TW202110425A - 抗Aβ疫苗治療 - Google Patents

抗Aβ疫苗治療 Download PDF

Info

Publication number
TW202110425A
TW202110425A TW109116790A TW109116790A TW202110425A TW 202110425 A TW202110425 A TW 202110425A TW 109116790 A TW109116790 A TW 109116790A TW 109116790 A TW109116790 A TW 109116790A TW 202110425 A TW202110425 A TW 202110425A
Authority
TW
Taiwan
Prior art keywords
vaccine composition
liposome vaccine
disease
amyloid
liposome
Prior art date
Application number
TW109116790A
Other languages
English (en)
Chinese (zh)
Inventor
安德烈亞 普法伊費爾
安德里亞斯 穆斯
Original Assignee
瑞士商Ac 免疫有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 瑞士商Ac 免疫有限公司 filed Critical 瑞士商Ac 免疫有限公司
Publication of TW202110425A publication Critical patent/TW202110425A/zh

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0007Nervous system antigens; Prions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018Lipids, e.g. in lipopeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW109116790A 2019-05-21 2020-05-20 抗Aβ疫苗治療 TW202110425A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP19175810.1 2019-05-21
EP19175810 2019-05-21
EP19185593.1 2019-07-10
EP19185593 2019-07-10
EP20171549 2020-04-27
EP20171549.7 2020-04-27
EP20172205 2020-04-29
EP20172205.5 2020-04-29

Publications (1)

Publication Number Publication Date
TW202110425A true TW202110425A (zh) 2021-03-16

Family

ID=70740677

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109116790A TW202110425A (zh) 2019-05-21 2020-05-20 抗Aβ疫苗治療

Country Status (15)

Country Link
US (1) US20220226447A1 (enExample)
EP (1) EP3972633A1 (enExample)
JP (1) JP7701734B2 (enExample)
KR (1) KR20220010552A (enExample)
CN (1) CN113853214A (enExample)
AU (1) AU2020277682A1 (enExample)
BR (1) BR112021023209A2 (enExample)
CA (1) CA3138145A1 (enExample)
CL (1) CL2021003051A1 (enExample)
IL (1) IL288252A (enExample)
MX (1) MX2021014102A (enExample)
MY (1) MY210394A (enExample)
SG (1) SG11202112329RA (enExample)
TW (1) TW202110425A (enExample)
WO (1) WO2020234405A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021260193A1 (en) * 2020-06-25 2021-12-30 Medimmune Limited Prevention of axonal damage using antibody binding to amyloid beta 1-42
KR20250137159A (ko) * 2023-01-26 2025-09-17 에이씨 이뮨 에스에이 항-a베타 백신 요법
WO2025109524A1 (en) * 2023-11-22 2025-05-30 Ac Immune Sa Assays and methods for assessing vaccine preparations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
KR101152557B1 (ko) * 2005-12-12 2012-09-07 에이씨 이뮨 에스.에이. 치료 백신
HUE055739T2 (hu) * 2009-03-18 2021-12-28 Ac Immune Sa Eljárás terápiás alkalmazásra
WO2012020124A1 (en) 2010-08-12 2012-02-16 Ac Immune S.A. Vaccine engineering
JP6027011B2 (ja) 2010-10-26 2016-11-16 エーシー イミューン ソシエテ アノニム 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物
CA2811188C (en) * 2011-09-23 2020-04-28 Andrea Pfeifer Vaccine therapy
AU2019253193B2 (en) 2018-04-10 2026-02-05 Ac Immune Sa Anti-abeta therapeutic vaccines

Also Published As

Publication number Publication date
WO2020234405A1 (en) 2020-11-26
CA3138145A1 (en) 2020-11-26
EP3972633A1 (en) 2022-03-30
JP7701734B2 (ja) 2025-07-02
JP2022533422A (ja) 2022-07-22
CL2021003051A1 (es) 2022-07-22
AU2020277682A1 (en) 2021-12-23
KR20220010552A (ko) 2022-01-25
SG11202112329RA (en) 2021-12-30
BR112021023209A2 (pt) 2022-01-18
MX2021014102A (es) 2022-02-11
CN113853214A (zh) 2021-12-28
US20220226447A1 (en) 2022-07-21
MY210394A (en) 2025-09-18
IL288252A (en) 2022-01-01

Similar Documents

Publication Publication Date Title
Monsonego et al. Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease
Zhang et al. Curcuminoids enhance amyloid-β uptake by macrophages of Alzheimer's disease patients
JP5889529B2 (ja) アミロイド原性疾患の処置
US12324855B2 (en) Method of safe administration of phosphorylated Tau peptide vaccine
CN106668852B (zh) 一种治疗和/或预防ⅰ型糖尿病的组合物及其应用
JP7701734B2 (ja) 抗aベータワクチン療法
JP3420245B2 (ja) ペプチドp277類似体及びこれを含む糖尿病の治療又は診断のための薬剤組成物
AU2021200093B2 (en) Treatment and prevention of alzheimer's disease (ad)
US20080248055A1 (en) Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes
Abicic et al. New-onset ocular myasthenia gravis after booster dose of COVID-19 vaccine
WO2015165980A2 (en) Treatment and prevention of alzheimer's disease (ad)
HK40058406A (en) Anti-abeta vaccine therapy
EA049756B1 (ru) Терапия с помощью вакцины против бета-амилоида
KR102388363B1 (ko) 알츠하이머병(ad)의 치료 및 예방
US20080226668A1 (en) Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes
US8871226B2 (en) Methods and compositions for the treatment and diagnosis of cancer
CN120583959A (zh) 抗Aβ疫苗治疗
US20050250691A1 (en) Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes
Pereira et al. Kinetics and dynamic evaluation of specific immunotherapy
CN118613496A (zh) 安全施用Tau磷酸肽缀合物的方法
Ferrucci et al. P1‐274: EEG and cognitive effects of transcranial direct current stimulation (tDCS) in patients with Alzheimer's disease