TW202221118A - 複製壓力路徑劑組合物及治療癌症之方法 - Google Patents

複製壓力路徑劑組合物及治療癌症之方法 Download PDF

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TW202221118A
TW202221118A TW110129785A TW110129785A TW202221118A TW 202221118 A TW202221118 A TW 202221118A TW 110129785 A TW110129785 A TW 110129785A TW 110129785 A TW110129785 A TW 110129785A TW 202221118 A TW202221118 A TW 202221118A
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Taiwan
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ecdna
tumor
cells
cancer
treatment
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TW110129785A
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Chinese (zh)
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克里斯汀 哈西格
雷恩 漢森
斯內紮娜 米盧蒂諾維奇
傑森 克斯坦森
扎卡里 賀比
蘇希爾 喬德利
安東尼 賽勒斯提
克里斯頓 透納
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美商無界生物公司
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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TW110129785A 2020-08-12 2021-08-12 複製壓力路徑劑組合物及治療癌症之方法 TW202221118A (zh)

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US202063064555P 2020-08-12 2020-08-12
US63/064,555 2020-08-12
US202163168120P 2021-03-30 2021-03-30
US63/168,120 2021-03-30

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CN (1) CN116368243A (enExample)
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BR112023002453A2 (pt) 2020-08-12 2023-05-02 Boundless Bio Inc Composições de agente de via de estresse de replicação e métodos para tratar câncer
EP4278185A1 (en) * 2021-01-18 2023-11-22 GBG Forschungs GmbH Method for predicting the response to cdk4/6 inhibitor therapy in cancer patients
EP4347582A4 (en) 2021-05-27 2025-05-07 Boundless Bio, Inc. CHECKPOINT KINASE-1 INHIBITORS AND USES THEREOF
CN114835640B (zh) * 2022-05-24 2024-02-13 中国药科大学 成纤维细胞生长因子受体抑制剂、制备方法及应用
EP4587026A1 (en) * 2022-09-15 2025-07-23 Recurium IP Holdings, LLC Combinations
CN116083576B (zh) * 2022-12-07 2024-01-30 上海市临床检验中心 一种基于CRISPR/Cas12a的KRAS热点基因突变检测系统和方法
CN116445411A (zh) * 2023-02-01 2023-07-18 复旦大学附属华山医院 一种小鼠结肠癌索托拉西布耐药细胞株及制备方法与应用
EP4770642A2 (en) * 2023-09-01 2026-07-08 Boundless Bio, Inc. Ribonucleotide reductase (rnr) compositions and methods of use
WO2025184572A1 (en) * 2024-03-01 2025-09-04 Zeno Management, Inc. Wee1 inhibitor combination therapy

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JPS567007A (en) 1979-06-29 1981-01-24 Toshiba Corp Coating film thickness measuring apparatus
WO2018136837A1 (en) * 2017-01-20 2018-07-26 The Jackson Laboratory A method of targeting patient-specific oncogenes in extrachromosomal dna to treat glioblastoma
MX2019012176A (es) * 2017-04-10 2020-02-19 Sierra Oncology Inc Metodos de combinacion de chk1(sra737)/parpi para inhibir el crecimiento tumoral.
US11193164B2 (en) * 2017-05-24 2021-12-07 The Regents Of The University Of California Methods of diagnosing and treating cancer targeting extrachromosomal DNA
AU2018278336A1 (en) * 2017-06-01 2020-01-16 Crt Pioneer Fund Lp Biomarkers and patient selection strategies
US20210047693A1 (en) * 2017-11-15 2021-02-18 The Regents Of The University Of California Methods of treating extrachromosomal dna expressing cancers
JP2021514979A (ja) * 2018-02-26 2021-06-17 シエラ オンコロジー， インコーポレイテッド Ｃｈｋ１阻害剤を含む癌の治療方法
WO2020123530A1 (en) * 2018-12-10 2020-06-18 The Regents Of The University Of California Compositions and methods for modulating transcriptional activity of amplified oncogenes contained on extrachromosomal dna
EP3966323A4 (en) * 2019-05-06 2024-04-24 The Regents Of The University Of Michigan Targeted therapy
BR112023002453A2 (pt) 2020-08-12 2023-05-02 Boundless Bio Inc Composições de agente de via de estresse de replicação e métodos para tratar câncer
EP4347582A4 (en) 2021-05-27 2025-05-07 Boundless Bio, Inc. CHECKPOINT KINASE-1 INHIBITORS AND USES THEREOF
KR20240101555A (ko) 2021-09-17 2024-07-02 바운드리스 바이오, 인크. 사이클릭 설폰아미드 리보뉴클레오타이드 환원효소(rnr) 억제제 및 이의 용도
EP4402134A4 (en) 2021-09-17 2025-10-15 Boundless Bio Inc SULFONAMIDE RIBONUCLEOTIDE REDUCTASE (RNR) INHIBITORS AND THEIR USES
US20230272485A1 (en) 2022-02-16 2023-08-31 Boundless Bio, Inc. Replication stress pathway agent compositions and methods for treating cancer

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CA3187760A1 (en) 2022-02-17
CN116368243A (zh) 2023-06-30
BR112023002453A2 (pt) 2023-05-02
WO2022035970A1 (en) 2022-02-17
US11547711B2 (en) 2023-01-10
US20230248728A1 (en) 2023-08-10
EP4196614A4 (en) 2024-12-18
MX2023001717A (es) 2023-04-13
US11642345B2 (en) 2023-05-09
US12246017B2 (en) 2025-03-11
EP4196614A1 (en) 2023-06-21
AU2021325905A1 (en) 2023-04-13
US20230078903A1 (en) 2023-03-16
JP2023537600A (ja) 2023-09-04
KR20230098134A (ko) 2023-07-03

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