BR112023002453A2 - Composições de agente de via de estresse de replicação e métodos para tratar câncer - Google Patents
Composições de agente de via de estresse de replicação e métodos para tratar câncerInfo
- Publication number
- BR112023002453A2 BR112023002453A2 BR112023002453A BR112023002453A BR112023002453A2 BR 112023002453 A2 BR112023002453 A2 BR 112023002453A2 BR 112023002453 A BR112023002453 A BR 112023002453A BR 112023002453 A BR112023002453 A BR 112023002453A BR 112023002453 A2 BR112023002453 A2 BR 112023002453A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- replication stress
- stress pathway
- agent compositions
- treat cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
COMPOSIÇÕES DE AGENTE DE VIA DE ESTRESSE DE REPLICAÇÃO E MÉTODOS PARA TRATAR CÂNCER. São providos aqui métodos de tratar câncer em um indivíduo, em que o câncer é positivo para DNA extracromossômico (ecDNA-positivo) ou terapeuticamente resistente, o método compreendendo administrar ao indivíduo uma quantidade terapeuticamente eficaz de um agente da via de estresse de replicação (RS) sozinho ou em combinação com uma terapêutica direcionada.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063064555P | 2020-08-12 | 2020-08-12 | |
US202163168120P | 2021-03-30 | 2021-03-30 | |
PCT/US2021/045556 WO2022035970A1 (en) | 2020-08-12 | 2021-08-11 | Replication stress pathway agent compositions and methods for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023002453A2 true BR112023002453A2 (pt) | 2023-05-02 |
Family
ID=80247345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023002453A BR112023002453A2 (pt) | 2020-08-12 | 2021-08-11 | Composições de agente de via de estresse de replicação e métodos para tratar câncer |
Country Status (11)
Country | Link |
---|---|
US (3) | US11547711B2 (pt) |
EP (1) | EP4196614A1 (pt) |
JP (1) | JP2023537600A (pt) |
KR (1) | KR20230098134A (pt) |
CN (1) | CN116368243A (pt) |
AU (1) | AU2021325905A1 (pt) |
BR (1) | BR112023002453A2 (pt) |
CA (1) | CA3187760A1 (pt) |
MX (1) | MX2023001717A (pt) |
TW (1) | TW202221118A (pt) |
WO (1) | WO2022035970A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116368243A (zh) | 2020-08-12 | 2023-06-30 | 无界生物公司 | 复制应激通路剂组合物和用于治疗癌症的方法 |
KR20240021188A (ko) | 2021-05-27 | 2024-02-16 | 바운드리스 바이오, 인크. | 체크포인트 키나제 1(chk1) 억제제 및 그의 용도 |
CN114835640B (zh) * | 2022-05-24 | 2024-02-13 | 中国药科大学 | 成纤维细胞生长因子受体抑制剂、制备方法及应用 |
WO2024059696A1 (en) * | 2022-09-15 | 2024-03-21 | Recurium Ip Holdings, Llc | Combinations |
CN116083576B (zh) * | 2022-12-07 | 2024-01-30 | 上海市临床检验中心 | 一种基于CRISPR/Cas12a的KRAS热点基因突变检测系统和方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS567007A (en) | 1979-06-29 | 1981-01-24 | Toshiba Corp | Coating film thickness measuring apparatus |
WO2018136837A1 (en) * | 2017-01-20 | 2018-07-26 | The Jackson Laboratory | A method of targeting patient-specific oncogenes in extrachromosomal dna to treat glioblastoma |
US11193164B2 (en) * | 2017-05-24 | 2021-12-07 | The Regents Of The University Of California | Methods of diagnosing and treating cancer targeting extrachromosomal DNA |
EP3709981A4 (en) * | 2017-11-15 | 2021-08-11 | The Regents of the University of California | METHOD OF TREATMENT OF EXTRACHROMOSOMAL DNA EXPRESSING CANCER |
CN112469391A (zh) * | 2018-02-26 | 2021-03-09 | 塞拉肿瘤学公司 | 包括chk1抑制剂的癌症的治疗方法 |
US20220010307A1 (en) * | 2018-12-10 | 2022-01-13 | The Regents Of The University Of California | Compositions and methods for modulating transcriptional activity of amplified oncogenes contained on extrachromosomal dna |
WO2020227255A1 (en) * | 2019-05-06 | 2020-11-12 | The Regents Of The University Of Michigan | Targeted therapy |
CN116368243A (zh) | 2020-08-12 | 2023-06-30 | 无界生物公司 | 复制应激通路剂组合物和用于治疗癌症的方法 |
-
2021
- 2021-08-11 CN CN202180069281.4A patent/CN116368243A/zh active Pending
- 2021-08-11 JP JP2023510340A patent/JP2023537600A/ja active Pending
- 2021-08-11 WO PCT/US2021/045556 patent/WO2022035970A1/en unknown
- 2021-08-11 AU AU2021325905A patent/AU2021325905A1/en active Pending
- 2021-08-11 KR KR1020237008613A patent/KR20230098134A/ko unknown
- 2021-08-11 BR BR112023002453A patent/BR112023002453A2/pt unknown
- 2021-08-11 MX MX2023001717A patent/MX2023001717A/es unknown
- 2021-08-11 EP EP21856647.9A patent/EP4196614A1/en active Pending
- 2021-08-11 CA CA3187760A patent/CA3187760A1/en active Pending
- 2021-08-12 TW TW110129785A patent/TW202221118A/zh unknown
-
2022
- 2022-01-04 US US17/568,434 patent/US11547711B2/en active Active
- 2022-10-21 US US18/048,573 patent/US11642345B2/en active Active
-
2023
- 2023-03-24 US US18/189,453 patent/US20230248728A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2022035970A1 (en) | 2022-02-17 |
US20220143022A1 (en) | 2022-05-12 |
AU2021325905A1 (en) | 2023-04-13 |
MX2023001717A (es) | 2023-04-13 |
KR20230098134A (ko) | 2023-07-03 |
US20230248728A1 (en) | 2023-08-10 |
US20230078903A1 (en) | 2023-03-16 |
CN116368243A (zh) | 2023-06-30 |
JP2023537600A (ja) | 2023-09-04 |
EP4196614A1 (en) | 2023-06-21 |
US11547711B2 (en) | 2023-01-10 |
CA3187760A1 (en) | 2022-02-17 |
US11642345B2 (en) | 2023-05-09 |
TW202221118A (zh) | 2022-06-01 |
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