TW202142555A - 冠狀病毒疫苗配製品 - Google Patents

冠狀病毒疫苗配製品 Download PDF

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Publication number
TW202142555A
TW202142555A TW110103013A TW110103013A TW202142555A TW 202142555 A TW202142555 A TW 202142555A TW 110103013 A TW110103013 A TW 110103013A TW 110103013 A TW110103013 A TW 110103013A TW 202142555 A TW202142555 A TW 202142555A
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Taiwan
Prior art keywords
cov
seq
fraction
amino acids
glycoprotein
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TW110103013A
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English (en)
Chinese (zh)
Inventor
蓋爾 史密斯
麥克 Ｊ 馬薩爾
景輝 田
Original Assignee
美商諾瓦瓦克斯股份有限公司
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Priority claimed from US16/997,001 external-priority patent/US10953089B1/en
Application filed by 美商諾瓦瓦克斯股份有限公司 filed Critical 美商諾瓦瓦克斯股份有限公司
Publication of TW202142555A publication Critical patent/TW202142555A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
TW110103013A 2020-01-27 2021-01-27 冠狀病毒疫苗配製品 TW202142555A (zh)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US202062966271P 2020-01-27 2020-01-27
US62/966,271 2020-01-27
US202062976858P 2020-02-14 2020-02-14
US62/976,858 2020-02-14
US202062983180P 2020-02-28 2020-02-28
US62/983,180 2020-02-28
US202063048945P 2020-07-07 2020-07-07
US63/048,945 2020-07-07
US202063051706P 2020-07-14 2020-07-14
US63/051,706 2020-07-14
US202063054182P 2020-07-20 2020-07-20
US63/054,182 2020-07-20
US16/997,001 US10953089B1 (en) 2020-01-27 2020-08-19 Coronavirus vaccine formulations
US16/997,001 2020-08-19
US202063129392P 2020-12-22 2020-12-22
US63/129,392 2020-12-22

Publications (1)

Publication Number Publication Date
TW202142555A true TW202142555A (zh) 2021-11-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW110103013A TW202142555A (zh) 2020-01-27 2021-01-27 冠狀病毒疫苗配製品

Country Status (13)

Country Link
US (1) US12691171B2 (enExample)
EP (1) EP4097123A4 (enExample)
JP (2) JP7792339B2 (enExample)
CN (1) CN115720581A (enExample)
AU (1) AU2021214064A1 (enExample)
BR (1) BR112022014830A2 (enExample)
CA (1) CA3165371A1 (enExample)
GB (1) GB2610070A (enExample)
IL (1) IL295142A (enExample)
MX (1) MX2022009167A (enExample)
TW (1) TW202142555A (enExample)
WO (1) WO2021154812A1 (enExample)
ZA (1) ZA202401922B (enExample)

Cited By (1)

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CN114031675A (zh) * 2022-01-10 2022-02-11 广州市锐博生物科技有限公司 基于SARS-CoV-2的S蛋白的疫苗和组合物

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CN118490818A (zh) 2020-04-22 2024-08-16 生物技术欧洲股份公司 冠状病毒疫苗
WO2021249116A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Coronavirus vaccine compositions, methods, and uses thereof
WO2021249011A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Hiv vaccine compositions, methods, and uses thereof
WO2022041760A1 (en) 2020-08-31 2022-03-03 Sichuan Clover Biopharmaceuticals, Inc. Methods and compositions for purification of trimeric fusion proteins
JP2024516309A (ja) * 2021-05-05 2024-04-12 ノババックス，インコーポレイテッド コロナウイルス組成物及びインフルエンザ組成物ならびにそれらの使用方法
CN113773372B (zh) * 2021-08-15 2024-08-02 北京科兴中维生物技术有限公司 重组蛋白及其制备方法和应用
WO2023025287A1 (zh) * 2021-08-26 2023-03-02 江苏瑞科生物技术股份有限公司 新型冠状病毒免疫原性物质、其制备方法和应用
CN116808189A (zh) * 2021-10-22 2023-09-29 江苏瑞科生物技术股份有限公司 一种含有佐剂的新型冠状病毒免疫组合物及其应用
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114031675A (zh) * 2022-01-10 2022-02-11 广州市锐博生物科技有限公司 基于SARS-CoV-2的S蛋白的疫苗和组合物

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MX2022009167A (es) 2022-08-17
CN115720581A (zh) 2023-02-28
ZA202401922B (en) 2025-04-30
EP4097123A1 (en) 2022-12-07
EP4097123A4 (en) 2024-02-14
JP7792339B2 (ja) 2025-12-25
IL295142A (en) 2022-09-01
WO2021154812A8 (en) 2022-02-24
JP2023512648A (ja) 2023-03-28
KR20220141302A (ko) 2022-10-19
US20230070886A1 (en) 2023-03-09
WO2021154812A1 (en) 2021-08-05
US12691171B2 (en) 2026-07-28
AU2021214064A1 (en) 2022-08-18
GB202212336D0 (en) 2022-10-12
CA3165371A1 (en) 2021-08-05
GB2610070A (en) 2023-02-22
BR112022014830A2 (pt) 2022-09-27
JP2026026092A (ja) 2026-02-16

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