TW202117015A - 使DUX4 pre-mRNA之剪接變化之反義寡核苷酸 - Google Patents

使DUX4 pre-mRNA之剪接變化之反義寡核苷酸 Download PDF

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TW202117015A
TW202117015A TW109123473A TW109123473A TW202117015A TW 202117015 A TW202117015 A TW 202117015A TW 109123473 A TW109123473 A TW 109123473A TW 109123473 A TW109123473 A TW 109123473A TW 202117015 A TW202117015 A TW 202117015A
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Taiwan
Prior art keywords
dux4
oligonucleotide
pharmaceutically acceptable
acceptable salt
sequence
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TW109123473A
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English (en)
Chinese (zh)
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小泉誠
中村晃史
片桐隆廣
三橋弘明
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日商第一三共股份有限公司
學校法人 東海大學
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Publication of TW202117015A publication Critical patent/TW202117015A/zh

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TW109123473A 2019-07-12 2020-07-10 使DUX4 pre-mRNA之剪接變化之反義寡核苷酸 TW202117015A (zh)

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JP2019-129735 2019-07-12
JP2019129735 2019-07-12

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TW202117015A true TW202117015A (zh) 2021-05-01

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US (1) US20220364086A1 (https=)
EP (1) EP3998108A4 (https=)
JP (1) JP7627495B2 (https=)
KR (1) KR20220032004A (https=)
CN (1) CN114026234A (https=)
AU (1) AU2020313255A1 (https=)
BR (1) BR112021024764A2 (https=)
CA (1) CA3142925A1 (https=)
IL (1) IL288596A (https=)
TW (1) TW202117015A (https=)
WO (1) WO2021010301A1 (https=)

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Publication number Priority date Publication date Assignee Title
KR20230023612A (ko) 2020-04-02 2023-02-17 마이레큘, 인크. 조작된 올리고뉴클레오티드를 사용한 표적화된 억제

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0787982A (ja) 1993-01-29 1995-04-04 Sankyo Co Ltd 修飾オリゴデオキシリボヌクレオチド
US6096881A (en) 1997-05-30 2000-08-01 Hybridon, Inc. Sulfur transfer reagents for oligonucleotide synthesis
JP4236812B2 (ja) 1997-09-12 2009-03-11 エクシコン エ／エス オリゴヌクレオチド類似体
ES2234563T5 (es) 1999-02-12 2018-01-17 Daiichi Sankyo Company, Limited Nuevos análogos de nucleósidos y oligonucleótidos
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
ES2596977T3 (es) * 2010-09-02 2017-01-13 Université de Mons Agentes útiles en el tratamiento de la distrofia muscular facioescapulohumeral
EP2736539B1 (en) * 2011-07-25 2017-08-23 Nationwide Children's Hospital, Inc. Recombinant virus products and methods for inhibition of expression of dux4
WO2013120038A2 (en) * 2012-02-10 2013-08-15 Regents Of The University Of Minnesota Morpholino targeting dux4 for treating fshd
WO2014109384A1 (ja) 2013-01-10 2014-07-17 塩野義製薬株式会社 架橋型核酸誘導体の製造方法
US20180237775A1 (en) * 2015-09-21 2018-08-23 Association Institut De Myologie Antisense oligonucleotides and uses thereof
JP6966463B2 (ja) * 2016-02-26 2021-11-17 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル 組換えウイルス産物及びｄｕｘ４エクソンスキッピングを誘導するための方法
CN109462995A (zh) 2016-05-04 2019-03-12 波涛生命科学有限公司 生物活性剂的方法和组合物
WO2019060432A2 (en) * 2017-09-19 2019-03-28 Children's National Medical Center GAPMERS AND METHODS OF USING THE SAME FOR THE TREATMENT OF MUSCLE DYSTROPHY
JP2019129735A (ja) 2018-01-30 2019-08-08 株式会社ＧＩＳｕｐｐｌｙ 有害動物の捕獲支援システム

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CN114026234A (zh) 2022-02-08
JP7627495B2 (ja) 2025-02-06
JPWO2021010301A1 (https=) 2021-01-21
BR112021024764A2 (pt) 2022-04-19
WO2021010301A1 (ja) 2021-01-21
IL288596A (en) 2022-02-01
KR20220032004A (ko) 2022-03-15
AU2020313255A1 (en) 2022-01-06
US20220364086A1 (en) 2022-11-17
EP3998108A4 (en) 2024-10-30
EP3998108A1 (en) 2022-05-18
CA3142925A1 (en) 2021-01-21

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