IFN-α、IFN-β、IFN-γ、IL-2、IL-3、IL-4、IL-6、IL-15、NGF、SCF、TNF-α、TPO 時，M-07e 細胞增殖。IL15 試劑如實例 1中所述取得。IL-2 自 R&D Systems 公司取得（#202-IL）。 IL-15 刺激細胞增殖 1. 收集細胞，再懸浮於不含任何細胞介素的 1640+10% FBS 中，並以 0.8-1×10 4細胞/90 μl/孔接種到 96 孔板 。2. 將測定板在 PBS+0.5% BSA 緩衝劑中製備為 10× 溶液，自 1000 nM 開始（最終濃度）4× 連續稀釋，共 9 個劑量。以 PBS 做為稀釋劑。 3. 將 10 μl 製備的 10× 化合物溶液一式兩份分配到每個測試孔中。在 37 oC 5% CO 2下孵育 72-96 小時。 4. 發光讀數提供了以 P22339 或 M181 構建體處理時（併用或不併用蛋白溶解酶）M07e 增殖的指標。
如圖 26 所示，未經蛋白質溶解處理時，M181 構建體（構建體 A）的增殖活性極小。相對的，以蛋白溶解酶處理 M181 構建體後，M181 構建體顯示的活性與 P22339 IL15 構建體非常相似。 實例 3 ： ICR 小鼠中 MK137/MH7 的最大耐受劑量確定
ICR小鼠係從北京維通利華實驗動物技術有限公司（Beijing Vital River Laboratory Animal Technology Co., Ltd.）獲得的。將雌性ICR小鼠按照體重隨機分成13組，每組6隻小鼠。將7個組的小鼠腹腔注射單劑量的媒介物（10 mM組胺酸、10 mM乙酸、240 mM蔗糖、0.02%吐溫20，pH 5.5）或0.3、1和3 mg/kg P22339，或10、30和100 mg/kg MK137/MH7，用於監測每種藥物在ICR小鼠中的一般的毒理學作用。整個研究期間，每天記錄體重，並且每天還對小鼠的毒性臨床體征進行監測。
其他6個組的小鼠同時腹腔注射單劑量的0.3、1和3 mg/kg P22339以及10、30和100 mg/kg MK137/MH7，用於評估每種藥物的藥物動力學（PK）。其示意圖示於圖27A中。在異氟烷/氧氣麻醉下，在給藥前和給藥後0.5、2、8、24、48、72、96、120、144和168小時，從眶後竇收集血液樣品。藉由ELISA測量P22339和MK137/MH7在不同給藥劑量和時間點的血清濃度。抗人IgG1 Fc抗體為捕獲抗體，而抗人IL15Ra抗體為檢測抗體。
記錄了全部78隻小鼠的存活時間，以確定每種藥物的最大耐受劑量（MTD）。此結果示於圖27B中，這表明用MK137/MH7構建體處理的小鼠具有更好的存活曲線以及有限的體重減輕（圖27C），表明MK137/MH7構建體相比P22339能被更好耐受。圖27B中，唯一死亡的小鼠與給藥3 mpk的P22339和100 mpk的MK137/MH7相關，其餘劑量均耐受。從該等結果可知，MK137/MH7單次團注的MTD為30 mg/kg，這遠高於P22339的MTD（1 mg/kg）。MK137/MH7顯示出相比於P22339具有更好的PK曲線（隨著T1/2的延長）以及更高的AUC，這表明相比P22339其具有大得多的治療窗。該等結果示於圖28A-28B中。 實例 4 ： MK137/MH7 對於外周血細胞和腫瘤浸潤淋巴細胞的劑量依賴性藥效動力學作用
雌性C57BL/6小鼠皮下接種1x10 7GL261細胞。當腫瘤體積達到約100-200 mm 3時，將動物按照腫瘤體積分組，每組7隻小鼠。小鼠腹腔注射單劑量的媒介物（10 mM組胺酸、10 mM乙酸、240 mM蔗糖、0.02%吐溫20，pH 5.5）或0.25 mg/kg P22339、或10 mg/kg和30 mg/kg MK137/MH7。處理5天後，使用二氧化碳對小鼠進行安樂死並且選擇5隻小鼠用於樣品收集。
收集血液樣品並且直接用於進一步的抗體染色。使用剪刀將腫瘤樣品切碎至小塊，並且之後進行酶消化以分離腫瘤浸潤淋巴細胞（TILS）。然後用針對某些生物標記的螢光軛合抗體對血細胞和TILS進行染色，以使用流式細胞儀鑒定NK細胞、CD8 +T細胞、CD4 +T細胞和Treg細胞用於進一步分析。
就淋巴細胞中NK百分比的增加而言，10 mpk的MK137/MH7在tils而非外周血細胞中示出了顯著的體內PD作用。圖29A-29B示出了P22339和MK137/MH7對於外周血細胞和TILS的PD作用。此資料顯示出MK137/MH7在10 mpk下在腫瘤而非外周血中示出了顯著的PD作用，這表明MK137/MH7具有大的治療窗。 實例 5 ： HT29+HH 異種移植模型中 MK137/MH7 的 PK/PD 相關性
NCG小鼠係缺乏功能性T細胞、B細胞和NK細胞並且具有下降的巨噬細胞和樹突狀細胞功能的三重免疫缺陷小鼠。該等特徵使得該等小鼠成為免疫腫瘤研究的良好模型。雌性NCG小鼠係從江蘇集萃藥康生物科技股份有限公司（Jiangsu GemPharmatech Co., Ltd.）獲得的，並且皮下接種3x10 6個高度表現基質金屬蛋白酶的HT29（人結腸腺癌）細胞和1x10 6個因能對IL15產生pSTAT5響應而選擇的HH（人白血病/淋巴瘤）細胞的混合物。當平均腫瘤大小達到400-600 mm 3時，將動物隨機分為每組3隻或4隻小鼠。腹腔內施用單劑量的媒介物（10 mM組胺酸、10 mM乙酸、240 mM蔗糖、0.02%吐溫20，pH 5.5）、P22339、MK137/MH7或MK138/MH7（不可裂解的），以測試血清PK和IL15誘導的腫瘤PD的相關性，其中對來自HT29+ HH腫瘤組織中HH細胞的pSTAT5傳訊進行了測量。
藉由ELISA對血清完整MK137/MH7和MK138/MH7進行了檢測。從MK137/MH7或MK138/MH7釋放的血清IL-15/IL-15Rα係藉由MSD經由其在HH細胞中的pSTAT5誘導水平測量的，將該等HH細胞在治療後的不同時間點摻入從NCG小鼠獲得的血清中。如所述地藉由ELISA和MSD檢測血清P22339水平。MK137/MH7、MK138/MH7和P22339的腫瘤PD係藉由在治療後的不同時間點進行MSD（藉由測量來自HT29+ HH腫瘤溶解物中HH細胞的pSTAT5傳訊）來評估的。
使用如上實例3（使用IRC小鼠）中所確定的最大耐受劑量（MTD），對HT29+HH異種移植模型中P22339和MK138/MH7的PK/PD相關性進行了測試。如圖30中所示，MK138/MH7在PK/PD方面優於P22339分子，這表明更強的傳訊和更大的治療窗。
有可能計算MK137/MH7和P22339構建體之間等效量的莫耳IL15，從而允許在此基礎上用該等分子進行給藥。當向HT29+HH異種移植模型施用等效的MK137/MH7（5 mpk）和P22339（2.5 mpk）劑量時，如藉由ELISA測量的在腫瘤微環境中獲得了類似的PD（圖31）。然而，當測量小鼠血清中IL15的量時，與P22339相反，MK137/MH7向血液中釋放非常少的IL15。這表明MK137/MH7相比P22339具有更好的安全特徵，因其活性更多地局限於腫瘤而非全身。作為對照，不可裂解的MK138/MH7在此模型中不具有活性。根據HT29+HH模型，2.5 mpk P22339示出了與5 mpk MK137/MH7相似的PD。如實例3中的ICR小鼠毒性研究所證明的，P22339和MK137/MH7的MTD分別為1 mpk和30 mpk。該等資料綜合表明MK137/MH7相比P22339具有更寬的治療窗。 實例 6 ： IL15 構建體組合
本文揭露了許多不同的具有可裂解的連接子的IL15構建體。有可能產生IL15構建體的組合，其中如揭露的一個IL15與至少一個其他IL15構建體組合。這將導致腫瘤微環境中蛋白酶表現的量不同。例如，表現大量特異性蛋白酶的腫瘤將非常快速地裂解一個IL15構建體中的蛋白酶可活化部分，其中沒有那樣高表現的第二蛋白酶將裂解第二蛋白酶可活化部分，這導致了較慢的IL15活化。如果期望，此IL15構建體的組合可以使得更多的構建體遞送的IL15在腫瘤微環境中停留更長時間。這可以解決與IL15遞送相關的一個問題，即與IL15全身施用相關的非常短的半衰期的問題。
無。
圖1示出了二價IL15構建體A。 圖2示出了二價IL15構建體B。 圖3示出了二價IL15構建體C。 圖4示出了二價IL15構建體D。 圖5示出了一價構建體E1和E2。 圖6示出了一價構建體E3。 圖7示出了一價構建體F1、F2和F3。 圖8示出了一價構建體G1和G2。 圖9示出了二價構建體H1和一價構建體H2。 圖10示出了一價構建體K1和K2。 圖11示出了一價構建體M。 圖12示出了一價構建體N。 圖13示出了一價構建體P。 圖14示出了一價構建體Q。 圖15-圖25示出了基於細胞的pSTAT5活化測定之結果。 圖26顯示IL15構建體在細胞增殖測定中具有活性。 圖27A-圖27C示出了用於IL15構建體的最大耐受劑量的圖形給藥方案（圖27A）、用IL15構建體處理的小鼠的存活曲線（圖27B）以及小鼠的體重變化（圖27C）。 圖28A-圖28B示出了在最大耐受劑量水平下，依據相關IL-15濃度，ICR小鼠中MK137/MH7的Cmax和暴露比P22339高53倍和98倍。 圖29A-圖29B顯示MK137/MH7對於外周血細胞和腫瘤浸潤淋巴細胞（TILS）的劑量依賴性藥效動力學作用。 圖30和圖31示出了HT29/HH異種移植小鼠模型中MK137/MH7的PD/PK特徵，其中MK137/MH7顯示出更大的治療窗。 
                         序列表
          <![CDATA[<110>  百濟神州有限公司（BeiGene, Ltd.）]]>
          <![CDATA[<120>  白介素15構建體和使用方法]]>
          <![CDATA[<130>  115244-TW-PA ]]>
          <![CDATA[<140>  TW 110134537]]>
          <![CDATA[<141>  2021-09-16]]>
          <![CDATA[<150>  PCT/CN2020/115594]]>
          <![CDATA[<151>  2020-09-16]]>
          <![CDATA[<150>  PCT/CN2021/106481]]>
          <![CDATA[<151>  2021-07-15]]>
          <![CDATA[<150>  PCT/CN2021/116077]]>
          <![CDATA[<151>  2021-09-01]]>
          <![CDATA[<160>  175   ]]>
          <![CDATA[<170>  PatentIn 3.5版]]>
          <![CDATA[<210>  1]]>
          <![CDATA[<211>  162]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  智人]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  人IL-15]]>
          <![CDATA[<400>  1]]>
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          Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
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          Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
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          Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
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          Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
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          Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
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          Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
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          <![CDATA[<223> IL15Rα]]>
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          Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
          1               5                   10                  15      
          Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
                      20                  25                  30          
          Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
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          Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
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          Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
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          Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                          85                  90                  95      
          Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
                      100                 105                 110         
          Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
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          Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
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          Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                          245                 250                 255     
          Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
                      260                 265         
          <![CDATA[<210>  3]]>
          <![CDATA[<211>  551]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  智人]]>
          <![CDATA[<220>]]>
          <![CDATA[<223> 人IL2Rβ]]>
          <![CDATA[<400>  3]]>
          Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
          1               5                   10                  15      
          Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
                      20                  25                  30          
          Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
                  35                  40                  45              
          Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
              50                  55                  60                  
          Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
          65                  70                  75                  80  
          Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                          85                  90                  95      
          Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
                      100                 105                 110         
          Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
                  115                 120                 125             
          Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
              130                 135                 140                 
          Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
          145                 150                 155                 160 
          Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                          165                 170                 175     
          Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
                      180                 185                 190         
          Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
                  195                 200                 205             
          Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
              210                 215                 220                 
          Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
          225                 230                 235                 240 
          Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                          245                 250                 255     
          Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
                      260                 265                 270         
          Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
                  275                 280                 285             
          Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
              290                 295                 300                 
          Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
          305                 310                 315                 320 
          Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                          325                 330                 335     
          Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
                      340                 345                 350         
          His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
                  355                 360                 365             
          Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
              370                 375                 380                 
          Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
          385                 390                 395                 400 
          Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                          405                 410                 415     
          Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
                      420                 425                 430         
          Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
                  435                 440                 445             
          Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
              450                 455                 460                 
          Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
          465                 470                 475                 480 
          Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                          485                 490                 495     
          Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
                      500                 505                 510         
          Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
                  515                 520                 525             
          Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
              530                 535                 540                 
          Gln Asp Pro Thr His Leu Val 
          545                 550     
          <![CDATA[<210>  4]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M123]]>
          <![CDATA[<400>  4]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Ser Ser Gly Leu 
                  195                 200                 205             
          Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Ser Gly Gly Ser 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                  435                 440                 445             
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
              450                 455                 460                 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
          465                 470                 475                 480 
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                          485                 490                 495     
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                      500                 505                 510         
          Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                  515                 520                 525             
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
              530                 535                 540                 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
          545                 550                 555                 560 
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                          565                 570                 575     
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                      580                 585                 590         
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                  595                 600                 605             
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
              610                 615                 620                 
          Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
          625                 630                 635                 640 
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                          645                 650                 655     
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 
          <![CDATA[<210>  5]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M135]]>
          <![CDATA[<400>  5]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                  435                 440                 445             
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
              450                 455                 460                 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
          465                 470                 475                 480 
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                          485                 490                 495     
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                      500                 505                 510         
          Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                  515                 520                 525             
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
              530                 535                 540                 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
          545                 550                 555                 560 
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                          565                 570                 575     
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                      580                 585                 590         
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                  595                 600                 605             
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
              610                 615                 620                 
          Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
          625                 630                 635                 640 
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                          645                 650                 655     
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 
          <![CDATA[<210>  6]]>
          <![CDATA[<211>  668]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M140]]>
          <![CDATA[<400>  6]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ser Gly Gly Ser Gly 
                  195                 200                 205             
          Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala 
              210                 215                 220                 
          Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn 
          225                 230                 235                 240 
          Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys 
                          245                 250                 255     
          Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu 
                      260                 265                 270         
          Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly 
                  275                 280                 285             
          Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg 
              290                 295                 300                 
          Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp 
          305                 310                 315                 320 
          Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln 
                          325                 330                 335     
          Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser 
                      340                 345                 350         
          Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr 
                  355                 360                 365             
          Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys 
              370                 375                 380                 
          Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln 
          385                 390                 395                 400 
          Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr 
                          405                 410                 415     
          Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala 
                      420                 425                 430         
          Leu Gly Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                  435                 440                 445             
          Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
              450                 455                 460                 
          Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
          465                 470                 475                 480 
          Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                          485                 490                 495     
          Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                      500                 505                 510         
          Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                  515                 520                 525             
          Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
              530                 535                 540                 
          Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
          545                 550                 555                 560 
          Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                          565                 570                 575     
          Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                      580                 585                 590         
          Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                  595                 600                 605             
          Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
              610                 615                 620                 
          Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
          625                 630                 635                 640 
          Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                          645                 650                 655     
          Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665             
          <![CDATA[<210>  7]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M145]]>
          <![CDATA[<400>  7]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu 
                  195                 200                 205             
          Tyr Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                  435                 440                 445             
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
              450                 455                 460                 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
          465                 470                 475                 480 
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                          485                 490                 495     
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                      500                 505                 510         
          Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                  515                 520                 525             
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
              530                 535                 540                 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
          545                 550                 555                 560 
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                          565                 570                 575     
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                      580                 585                 590         
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                  595                 600                 605             
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
              610                 615                 620                 
          Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
          625                 630                 635                 640 
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                          645                 650                 655     
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 
          <![CDATA[<210>  8]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M175]]>
          <![CDATA[<400>  8]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Ser Ser Gly Leu 
                  195                 200                 205             
          Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Ser Gly Gly Ser 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                  435                 440                 445             
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
              450                 455                 460                 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
          465                 470                 475                 480 
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                          485                 490                 495     
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                      500                 505                 510         
          Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                  515                 520                 525             
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
              530                 535                 540                 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
          545                 550                 555                 560 
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                          565                 570                 575     
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                      580                 585                 590         
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                  595                 600                 605             
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
              610                 615                 620                 
          Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
          625                 630                 635                 640 
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                          645                 650                 655     
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 
          <![CDATA[<210>  9]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M176]]>
          <![CDATA[<400>  9]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                  435                 440                 445             
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
              450                 455                 460                 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
          465                 470                 475                 480 
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                          485                 490                 495     
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                      500                 505                 510         
          Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                  515                 520                 525             
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
              530                 535                 540                 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
          545                 550                 555                 560 
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                          565                 570                 575     
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                      580                 585                 590         
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                  595                 600                 605             
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
              610                 615                 620                 
          Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
          625                 630                 635                 640 
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                          645                 650                 655     
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 
          <![CDATA[<210>  10]]>
          <![CDATA[<211>  670]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M177]]>
          <![CDATA[<400>  10]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu 
                  195                 200                 205             
          Tyr Ser Gly Trp Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
              210                 215                 220                 
          Gly Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg 
          225                 230                 235                 240 
          Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr 
                          245                 250                 255     
          Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr 
                      260                 265                 270         
          Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile 
                  275                 280                 285             
          Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr 
              290                 295                 300                 
          Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile 
          305                 310                 315                 320 
          Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser 
                          325                 330                 335     
          Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu 
                      340                 345                 350         
          Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala 
                  355                 360                 365             
          Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr 
              370                 375                 380                 
          Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp 
          385                 390                 395                 400 
          Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe 
                          405                 410                 415     
          Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro 
                      420                 425                 430         
          Ala Ala Leu Gly Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                  435                 440                 445             
          Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
              450                 455                 460                 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
          465                 470                 475                 480 
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                          485                 490                 495     
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                      500                 505                 510         
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                  515                 520                 525             
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
              530                 535                 540                 
          Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
          545                 550                 555                 560 
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                          565                 570                 575     
          Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                      580                 585                 590         
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                  595                 600                 605             
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
              610                 615                 620                 
          Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
          625                 630                 635                 640 
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                          645                 650                 655     
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 670 
          <![CDATA[<210>  11]]>
          <![CDATA[<211>  671]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M178]]>
          <![CDATA[<400>  11]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu 
                  195                 200                 205             
          Tyr Ser Gly Arg Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
              210                 215                 220                 
          Ser Gly Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser 
          225                 230                 235                 240 
          Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp 
                          245                 250                 255     
          Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln 
                      260                 265                 270         
          Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu 
                  275                 280                 285             
          Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val 
              290                 295                 300                 
          Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala 
          305                 310                 315                 320 
          Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile 
                          325                 330                 335     
          Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp 
                      340                 345                 350         
          Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu 
                  355                 360                 365             
          Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu 
              370                 375                 380                 
          Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro 
          385                 390                 395                 400 
          Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu 
                          405                 410                 415     
          Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys 
                      420                 425                 430         
          Pro Ala Ala Leu Gly Lys Asp Glu Pro Lys Ser Cys Asp Lys Thr His 
                  435                 440                 445             
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
              450                 455                 460                 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
          465                 470                 475                 480 
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                          485                 490                 495     
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                      500                 505                 510         
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                  515                 520                 525             
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
              530                 535                 540                 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
          545                 550                 555                 560 
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                          565                 570                 575     
          Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                      580                 585                 590         
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                  595                 600                 605             
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
              610                 615                 620                 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
          625                 630                 635                 640 
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                          645                 650                 655     
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 670     
          <![CDATA[<210>  12]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M207]]>
          <![CDATA[<400>  12]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                  435                 440                 445             
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
              450                 455                 460                 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
          465                 470                 475                 480 
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                          485                 490                 495     
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                      500                 505                 510         
          Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                  515                 520                 525             
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
              530                 535                 540                 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
          545                 550                 555                 560 
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                          565                 570                 575     
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                      580                 585                 590         
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                  595                 600                 605             
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
              610                 615                 620                 
          Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
          625                 630                 635                 640 
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                          645                 650                 655     
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 
          <![CDATA[<210>  13]]>
          <![CDATA[<211>  644]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M231]]>
          <![CDATA[<400>  13]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Glu Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Glu Pro Lys Ser 
                          405                 410                 415     
          Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                      420                 425                 430         
          Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                  435                 440                 445             
          Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
              450                 455                 460                 
          His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
          465                 470                 475                 480 
          Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                          485                 490                 495     
          Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                      500                 505                 510         
          Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                  515                 520                 525             
          Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
              530                 535                 540                 
          Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
          545                 550                 555                 560 
          Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                          565                 570                 575     
          Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                      580                 585                 590         
          Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                  595                 600                 605             
          Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
              610                 615                 620                 
          Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
          625                 630                 635                 640 
          Ser Pro Gly Lys 
          <![CDATA[<210>  14]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M233]]>
          <![CDATA[<400>  14]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                  435                 440                 445             
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
              450                 455                 460                 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
          465                 470                 475                 480 
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                          485                 490                 495     
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                      500                 505                 510         
          Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                  515                 520                 525             
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
              530                 535                 540                 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
          545                 550                 555                 560 
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                          565                 570                 575     
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                      580                 585                 590         
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                  595                 600                 605             
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
              610                 615                 620                 
          Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
          625                 630                 635                 640 
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                          645                 650                 655     
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 
          <![CDATA[<210>  15]]>
          <![CDATA[<211>  437]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M234]]>
          <![CDATA[<400>  15]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp 
                  435         
          <![CDATA[<210>  16]]>
          <![CDATA[<211>  674]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M238]]>
          <![CDATA[<400>  16]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
                  435                 440                 445             
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
              450                 455                 460                 
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
          465                 470                 475                 480 
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                          485                 490                 495     
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                      500                 505                 510         
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                  515                 520                 525             
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
              530                 535                 540                 
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
          545                 550                 555                 560 
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                          565                 570                 575     
          Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                      580                 585                 590         
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                  595                 600                 605             
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
              610                 615                 620                 
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
          625                 630                 635                 640 
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                          645                 650                 655     
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                      660                 665                 670         
          Gly Lys 
          <![CDATA[<210>  17]]>
          <![CDATA[<211>  679]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M239]]>
          <![CDATA[<400>  17]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
                  435                 440                 445             
          Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
              450                 455                 460                 
          Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
          465                 470                 475                 480 
          Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                          485                 490                 495     
          Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                      500                 505                 510         
          Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                  515                 520                 525             
          Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
              530                 535                 540                 
          Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
          545                 550                 555                 560 
          Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                          565                 570                 575     
          Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                      580                 585                 590         
          Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                  595                 600                 605             
          Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
              610                 615                 620                 
          Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
          625                 630                 635                 640 
          Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                          645                 650                 655     
          Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                      660                 665                 670         
          Leu Ser Leu Ser Pro Gly Lys 
                  675                 
          <![CDATA[<210>  18]]>
          <![CDATA[<211>  649]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M240]]>
          <![CDATA[<400>  18]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Glu Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Gly Gly Gly 
                          405                 410                 415     
          Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                      420                 425                 430         
          Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                  435                 440                 445             
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
              450                 455                 460                 
          Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
          465                 470                 475                 480 
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                          485                 490                 495     
          Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                      500                 505                 510         
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                  515                 520                 525             
          Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
              530                 535                 540                 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
          545                 550                 555                 560 
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                          565                 570                 575     
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                      580                 585                 590         
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                  595                 600                 605             
          Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
              610                 615                 620                 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
          625                 630                 635                 640 
          Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                          645                 
          <![CDATA[<210>  19]]>
          <![CDATA[<211>  665]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M241]]>
          <![CDATA[<400>  19]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Gly Ala Val 
              210                 215                 220                 
          Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile 
          225                 230                 235                 240 
          Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln 
                          245                 250                 255     
          Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu 
                      260                 265                 270         
          Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala 
                  275                 280                 285             
          Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val 
              290                 295                 300                 
          Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe 
          305                 310                 315                 320 
          Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val 
                          325                 330                 335     
          Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln 
                      340                 345                 350         
          Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu 
                  355                 360                 365             
          Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
              370                 375                 380                 
          Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr 
          385                 390                 395                 400 
          Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp 
                          405                 410                 415     
          Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Gly Gly Gly Gly 
                      420                 425                 430         
          Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                  435                 440                 445             
          Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
              450                 455                 460                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
          465                 470                 475                 480 
          Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                          485                 490                 495     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                      500                 505                 510         
          Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                  515                 520                 525             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
              530                 535                 540                 
          Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
          545                 550                 555                 560 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                          565                 570                 575     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                      580                 585                 590         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                  595                 600                 605             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
              610                 615                 620                 
          Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
          625                 630                 635                 640 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                          645                 650                 655     
          Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665 
          <![CDATA[<210>  20]]>
          <![CDATA[<211>  658]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M243]]>
          <![CDATA[<400>  20]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Gly Ala Val 
              210                 215                 220                 
          Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile 
          225                 230                 235                 240 
          Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln 
                          245                 250                 255     
          Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu 
                      260                 265                 270         
          Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala 
                  275                 280                 285             
          Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val 
              290                 295                 300                 
          Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe 
          305                 310                 315                 320 
          Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val 
                          325                 330                 335     
          Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln 
                      340                 345                 350         
          Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu 
                  355                 360                 365             
          Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
              370                 375                 380                 
          Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr 
          385                 390                 395                 400 
          Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp 
                          405                 410                 415     
          Ser Pro Trp Ser Gln Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
                      420                 425                 430         
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                  435                 440                 445             
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
              450                 455                 460                 
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
          465                 470                 475                 480 
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                          485                 490                 495     
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                      500                 505                 510         
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                  515                 520                 525             
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
              530                 535                 540                 
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
          545                 550                 555                 560 
          Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                          565                 570                 575     
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                      580                 585                 590         
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                  595                 600                 605             
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
              610                 615                 620                 
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
          625                 630                 635                 640 
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                          645                 650                 655     
          Gly Lys 
          <![CDATA[<210>  21]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M244]]>
          <![CDATA[<400>  21]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
          65                  70                  75                  80  
          Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu 
                          85                  90                  95      
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                      100                 105                 110         
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                  115                 120                 125             
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
              130                 135                 140                 
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
          145                 150                 155                 160 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
                          165                 170                 175     
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                      180                 185                 190         
          Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val 
                  195                 200                 205             
          Ser Leu Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser 
              210                 215                 220                 
          Gly Gly Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn 
          225                 230                 235                 240 
          Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys 
                          245                 250                 255     
          Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu 
                      260                 265                 270         
          Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly 
                  275                 280                 285             
          Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg 
              290                 295                 300                 
          Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp 
          305                 310                 315                 320 
          Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln 
                          325                 330                 335     
          Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser 
                      340                 345                 350         
          Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr 
                  355                 360                 365             
          Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys 
              370                 375                 380                 
          Gln Lys Gln Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln 
          385                 390                 395                 400 
          Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr 
                          405                 410                 415     
          Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala 
                      420                 425                 430         
          Leu Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                  435                 440                 445             
          Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
              450                 455                 460                 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
          465                 470                 475                 480 
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                          485                 490                 495     
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                      500                 505                 510         
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                  515                 520                 525             
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
              530                 535                 540                 
          Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
          545                 550                 555                 560 
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                          565                 570                 575     
          Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                      580                 585                 590         
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                  595                 600                 605             
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
              610                 615                 620                 
          Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
          625                 630                 635                 640 
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                          645                 650                 655     
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                      660                 665                 
          <![CDATA[<210>  22]]>
          <![CDATA[<211>  673]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M245]]>
          <![CDATA[<400>  22]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Ser Gly Gly Ser Gly Gly Gly 
          65                  70                  75                  80  
          Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp Val 
                          85                  90                  95      
          Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
                      100                 105                 110         
          His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
                  115                 120                 125             
          Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
              130                 135                 140                 
          Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
          145                 150                 155                 160 
          Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
                          165                 170                 175     
          Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
                      180                 185                 190         
          Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly 
                  195                 200                 205             
          Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly Gly Gly Ser Ser 
              210                 215                 220                 
          Gly Gly Ser Gly Gly Ser Gly Gly Gly Thr Ser Gln Phe Thr Cys Phe 
          225                 230                 235                 240 
          Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala 
                          245                 250                 255     
          Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg 
                      260                 265                 270         
          Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala 
                  275                 280                 285             
          Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val 
              290                 295                 300                 
          Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg 
          305                 310                 315                 320 
          Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met 
                          325                 330                 335     
          Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn 
                      340                 345                 350         
          Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu 
                  355                 360                 365             
          Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala 
              370                 375                 380                 
          Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu Glu Thr 
          385                 390                 395                 400 
          Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu 
                          405                 410                 415     
          Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe 
                      420                 425                 430         
          Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
                  435                 440                 445             
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
              450                 455                 460                 
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
          465                 470                 475                 480 
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                          485                 490                 495     
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                      500                 505                 510         
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                  515                 520                 525             
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
              530                 535                 540                 
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
          545                 550                 555                 560 
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                          565                 570                 575     
          Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                      580                 585                 590         
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                  595                 600                 605             
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
              610                 615                 620                 
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
          625                 630                 635                 640 
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                          645                 650                 655     
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                      660                 665                 670         
          Gly 
          <![CDATA[<210>  23]]>
          <![CDATA[<211>  657]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M246]]>
          <![CDATA[<400>  23]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Thr Ser Gln 
          225                 230                 235                 240 
          Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser 
                          245                 250                 255     
          Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro 
                      260                 265                 270         
          Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln 
                  275                 280                 285             
          Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys 
              290                 295                 300                 
          Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly 
          305                 310                 315                 320 
          Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn 
                          325                 330                 335     
          Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr 
                      340                 345                 350         
          His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe 
                  355                 360                 365             
          Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr 
              370                 375                 380                 
          Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile 
          385                 390                 395                 400 
          Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg 
                          405                 410                 415     
          Val Lys Pro Leu Gln Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
                      420                 425                 430         
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                  435                 440                 445             
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
              450                 455                 460                 
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
          465                 470                 475                 480 
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                          485                 490                 495     
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                      500                 505                 510         
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                  515                 520                 525             
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
              530                 535                 540                 
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
          545                 550                 555                 560 
          Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                          565                 570                 575     
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                      580                 585                 590         
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                  595                 600                 605             
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
              610                 615                 620                 
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
          625                 630                 635                 640 
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                          645                 650                 655     
          Gly 
          <![CDATA[<210>  24]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M247]]>
          <![CDATA[<400>  24]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Thr Ser Gln 
          225                 230                 235                 240 
          Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser 
                          245                 250                 255     
          Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro 
                      260                 265                 270         
          Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln 
                  275                 280                 285             
          Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys 
              290                 295                 300                 
          Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly 
          305                 310                 315                 320 
          Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn 
                          325                 330                 335     
          Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr 
                      340                 345                 350         
          His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe 
                  355                 360                 365             
          Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr 
              370                 375                 380                 
          Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile 
          385                 390                 395                 400 
          Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg 
                          405                 410                 415     
          Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln 
                      420                 425                 430         
          Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Glu Pro 
                  435                 440                 445             
          Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
              450                 455                 460                 
          Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
          465                 470                 475                 480 
          Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                          485                 490                 495     
          Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                      500                 505                 510         
          Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                  515                 520                 525             
          Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
              530                 535                 540                 
          Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
          545                 550                 555                 560 
          Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                          565                 570                 575     
          Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                      580                 585                 590         
          Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                  595                 600                 605             
          Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
              610                 615                 620                 
          Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
          625                 630                 635                 640 
          Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                          645                 650                 655     
          Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                      660                 665                 670         
          Ser Leu Ser Pro Gly 
                  675         
          <![CDATA[<210>  25]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M248]]>
          <![CDATA[<400>  25]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Thr Ser Gln 
          225                 230                 235                 240 
          Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser 
                          245                 250                 255     
          Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro 
                      260                 265                 270         
          Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln 
                  275                 280                 285             
          Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys 
              290                 295                 300                 
          Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly 
          305                 310                 315                 320 
          Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn 
                          325                 330                 335     
          Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr 
                      340                 345                 350         
          His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe 
                  355                 360                 365             
          Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr 
              370                 375                 380                 
          Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile 
          385                 390                 395                 400 
          Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg 
                          405                 410                 415     
          Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln 
                      420                 425                 430         
          Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
              450                 455                 460                 
          Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
          465                 470                 475                 480 
          Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                          485                 490                 495     
          Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                      500                 505                 510         
          Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                  515                 520                 525             
          Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
              530                 535                 540                 
          Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
          545                 550                 555                 560 
          Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                          565                 570                 575     
          Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                      580                 585                 590         
          Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                  595                 600                 605             
          Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
              610                 615                 620                 
          Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
          625                 630                 635                 640 
          Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                          645                 650                 655     
          Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                      660                 665                 670         
          Ser Leu Ser Pro Gly 
                  675         
          <![CDATA[<210>  26]]>
          <![CDATA[<211>  682]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M249]]>
          <![CDATA[<400>  26]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Thr Ser Gln 
          225                 230                 235                 240 
          Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser 
                          245                 250                 255     
          Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro 
                      260                 265                 270         
          Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln 
                  275                 280                 285             
          Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys 
              290                 295                 300                 
          Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly 
          305                 310                 315                 320 
          Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn 
                          325                 330                 335     
          Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr 
                      340                 345                 350         
          His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe 
                  355                 360                 365             
          Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr 
              370                 375                 380                 
          Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile 
          385                 390                 395                 400 
          Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg 
                          405                 410                 415     
          Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln 
                      420                 425                 430         
          Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
              450                 455                 460                 
          Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
          465                 470                 475                 480 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                          485                 490                 495     
          Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                      500                 505                 510         
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                  515                 520                 525             
          Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
              530                 535                 540                 
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
          545                 550                 555                 560 
          Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                          565                 570                 575     
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                      580                 585                 590         
          Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                  595                 600                 605             
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
              610                 615                 620                 
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
          625                 630                 635                 640 
          Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                          645                 650                 655     
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                      660                 665                 670         
          Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                  675                 680         
          <![CDATA[<210>  27]]>
          <![CDATA[<211>  687]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M327]]>
          <![CDATA[<400>  27]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Asn Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
              450                 455                 460                 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
          465                 470                 475                 480 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                          485                 490                 495     
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                      500                 505                 510         
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                  515                 520                 525             
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
              530                 535                 540                 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
          545                 550                 555                 560 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                          565                 570                 575     
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                      580                 585                 590         
          Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                  595                 600                 605             
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
              610                 615                 620                 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
          625                 630                 635                 640 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                          645                 650                 655     
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                      660                 665                 670         
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685         
          <![CDATA[<210>  28]]>
          <![CDATA[<211>  688]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M328]]>
          <![CDATA[<400>  28]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Asn Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Ala Pro Ala Pro Ala Pro Glu Pro Lys Ser Ser Asp Lys Thr 
              450                 455                 460                 
          His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
          465                 470                 475                 480 
          Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                          485                 490                 495     
          Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                      500                 505                 510         
          Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                  515                 520                 525             
          Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
              530                 535                 540                 
          Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
          545                 550                 555                 560 
          Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                          565                 570                 575     
          Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                      580                 585                 590         
          Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                  595                 600                 605             
          Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
              610                 615                 620                 
          Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
          625                 630                 635                 640 
          Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                          645                 650                 655     
          Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                      660                 665                 670         
          Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685             
          <![CDATA[<210>  29]]>
          <![CDATA[<211>  688]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M329]]>
          <![CDATA[<400>  29]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Asn Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Ala Pro Ala Pro Ala Pro Glu Pro Lys Ser Ser Asp Lys Thr 
              450                 455                 460                 
          His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
          465                 470                 475                 480 
          Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                          485                 490                 495     
          Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                      500                 505                 510         
          Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                  515                 520                 525             
          Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
              530                 535                 540                 
          Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
          545                 550                 555                 560 
          Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                          565                 570                 575     
          Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                      580                 585                 590         
          Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                  595                 600                 605             
          Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
              610                 615                 620                 
          Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
          625                 630                 635                 640 
          Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                          645                 650                 655     
          Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                      660                 665                 670         
          Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685             
          <![CDATA[<210>  30]]>
          <![CDATA[<211>  689]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M330]]>
          <![CDATA[<400>  30]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Ala Val 
          225                 230                 235                 240 
          Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile 
                          245                 250                 255     
          Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln 
                      260                 265                 270         
          Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu 
                  275                 280                 285             
          Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala 
              290                 295                 300                 
          Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val 
          305                 310                 315                 320 
          Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe 
                          325                 330                 335     
          Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val 
                      340                 345                 350         
          Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln 
                  355                 360                 365             
          Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu 
              370                 375                 380                 
          Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
          385                 390                 395                 400 
          Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr 
                          405                 410                 415     
          Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp 
                      420                 425                 430         
          Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu 
                  435                 440                 445             
          Gly Lys Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
              450                 455                 460                 
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
          465                 470                 475                 480 
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                          485                 490                 495     
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                      500                 505                 510         
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                  515                 520                 525             
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
              530                 535                 540                 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
          545                 550                 555                 560 
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                          565                 570                 575     
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                      580                 585                 590         
          Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                  595                 600                 605             
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
              610                 615                 620                 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
          625                 630                 635                 640 
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                          645                 650                 655     
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                      660                 665                 670         
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                  675                 680                 685             
          Lys 
          <![CDATA[<210>  31]]>
          <![CDATA[<211>  689]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M331]]>
          <![CDATA[<400>  31]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Ala Val 
          225                 230                 235                 240 
          Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile 
                          245                 250                 255     
          Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln 
                      260                 265                 270         
          Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu 
                  275                 280                 285             
          Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala 
              290                 295                 300                 
          Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val 
          305                 310                 315                 320 
          Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe 
                          325                 330                 335     
          Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val 
                      340                 345                 350         
          Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln 
                  355                 360                 365             
          Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu 
              370                 375                 380                 
          Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
          385                 390                 395                 400 
          Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr 
                          405                 410                 415     
          Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp 
                      420                 425                 430         
          Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu 
                  435                 440                 445             
          Gly Lys Asp Thr Glu Ala Ala Ala Lys Glu Pro Lys Ser Ser Asp Lys 
              450                 455                 460                 
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
          465                 470                 475                 480 
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                          485                 490                 495     
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                      500                 505                 510         
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                  515                 520                 525             
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
              530                 535                 540                 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
          545                 550                 555                 560 
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                          565                 570                 575     
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                      580                 585                 590         
          Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                  595                 600                 605             
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
              610                 615                 620                 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
          625                 630                 635                 640 
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                          645                 650                 655     
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                      660                 665                 670         
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                  675                 680                 685             
          Lys 
          <![CDATA[<210>  32]]>
          <![CDATA[<211>  689]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體A-M332]]>
          <![CDATA[<400>  32]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Ala Val 
          225                 230                 235                 240 
          Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile 
                          245                 250                 255     
          Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln 
                      260                 265                 270         
          Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu 
                  275                 280                 285             
          Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala 
              290                 295                 300                 
          Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val 
          305                 310                 315                 320 
          Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe 
                          325                 330                 335     
          Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val 
                      340                 345                 350         
          Val His Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln 
                  355                 360                 365             
          Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu 
              370                 375                 380                 
          Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
          385                 390                 395                 400 
          Lys Gln Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr 
                          405                 410                 415     
          Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp 
                      420                 425                 430         
          Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu 
                  435                 440                 445             
          Gly Lys Asp Thr Glu Ala Ala Ala Lys Glu Pro Lys Ser Ser Asp Lys 
              450                 455                 460                 
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
          465                 470                 475                 480 
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                          485                 490                 495     
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                      500                 505                 510         
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                  515                 520                 525             
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
              530                 535                 540                 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
          545                 550                 555                 560 
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                          565                 570                 575     
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                      580                 585                 590         
          Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                  595                 600                 605             
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
              610                 615                 620                 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
          625                 630                 635                 640 
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                          645                 650                 655     
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                      660                 665                 670         
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                  675                 680                 685             
          Lys 
          <![CDATA[<210>  33]]>
          <![CDATA[<211>  358]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體B-M43，與M24（SEQ ID NO:34）配對]]>
          <![CDATA[<400>  33]]>
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          1               5                   10                  15      
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                      20                  25                  30          
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                  35                  40                  45              
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
              50                  55                  60                  
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
          65                  70                  75                  80  
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                          85                  90                  95      
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                      100                 105                 110         
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                  115                 120                 125             
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
              130                 135                 140                 
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
          145                 150                 155                 160 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                          165                 170                 175     
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                      180                 185                 190         
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                  195                 200                 205             
          Ala Leu Gly Lys Asp Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser 
              210                 215                 220                 
          Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His 
          225                 230                 235                 240 
          Gly Gly Ser Gly Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
                          245                 250                 255     
          Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Ser Glu 
                      260                 265                 270         
          Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
                  275                 280                 285             
          Leu Glu Phe Gln Val Ile Ser Cys Glu Ser Gly Asp Ala Ser Ile His 
              290                 295                 300                 
          Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
          305                 310                 315                 320 
          Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
                          325                 330                 335     
          Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
                      340                 345                 350         
          Met Phe Ile Asn Thr Ser 
                  355             
          <![CDATA[<210>  34]]>
          <![CDATA[<211>  305]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體B-M24]]>
          <![CDATA[<400>  34]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Cys Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Glu Pro Lys Ser Cys Asp Lys 
          65                  70                  75                  80  
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                          85                  90                  95      
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                      100                 105                 110         
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                  115                 120                 125             
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
              130                 135                 140                 
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
          145                 150                 155                 160 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                          165                 170                 175     
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                      180                 185                 190         
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                  195                 200                 205             
          Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
              210                 215                 220                 
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
          225                 230                 235                 240 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                          245                 250                 255     
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                      260                 265                 270         
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                  275                 280                 285             
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
              290                 295                 300                 
          Lys 
          305 
          <![CDATA[<210>  35]]>
          <![CDATA[<211>  349]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體B-M61，與M60（SEQ ID NO:36）配對]]>
          <![CDATA[<400>  35]]>
          Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser 
          1               5                   10                  15      
          Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val 
                      20                  25                  30          
          His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu 
                  35                  40                  45              
          Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro 
              50                  55                  60                  
          Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu 
          65                  70                  75                  80  
          Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys 
                          85                  90                  95      
          Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val 
                      100                 105                 110         
          His Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala 
                  115                 120                 125             
          Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser 
              130                 135                 140                 
          Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys 
          145                 150                 155                 160 
          Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu 
                          165                 170                 175     
          Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser 
                      180                 185                 190         
          Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly 
                  195                 200                 205             
          Lys Asp Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly Gly 
              210                 215                 220                 
          Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Asn Trp Val Asn Val 
          225                 230                 235                 240 
          Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                          245                 250                 255     
          Asp Ala Thr Leu Tyr Ser Glu Ser Asp Val His Pro Ser Cys Lys Val 
                      260                 265                 270         
          Thr Ala Met Lys Cys Phe Leu Leu Glu Phe Gln Val Ile Ser Cys Glu 
                  275                 280                 285             
          Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
              290                 295                 300                 
          Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
          305                 310                 315                 320 
          Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                          325                 330                 335     
          Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
                      340                 345                 
          <![CDATA[<210>  36]]>
          <![CDATA[<211>  305]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體B-M60]]>
          <![CDATA[<400>  36]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Cys Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Glu Pro Lys Ser Ser Asp Lys 
          65                  70                  75                  80  
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                          85                  90                  95      
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                      100                 105                 110         
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                  115                 120                 125             
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
              130                 135                 140                 
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
          145                 150                 155                 160 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                          165                 170                 175     
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                      180                 185                 190         
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                  195                 200                 205             
          Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
              210                 215                 220                 
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
          225                 230                 235                 240 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                          245                 250                 255     
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                      260                 265                 270         
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                  275                 280                 285             
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
              290                 295                 300                 
          Lys 
          305 
          <![CDATA[<210>  37]]>
          <![CDATA[<211>  352]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體B-M62，與M60（SEQ ID NO:38）配對]]>
          <![CDATA[<400>  37]]>
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          1               5                   10                  15      
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                      20                  25                  30          
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                  35                  40                  45              
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
              50                  55                  60                  
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
          65                  70                  75                  80  
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                          85                  90                  95      
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                      100                 105                 110         
          Gln Val Val His Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile 
                  115                 120                 125             
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
              130                 135                 140                 
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
          145                 150                 155                 160 
          Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr 
                          165                 170                 175     
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                      180                 185                 190         
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                  195                 200                 205             
          Ala Leu Gly Lys Asp Gly Gly Gly Ser Ile Ser Ser Gly Leu Leu Ser 
              210                 215                 220                 
          Gly Arg Ser Asp Asn His Gly Gly Gly Ser Ser Gly Gly Ser Asn Trp 
          225                 230                 235                 240 
          Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
                          245                 250                 255     
          Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
                      260                 265                 270         
          Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
                  275                 280                 285             
          Ser Cys Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
              290                 295                 300                 
          Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
          305                 310                 315                 320 
          Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
                          325                 330                 335     
          Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
                      340                 345                 350         
          <![CDATA[<210>  38]]>
          <![CDATA[<211>  305]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體B-M60]]>
          <![CDATA[<400>  38]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Cys Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Glu Pro Lys Ser Ser Asp Lys 
          65                  70                  75                  80  
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                          85                  90                  95      
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                      100                 105                 110         
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                  115                 120                 125             
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
              130                 135                 140                 
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
          145                 150                 155                 160 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                          165                 170                 175     
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                      180                 185                 190         
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                  195                 200                 205             
          Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
              210                 215                 220                 
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
          225                 230                 235                 240 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                          245                 250                 255     
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                      260                 265                 270         
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                  275                 280                 285             
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
              290                 295                 300                 
          Lys 
          305 
          <![CDATA[<210>  39]]>
          <![CDATA[<211>  678]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體C-M101]]>
          <![CDATA[<400>  39]]>
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          1               5                   10                  15      
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                      20                  25                  30          
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                  35                  40                  45              
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
              50                  55                  60                  
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
          65                  70                  75                  80  
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                          85                  90                  95      
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                      100                 105                 110         
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                  115                 120                 125             
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
              130                 135                 140                 
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
          145                 150                 155                 160 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                          165                 170                 175     
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                      180                 185                 190         
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                  195                 200                 205             
          Ala Leu Gly Lys Asp Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser 
              210                 215                 220                 
          Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Gly Arg Ser 
          225                 230                 235                 240 
          Asp Asn His Gly Gly Ser Gly Asn Trp Val Asn Val Ile Ser Asp Leu 
                          245                 250                 255     
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                      260                 265                 270         
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                  275                 280                 285             
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
              290                 295                 300                 
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
          305                 310                 315                 320 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
                          325                 330                 335     
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                      340                 345                 350         
          Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Ser Gly Gly Gly 
                  355                 360                 365             
          Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Ile Thr Cys 
              370                 375                 380                 
          Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr 
          385                 390                 395                 400 
          Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg 
                          405                 410                 415     
          Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr 
                      420                 425                 430         
          Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Glu Pro 
                  435                 440                 445             
          Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
              450                 455                 460                 
          Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
          465                 470                 475                 480 
          Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                          485                 490                 495     
          Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                      500                 505                 510         
          Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                  515                 520                 525             
          Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
              530                 535                 540                 
          Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
          545                 550                 555                 560 
          Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                          565                 570                 575     
          Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                      580                 585                 590         
          Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                  595                 600                 605             
          Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
              610                 615                 620                 
          Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
          625                 630                 635                 640 
          Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                          645                 650                 655     
          Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                      660                 665                 670         
          Ser Leu Ser Pro Gly Lys 
                  675             
          <![CDATA[<210>  40]]>
          <![CDATA[<211>  674]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體C-M148]]>
          <![CDATA[<400>  40]]>
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          1               5                   10                  15      
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                      20                  25                  30          
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                  35                  40                  45              
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
              50                  55                  60                  
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
          65                  70                  75                  80  
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                          85                  90                  95      
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                      100                 105                 110         
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                  115                 120                 125             
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
              130                 135                 140                 
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
          145                 150                 155                 160 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                          165                 170                 175     
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                      180                 185                 190         
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                  195                 200                 205             
          Ala Leu Gly Lys Asp Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser 
              210                 215                 220                 
          Gly Gly Ile Pro Val Ser Leu Arg Ser Gly Gly Gly Gly Ser Asn Trp 
          225                 230                 235                 240 
          Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
                          245                 250                 255     
          Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
                      260                 265                 270         
          Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
                  275                 280                 285             
          Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
              290                 295                 300                 
          Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
          305                 310                 315                 320 
          Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
                          325                 330                 335     
          Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
                      340                 345                 350         
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro Met 
              370                 375                 380                 
          Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser 
          385                 390                 395                 400 
          Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr 
                          405                 410                 415     
          Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His 
                      420                 425                 430         
          Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp 
                  435                 440                 445             
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
              450                 455                 460                 
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
          465                 470                 475                 480 
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                          485                 490                 495     
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                      500                 505                 510         
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                  515                 520                 525             
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
              530                 535                 540                 
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
          545                 550                 555                 560 
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                          565                 570                 575     
          Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                      580                 585                 590         
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                  595                 600                 605             
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
              610                 615                 620                 
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
          625                 630                 635                 640 
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                          645                 650                 655     
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                      660                 665                 670         
          Gly Lys 
          <![CDATA[<210>  41]]>
          <![CDATA[<211>  687]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體C-M174]]>
          <![CDATA[<400>  41]]>
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          1               5                   10                  15      
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                      20                  25                  30          
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                  35                  40                  45              
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
              50                  55                  60                  
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
          65                  70                  75                  80  
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                          85                  90                  95      
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                      100                 105                 110         
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                  115                 120                 125             
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
              130                 135                 140                 
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
          145                 150                 155                 160 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                          165                 170                 175     
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                      180                 185                 190         
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                  195                 200                 205             
          Ala Leu Gly Lys Asp Gly Gly Gly Gly Ser Ser Gly Arg Ile Gly Phe 
              210                 215                 220                 
          Leu Arg Thr Ala Gly Gly Gly Gly Ser Asn Trp Val Asn Val Ile Ser 
          225                 230                 235                 240 
          Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
                          245                 250                 255     
          Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
                      260                 265                 270         
          Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
                  275                 280                 285             
          Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
              290                 295                 300                 
          Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
          305                 310                 315                 320 
          Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
                          325                 330                 335     
          Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser 
                      340                 345                 350         
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                  355                 360                 365             
          Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
              370                 375                 380                 
          Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
          385                 390                 395                 400 
          Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                          405                 410                 415     
          Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
                      420                 425                 430         
          Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala 
                  435                 440                 445             
          Pro Pro Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
              450                 455                 460                 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
          465                 470                 475                 480 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                          485                 490                 495     
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                      500                 505                 510         
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                  515                 520                 525             
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
              530                 535                 540                 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
          545                 550                 555                 560 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                          565                 570                 575     
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                      580                 585                 590         
          Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                  595                 600                 605             
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
              610                 615                 620                 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
          625                 630                 635                 640 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                          645                 650                 655     
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                      660                 665                 670         
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685         
          <![CDATA[<210>  42]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體D-M232]]>
          <![CDATA[<400>  42]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Gly Gly Gly 
                  435                 440                 445             
          Ser Ile Pro Val Ser Leu Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly 
              450                 455                 460                 
          Ser Gly Gly Ser Gly Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
          465                 470                 475                 480 
          His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
                          485                 490                 495     
          Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                      500                 505                 510         
          Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                  515                 520                 525             
          Pro Ser Leu Lys Cys Ile Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser 
              530                 535                 540                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val 
          545                 550                 555                 560 
          Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                          565                 570                 575     
          Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
                      580                 585                 590         
          Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
                  595                 600                 605             
          Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
              610                 615                 620                 
          Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
          625                 630                 635                 640 
          Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                          645                 650                 655     
          Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
                      660                 665                 
          <![CDATA[<210>  43]]>
          <![CDATA[<211>  680]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體D-M1001]]>
          <![CDATA[<400>  43]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Gly Gly Gly Ser 
                  435                 440                 445             
          Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Pro Val Ser Leu Arg Ser 
              450                 455                 460                 
          Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
          465                 470                 475                 480 
          Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
                          485                 490                 495     
          Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                      500                 505                 510         
          Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
                  515                 520                 525             
          Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala 
              530                 535                 540                 
          Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
          545                 550                 555                 560 
          Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
                          565                 570                 575     
          Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
                      580                 585                 590         
          Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
                  595                 600                 605             
          Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
              610                 615                 620                 
          Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
          625                 630                 635                 640 
          Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
                          645                 650                 655     
          Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
                      660                 665                 670         
          Val Gln Met Phe Ile Asn Thr Ser 
                  675                 680 
          <![CDATA[<210>  44]]>
          <![CDATA[<211>  685]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體D-M1002]]>
          <![CDATA[<400>  44]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Asn Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Pro 
              450                 455                 460                 
          Val Ser Leu Arg Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro 
          465                 470                 475                 480 
          Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
                          485                 490                 495     
          Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
                      500                 505                 510         
          Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
                  515                 520                 525             
          His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
              530                 535                 540                 
          His Gln Arg Pro Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser 
          545                 550                 555                 560 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val 
                          565                 570                 575     
          Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                      580                 585                 590         
          Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
                  595                 600                 605             
          Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
              610                 615                 620                 
          Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
          625                 630                 635                 640 
          Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
                          645                 650                 655     
          Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                      660                 665                 670         
          Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
                  675                 680                 685 
          <![CDATA[<210>  45]]>
          <![CDATA[<211>  690]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體D-M1003]]>
          <![CDATA[<400>  45]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
          225                 230                 235                 240 
          Ser Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg 
                          245                 250                 255     
          Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr 
                      260                 265                 270         
          Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr 
                  275                 280                 285             
          Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile 
              290                 295                 300                 
          Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr 
          305                 310                 315                 320 
          Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile 
                          325                 330                 335     
          Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser 
                      340                 345                 350         
          Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu 
                  355                 360                 365             
          Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala 
              370                 375                 380                 
          Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr 
          385                 390                 395                 400 
          Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp 
                          405                 410                 415     
          Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe 
                      420                 425                 430         
          Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro 
                  435                 440                 445             
          Ala Ala Leu Gly Lys Asp Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly 
              450                 455                 460                 
          Ser Gly Gly Ile Pro Val Ser Leu Arg Ser Gly Gly Gly Gly Ser Ile 
          465                 470                 475                 480 
          Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
                          485                 490                 495     
          Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
                      500                 505                 510         
          Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                  515                 520                 525             
          Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
              530                 535                 540                 
          Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly Ser 
          545                 550                 555                 560 
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln 
                          565                 570                 575     
          Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
                      580                 585                 590         
          Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
                  595                 600                 605             
          Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
              610                 615                 620                 
          Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
          625                 630                 635                 640 
          Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
                          645                 650                 655     
          Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                      660                 665                 670         
          Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
                  675                 680                 685             
          Thr Ser 
              690 
          <![CDATA[<210>  46]]>
          <![CDATA[<211>  681]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體D-M1004]]>
          <![CDATA[<400>  46]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr Gly Gly Gly 
                  435                 440                 445             
          Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Pro Val Ser Leu Arg 
              450                 455                 460                 
          Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
          465                 470                 475                 480 
          His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
                          485                 490                 495     
          Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                      500                 505                 510         
          Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                  515                 520                 525             
          Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
              530                 535                 540                 
          Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
          545                 550                 555                 560 
          Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu 
                          565                 570                 575     
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                      580                 585                 590         
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                  595                 600                 605             
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
              610                 615                 620                 
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
          625                 630                 635                 640 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
                          645                 650                 655     
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                      660                 665                 670         
          Ile Val Gln Met Phe Ile Asn Thr Ser 
                  675                 680     
          <![CDATA[<210>  47]]>
          <![CDATA[<211>  681]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體D-M1005]]>
          <![CDATA[<400>  47]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr Gly Gly Gly 
                  435                 440                 445             
          Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Pro Val Ser Leu Arg 
              450                 455                 460                 
          Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
          465                 470                 475                 480 
          His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
                          485                 490                 495     
          Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                      500                 505                 510         
          Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                  515                 520                 525             
          Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
              530                 535                 540                 
          Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
          545                 550                 555                 560 
          Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu 
                          565                 570                 575     
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                      580                 585                 590         
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                  595                 600                 605             
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
              610                 615                 620                 
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
          625                 630                 635                 640 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
                          645                 650                 655     
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                      660                 665                 670         
          Ile Val Gln Met Phe Ile Asn Thr Ser 
                  675                 680     
          <![CDATA[<210>  48]]>
          <![CDATA[<211>  681]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體D-M1006]]>
          <![CDATA[<400>  48]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Gln Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr Gly Gly Gly 
                  435                 440                 445             
          Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Pro Val Ser Leu Arg 
              450                 455                 460                 
          Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
          465                 470                 475                 480 
          His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
                          485                 490                 495     
          Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                      500                 505                 510         
          Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                  515                 520                 525             
          Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
              530                 535                 540                 
          Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
          545                 550                 555                 560 
          Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu 
                          565                 570                 575     
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                      580                 585                 590         
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                  595                 600                 605             
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
              610                 615                 620                 
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser 
          625                 630                 635                 640 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
                          645                 650                 655     
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                      660                 665                 670         
          Ile Val Gln Met Phe Ile Gln Thr Ser 
                  675                 680     
          <![CDATA[<210>  49]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E1-MK107，與MH2（SEQ ID NO:50）配對]]>
          <![CDATA[<400>  49]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          65                  70                  75                  80  
          Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                          85                  90                  95      
          Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                      100                 105                 110         
          Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
                  115                 120                 125             
          Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
              130                 135                 140                 
          His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
          145                 150                 155                 160 
          Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                          165                 170                 175     
          Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                      180                 185                 190         
          Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu 
                  195                 200                 205             
          Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
              210                 215                 220                 
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          225                 230                 235                 240 
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          245                 250                 255     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      260                 265                 270         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  275                 280                 285             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              290                 295                 300                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          305                 310                 315                 320 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          325                 330                 335     
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                      340                 345                 350         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  355                 360                 365             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              370                 375                 380                 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
          385                 390                 395                 400 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          405                 410                 415     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      420                 425                 430         
          Ala Leu Gly Lys Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                  435                 440                 445             
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
              450                 455                 460                 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
          465                 470                 475                 480 
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                          485                 490                 495     
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                      500                 505                 510         
          Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                  515                 520                 525             
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
              530                 535                 540                 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
          545                 550                 555                 560 
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
                          565                 570                 575     
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
                      580                 585                 590         
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                  595                 600                 605             
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
              610                 615                 620                 
          Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
          625                 630                 635                 640 
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                          645                 650                 655     
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      660                 665                 
          <![CDATA[<210>  50]]>
          <![CDATA[<211>  232]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  MH2]]>
          <![CDATA[<400>  50]]>
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly Lys 
          225                 230         
          <![CDATA[<210>  51]]>
          <![CDATA[<211>  678]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK114，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  51]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Thr Ser Gln 
          225                 230                 235                 240 
          Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser 
                          245                 250                 255     
          Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro 
                      260                 265                 270         
          Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln 
                  275                 280                 285             
          Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys 
              290                 295                 300                 
          Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly 
          305                 310                 315                 320 
          Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn 
                          325                 330                 335     
          Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr 
                      340                 345                 350         
          His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe 
                  355                 360                 365             
          Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr 
              370                 375                 380                 
          Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile 
          385                 390                 395                 400 
          Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg 
                          405                 410                 415     
          Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln 
                      420                 425                 430         
          Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
              450                 455                 460                 
          Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
          465                 470                 475                 480 
          Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                          485                 490                 495     
          Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                      500                 505                 510         
          Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                  515                 520                 525             
          Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
              530                 535                 540                 
          Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
          545                 550                 555                 560 
          Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                          565                 570                 575     
          Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
                      580                 585                 590         
          Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                  595                 600                 605             
          Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
              610                 615                 620                 
          Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
          625                 630                 635                 640 
          Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                          645                 650                 655     
          Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                      660                 665                 670         
          Ser Leu Ser Pro Gly Lys 
                  675             
          <![CDATA[<210>  52]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MH7]]>
          <![CDATA[<400>  52]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  53]]>
          <![CDATA[<211>  678]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK115，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  53]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Thr Ser Gln 
          225                 230                 235                 240 
          Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser 
                          245                 250                 255     
          Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro 
                      260                 265                 270         
          Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln 
                  275                 280                 285             
          Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys 
              290                 295                 300                 
          Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly 
          305                 310                 315                 320 
          Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn 
                          325                 330                 335     
          Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr 
                      340                 345                 350         
          His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe 
                  355                 360                 365             
          Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr 
              370                 375                 380                 
          Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile 
          385                 390                 395                 400 
          Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg 
                          405                 410                 415     
          Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln 
                      420                 425                 430         
          Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
              450                 455                 460                 
          Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
          465                 470                 475                 480 
          Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                          485                 490                 495     
          Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                      500                 505                 510         
          Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                  515                 520                 525             
          Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
              530                 535                 540                 
          Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
          545                 550                 555                 560 
          Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                          565                 570                 575     
          Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
                      580                 585                 590         
          Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                  595                 600                 605             
          Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
              610                 615                 620                 
          Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
          625                 630                 635                 640 
          Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                          645                 650                 655     
          Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                      660                 665                 670         
          Ser Leu Ser Pro Gly Lys 
                  675             
          <![CDATA[<210>  54]]>
          <![CDATA[<211>  687]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK117，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  54]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Asn Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
              450                 455                 460                 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
          465                 470                 475                 480 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                          485                 490                 495     
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                      500                 505                 510         
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                  515                 520                 525             
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
              530                 535                 540                 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
          545                 550                 555                 560 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                          565                 570                 575     
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                      580                 585                 590         
          Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
                  595                 600                 605             
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
              610                 615                 620                 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
          625                 630                 635                 640 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                          645                 650                 655     
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                      660                 665                 670         
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685         
          <![CDATA[<210>  55]]>
          <![CDATA[<211>  687]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK118，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  55]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Gln Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
              450                 455                 460                 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
          465                 470                 475                 480 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                          485                 490                 495     
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                      500                 505                 510         
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                  515                 520                 525             
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
              530                 535                 540                 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
          545                 550                 555                 560 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                          565                 570                 575     
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                      580                 585                 590         
          Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
                  595                 600                 605             
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
              610                 615                 620                 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
          625                 630                 635                 640 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                          645                 650                 655     
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                      660                 665                 670         
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685         
          <![CDATA[<210>  56]]>
          <![CDATA[<211>  687]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK119，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  56]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Gln Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
              450                 455                 460                 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
          465                 470                 475                 480 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                          485                 490                 495     
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                      500                 505                 510         
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                  515                 520                 525             
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
              530                 535                 540                 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
          545                 550                 555                 560 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                          565                 570                 575     
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                      580                 585                 590         
          Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
                  595                 600                 605             
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
              610                 615                 620                 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
          625                 630                 635                 640 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                          645                 650                 655     
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                      660                 665                 670         
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685         
          <![CDATA[<210>  57]]>
          <![CDATA[<211>  687]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK120，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  57]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Gln Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
              450                 455                 460                 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
          465                 470                 475                 480 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                          485                 490                 495     
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                      500                 505                 510         
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                  515                 520                 525             
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
              530                 535                 540                 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
          545                 550                 555                 560 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                          565                 570                 575     
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                      580                 585                 590         
          Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
                  595                 600                 605             
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
              610                 615                 620                 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
          625                 630                 635                 640 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                          645                 650                 655     
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                      660                 665                 670         
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685         
          <![CDATA[<210>  58]]>
          <![CDATA[<211>  689]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK121，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  58]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Ala Val 
          225                 230                 235                 240 
          Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile 
                          245                 250                 255     
          Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln 
                      260                 265                 270         
          Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu 
                  275                 280                 285             
          Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala 
              290                 295                 300                 
          Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val 
          305                 310                 315                 320 
          Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe 
                          325                 330                 335     
          Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val 
                      340                 345                 350         
          Val His Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln 
                  355                 360                 365             
          Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu 
              370                 375                 380                 
          Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
          385                 390                 395                 400 
          Lys Gln Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr 
                          405                 410                 415     
          Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp 
                      420                 425                 430         
          Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu 
                  435                 440                 445             
          Gly Lys Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
              450                 455                 460                 
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
          465                 470                 475                 480 
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                          485                 490                 495     
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                      500                 505                 510         
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                  515                 520                 525             
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
              530                 535                 540                 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
          545                 550                 555                 560 
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                          565                 570                 575     
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                      580                 585                 590         
          Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
                  595                 600                 605             
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
              610                 615                 620                 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
          625                 630                 635                 640 
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                          645                 650                 655     
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                      660                 665                 670         
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                  675                 680                 685             
          Lys 
          <![CDATA[<210>  59]]>
          <![CDATA[<211>  687]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK123，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  59]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Asn Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
              450                 455                 460                 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
          465                 470                 475                 480 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                          485                 490                 495     
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                      500                 505                 510         
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                  515                 520                 525             
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
              530                 535                 540                 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
          545                 550                 555                 560 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                          565                 570                 575     
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                      580                 585                 590         
          Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
                  595                 600                 605             
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
              610                 615                 620                 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
          625                 630                 635                 640 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                          645                 650                 655     
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                      660                 665                 670         
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685         
          <![CDATA[<210>  60]]>
          <![CDATA[<211>  689]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK124，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  60]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Ala Val 
          225                 230                 235                 240 
          Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile 
                          245                 250                 255     
          Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln 
                      260                 265                 270         
          Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu 
                  275                 280                 285             
          Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala 
              290                 295                 300                 
          Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val 
          305                 310                 315                 320 
          Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe 
                          325                 330                 335     
          Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val 
                      340                 345                 350         
          Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln 
                  355                 360                 365             
          Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu 
              370                 375                 380                 
          Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
          385                 390                 395                 400 
          Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr 
                          405                 410                 415     
          Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp 
                      420                 425                 430         
          Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu 
                  435                 440                 445             
          Gly Lys Asp Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
              450                 455                 460                 
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
          465                 470                 475                 480 
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                          485                 490                 495     
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                      500                 505                 510         
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                  515                 520                 525             
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
              530                 535                 540                 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
          545                 550                 555                 560 
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                          565                 570                 575     
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                      580                 585                 590         
          Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
                  595                 600                 605             
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
              610                 615                 620                 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
          625                 630                 635                 640 
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                          645                 650                 655     
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                      660                 665                 670         
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                  675                 680                 685             
          Lys 
          <![CDATA[<210>  61]]>
          <![CDATA[<211>  687]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK125，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  61]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Val Asn Gly 
          225                 230                 235                 240 
          Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys 
                          245                 250                 255     
          Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His 
                      260                 265                 270         
          Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro 
                  275                 280                 285             
          Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp 
              290                 295                 300                 
          Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys 
          305                 310                 315                 320 
          Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro 
                          325                 330                 335     
          Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His 
                      340                 345                 350         
          Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser 
                  355                 360                 365             
          His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro 
              370                 375                 380                 
          Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln 
          385                 390                 395                 400 
          Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe 
                          405                 410                 415     
          Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro 
                      420                 425                 430         
          Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys 
                  435                 440                 445             
          Asp Thr Glu Ala Ala Ala Lys Glu Pro Lys Ser Ser Asp Lys Thr His 
              450                 455                 460                 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
          465                 470                 475                 480 
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                          485                 490                 495     
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                      500                 505                 510         
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                  515                 520                 525             
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
              530                 535                 540                 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
          545                 550                 555                 560 
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                          565                 570                 575     
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                      580                 585                 590         
          Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
                  595                 600                 605             
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
              610                 615                 620                 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
          625                 630                 635                 640 
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                          645                 650                 655     
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                      660                 665                 670         
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685         
          <![CDATA[<210>  62]]>
          <![CDATA[<211>  690]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK126，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  62]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Ala Val 
          225                 230                 235                 240 
          Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile 
                          245                 250                 255     
          Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln 
                      260                 265                 270         
          Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu 
                  275                 280                 285             
          Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala 
              290                 295                 300                 
          Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val 
          305                 310                 315                 320 
          Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe 
                          325                 330                 335     
          Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val 
                      340                 345                 350         
          Val His Val Glu Thr His Arg Ala Asn Ile Ser Trp Glu Ile Ser Gln 
                  355                 360                 365             
          Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu 
              370                 375                 380                 
          Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
          385                 390                 395                 400 
          Lys Gln Glu Trp Ile Thr Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr 
                          405                 410                 415     
          Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp 
                      420                 425                 430         
          Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu 
                  435                 440                 445             
          Gly Lys Asp Thr Ala Pro Ala Pro Ala Pro Glu Pro Lys Ser Ser Asp 
              450                 455                 460                 
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
          465                 470                 475                 480 
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                          485                 490                 495     
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                      500                 505                 510         
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                  515                 520                 525             
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
              530                 535                 540                 
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
          545                 550                 555                 560 
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                          565                 570                 575     
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                      580                 585                 590         
          Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                  595                 600                 605             
          Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
              610                 615                 620                 
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
          625                 630                 635                 640 
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                          645                 650                 655     
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                      660                 665                 670         
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                  675                 680                 685             
          Gly Lys 
              690 
          <![CDATA[<210>  63]]>
          <![CDATA[<211>  669]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E2-M111，與MH2（SEQ ID NO:64）配對]]>
          <![CDATA[<400>  63]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Gly Gly Gly 
                  435                 440                 445             
          Ser Ile Pro Val Ser Leu Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly 
              450                 455                 460                 
          Ser Gly Gly Ser Gly Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
          465                 470                 475                 480 
          His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
                          485                 490                 495     
          Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                      500                 505                 510         
          Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                  515                 520                 525             
          Pro Ser Leu Lys Cys Ile Arg Ser Gly Gly Ser Gly Gly Gly Gly Ser 
              530                 535                 540                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val 
          545                 550                 555                 560 
          Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                          565                 570                 575     
          Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
                      580                 585                 590         
          Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
                  595                 600                 605             
          Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
              610                 615                 620                 
          Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
          625                 630                 635                 640 
          Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                          645                 650                 655     
          Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
                      660                 665                 
          <![CDATA[<210>  64]]>
          <![CDATA[<211>  232]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E2-MH2]]>
          <![CDATA[<400>  64]]>
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly Lys 
          225                 230         
          <![CDATA[<210>  65]]>
          <![CDATA[<211>  681]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E2-M2001，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  65]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr Gly Gly Gly 
                  435                 440                 445             
          Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Pro Val Ser Leu Arg 
              450                 455                 460                 
          Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
          465                 470                 475                 480 
          His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
                          485                 490                 495     
          Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                      500                 505                 510         
          Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                  515                 520                 525             
          Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
              530                 535                 540                 
          Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
          545                 550                 555                 560 
          Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu 
                          565                 570                 575     
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                      580                 585                 590         
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                  595                 600                 605             
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
              610                 615                 620                 
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
          625                 630                 635                 640 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
                          645                 650                 655     
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                      660                 665                 670         
          Ile Val Gln Met Phe Ile Asn Thr Ser 
                  675                 680     
          <![CDATA[<210>  66]]>
          <![CDATA[<211>  681]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E2-M2002，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  66]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Gln Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr Gly Gly Gly 
                  435                 440                 445             
          Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Pro Val Ser Leu Arg 
              450                 455                 460                 
          Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
          465                 470                 475                 480 
          His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
                          485                 490                 495     
          Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                      500                 505                 510         
          Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                  515                 520                 525             
          Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
              530                 535                 540                 
          Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
          545                 550                 555                 560 
          Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu 
                          565                 570                 575     
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                      580                 585                 590         
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                  595                 600                 605             
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
              610                 615                 620                 
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser 
          625                 630                 635                 640 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
                          645                 650                 655     
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                      660                 665                 670         
          Ile Val Gln Met Phe Ile Gln Thr Ser 
                  675                 680     
          <![CDATA[<210>  67]]>
          <![CDATA[<211>  680]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK136，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  67]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Thr 
          225                 230                 235                 240 
          Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val 
                          245                 250                 255     
          Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala 
                      260                 265                 270         
          Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val 
                  275                 280                 285             
          Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser 
              290                 295                 300                 
          Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg 
          305                 310                 315                 320 
          Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe 
                          325                 330                 335     
          Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val 
                      340                 345                 350         
          Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
                  355                 360                 365             
          Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
              370                 375                 380                 
          His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
          385                 390                 395                 400 
          Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
                          405                 410                 415     
          Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
                      420                 425                 430         
          Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser 
                  435                 440                 445             
          Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
              450                 455                 460                 
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
          465                 470                 475                 480 
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                          485                 490                 495     
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                      500                 505                 510         
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                  515                 520                 525             
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
              530                 535                 540                 
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
          545                 550                 555                 560 
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                          565                 570                 575     
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
                      580                 585                 590         
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                  595                 600                 605             
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
              610                 615                 620                 
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
          625                 630                 635                 640 
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                          645                 650                 655     
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                      660                 665                 670         
          Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680 
          <![CDATA[<210>  68]]>
          <![CDATA[<211>  680]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK137，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  68]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Thr 
          225                 230                 235                 240 
          Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val 
                          245                 250                 255     
          Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala 
                      260                 265                 270         
          Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val 
                  275                 280                 285             
          Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser 
              290                 295                 300                 
          Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg 
          305                 310                 315                 320 
          Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe 
                          325                 330                 335     
          Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val 
                      340                 345                 350         
          Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
                  355                 360                 365             
          Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
              370                 375                 380                 
          His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
          385                 390                 395                 400 
          Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
                          405                 410                 415     
          Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
                      420                 425                 430         
          Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser 
                  435                 440                 445             
          Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
              450                 455                 460                 
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
          465                 470                 475                 480 
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                          485                 490                 495     
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                      500                 505                 510         
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                  515                 520                 525             
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
              530                 535                 540                 
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
          545                 550                 555                 560 
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                          565                 570                 575     
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
                      580                 585                 590         
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                  595                 600                 605             
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
              610                 615                 620                 
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
          625                 630                 635                 640 
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                          645                 650                 655     
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                      660                 665                 670         
          Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680 
          <![CDATA[<210>  69]]>
          <![CDATA[<211>  680]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK138，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  69]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Thr 
          225                 230                 235                 240 
          Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val 
                          245                 250                 255     
          Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala 
                      260                 265                 270         
          Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val 
                  275                 280                 285             
          Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser 
              290                 295                 300                 
          Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg 
          305                 310                 315                 320 
          Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe 
                          325                 330                 335     
          Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val 
                      340                 345                 350         
          Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
                  355                 360                 365             
          Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
              370                 375                 380                 
          His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
          385                 390                 395                 400 
          Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
                          405                 410                 415     
          Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
                      420                 425                 430         
          Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser 
                  435                 440                 445             
          Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
              450                 455                 460                 
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
          465                 470                 475                 480 
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                          485                 490                 495     
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                      500                 505                 510         
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                  515                 520                 525             
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
              530                 535                 540                 
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
          545                 550                 555                 560 
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                          565                 570                 575     
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
                      580                 585                 590         
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                  595                 600                 605             
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
              610                 615                 620                 
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
          625                 630                 635                 640 
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                          645                 650                 655     
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                      660                 665                 670         
          Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680 
          <![CDATA[<210>  70]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK139，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  70]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                  435                 440                 445             
          Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
              450                 455                 460                 
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
          465                 470                 475                 480 
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                          485                 490                 495     
          Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                      500                 505                 510         
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                  515                 520                 525             
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
              530                 535                 540                 
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
          545                 550                 555                 560 
          Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                          565                 570                 575     
          Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
                      580                 585                 590         
          Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                  595                 600                 605             
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
              610                 615                 620                 
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
          625                 630                 635                 640 
          Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                          645                 650                 655     
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                      660                 665                 670         
          Leu Ser Pro Gly Lys 
                  675         
          <![CDATA[<210>  71]]>
          <![CDATA[<211>  674]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK140，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  71]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Thr Ser Gln Phe Thr Cys Phe 
          225                 230                 235                 240 
          Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln Asp Gly Ala 
                          245                 250                 255     
          Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg 
                      260                 265                 270         
          Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala 
                  275                 280                 285             
          Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val 
              290                 295                 300                 
          Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg 
          305                 310                 315                 320 
          Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met 
                          325                 330                 335     
          Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Ala Gln 
                      340                 345                 350         
          Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu 
                  355                 360                 365             
          Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala 
              370                 375                 380                 
          Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr 
          385                 390                 395                 400 
          Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu 
                          405                 410                 415     
          Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe 
                      420                 425                 430         
          Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                  435                 440                 445             
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
              450                 455                 460                 
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
          465                 470                 475                 480 
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                          485                 490                 495     
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                      500                 505                 510         
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                  515                 520                 525             
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
              530                 535                 540                 
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
          545                 550                 555                 560 
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                          565                 570                 575     
          Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                      580                 585                 590         
          Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                  595                 600                 605             
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
              610                 615                 620                 
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
          625                 630                 635                 640 
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                          645                 650                 655     
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                      660                 665                 670         
          Gly Lys 
          <![CDATA[<210>  72]]>
          <![CDATA[<211>  680]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK141，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  72]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Thr 
          225                 230                 235                 240 
          Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val 
                          245                 250                 255     
          Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala 
                      260                 265                 270         
          Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val 
                  275                 280                 285             
          Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser 
              290                 295                 300                 
          Gln Lys Leu Thr Thr Gln Asp Ile Val Thr Leu Arg Val Leu Cys Arg 
          305                 310                 315                 320 
          Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe 
                          325                 330                 335     
          Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val 
                      340                 345                 350         
          Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
                  355                 360                 365             
          Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
              370                 375                 380                 
          His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
          385                 390                 395                 400 
          Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
                          405                 410                 415     
          Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
                      420                 425                 430         
          Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser 
                  435                 440                 445             
          Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
              450                 455                 460                 
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
          465                 470                 475                 480 
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                          485                 490                 495     
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                      500                 505                 510         
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                  515                 520                 525             
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
              530                 535                 540                 
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
          545                 550                 555                 560 
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                          565                 570                 575     
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
                      580                 585                 590         
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                  595                 600                 605             
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
              610                 615                 620                 
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
          625                 630                 635                 640 
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                          645                 650                 655     
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                      660                 665                 670         
          Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680 
          <![CDATA[<210>  73]]>
          <![CDATA[<211>  686]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK146，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  73]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                          85                  90                  95      
          Ser Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu 
                      100                 105                 110         
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                  115                 120                 125             
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
              130                 135                 140                 
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
          145                 150                 155                 160 
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser 
                          165                 170                 175     
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
                      180                 185                 190         
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                  195                 200                 205             
          Ile Val Gln Met Phe Ile Gln Thr Ser Gly Gly Gly Ser Val Pro Leu 
              210                 215                 220                 
          Ser Leu Tyr Ser Gly Arg Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly 
          225                 230                 235                 240 
          Ser Gly Ser Gly Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg 
                          245                 250                 255     
          Ala Gln Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr 
                      260                 265                 270         
          Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr 
                  275                 280                 285             
          Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile 
              290                 295                 300                 
          Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr 
          305                 310                 315                 320 
          Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile 
                          325                 330                 335     
          Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser 
                      340                 345                 350         
          Leu Gln Val Val His Val Glu Thr His Arg Ala Gln Ile Ser Trp Glu 
                  355                 360                 365             
          Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala 
              370                 375                 380                 
          Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr 
          385                 390                 395                 400 
          Leu Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp 
                          405                 410                 415     
          Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe 
                      420                 425                 430         
          Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro 
                  435                 440                 445             
          Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr 
              450                 455                 460                 
          Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
          465                 470                 475                 480 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          485                 490                 495     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      500                 505                 510         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  515                 520                 525             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              530                 535                 540                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          545                 550                 555                 560 
          Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                          565                 570                 575     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                      580                 585                 590         
          Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
                  595                 600                 605             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              610                 615                 620                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          625                 630                 635                 640 
          Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          645                 650                 655     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      660                 665                 670         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680                 685     
          <![CDATA[<210>  74]]>
          <![CDATA[<211>  680]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK145，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  74]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Thr 
          225                 230                 235                 240 
          Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val 
                          245                 250                 255     
          Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala 
                      260                 265                 270         
          Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val 
                  275                 280                 285             
          Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser 
              290                 295                 300                 
          Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg 
          305                 310                 315                 320 
          Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe 
                          325                 330                 335     
          Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val 
                      340                 345                 350         
          Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
                  355                 360                 365             
          Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
              370                 375                 380                 
          His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
          385                 390                 395                 400 
          Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
                          405                 410                 415     
          Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
                      420                 425                 430         
          Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser 
                  435                 440                 445             
          Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
              450                 455                 460                 
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
          465                 470                 475                 480 
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                          485                 490                 495     
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                      500                 505                 510         
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                  515                 520                 525             
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
              530                 535                 540                 
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
          545                 550                 555                 560 
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                          565                 570                 575     
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                      580                 585                 590         
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                  595                 600                 605             
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
              610                 615                 620                 
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
          625                 630                 635                 640 
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                          645                 650                 655     
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                      660                 665                 670         
          Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680 
          <![CDATA[<210>  75]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MH8]]>
          <![CDATA[<400>  75]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  76]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK149，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  76]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                  435                 440                 445             
          Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
              450                 455                 460                 
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
          465                 470                 475                 480 
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                          485                 490                 495     
          Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                      500                 505                 510         
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                  515                 520                 525             
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
              530                 535                 540                 
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
          545                 550                 555                 560 
          Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                          565                 570                 575     
          Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                      580                 585                 590         
          Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                  595                 600                 605             
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
              610                 615                 620                 
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
          625                 630                 635                 640 
          Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                          645                 650                 655     
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                      660                 665                 670         
          Leu Ser Pro Gly Lys 
                  675         
          <![CDATA[<210>  77]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK150，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  77]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Gln 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                  435                 440                 445             
          Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
              450                 455                 460                 
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
          465                 470                 475                 480 
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                          485                 490                 495     
          Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                      500                 505                 510         
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                  515                 520                 525             
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
              530                 535                 540                 
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
          545                 550                 555                 560 
          Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                          565                 570                 575     
          Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                      580                 585                 590         
          Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                  595                 600                 605             
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
              610                 615                 620                 
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
          625                 630                 635                 640 
          Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                          645                 650                 655     
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                      660                 665                 670         
          Leu Ser Pro Gly Lys 
                  675         
          <![CDATA[<210>  78]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK151，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  78]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Gln 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Lys Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                  435                 440                 445             
          Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
              450                 455                 460                 
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
          465                 470                 475                 480 
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                          485                 490                 495     
          Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                      500                 505                 510         
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                  515                 520                 525             
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
              530                 535                 540                 
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
          545                 550                 555                 560 
          Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                          565                 570                 575     
          Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                      580                 585                 590         
          Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                  595                 600                 605             
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
              610                 615                 620                 
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
          625                 630                 635                 640 
          Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                          645                 650                 655     
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                      660                 665                 670         
          Leu Ser Pro Gly Lys 
                  675         
          <![CDATA[<210>  79]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK152，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  79]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Gln 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Arg Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                  435                 440                 445             
          Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
              450                 455                 460                 
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
          465                 470                 475                 480 
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                          485                 490                 495     
          Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                      500                 505                 510         
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                  515                 520                 525             
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
              530                 535                 540                 
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
          545                 550                 555                 560 
          Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                          565                 570                 575     
          Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                      580                 585                 590         
          Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                  595                 600                 605             
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
              610                 615                 620                 
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
          625                 630                 635                 640 
          Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                          645                 650                 655     
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                      660                 665                 670         
          Leu Ser Pro Gly Lys 
                  675         
          <![CDATA[<210>  80]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK153，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  80]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Gln 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Gln Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                  435                 440                 445             
          Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
              450                 455                 460                 
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
          465                 470                 475                 480 
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                          485                 490                 495     
          Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                      500                 505                 510         
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                  515                 520                 525             
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
              530                 535                 540                 
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
          545                 550                 555                 560 
          Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                          565                 570                 575     
          Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                      580                 585                 590         
          Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                  595                 600                 605             
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
              610                 615                 620                 
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
          625                 630                 635                 640 
          Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                          645                 650                 655     
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                      660                 665                 670         
          Leu Ser Pro Gly Lys 
                  675         
          <![CDATA[<210>  81]]>
          <![CDATA[<211>  680]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK154，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  81]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Gln 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Thr 
          225                 230                 235                 240 
          Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val 
                          245                 250                 255     
          Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala 
                      260                 265                 270         
          Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val 
                  275                 280                 285             
          Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser 
              290                 295                 300                 
          Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg 
          305                 310                 315                 320 
          Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe 
                          325                 330                 335     
          Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val 
                      340                 345                 350         
          Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
                  355                 360                 365             
          Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
              370                 375                 380                 
          His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
          385                 390                 395                 400 
          Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
                          405                 410                 415     
          Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
                      420                 425                 430         
          Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser 
                  435                 440                 445             
          Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
              450                 455                 460                 
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
          465                 470                 475                 480 
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                          485                 490                 495     
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                      500                 505                 510         
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                  515                 520                 525             
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
              530                 535                 540                 
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
          545                 550                 555                 560 
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                          565                 570                 575     
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                      580                 585                 590         
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                  595                 600                 605             
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
              610                 615                 620                 
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
          625                 630                 635                 640 
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                          645                 650                 655     
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                      660                 665                 670         
          Ser Leu Ser Leu Ser Pro Gly Lys 
                  675                 680 
          <![CDATA[<210>  82]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK155，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  82]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Gln 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                  435                 440                 445             
          Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
              450                 455                 460                 
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
          465                 470                 475                 480 
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                          485                 490                 495     
          Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                      500                 505                 510         
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                  515                 520                 525             
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
              530                 535                 540                 
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
          545                 550                 555                 560 
          Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                          565                 570                 575     
          Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
                      580                 585                 590         
          Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                  595                 600                 605             
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
              610                 615                 620                 
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
          625                 630                 635                 640 
          Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                          645                 650                 655     
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                      660                 665                 670         
          Leu Ser Pro Gly Lys 
                  675         
          <![CDATA[<210>  83]]>
          <![CDATA[<211>  451]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F1-M109，與MH110（SEQ ID NO:84）配對]]>
          <![CDATA[<400>  83]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
          225                 230                 235                 240 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Thr Cys Pro 
                          245                 250                 255     
          Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser 
                      260                 265                 270         
          Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys 
                  275                 280                 285             
          Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn 
              290                 295                 300                 
          Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Ser Gly Gly 
          305                 310                 315                 320 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          325                 330                 335     
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      340                 345                 350         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  355                 360                 365             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              370                 375                 380                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          385                 390                 395                 400 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          405                 410                 415     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      420                 425                 430         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  435                 440                 445             
          Asn Thr Ser 
              450     
          <![CDATA[<210>  84]]>
          <![CDATA[<211>  445]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F1-MH110]]>
          <![CDATA[<400>  84]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp 
                  435                 440                 445 
          <![CDATA[<210>  85]]>
          <![CDATA[<211>  453]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F1-M2003，與MH2004（SEQ ID NO:86）配對]]>
          <![CDATA[<400>  85]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly Gly 
          225                 230                 235                 240 
          Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
                          245                 250                 255     
          Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
                      260                 265                 270         
          Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
                  275                 280                 285             
          Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
              290                 295                 300                 
          Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
          305                 310                 315                 320 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
                          325                 330                 335     
          Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
                      340                 345                 350         
          Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
                  355                 360                 365             
          Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
              370                 375                 380                 
          Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
          385                 390                 395                 400 
          Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                          405                 410                 415     
          Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
                      420                 425                 430         
          Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
                  435                 440                 445             
          Phe Ile Asn Thr Ser 
              450             
          <![CDATA[<210>  86]]>
          <![CDATA[<211>  445]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F1-MH2004]]>
          <![CDATA[<400>  86]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
                  435                 440                 445 
          <![CDATA[<210>  87]]>
          <![CDATA[<211>  453]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F1-M2003，與M2005（SEQ ID NO:88）配對]]>
          <![CDATA[<400>  87]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly Gly 
          225                 230                 235                 240 
          Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
                          245                 250                 255     
          Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
                      260                 265                 270         
          Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
                  275                 280                 285             
          Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
              290                 295                 300                 
          Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
          305                 310                 315                 320 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
                          325                 330                 335     
          Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
                      340                 345                 350         
          Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
                  355                 360                 365             
          Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
              370                 375                 380                 
          Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
          385                 390                 395                 400 
          Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                          405                 410                 415     
          Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
                      420                 425                 430         
          Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
                  435                 440                 445             
          Phe Ile Asn Thr Ser 
              450             
          <![CDATA[<210>  88]]>
          <![CDATA[<211>  445]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F1-M2005]]>
          <![CDATA[<400>  88]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Gln Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Ala Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
                  435                 440                 445 
          <![CDATA[<210>  89]]>
          <![CDATA[<211>  419]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F2-M005，與MK5（SEQ ID NO:90）配對]]>
          <![CDATA[<400>  89]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Glu Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln 
          <![CDATA[<210>  90]]>
          <![CDATA[<211>  462]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F2-MK5]]>
          <![CDATA[<400>  90]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile 
          225                 230                 235                 240 
          Pro Val Ser Leu Arg Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val 
                          245                 250                 255     
          Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                      260                 265                 270         
          Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
                  275                 280                 285             
          Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
              290                 295                 300                 
          Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
          305                 310                 315                 320 
          Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
                          325                 330                 335     
          Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
                      340                 345                 350         
          Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly 
                  355                 360                 365             
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
              370                 375                 380                 
          Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
          385                 390                 395                 400 
          Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                          405                 410                 415     
          Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                      420                 425                 430         
          Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
                  435                 440                 445             
          Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro 
              450                 455                 460         
          <![CDATA[<210>  91]]>
          <![CDATA[<211>  444]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F2-M2006，與MK5（SEQ ID NO:90）配對]]>
          <![CDATA[<400>  91]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr 
          225                 230                 235                 240 
          Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp 
                          245                 250                 255     
          Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg 
                      260                 265                 270         
          Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser 
                  275                 280                 285             
          Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr 
              290                 295                 300                 
          Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg 
          305                 310                 315                 320 
          Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg 
                          325                 330                 335     
          Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg 
                      340                 345                 350         
          Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg 
                  355                 360                 365             
          His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu 
              370                 375                 380                 
          Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu 
          385                 390                 395                 400 
          Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys 
                          405                 410                 415     
          Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu 
                      420                 425                 430         
          Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp 
                  435                 440                 
          <![CDATA[<210>  92]]>
          <![CDATA[<211>  419]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F3-M006，與MK6（SEQ ID NO:93）配對]]>
          <![CDATA[<400>  92]]>
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          1               5                   10                  15      
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                      20                  25                  30          
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                  35                  40                  45              
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
              50                  55                  60                  
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
          65                  70                  75                  80  
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                          85                  90                  95      
          Asp Phe Lys Pro Glu Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                      100                 105                 110         
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                  115                 120                 125             
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
              130                 135                 140                 
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
          145                 150                 155                 160 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                          165                 170                 175     
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Gly Gly Gly 
                      180                 185                 190         
          Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                  195                 200                 205             
          Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
              210                 215                 220                 
          Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
          225                 230                 235                 240 
          His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                          245                 250                 255     
          Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                      260                 265                 270         
          Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                  275                 280                 285             
          Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
              290                 295                 300                 
          Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
          305                 310                 315                 320 
          Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                          325                 330                 335     
          Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                      340                 345                 350         
          Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                  355                 360                 365             
          Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
              370                 375                 380                 
          Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
          385                 390                 395                 400 
          Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                          405                 410                 415     
          Ser Pro Gly 
          <![CDATA[<210>  93]]>
          <![CDATA[<211>  462]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F3-MK6]]>
          <![CDATA[<400>  93]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Asn Thr Ser Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly 
              210                 215                 220                 
          Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Lys Thr His 
          225                 230                 235                 240 
          Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                          245                 250                 255     
          Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                      260                 265                 270         
          Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                  275                 280                 285             
          Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
              290                 295                 300                 
          Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
          305                 310                 315                 320 
          Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                          325                 330                 335     
          Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                      340                 345                 350         
          Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                  355                 360                 365             
          Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
              370                 375                 380                 
          Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
          385                 390                 395                 400 
          Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                          405                 410                 415     
          Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                      420                 425                 430         
          Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                  435                 440                 445             
          His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
              450                 455                 460         
          <![CDATA[<210>  94]]>
          <![CDATA[<211>  444]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體F3-M2007，與MK6（SEQ ID NO:93）配對]]>
          <![CDATA[<400>  94]]>
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          1               5                   10                  15      
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                      20                  25                  30          
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                  35                  40                  45              
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
              50                  55                  60                  
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
          65                  70                  75                  80  
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                          85                  90                  95      
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                      100                 105                 110         
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                  115                 120                 125             
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
              130                 135                 140                 
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
          145                 150                 155                 160 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                          165                 170                 175     
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                      180                 185                 190         
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                  195                 200                 205             
          Ala Leu Gly Lys Asp Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys 
              210                 215                 220                 
          Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
          225                 230                 235                 240 
          Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                          245                 250                 255     
          Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                      260                 265                 270         
          Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                  275                 280                 285             
          Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
              290                 295                 300                 
          Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
          305                 310                 315                 320 
          Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                          325                 330                 335     
          Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
                      340                 345                 350         
          Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
                  355                 360                 365             
          Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
              370                 375                 380                 
          Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
          385                 390                 395                 400 
          Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                          405                 410                 415     
          Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                      420                 425                 430         
          His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                  435                 440                 
          <![CDATA[<210>  95]]>
          <![CDATA[<211>  584]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體G1-M108，與MH4（SEQ ID NO: 96）配對]]>
          <![CDATA[<400>  95]]>
          Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          1               5                   10                  15      
          Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                      20                  25                  30          
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                  35                  40                  45              
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
              50                  55                  60                  
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
          65                  70                  75                  80  
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                          85                  90                  95      
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                      100                 105                 110         
          Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
                  115                 120                 125             
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
              130                 135                 140                 
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
          145                 150                 155                 160 
          Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                          165                 170                 175     
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                      180                 185                 190         
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                  195                 200                 205             
          Ala Leu Gly Lys Asp Gly Gly Gly Ser Ile Pro Val Ser Leu Arg Ser 
              210                 215                 220                 
          Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Asn Trp 
          225                 230                 235                 240 
          Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
                          245                 250                 255     
          Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
                      260                 265                 270         
          Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
                  275                 280                 285             
          Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
              290                 295                 300                 
          Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
          305                 310                 315                 320 
          Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
                          325                 330                 335     
          Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
                      340                 345                 350         
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                  355                 360                 365             
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
              370                 375                 380                 
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
          385                 390                 395                 400 
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                          405                 410                 415     
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                      420                 425                 430         
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                  435                 440                 445             
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
              450                 455                 460                 
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
          465                 470                 475                 480 
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
                          485                 490                 495     
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                      500                 505                 510         
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                  515                 520                 525             
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
              530                 535                 540                 
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
          545                 550                 555                 560 
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                          565                 570                 575     
          Ser Leu Ser Leu Ser Pro Gly Lys 
                      580                 
          <![CDATA[<210>  96]]>
          <![CDATA[<211>  297]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體G1-MH4]]>
          <![CDATA[<400>  96]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
          65                  70                  75                  80  
          Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                          85                  90                  95      
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                      100                 105                 110         
          Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                  115                 120                 125             
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
              130                 135                 140                 
          Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
          145                 150                 155                 160 
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                          165                 170                 175     
          Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                      180                 185                 190         
          Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                  195                 200                 205             
          Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
              210                 215                 220                 
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
          225                 230                 235                 240 
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                          245                 250                 255     
          Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                      260                 265                 270         
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                  275                 280                 285             
          Lys Ser Leu Ser Leu Ser Pro Gly Lys 
              290                 295         
          <![CDATA[<210>  97]]>
          <![CDATA[<211>  583]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體G2-M112，與MK113（SEQ ID NO: 98）配對]]>
          <![CDATA[<400>  97]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Asn Trp Val Asn Val Ile Ser Asp Leu 
          225                 230                 235                 240 
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                          245                 250                 255     
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                      260                 265                 270         
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
                  275                 280                 285             
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
              290                 295                 300                 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
          305                 310                 315                 320 
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                          325                 330                 335     
          Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Ser Ile Pro Val 
                      340                 345                 350         
          Ser Leu Arg Ser Gly Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser 
                  355                 360                 365             
          Gly Gly Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser 
              370                 375                 380                 
          Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp 
          385                 390                 395                 400 
          Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln 
                          405                 410                 415     
          Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu 
                      420                 425                 430         
          Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val 
                  435                 440                 445             
          Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala 
              450                 455                 460                 
          Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile 
          465                 470                 475                 480 
          Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp 
                          485                 490                 495     
          Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu 
                      500                 505                 510         
          Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu 
                  515                 520                 525             
          Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro 
              530                 535                 540                 
          Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu 
          545                 550                 555                 560 
          Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys 
                          565                 570                 575     
          Pro Ala Ala Leu Gly Lys Asp 
                      580             
          <![CDATA[<210>  98]]>
          <![CDATA[<211>  296]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體G2-MK113]]>
          <![CDATA[<400>  98]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
          225                 230                 235                 240 
          Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                          245                 250                 255     
          Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
                      260                 265                 270         
          Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
                  275                 280                 285             
          Thr Pro Ser Leu Lys Cys Ile Arg 
              290                 295     
          <![CDATA[<210>  99]]>
          <![CDATA[<211>  900]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體H1-M001，與MH333LC（SEQ ID NO:100）配對]]>
          <![CDATA[<400>  99]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
                      20                  25                  30          
          Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                          85                  90                  95      
          Lys Pro Tyr Gly Thr Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                  115                 120                 125             
          Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
              130                 135                 140                 
          Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
          145                 150                 155                 160 
          Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                          165                 170                 175     
          Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                      180                 185                 190         
          Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                  195                 200                 205             
          Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
              210                 215                 220                 
          Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe 
          225                 230                 235                 240 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          245                 250                 255     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      260                 265                 270         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  275                 280                 285             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              290                 295                 300                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          305                 310                 315                 320 
          Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
                          325                 330                 335     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                      340                 345                 350         
          Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                  355                 360                 365             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              370                 375                 380                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          385                 390                 395                 400 
          Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          405                 410                 415     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      420                 425                 430         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn 
              450                 455                 460                 
          Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln 
          465                 470                 475                 480 
          Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn 
                          485                 490                 495     
          Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn 
                      500                 505                 510         
          Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile 
                  515                 520                 525             
          Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met 
              530                 535                 540                 
          Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro 
          545                 550                 555                 560 
          Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser 
                          565                 570                 575     
          Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe 
                      580                 585                 590         
          Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu 
                  595                 600                 605             
          Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr 
              610                 615                 620                 
          Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly 
          625                 630                 635                 640 
          Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr 
                          645                 650                 655     
          Lys Pro Ala Ala Leu Gly Lys Asp Gly Gly Gly Ser Ser Gly Gly Ser 
                      660                 665                 670         
          Gly Gly Ser Gly Gly Ile Pro Val Ser Leu Arg Ser Gly Gly Gly Gly 
                  675                 680                 685             
          Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
              690                 695                 700                 
          Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
          705                 710                 715                 720 
          Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                          725                 730                 735     
          Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
                      740                 745                 750         
          Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              770                 775                 780                 
          Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
          785                 790                 795                 800 
          Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
                          805                 810                 815     
          Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
                      820                 825                 830         
          Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
                  835                 840                 845             
          Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
              850                 855                 860                 
          Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
          865                 870                 875                 880 
          Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
                          885                 890                 895     
          Ile Asn Thr Ser 
                      900 
          <![CDATA[<210>  100]]>
          <![CDATA[<211>  215]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體H1-MH333 LC]]>
          <![CDATA[<400>  100]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Val 
                      20                  25                  30          
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                          85                  90                  95      
          Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
                      100                 105                 110         
          Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                  115                 120                 125             
          Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
              130                 135                 140                 
          Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
          145                 150                 155                 160 
          Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                          165                 170                 175     
          Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
                      180                 185                 190         
          Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                  195                 200                 205             
          Ser Phe Asn Arg Gly Glu Cys 
              210                 215 
          <![CDATA[<210>  101]]>
          <![CDATA[<211>  900]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體H2-M002，與MH2 SEQ ID NO: 102和MH333 LC SEQ ID NO:100配對]]>
          <![CDATA[<400>  101]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
                      20                  25                  30          
          Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                          85                  90                  95      
          Lys Pro Tyr Gly Thr Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                  115                 120                 125             
          Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
              130                 135                 140                 
          Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
          145                 150                 155                 160 
          Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                          165                 170                 175     
          Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                      180                 185                 190         
          Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                  195                 200                 205             
          Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
              210                 215                 220                 
          Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe 
          225                 230                 235                 240 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          245                 250                 255     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      260                 265                 270         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  275                 280                 285             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              290                 295                 300                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          305                 310                 315                 320 
          Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
                          325                 330                 335     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                      340                 345                 350         
          Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
                  355                 360                 365             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              370                 375                 380                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          385                 390                 395                 400 
          Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          405                 410                 415     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      420                 425                 430         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn 
              450                 455                 460                 
          Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln 
          465                 470                 475                 480 
          Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn 
                          485                 490                 495     
          Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn 
                      500                 505                 510         
          Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile 
                  515                 520                 525             
          Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met 
              530                 535                 540                 
          Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro 
          545                 550                 555                 560 
          Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser 
                          565                 570                 575     
          Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe 
                      580                 585                 590         
          Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu 
                  595                 600                 605             
          Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr 
              610                 615                 620                 
          Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly 
          625                 630                 635                 640 
          Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr 
                          645                 650                 655     
          Lys Pro Ala Ala Leu Gly Lys Asp Gly Gly Gly Ser Ser Gly Gly Ser 
                      660                 665                 670         
          Gly Gly Ser Gly Gly Ile Pro Val Ser Leu Arg Ser Gly Gly Gly Gly 
                  675                 680                 685             
          Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
              690                 695                 700                 
          Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
          705                 710                 715                 720 
          Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
                          725                 730                 735     
          Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
                      740                 745                 750         
          Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              770                 775                 780                 
          Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
          785                 790                 795                 800 
          Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
                          805                 810                 815     
          Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
                      820                 825                 830         
          Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
                  835                 840                 845             
          Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
              850                 855                 860                 
          Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
          865                 870                 875                 880 
          Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
                          885                 890                 895     
          Ile Asn Thr Ser 
                      900 
          <![CDATA[<210>  102]]>
          <![CDATA[<211>  446]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體H2-MH2]]>
          <![CDATA[<400>  102]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
                      20                  25                  30          
          Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                          85                  90                  95      
          Lys Pro Tyr Gly Thr Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                  115                 120                 125             
          Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
              130                 135                 140                 
          Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
          145                 150                 155                 160 
          Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                          165                 170                 175     
          Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                      180                 185                 190         
          Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                  195                 200                 205             
          Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
              210                 215                 220                 
          Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe 
          225                 230                 235                 240 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          245                 250                 255     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      260                 265                 270         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  275                 280                 285             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              290                 295                 300                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          305                 310                 315                 320 
          Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
                          325                 330                 335     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
                      340                 345                 350         
          Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
                  355                 360                 365             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              370                 375                 380                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          385                 390                 395                 400 
          Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          405                 410                 415     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      420                 425                 430         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                  435                 440                 445     
          <![CDATA[<210>  103]]>
          <![CDATA[<211>  673]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體K1-MK3，與MH3（SEQ ID NO: 104）和MH333 LC（SEQ ID NO:100）配對]]>
          <![CDATA[<400>  103]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
                      20                  25                  30          
          Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                          85                  90                  95      
          Lys Pro Tyr Gly Thr Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                  115                 120                 125             
          Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
              130                 135                 140                 
          Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
          145                 150                 155                 160 
          Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                          165                 170                 175     
          Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                      180                 185                 190         
          Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                  195                 200                 205             
          Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
              210                 215                 220                 
          Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe 
          225                 230                 235                 240 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          245                 250                 255     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      260                 265                 270         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  275                 280                 285             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              290                 295                 300                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          305                 310                 315                 320 
          Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
                          325                 330                 335     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                      340                 345                 350         
          Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
                  355                 360                 365             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              370                 375                 380                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          385                 390                 395                 400 
          Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          405                 410                 415     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      420                 425                 430         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
                  435                 440                 445             
          Gly Ser Ile Pro Val Ser Leu Arg Ser Gly Gly Gly Gly Ser Ile Thr 
              450                 455                 460                 
          Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
          465                 470                 475                 480 
          Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
                          485                 490                 495     
          Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
                      500                 505                 510         
          Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                  515                 520                 525             
          Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly Ser Gly 
              530                 535                 540                 
          Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn 
          545                 550                 555                 560 
          Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
                          565                 570                 575     
          Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
                      580                 585                 590         
          Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
                  595                 600                 605             
          Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
              610                 615                 620                 
          Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
          625                 630                 635                 640 
          Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
                          645                 650                 655     
          Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
                      660                 665                 670         
          Ser 
          <![CDATA[<210>  104]]>
          <![CDATA[<211>  665]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體K1-MH3]]>
          <![CDATA[<400>  104]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
                      20                  25                  30          
          Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                          85                  90                  95      
          Lys Pro Tyr Gly Thr Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                  115                 120                 125             
          Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
              130                 135                 140                 
          Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
          145                 150                 155                 160 
          Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                          165                 170                 175     
          Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                      180                 185                 190         
          Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                  195                 200                 205             
          Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
              210                 215                 220                 
          Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe 
          225                 230                 235                 240 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          245                 250                 255     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      260                 265                 270         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  275                 280                 285             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              290                 295                 300                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          305                 310                 315                 320 
          Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
                          325                 330                 335     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
                      340                 345                 350         
          Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
                  355                 360                 365             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              370                 375                 380                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          385                 390                 395                 400 
          Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          405                 410                 415     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      420                 425                 430         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn 
              450                 455                 460                 
          Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln 
          465                 470                 475                 480 
          Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn 
                          485                 490                 495     
          Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn 
                      500                 505                 510         
          Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile 
                  515                 520                 525             
          Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met 
              530                 535                 540                 
          Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro 
          545                 550                 555                 560 
          Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Ala Asn Ile Ser 
                          565                 570                 575     
          Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe 
                      580                 585                 590         
          Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu 
                  595                 600                 605             
          Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu Glu Thr Leu Thr 
              610                 615                 620                 
          Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly 
          625                 630                 635                 640 
          Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr 
                          645                 650                 655     
          Lys Pro Ala Ala Leu Gly Lys Asp Thr 
                      660                 665 
          <![CDATA[<210>  105]]>
          <![CDATA[<211>  682]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體K2-MK4，與MH3（SEQ ID NO: 106）和MH333 LC（SEQ ID NO:100）配對]]>
          <![CDATA[<400>  105]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
                      20                  25                  30          
          Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                          85                  90                  95      
          Lys Pro Tyr Gly Thr Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                  115                 120                 125             
          Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
              130                 135                 140                 
          Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
          145                 150                 155                 160 
          Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                          165                 170                 175     
          Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                      180                 185                 190         
          Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                  195                 200                 205             
          Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
              210                 215                 220                 
          Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe 
          225                 230                 235                 240 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          245                 250                 255     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      260                 265                 270         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  275                 280                 285             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              290                 295                 300                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          305                 310                 315                 320 
          Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
                          325                 330                 335     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                      340                 345                 350         
          Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
                  355                 360                 365             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              370                 375                 380                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          385                 390                 395                 400 
          Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          405                 410                 415     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      420                 425                 430         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
                  435                 440                 445             
          Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ile Pro Val Ser Leu 
              450                 455                 460                 
          Arg Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val Ile Ser Asp Leu 
          465                 470                 475                 480 
          Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
                          485                 490                 495     
          Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
                      500                 505                 510         
          Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
                  515                 520                 525             
          Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
              530                 535                 540                 
          Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
          545                 550                 555                 560 
          Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
                          565                 570                 575     
          Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Ser Gly Gly Gly 
                      580                 585                 590         
          Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Ile Thr Cys 
                  595                 600                 605             
          Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr 
              610                 615                 620                 
          Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg 
          625                 630                 635                 640 
          Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr 
                          645                 650                 655     
          Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro 
                      660                 665                 670         
          Ala Leu Val His Gln Arg Pro Ala Pro Pro 
                  675                 680         
          <![CDATA[<210>  106]]>
          <![CDATA[<211>  665]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體K2-MH3]]>
          <![CDATA[<400>  106]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
                      20                  25                  30          
          Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                          85                  90                  95      
          Lys Pro Tyr Gly Thr Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                  115                 120                 125             
          Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
              130                 135                 140                 
          Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
          145                 150                 155                 160 
          Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                          165                 170                 175     
          Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                      180                 185                 190         
          Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                  195                 200                 205             
          Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
              210                 215                 220                 
          Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe 
          225                 230                 235                 240 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          245                 250                 255     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      260                 265                 270         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  275                 280                 285             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              290                 295                 300                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          305                 310                 315                 320 
          Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
                          325                 330                 335     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
                      340                 345                 350         
          Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
                  355                 360                 365             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              370                 375                 380                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          385                 390                 395                 400 
          Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          405                 410                 415     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      420                 425                 430         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn 
              450                 455                 460                 
          Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln 
          465                 470                 475                 480 
          Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn 
                          485                 490                 495     
          Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn 
                      500                 505                 510         
          Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile 
                  515                 520                 525             
          Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met 
              530                 535                 540                 
          Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro 
          545                 550                 555                 560 
          Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Ala Asn Ile Ser 
                          565                 570                 575     
          Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe 
                      580                 585                 590         
          Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu 
                  595                 600                 605             
          Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Thr Leu Glu Thr Leu Thr 
              610                 615                 620                 
          Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly 
          625                 630                 635                 640 
          Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr 
                          645                 650                 655     
          Lys Pro Ala Ala Leu Gly Lys Asp Thr 
                      660                 665 
          <![CDATA[<210>  107]]>
          <![CDATA[<211>  346]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體M-MK143，與MK144（SEQ ID NO:108）和MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  107]]>
          Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser 
          1               5                   10                  15      
          Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val 
                      20                  25                  30          
          His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu 
                  35                  40                  45              
          Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro 
              50                  55                  60                  
          Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu 
          65                  70                  75                  80  
          Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys 
                          85                  90                  95      
          Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val 
                      100                 105                 110         
          His Val Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala 
                  115                 120                 125             
          Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser 
              130                 135                 140                 
          Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys 
          145                 150                 155                 160 
          Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu 
                          165                 170                 175     
          Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser 
                      180                 185                 190         
          Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly 
                  195                 200                 205             
          Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg Ser Ala Ser Gly Gly Ser 
              210                 215                 220                 
          Gly Gly Gly Gly Ser Gly Ser Gly Asn Trp Val Asn Val Ile Ser Asp 
          225                 230                 235                 240 
          Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
                          245                 250                 255     
          Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
                      260                 265                 270         
          Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Cys Glu Ser Gly Asp 
                  275                 280                 285             
          Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Gln Asp 
              290                 295                 300                 
          Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
          305                 310                 315                 320 
          Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
                          325                 330                 335     
          His Ile Val Gln Met Phe Ile Gln Thr Ser 
                      340                 345     
          <![CDATA[<210>  108]]>
          <![CDATA[<211>  305]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體M-MK144]]>
          <![CDATA[<400>  108]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Cys Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Glu Pro Lys Ser Ser Asp Lys 
          65                  70                  75                  80  
          Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                          85                  90                  95      
          Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                      100                 105                 110         
          Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                  115                 120                 125             
          Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
              130                 135                 140                 
          Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
          145                 150                 155                 160 
          Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                          165                 170                 175     
          Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                      180                 185                 190         
          Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                  195                 200                 205             
          Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
              210                 215                 220                 
          Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
          225                 230                 235                 240 
          Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                          245                 250                 255     
          Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                      260                 265                 270         
          Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                  275                 280                 285             
          Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
              290                 295                 300                 
          Lys 
          305 
          <![CDATA[<210>  109]]>
          <![CDATA[<211>  680]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體N-MK142，與MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  109]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Thr Cys 
          225                 230                 235                 240 
          Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr 
                          245                 250                 255     
          Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg 
                      260                 265                 270         
          Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr 
                  275                 280                 285             
          Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro 
              290                 295                 300                 
          Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly Ser Gly Gly 
          305                 310                 315                 320 
          Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp 
                          325                 330                 335     
          Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
                      340                 345                 350         
          Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
                  355                 360                 365             
          Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
              370                 375                 380                 
          Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
          385                 390                 395                 400 
          Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
                          405                 410                 415     
          Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
                      420                 425                 430         
          Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Gln Thr Ser 
                  435                 440                 445             
          Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg Ser Ala Ser 
              450                 455                 460                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Thr Ser Gln Phe 
          465                 470                 475                 480 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          485                 490                 495     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      500                 505                 510         
          Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  515                 520                 525             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              530                 535                 540                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          545                 550                 555                 560 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          565                 570                 575     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      580                 585                 590         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  595                 600                 605             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              610                 615                 620                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          625                 630                 635                 640 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          645                 650                 655     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      660                 665                 670         
          Leu Ala Phe Arg Thr Lys Pro Ala 
                  675                 680 
          <![CDATA[<210>  110]]>
          <![CDATA[<211>  73]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體P-MK147，與MK148（SEQ ID NO:111）和MH7（SEQ ID NO:52）配對]]>
          <![CDATA[<400>  110]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Cys Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg 
          65                  70              
          <![CDATA[<210>  111]]>
          <![CDATA[<211>  583]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體P-MK148]]>
          <![CDATA[<400>  111]]>
          Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
          1               5                   10                  15      
          Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
                      20                  25                  30          
          Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                  35                  40                  45              
          Val Ile Ser Cys Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
              50                  55                  60                  
          Asn Leu Ile Ile Leu Ala Gln Asp Ser Leu Ser Ser Asn Gly Asn Val 
          65                  70                  75                  80  
          Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                          85                  90                  95      
          Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Gln 
                      100                 105                 110         
          Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg Ser 
                  115                 120                 125             
          Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Thr Ser 
              130                 135                 140                 
          Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp 
          145                 150                 155                 160 
          Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
                          165                 170                 175     
          Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
                      180                 185                 190         
          Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                  195                 200                 205             
          Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
              210                 215                 220                 
          Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
          225                 230                 235                 240 
          Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
                          245                 250                 255     
          Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
                      260                 265                 270         
          Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                  275                 280                 285             
          Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
              290                 295                 300                 
          Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
          305                 310                 315                 320 
          Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
                          325                 330                 335     
          Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly 
                      340                 345                 350         
          Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                  355                 360                 365             
          Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
              370                 375                 380                 
          Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
          385                 390                 395                 400 
          Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                          405                 410                 415     
          Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                      420                 425                 430         
          Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                  435                 440                 445             
          Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
              450                 455                 460                 
          Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
          465                 470                 475                 480 
          Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
                          485                 490                 495     
          Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                      500                 505                 510         
          Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                  515                 520                 525             
          Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
              530                 535                 540                 
          Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
          545                 550                 555                 560 
          Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                          565                 570                 575     
          Leu Ser Leu Ser Pro Gly Lys 
                      580             
          <![CDATA[<210>  112]]>
          <![CDATA[<211>  232]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（99-330）]]>
          <![CDATA[<400>  112]]>
          Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly Lys 
          225                 230         
          <![CDATA[<210>  113]]>
          <![CDATA[<211>  232]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（99-330，C103S）]]>
          <![CDATA[<400>  113]]>
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly Lys 
          225                 230         
          <![CDATA[<210>  114]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（104-330）]]>
          <![CDATA[<400>  114]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  115]]>
          <![CDATA[<211>  231]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（99-329，C103S）]]>
          <![CDATA[<400>  115]]>
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly 
          225                 230     
          <![CDATA[<210>  116]]>
          <![CDATA[<211>  226]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（104-329）]]>
          <![CDATA[<400>  116]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly 
          225     
          <![CDATA[<210>  117]]>
          <![CDATA[<211>  232]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（99-330，C103S，S354C，T366W）杵]]>
          <![CDATA[<400>  117]]>
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly Lys 
          225                 230         
          <![CDATA[<210>  118]]>
          <![CDATA[<211>  232]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（99-330，C103S，Y349C，T366S，L368A，Y407V） ]]>
                 臼
          <![CDATA[<400>  118]]>
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly Lys 
          225                 230         
          <![CDATA[<210>  119]]>
          <![CDATA[<211>  231]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（99-329，C103S，S354C，T366W）杵]]>
          <![CDATA[<400>  119]]>
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly 
          225                 230     
          <![CDATA[<210>  120]]>
          <![CDATA[<211>  231]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（99-329，C103S，Y349C，T366S，L368A，Y407V） ]]>
                 臼
          <![CDATA[<400>  120]]>
          Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
          1               5                   10                  15      
          Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                      20                  25                  30          
          Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                  35                  40                  45              
          Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
              50                  55                  60                  
          Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
          65                  70                  75                  80  
          Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                          85                  90                  95      
          Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                      100                 105                 110         
          Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                  115                 120                 125             
          Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
              130                 135                 140                 
          Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
          145                 150                 155                 160 
          Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                          165                 170                 175     
          Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
                      180                 185                 190         
          Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                  195                 200                 205             
          Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
              210                 215                 220                 
          Ser Leu Ser Leu Ser Pro Gly 
          225                 230     
          <![CDATA[<210>  121]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（104-330，S354C，T366W）杵]]>
          <![CDATA[<400>  121]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  122]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（104-330，S354C，T366W）杵]]>
          <![CDATA[<400>  122]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  123]]>
          <![CDATA[<211>  226]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（104-329，S354C，T366W）杵]]>
          <![CDATA[<400>  123]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly 
          225     
          <![CDATA[<210>  124]]>
          <![CDATA[<211>  226]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IgHG1（104-329，Y349C，T366S，L368A，Y407V）臼]]>
          <![CDATA[<400>  124]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly 
          225     
          <![CDATA[<210>  125]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IGHG1（104-330，T366W），杵]]>
          <![CDATA[<400>  125]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  126]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  IgGGHG1-Fc，IGHG1（104-330，T366S，L368A，Y407V）臼]]>
          <![CDATA[<400>  126]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  127]]>
          <![CDATA[<211>  20]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  127]]>
          Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
          1               5                   10                  15      
          Gly Ser Leu Gln 
                      20  
          <![CDATA[<210>  128]]>
          <![CDATA[<211>  3]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  128]]>
          Gly Gly Ser 
          1           
          <![CDATA[<210>  129]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  129]]>
          Gly Gly Gly Ser 
          1               
          <![CDATA[<210>  130]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  130]]>
          Gly Gly Gly Gly Ser 
          1               5   
          <![CDATA[<210>  131]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  131]]>
          Gly Gly Gly Ser Ser Gly Gly Ser 
          1               5               
          <![CDATA[<210>  132]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  132]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          1               5                   10  
          <![CDATA[<210>  133]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  133]]>
          Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly 
          1               5                   10          
          <![CDATA[<210>  134]]>
          <![CDATA[<211>  13]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  134]]>
          Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
          1               5                   10              
          <![CDATA[<210>  135]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  135]]>
          Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
          1               5                   10                  
          <![CDATA[<210>  136]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  136]]>
          Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
          1               5                   10                  15  
          <![CDATA[<210>  137]]>
          <![CDATA[<211>  24]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  137]]>
          Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
          1               5                   10                  15      
          Gly Ser Gly Gly Gly Gly Ser Gly 
                      20                  
          <![CDATA[<210>  138]]>
          <![CDATA[<211>  25]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  138]]>
          Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Ser 
          1               5                   10                  15      
          Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                      20                  25  
          <![CDATA[<210>  139]]>
          <![CDATA[<211>  25]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  139]]>
          Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Gly Gly Ser Ser Gly Gly Ser 
                      20                  25  
          <![CDATA[<210>  140]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  140]]>
          Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Gly 
          1               5                   10      
          <![CDATA[<210>  141]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  141]]>
          Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Ser 
          <![CDATA[<210>  142]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  142]]>
          Gly Gly Ser Gly 
          1               
          <![CDATA[<210>  143]]>
          <![CDATA[<211>  22]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  GGGSSGGSGGSGGSGGGSGGGS]]>
          <![CDATA[<400>  143]]>
          Gly Gly Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
          1               5                   10                  15      
          Gly Ser Gly Gly Gly Ser 
                      20          
          <![CDATA[<210>  144]]>
          <![CDATA[<211>  26]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  144]]>
          Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
                      20                  25      
          <![CDATA[<210>  145]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  145]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          1               5                   10                  15  
          <![CDATA[<210>  146]]>
          <![CDATA[<211>  20]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  146]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Gly Ser 
                      20  
          <![CDATA[<210>  147]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  147]]>
          Gly Gly Gly Gly Ser Ser Gly 
          1               5           
          <![CDATA[<210>  148]]>
          <![CDATA[<211>  24]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  148]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
          1               5                   10                  15      
          Gly Gly Ser Gly Gly Ser Gly Gly 
                      20                  
          <![CDATA[<210>  149]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  149]]>
          Ser Gly Gly Ser Gly Gly Gly Gly Ser 
          1               5                   
          <![CDATA[<210>  150]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  連接子]]>
          <![CDATA[<400>  150]]>
          Ser Gly Gly Ser Gly Gly 
          1               5       
          <![CDATA[<210>  151]]>
          <![CDATA[<211>  13]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  151]]>
          Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His 
          1               5                   10              
          <![CDATA[<210>  152]]>
          <![CDATA[<211>  13]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  152]]>
          Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Ala Asn Pro 
          1               5                   10              
          <![CDATA[<210>  153]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  153]]>
          Leu Ser Gly Arg Ser Asp Asn His 
          1               5               
          <![CDATA[<210>  154]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  154]]>
          Leu Ser Gly Arg Ser Ala Asn Pro 
          1               5               
          <![CDATA[<210>  155]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  155]]>
          Pro Leu Gly Leu Ala Gly 
          1               5       
          <![CDATA[<210>  156]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  156]]>
          Ile Pro Val Ser Leu Arg Ser Gly 
          1               5               
          <![CDATA[<210>  157]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  157]]>
          Gly Pro Gln Gly Ile Ala Gly Gln 
          1               5               
          <![CDATA[<210>  158]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  158]]>
          Val Pro Met Ser Met Arg Gly Gly 
          1               5               
          <![CDATA[<210>  159]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  159]]>
          Arg Pro Met Ser Met Ile Met Gly 
          1               5               
          <![CDATA[<210>  160]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  160]]>
          Val Pro Leu Ser Leu Thr Met Gly 
          1               5               
          <![CDATA[<210>  161]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  161]]>
          Val Pro Leu Ser Leu Tyr Ser Gly 
          1               5               
          <![CDATA[<210>  162]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  162]]>
          Ile Pro Glu Ser Leu Arg Ala Gly 
          1               5               
          <![CDATA[<210>  163]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  163]]>
          Ile Pro Val Ser Leu Arg Ser Gly Trp Arg 
          1               5                   10  
          <![CDATA[<210>  164]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  164]]>
          Ile Pro Val Ser Leu Arg Ser Gly Arg Ser Ala 
          1               5                   10      
          <![CDATA[<210>  165]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  165]]>
          Val Pro Leu Ser Leu Tyr Ser Gly Trp Arg 
          1               5                   10  
          <![CDATA[<210>  166]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  166]]>
          Val Pro Leu Ser Leu Tyr Ser Gly Arg Ser Ala 
          1               5                   10      
          <![CDATA[<210>  167]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  167]]>
          Gly Ala Ala Asn Leu Val Arg Gly 
          1               5               
          <![CDATA[<210>  168]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  168]]>
          Gly Tyr Ala Glu Leu Arg Met Gly 
          1               5               
          <![CDATA[<210>  169]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  169]]>
          Met Pro Tyr Asp Leu Tyr His Pro 
          1               5               
          <![CDATA[<210>  170]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  170]]>
          Arg Ile Gly Phe Leu Arg Thr Ala 
          1               5               
          <![CDATA[<210>  171]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  蛋白酶可活化部分]]>
          <![CDATA[<400>  171]]>
          Ala Arg Tyr Arg Trp Leu Thr Ala 
          1               5               
          <![CDATA[<210>  172]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體E3-MK157，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  172]]>
          Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
          1               5                   10                  15      
          Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                      20                  25                  30          
          Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
                  35                  40                  45              
          Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
              50                  55                  60                  
          Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
          65                  70                  75                  80  
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                          85                  90                  95      
          Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                      100                 105                 110         
          Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
                  115                 120                 125             
          His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
              130                 135                 140                 
          Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
          145                 150                 155                 160 
          Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Asn 
                          165                 170                 175     
          Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                      180                 185                 190         
          Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
                  195                 200                 205             
          Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg 
              210                 215                 220                 
          Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe 
          225                 230                 235                 240 
          Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln 
                          245                 250                 255     
          Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
                      260                 265                 270         
          Arg Arg Arg Trp Lys Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala 
                  275                 280                 285             
          Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu 
              290                 295                 300                 
          Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val 
          305                 310                 315                 320 
          Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu 
                          325                 330                 335     
          Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His 
                      340                 345                 350         
          Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu 
                  355                 360                 365             
          Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp 
              370                 375                 380                 
          Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser 
          385                 390                 395                 400 
          Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val 
                          405                 410                 415     
          Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro 
                      420                 425                 430         
          Leu Ala Phe Arg Thr Lys Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                  435                 440                 445             
          Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
              450                 455                 460                 
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
          465                 470                 475                 480 
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                          485                 490                 495     
          Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                      500                 505                 510         
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                  515                 520                 525             
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
              530                 535                 540                 
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
          545                 550                 555                 560 
          Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                          565                 570                 575     
          Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                      580                 585                 590         
          Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                  595                 600                 605             
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
              610                 615                 620                 
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
          625                 630                 635                 640 
          Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                          645                 650                 655     
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                      660                 665                 670         
          Leu Ser Pro Gly Lys 
                  675         
          <![CDATA[<210>  173]]>
          <![CDATA[<211>  677]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體N-MK156，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  173]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Thr Cys 
          225                 230                 235                 240 
          Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr 
                          245                 250                 255     
          Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg 
                      260                 265                 270         
          Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr 
                  275                 280                 285             
          Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro 
              290                 295                 300                 
          Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly Ser Gly Gly 
          305                 310                 315                 320 
          Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp 
                          325                 330                 335     
          Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
                      340                 345                 350         
          Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
                  355                 360                 365             
          Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
              370                 375                 380                 
          Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
          385                 390                 395                 400 
          Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser Asn Gly Gln Val Thr Glu 
                          405                 410                 415     
          Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
                      420                 425                 430         
          Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Gln Thr Ser 
                  435                 440                 445             
          Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly Arg Ser Ala Ser 
              450                 455                 460                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Ser Gln Phe Thr Cys Phe 
          465                 470                 475                 480 
          Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val Trp Ser Gln Asp Gly Ala 
                          485                 490                 495     
          Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg 
                      500                 505                 510         
          Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala 
                  515                 520                 525             
          Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val 
              530                 535                 540                 
          Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg 
          545                 550                 555                 560 
          Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met 
                          565                 570                 575     
          Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Ala Gln 
                      580                 585                 590         
          Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu 
                  595                 600                 605             
          Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala 
              610                 615                 620                 
          Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr 
          625                 630                 635                 640 
          Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu 
                          645                 650                 655     
          Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe 
                      660                 665                 670         
          Arg Thr Lys Pro Ala 
                  675         
          <![CDATA[<210>  174]]>
          <![CDATA[<211>  672]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體N-MK165，與MH8（SEQ ID NO:75）配對]]>
          <![CDATA[<400>  174]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser 
          225                 230                 235                 240 
          Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
                          245                 250                 255     
          Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
                      260                 265                 270         
          Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
                  275                 280                 285             
          Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln 
              290                 295                 300                 
          Arg Pro Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
          305                 310                 315                 320 
          Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser 
                          325                 330                 335     
          Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
                      340                 345                 350         
          Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
                  355                 360                 365             
          Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
              370                 375                 380                 
          Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Gln 
          385                 390                 395                 400 
          Asn Ser Leu Ser Ser Asn Gly Gln Val Thr Glu Ser Gly Cys Lys Glu 
                          405                 410                 415     
          Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
                      420                 425                 430         
          Val His Ile Val Gln Met Phe Ile Gln Thr Ser Gly Gly Gly Ser Val 
                  435                 440                 445             
          Pro Leu Ser Leu Tyr Ser Gly Arg Ser Ala Ser Gly Gly Ser Gly Gly 
              450                 455                 460                 
          Gly Gly Ser Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
          465                 470                 475                 480 
          Gln Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
                          485                 490                 495     
          Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
                      500                 505                 510         
          Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
                  515                 520                 525             
          Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
              530                 535                 540                 
          Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
          545                 550                 555                 560 
          Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
                          565                 570                 575     
          Gln Val Val His Val Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile 
                      580                 585                 590         
          Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
                  595                 600                 605             
          Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
              610                 615                 620                 
          Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr 
          625                 630                 635                 640 
          Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
                          645                 650                 655     
          Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                      660                 665                 670         
          <![CDATA[<210>  175]]>
          <![CDATA[<211>  891]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  構建體Q-MK14，與MH2（SEQ ID NO: 102）和MH333 LC（SEQ ID NO: 100）配對]]>
          <![CDATA[<400>  175]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
                      20                  25                  30          
          Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                          85                  90                  95      
          Lys Pro Tyr Gly Thr Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                  115                 120                 125             
          Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
              130                 135                 140                 
          Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
          145                 150                 155                 160 
          Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                          165                 170                 175     
          Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                      180                 185                 190         
          Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
                  195                 200                 205             
          Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
              210                 215                 220                 
          Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe 
          225                 230                 235                 240 
          Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                          245                 250                 255     
          Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                      260                 265                 270         
          Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                  275                 280                 285             
          Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
              290                 295                 300                 
          Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
          305                 310                 315                 320 
          Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
                          325                 330                 335     
          Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                      340                 345                 350         
          Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
                  355                 360                 365             
          Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
              370                 375                 380                 
          Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
          385                 390                 395                 400 
          Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                          405                 410                 415     
          Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                      420                 425                 430         
          Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
                  435                 440                 445             
          Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp 
              450                 455                 460                 
          Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys 
          465                 470                 475                 480 
          Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
                          485                 490                 495     
          Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu 
                      500                 505                 510         
          Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro 
                  515                 520                 525             
          Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
              530                 535                 540                 
          Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
          545                 550                 555                 560 
          Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
                          565                 570                 575     
          Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
                      580                 585                 590         
          Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                  595                 600                 605             
          Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Gln Asn Ser Leu Ser Ser 
              610                 615                 620                 
          Asn Gly Gln Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
          625                 630                 635                 640 
          Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
                          645                 650                 655     
          Met Phe Ile Gln Thr Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr 
                      660                 665                 670         
          Ser Gly Arg Ser Ala Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr 
                  675                 680                 685             
          Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Gln Ile Ser Cys Val 
              690                 695                 700                 
          Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala 
          705                 710                 715                 720 
          Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val 
                          725                 730                 735     
          Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser 
                      740                 745                 750         
          Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg 
                  755                 760                 765             
          Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe 
              770                 775                 780                 
          Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val 
          785                 790                 795                 800 
          Glu Thr His Arg Ala Gln Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
                          805                 810                 815     
          Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
                      820                 825                 830         
          His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
                  835                 840                 845             
          Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
              850                 855                 860                 
          Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
          865                 870                 875                 880 
          Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
                          885                 890

Claims (28)

  1. 一種介白素15（IL15）構建體，其包含至少一種IL15分子、至少一種IL15受體α（IL15Ra）結構域、至少一種蛋白酶可活化部分和至少一種IgG1 Fc區。
  2. 如請求項1所述的介白素15構建體，其中該構建體包含二價同源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IL15受體α（IL15Ra）結構域，連接至； b) 第一連接子（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 介白素2受體β（IL2Rb）結構域；和 f) IgG1 Fc區，其中該二價IL15構建體包含： (i) 示於SEQ ID NO:4（M123）的同源二聚體； (ii) 示於SEQ ID NO:5（M135）的同源二聚體； (iii) 示於SEQ ID NO:6（M140）的同源二聚體； (iv) 示於SEQ ID NO:7（M145）的同源二聚體； (v) 示於SEQ ID NO:8（M175）的同源二聚體； (vi) 示於SEQ ID NO:9（M176）的同源二聚體； (vii) 示於SEQ ID NO:10（M177）的同源二聚體； (viii) 示於SEQ ID NO:11（M178）的同源二聚體； (ix) 示於SEQ ID NO:12（M207）的同源二聚體； (x) 示於SEQ ID NO:13（M231）的同源二聚體； (xi) 示於SEQ ID NO:14（M233）的同源二聚體； (xii) 示於SEQ ID NO:15（M234）的同源二聚體； (xiii) 示於SEQ ID NO:16（M238）的同源二聚體； (xiv) 示於SEQ ID NO:17（M239）的同源二聚體； (xv) 示於SEQ ID NO:18（M240）的同源二聚體； (xvi) 示於SEQ ID NO:19（M241）的同源二聚體； (xvii) 示於SEQ ID NO:20（M243）的同源二聚體； (xviii) 示於SEQ ID NO:21（M244）的同源二聚體； (xix) 示於SEQ ID NO:22（M245）的同源二聚體； (xx) 示於SEQ ID NO:23（M246）的同源二聚體； (xxi) 示於SEQ ID NO:24（M247）的同源二聚體； (xxii) 示於SEQ ID NO:25（M248）的同源二聚體； (xxiii) 示於SEQ ID NO:26（M249）的同源二聚體； (xxiv) 示於SEQ ID NO:27（M327）的同源二聚體； (xxv) 示於SEQ ID NO:28（M328）的同源二聚體； (xxvi) 示於SEQ ID NO:29（M329）的同源二聚體； (xxvii) 示於SEQ ID NO:30（M330）的同源二聚體； (xxviii) 示於SEQ ID NO:31（M331）的同源二聚體；或 (xxix) 示於SEQ ID NO:32（M332）的同源二聚體。
  3. 如請求項1所述的介白素15構建體，其中該構建體包含二價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 介白素2受體β（IL2Rb）結構域，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域， 該結構域包含第一分子和第二分子，其從N-末端至C-末端包含： x) IL15受體α（IL15Ra）結構域；和 y) IgG1 Fc區，其中該二價異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:33（M43）的第一分子和示於SEQ ID NO:34（M24）的第二分子； (ii) 示於SEQ ID NO:35（M61）的第一分子和示於SEQ ID NO:36（M60）的第二分子；或 (iii) 示於SEQ ID NO:37（M62）的第一分子和示於SEQ ID NO:38（M60）的第二分子。
  4. 如請求項1所述的介白素15構建體，其中該構建體包含二價同源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IgG1 Fc區，連接至； b) 第一連接子（L1），連接至； c) 介白素2受體β（IL2Rb）結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域，連接至； f) 第三連接子（L3），連接至； g) IL15結構域；和 其中該二價IL15構建體包含： (i) 示於SEQ ID NO:42（M232）的同源二聚體； (ii) 示於SEQ ID NO:43（M1001）的同源二聚體； (iii) 示於SEQ ID NO:44（M1002）的同源二聚體； (vi) 示於SEQ ID NO:45（M1003）的同源二聚體； (v) 示於SEQ ID NO:46（M1004）的同源二聚體； (vi) 示於SEQ ID NO:47（M1005）的同源二聚體；或 (vii) 示於SEQ ID NO:48（M1006）的同源二聚體。
  5. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IL15受體α（IL15Ra）結構域，連接至； b) 第一連接子（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 介白素2受體β（IL2Rb）結構域；和 f) 第一IgG1 Fc區， 作為第一分子和第二分子，包含第二IgG1 Fc區，其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:49（MK107）的第一分子和示於SEQ ID NO:50（MH2）的第二分子。
  6. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 第一連接子（L1），連接至； c) 介白素2受體β（IL2Rb）結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），至； e) IL15受體α（IL15Ra）結構域，連接至； f) 第三連接子（L3），連接至； g) IL15結構域； 作為第一分子和第二分子，包含第二IgG1 Fc區，其中該一價異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:63（M111）的第一分子和示於SEQ ID NO:64（MH2）的第二分子； (ii) 示於SEQ ID NO:65（M2001）的第一分子和示於SEQ ID NO:52（MH7）的第二分子；或 (iii) 示於SEQ ID NO:66（M2002）的第一分子和示於SEQ ID NO:52（MH7）的第二分子。
  7. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) IL15受體α（IL15Ra）結構域，連接至； b) 第一連接子（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 介白素2受體β（IL2Rb）結構域，連接至； f) 第三連接子（L3），連接至； g) 第一IgG1 Fc區， 作為第一分子和第二分子，包含第二IgG1 Fc區，其中該一價異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:51（MK114）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (ii) 示於SEQ ID NO:53（MK115）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (iii) 示於SEQ ID NO:54（MK117）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (iv) 示於SEQ ID NO:55（MK118）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (v) 示於SEQ ID NO:56（MK119）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (vi) 示於SEQ ID NO:57（MK120）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (vii) 示於SEQ ID NO:58（MK121）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (viii) 示於SEQ ID NO:59（MK123）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (ix) 示於SEQ ID NO:60（MK124）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (x) 示於SEQ ID NO:61（MK125）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xi) 示於SEQ ID NO:62（MK126）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xii) 示於SEQ ID NO:67（MK136）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xiii) 示於SEQ ID NO:68（MK137）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xiv) 示於SEQ ID NO:69（MK138）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xv) 示於SEQ ID NO:70（MK139）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xvi) 示於SEQ ID NO:71（MK140）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xvii) 示於SEQ ID NO:72（MK141）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xviii) 示於SEQ ID NO:73（MK146）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (xix) 示於SEQ ID NO:74（MK145）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xx) 示於SEQ ID NO:76（MK149）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxi) 示於SEQ ID NO:77（MK150）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxii) 示於SEQ ID NO:78（MK151）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxiii) 示於SEQ ID NO:79（MK152）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxiv) 示於SEQ ID NO:80（MK153）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxv) 示於SEQ ID NO:81（MK154）的第一分子和示於SEQ ID NO:75（MH8）的第二分子； (xxvi) 示於SEQ ID NO:82（MK155）的第一分子和示於SEQ ID NO:52（MH7）的第二分子；或 (xxvii) 示於SEQ ID NO:172（MK157）的第一分子和示於SEQ ID NO:75（MH8）的第二分子。
  8. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15受體α（IL15Ra）結構域，連接至； d) 第二連接子（L2），連接至； e) IL15結構域； 作為第一分子和第二分子，包含： x) 第二IgG1 Fc區； y) 連接子（L3），連接至； z) 介白素2受體β（IL2Rb）結構域； 其中該一價異源二聚體IL15構建體包含： (i) 示於SEQ ID NO:83（M109）和示於SEQ ID NO:84（MH110）的異源二聚體； (ii) 示於SEQ ID NO:85（M2003）和示於SEQ ID NO:86（MH2004）的異源二聚體；或 (iii) 示於SEQ ID NO:87（M2003）和示於SEQ ID NO:88（MH2005）的異源二聚體。
  9. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 介白素2受體β（IL2Rb）結構域，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域和； d) 第一IgG1 Fc區； 作為第一分子和第二分子，包含： x) IL15受體α（IL15Ra）結構域，連接至； y) 連接子（L3），連接至； z) 第二IgG1 Fc區， 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:95（M108）的第一分子和示於SEQ ID NO:96（MH4）的第二分子。
  10. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 第一連接子（L1），連接至； c) IL15結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) 介白素2受體β（IL2Rb）結構域； 作為第一分子和第二分子，包含： x) 第二IgG1 Fc區，連接至； y) 連接子（L3），連接至； z) IL15受體α（IL15Ra）結構域， 其中該一價異源二聚體IL15構建體包含： 示於SEQ ID NO:97（M112）的第一分子和示於SEQ ID NO:98（MK113）的第二分子。
  11. 如請求項1所述的介白素15構建體，其中該構建體包含二價同源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； b) 第一連接子（L1），連接至； c) 介白素2受體β（IL2Rb）結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域，連接第三連接子（L3）至； f) IL15結構域； 其中該二價同源二聚體IL15構建體包含示於SEQ ID NO:99（M001）的序列和示於SEQ ID NO:100（MH333LC）的序列。
  12. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； b) 第一連接子（L1），連接至； c) 介白素2受體β（IL2Rb）結構域，連接至； d) 含有蛋白酶可活化部分的第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域，連接至第三連接子（L3），連接至； f) IL15結構域； 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:101（M002）的序列、示於SEQ ID NO:102（MH2）的序列和示於SEQ ID NO:100（MH333LC）的序列。
  13. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15受體α（IL15Ra）結構域，連接至； d) 第二連接子（L2），連接至； e) IL15結構域； 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:103（MK3）的序列，和 x) 包含第二IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； y) 第一連接子（L3），連接至； z) 介白素2受體β（IL2Rb）結構域， 其中該序列示於SEQ ID NO:104（MH3）以及示於SEQ ID NO:100（MH333LC）。
  14. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的第一腫瘤相關抗原（TAA）結合抗體，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域，連接至； d) 第二連接子（L2），連接至； e) IL15受體α（IL15Ra）結構域， 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:105（MK4）的序列，和 x) 具有第二IgG1 Fc區的第一腫瘤相關抗原（TAA）結合抗體，連接至； y) 第一連接子（L3），示於； z) 介白素2受體β（IL2Rb）結構域， 其中該序列示於SEQ ID NO:106（MH3）以及示於SEQ ID NO:100（MH333LC）。
  15. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 介白素2受體β（IL2Rb）結構域，連接至； b) 含有蛋白酶可活化部分的第一連接子（L1），連接至； c) IL15結構域； 作為第一分子；和 第二分子，包含 x) IL15受體α（IL15Ra）結構域；和 y) 第一IgG1 Fc區， 以及第三分子，包含第二IgG1 Fc區，其中該一價異源二聚體IL15構建體包含： 示於SEQ ID NO:107（MK143）的第一分子、示於SEQ ID NO:108（MK144）的第二分子和示於SEQ ID NO:52（H7）的第三分子。
  16. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 第一IgG1 Fc區，連接至； b) 第一連接子（L1），連接至； c) IL15受體α（IL15Ra）結構域，連接至； d) 第二連接子（L2），連接至； e) IL15結構域； f) 含有蛋白酶可活化部分的第三連接子（L3），連接至； g) 介白素2受體β（IL2Rb）結構域； 作為第一分子和第二分子，包含第二IgG1 Fc區，其中該一價異源二聚體IL15構建體包含： (i)    示於SEQ ID NO:109（MK142）的第一分子和示於SEQ ID NO:52（MH7）的第二分子； (ii)   示於SEQ ID NO:173（MK156）的第一分子和示於SEQ ID NO:75（MH8）的第二分子；或 (iii)  示於SEQ ID NO:174（MK165）的第一分子和示於SEQ ID NO:75（MH8）的第二分子。
  17. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 作為第一分子的IL15受體α（IL15Ra）結構域，經由二硫鍵連接至； b) IL15結構域，連接至； c) 含有蛋白酶可活化部分的第一連接子（L1），連接至； d) 介白素2受體β（IL2Rb）結構域，連接至； e) 第二連接子（L2），連接至 f) 第一IgG1 Fc區， 以及第二分子，包含第二IgG1 Fc區，其中該一價異源二聚體IL15構建體包含：示於SEQ ID NO:110（MK147）的第一分子、和示於SEQ ID NO:111（MK148）的第二分子、和示於SEQ ID NO:52（MH7）的第三分子。
  18. 如請求項1所述的介白素15構建體，其中該構建體包含一價異源二聚體介白素15（IL15）構建體，該構建體從N-末端至C-末端包含： a) 具有第一IgG1 Fc區的腫瘤相關抗原（TAA）結合抗體，連接至； b) 第一連接子（L1），連接至； c) IL15受體α（IL15Ra）結構域，連接至； d) 第二連接子（L2），連接至； e) IL15結構域，連接至； f) 含有蛋白酶可活化部分的第三連接子（L3），連接至； g) 介白素2受體β（IL2Rb）結構域；和 其中該一價異源二聚體IL15構建體包含示於SEQ ID NO:175（MK14）的序列、示於SEQ ID NO:102（MH2）的序列和示於SEQ ID NO:100（MH333LC）的序列。
  19. 一種藥物組成物，該藥物組成物包含與至少一種另外的介白素15構建體組合的如請求項1至18中任一項所述的介白素15構建體。
  20. 一種治療癌症的方法，該方法包括向有需要的患者施用有效量的如請求項1至16中任一項所述的介白素15構建體。
  21. 如請求項20所述的方法，其中該癌症是胃癌、大腸癌、胰臟癌、乳癌、頭頸癌、腎癌、肝癌、小細胞肺癌、非小細胞肺癌、卵巢癌、皮膚癌、間皮瘤、淋巴瘤、白血病、骨髓瘤和肉瘤。
  22. 如請求項20所述的方法，其中將該介白素15構建體與另一種治療劑組合施用。
  23. 如請求項22所述的方法，其中該治療劑為免疫檢查點劑。
  24. 如請求項23所述的方法，其中該免疫檢查點劑為PD-1、PD-L1、PD-L2、TIM3、LAG-3、OX40或TIGIT抗體。
  25. 一種增加免疫細胞的存活的方法，該方法包括在向患者施用有效量的免疫細胞之前、期間或之後施用如請求項1至18中任一項所述的介白素15構建體。
  26. 如請求項25所述的方法，其中該免疫細胞表現嵌合抗原受體（CAR）。
  27. 如請求項26所述的方法，其中該免疫細胞是NK細胞。
  28. 如請求項26所述的方法，其中該免疫細胞是T細胞。
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