TW202045725A - 用於治療核纖層病的組成物及方法 - Google Patents
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
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- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962812021P | 2019-02-28 | 2019-02-28 | |
| US62/812,021 | 2019-02-28 |
Publications (1)
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|---|---|
| TW202045725A true TW202045725A (zh) | 2020-12-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| TW109106729A TW202045725A (zh) | 2019-02-28 | 2020-03-02 | 用於治療核纖層病的組成物及方法 |
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| EP (1) | EP3931336A4 (ru) |
| JP (1) | JP2022522196A (ru) |
| KR (1) | KR20210144696A (ru) |
| CN (1) | CN113840927A (ru) |
| AU (1) | AU2020229382A1 (ru) |
| BR (1) | BR112021016783A2 (ru) |
| CA (1) | CA3131776A1 (ru) |
| CL (1) | CL2021002262A1 (ru) |
| CO (1) | CO2021012310A2 (ru) |
| EA (1) | EA202192376A1 (ru) |
| IL (1) | IL285886A (ru) |
| MA (1) | MA55087A (ru) |
| MX (1) | MX2021010301A (ru) |
| SG (1) | SG11202109362XA (ru) |
| TW (1) | TW202045725A (ru) |
| WO (1) | WO2020176896A1 (ru) |
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| WO2018213786A1 (en) * | 2017-05-19 | 2018-11-22 | Encoded Therapeutics, Inc. | High activity regulatory elements |
| WO2022140402A1 (en) * | 2020-12-23 | 2022-06-30 | University Of Florida Research Foundation, Incorporated | Increased packaging efficiency of vector for cardiac gene therapy |
| GB202100311D0 (en) * | 2021-01-11 | 2021-02-24 | Univ Court Of The Univ Of Aberdeen | Treatment for Lipodystrophy |
| US20220362319A1 (en) * | 2021-05-12 | 2022-11-17 | PPM Labs LLC | Cannabinoid Concentration Process |
| EP4198053A1 (en) * | 2021-12-15 | 2023-06-21 | Universitätsklinikum Hamburg-Eppendorf | Lmna gene expression for treatment of laminopathies |
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|---|---|---|---|---|
| ATE547536T1 (de) * | 2002-10-18 | 2012-03-15 | Us Gov Health & Human Serv | Lmna-gen und seine beteiligung an progeria hutchinson-gilford (hgps) und arteriosklerose |
| US7838531B2 (en) * | 2002-10-18 | 2010-11-23 | The United States Of America As Represented By The Department Of Health And Human Services | Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis |
| US8258109B2 (en) * | 2005-10-20 | 2012-09-04 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulation of LMNA expression |
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2020
- 2020-02-28 EP EP20762666.4A patent/EP3931336A4/en not_active Withdrawn
- 2020-02-28 SG SG11202109362XA patent/SG11202109362XA/en unknown
- 2020-02-28 KR KR1020217029735A patent/KR20210144696A/ko unknown
- 2020-02-28 CN CN202080031386.6A patent/CN113840927A/zh active Pending
- 2020-02-28 AU AU2020229382A patent/AU2020229382A1/en not_active Abandoned
- 2020-02-28 BR BR112021016783A patent/BR112021016783A2/pt not_active Application Discontinuation
- 2020-02-28 US US17/433,927 patent/US20220193264A1/en active Pending
- 2020-02-28 MA MA055087A patent/MA55087A/fr unknown
- 2020-02-28 JP JP2021550184A patent/JP2022522196A/ja active Pending
- 2020-02-28 EA EA202192376A patent/EA202192376A1/ru unknown
- 2020-02-28 MX MX2021010301A patent/MX2021010301A/es unknown
- 2020-02-28 WO PCT/US2020/020520 patent/WO2020176896A1/en active Application Filing
- 2020-02-28 CA CA3131776A patent/CA3131776A1/en active Pending
- 2020-03-02 TW TW109106729A patent/TW202045725A/zh unknown
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2021
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- 2021-08-27 CL CL2021002262A patent/CL2021002262A1/es unknown
- 2021-09-21 CO CONC2021/0012310A patent/CO2021012310A2/es unknown
Also Published As
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| KR20210144696A (ko) | 2021-11-30 |
| BR112021016783A2 (pt) | 2021-11-09 |
| CN113840927A (zh) | 2021-12-24 |
| WO2020176896A1 (en) | 2020-09-03 |
| CA3131776A1 (en) | 2020-09-03 |
| JP2022522196A (ja) | 2022-04-14 |
| EA202192376A1 (ru) | 2021-12-27 |
| AU2020229382A1 (en) | 2021-09-16 |
| US20220193264A1 (en) | 2022-06-23 |
| IL285886A (en) | 2021-10-31 |
| SG11202109362XA (en) | 2021-09-29 |
| MX2021010301A (es) | 2021-11-12 |
| EP3931336A4 (en) | 2023-01-04 |
| MA55087A (fr) | 2022-01-05 |
| CO2021012310A2 (es) | 2021-09-30 |
| EP3931336A1 (en) | 2022-01-05 |
| CL2021002262A1 (es) | 2022-05-27 |
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