TW202102233A - 用於hiv治療之化合物 - Google Patents

用於hiv治療之化合物 Download PDF

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Publication number
TW202102233A
TW202102233A TW109107136A TW109107136A TW202102233A TW 202102233 A TW202102233 A TW 202102233A TW 109107136 A TW109107136 A TW 109107136A TW 109107136 A TW109107136 A TW 109107136A TW 202102233 A TW202102233 A TW 202102233A
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TW
Taiwan
Prior art keywords
fluoro
purin
acid
ethynyl
amino
Prior art date
Application number
TW109107136A
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English (en)
Chinese (zh)
Inventor
拉 羅莎 馬薩 艾利西亞 德
約翰 Ｆ 米勒
大衛 提米爾庫夫
埃米爾 约翰 斐堤森
Ｂ 納拉席姆胡魯 奈都
維森特 薩瑪諾
Original Assignee
英商葛蘭素史密斯克藍智慧財產權有限公司
美商 Ｖｉｉｖ 醫療保健公司
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=69845479&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW202102233(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 英商葛蘭素史密斯克藍智慧財產權有限公司, 美商 Ｖｉｉｖ 醫療保健公司 filed Critical 英商葛蘭素史密斯克藍智慧財產權有限公司
Publication of TW202102233A publication Critical patent/TW202102233A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
TW109107136A 2019-03-06 2020-03-04 用於hiv治療之化合物 TW202102233A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962814316P 2019-03-06 2019-03-06
US62/814,316 2019-03-06

Publications (1)

Publication Number Publication Date
TW202102233A true TW202102233A (zh) 2021-01-16

Family

ID=69845479

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109107136A TW202102233A (zh) 2019-03-06 2020-03-04 用於hiv治療之化合物

Country Status (22)

Country Link
US (4) US12240853B2 (https=)
EP (1) EP3934760A1 (https=)
JP (1) JP2022525013A (https=)
KR (1) KR20210136052A (https=)
CN (1) CN113811360A (https=)
AR (1) AR118240A1 (https=)
AU (1) AU2020231934B2 (https=)
BR (1) BR112021017604A2 (https=)
CA (1) CA3132112A1 (https=)
CL (1) CL2021002309A1 (https=)
CO (1) CO2021012579A2 (https=)
CR (1) CR20210460A (https=)
EA (1) EA202192433A1 (https=)
IL (1) IL285894A (https=)
MA (1) MA55200A (https=)
MX (1) MX2021010700A (https=)
PE (1) PE20212089A1 (https=)
PH (1) PH12021500034A1 (https=)
SG (1) SG11202109253SA (https=)
TW (1) TW202102233A (https=)
WO (1) WO2020178767A1 (https=)
ZA (1) ZA202106096B (https=)

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JP7703538B2 (ja) * 2019-12-09 2025-07-07 ヴィーブ、ヘルスケア、カンパニー カボテグラビルを含んでなる医薬組成物
WO2021188959A1 (en) * 2020-03-20 2021-09-23 Gilead Sciences, Inc. Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
KR102918401B1 (ko) * 2020-12-30 2026-01-26 서던 유니버시티 오브 사이언스 앤드 테크놀로지 코로나 바이러스 감염을 치료하기 위한 방법 및 변형된 뉴클레오사이드
EP4281081A4 (en) * 2021-01-25 2025-05-14 Brii Biosciences, Inc. ADENOSINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
EP4281083A4 (en) * 2021-01-25 2025-01-01 Brii Biosciences, Inc. COMBINATION THERAPY FOR HIV WITH ADENOSINE DERIVATIVE AND CAPSID INHIBITORS
WO2022182604A1 (en) * 2021-02-23 2022-09-01 Viiv Healthcare Company Compounds useful in hiv treatment
CR20250310A (es) * 2023-01-30 2025-08-25 Merck Sharp & Dohme Llc Profármacos de inhibidores de la transcriptasa inversa de nucleósidos sustituidos en 4'
AU2024353051A1 (en) 2023-09-27 2026-03-12 ViiV Healthcare UK (No.3) Limited Pharmaceutical compositions
AU2023466962A1 (en) 2023-09-27 2026-03-12 ViiV Healthcare UK (No.3) Limited Pharmaceutical composition of cabotegravir

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Publication number Publication date
AU2020231934B2 (en) 2023-04-20
US20220411425A1 (en) 2022-12-29
PE20212089A1 (es) 2021-11-04
EA202192433A1 (ru) 2021-12-28
JP2022525013A (ja) 2022-05-11
CN113811360A (zh) 2021-12-17
EP3934760A1 (en) 2022-01-12
US20230174534A1 (en) 2023-06-08
US20260035371A1 (en) 2026-02-05
CA3132112A1 (en) 2020-09-10
CL2021002309A1 (es) 2022-09-20
SG11202109253SA (en) 2021-09-29
MX2021010700A (es) 2021-10-01
MA55200A (fr) 2022-01-12
IL285894A (en) 2021-10-31
BR112021017604A2 (pt) 2021-11-16
WO2020178767A1 (en) 2020-09-10
CR20210460A (es) 2022-02-03
AU2020231934A1 (en) 2021-09-23
US20240182473A1 (en) 2024-06-06
KR20210136052A (ko) 2021-11-16
AU2020231934A8 (en) 2022-03-24
AR118240A1 (es) 2021-09-22
PH12021500034A1 (en) 2022-06-06
US12240853B2 (en) 2025-03-04
ZA202106096B (en) 2023-03-29
CO2021012579A2 (es) 2021-10-20

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